Cytochrome P-450 CYP2C19 Inhibitors (weak)

Accession Number

DBCAT003040

Description

Not Available

Drugs

Drug	Drug Description
Manidipine	A dihydropyridine calcium channel blocker used to treat hypertension.
Artenimol	For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with DB13941.
Lopinavir	An HIV-1 protease inhibitor used in combination with ritonavir to treat human immunodeficiency virus (HIV) infection.
Omeprazole	A proton pump inhibitor used to treat GERD associated conditions such as heartburn and gastric acid hypersecretion, and to promote healing of tissue damage and ulcers caused by gastric acid and H. pylori infection.
Voriconazole	A triazole compound used to treat fungal infections.
Esomeprazole	A proton pump inhibitor used to treat GERD, reduce the risk of NSAID associated gastric ulcers, eradicate H. pylori, and to treat conditions causing gastric acid hypersecretion.
Pantoprazole	A proton pump inhibitor used to treat erosive esophagitis, gastric acid hypersecretion, and to promote healing of tissue damage caused by gastric acid.
Rucaparib	A poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults.
Dovitinib	Investigated for use/treatment in multiple myeloma and solid tumors.
Oritavancin	An antibacterial agent used to treat acute bacterial skin and skin structure infections caused by susceptible Gram-positive bacteria.
Zonisamide	A sulfonamide anticonvulsant used to treat partial seizures.
Luliconazole	A topical antifungal agent used to treat fungal infections.
Bortezomib	A proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies.
Nilutamide	An antineoplastic hormone used to treat prostate cancer.
Sitaxentan	Investigated for use/treatment in pulmonary hypertension, connective tissue diseases, hypertension, and congestive heart failure.
Clozapine	An atypical or second-generation antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients.
Ethanol	For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical...
Nilvadipine	A calcium channel blocker used to manage arterial hypertension.
Olanzapine	An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
Tipranavir	A protease inhibitor used to treat HIV-1 resistant to more than 1 protease inhibitor.
Naloxegol	A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
Midostaurin	An antineoplastic agent used to treat high-risk acute myeloid leukemia (AML) with specific mutations, aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematologic neoplasm (SM-AHN), or mast cell leukemia (MCL).
Etoricoxib	A selective COX-2 inhibitor used to relieve moderate post-surgical dental pain as a short-term treatment and inflammatory and painful symptoms of various forms of arthritis.
Sildenafil	A phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
Citalopram	A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression.
Memantine	An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's.
Dexlansoprazole	A proton pump inhibitor used to treat erosive esophagitis, heartburn, and gastroesophageal reflux disease (GERD).
Isoniazid	An antibiotic used to treat mycobacterial infections; most commonly use in combination with other antimycobacterial agents for the treatment of active or latent tuberculosis.
Clinafloxacin	Clinafloxacin is a fluoroquinolone antibacterial currently under research. It has been proven to present good antibiotic properties. However, its approval and release have been halted due to the presence of...
Fenofibrate	A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
Loratadine	A second generation antihistamine used to manage the symptoms of allergic rhinitis.
Aprepitant	A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
Ubrogepant	An oral CGRP antagonist used in the acute treatment of migraine with or without aura.
Amiodarone	A class III antiarrhythmic indicated for the treatment of recurrent hemodynamically unstable ventricular tachycardia and recurrent ventricular fibrillation.
Osilodrostat	An oral inhibitor of cortisol synthesis used to treat Cushing's disease by normalizing hypercortisolism.
Clascoterone	An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older.
Tirbanibulin	A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp.
Valproic acid	An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
Somatotropin	A recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults.
Ethambutol	An antituberculosis agent used in the prophylaxis and treatment of tuberculosis (TB).
Rotigotine	A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome.
Lonapegsomatropin	A human growth hormone indicated in the treatment of growth failure due to inadequate endogenous growth hormone secretion.
Cariprazine	An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
Tecovirimat	An antiviral medication used to treat smallpox, monkeypox, and cowpox.
Pirtobrutinib	A kinase inhibitor used to treat relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy.
Vardenafil	A phosphodiesterase 5 inhibitor used to treat erectile dysfunction.

Drugs & Drug Targets

Drug	Target	Type
Manidipine	Voltage-dependent L-type calcium channel	target
Manidipine	Voltage-dependent T-type calcium channel	target
Manidipine	Cytochrome P450 2C9	enzyme
Manidipine	Cytochrome P450 2D6	enzyme
Manidipine	Cytochrome P450 1A1	enzyme
Manidipine	Cytochrome P450 2B6	enzyme
Manidipine	Cytochrome P450 2C19	enzyme
Manidipine	Cytochrome P450 3A4	enzyme
Manidipine	Voltage-dependent T-type calcium channel subunit alpha-1G	target
Manidipine	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Manidipine	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Manidipine	Voltage-dependent L-type calcium channel subunit alpha-1D	target
Manidipine	Voltage-dependent L-type calcium channel subunit alpha-1C	target
Manidipine	Cruzipain	target
Artenimol	Actin, cytoplasmic 2	target
Artenimol	Alpha-aminoadipic semialdehyde dehydrogenase	target
Artenimol	Annexin A2	target
Artenimol	ATP synthase subunit alpha, mitochondrial	target
Artenimol	ATP synthase subunit g, mitochondrial	target
Artenimol	ATP synthase subunit O, mitochondrial	target
Artenimol	Calpastatin	target
Artenimol	T-complex protein 1 subunit gamma	target
Artenimol	Cofilin-1	target
Artenimol	Chloride intracellular channel protein 1	target
Artenimol	Cysteine and glycine-rich protein 1	target
Artenimol	Dihydropyrimidinase-related protein 2	target
Artenimol	Desmoplakin	target
Artenimol	Elongation factor 1-alpha 1	target
Artenimol	Alpha-enolase	target
Artenimol	Filamin-A	target
Artenimol	Alpha-ketoglutarate-dependent dioxygenase FTO	target
Artenimol	Glucose-6-phosphate 1-dehydrogenase	target
Artenimol	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	target
Artenimol	Glucose-6-phosphate isomerase	target
Artenimol	Heterogeneous nuclear ribonucleoproteins A2/B1	target
Artenimol	Heterogeneous nuclear ribonucleoprotein D0	target
Artenimol	Heterogeneous nuclear ribonucleoprotein K	target
Artenimol	Heterochromatin protein 1-binding protein 3	target
Artenimol	Heat shock protein beta-1	target
Artenimol	Ras GTPase-activating-like protein IQGAP1	target
Artenimol	Far upstream element-binding protein 2	target
Artenimol	L-lactate dehydrogenase A chain	target
Artenimol	L-lactate dehydrogenase B chain	target
Artenimol	Galectin-1	target
Artenimol	Microtubule-associated protein 4	target
Artenimol	Malate dehydrogenase, cytoplasmic	target
Artenimol	Puromycin-sensitive aminopeptidase	target
Artenimol	Profilin-1	target
Artenimol	Phosphoglycerate kinase 1	target
Artenimol	Pyruvate kinase PKM	target
Artenimol	Peptidyl-prolyl cis-trans isomerase A	target
Artenimol	Peroxiredoxin-1	target
Artenimol	Large ribosomal subunit protein uL16	target
Artenimol	Large ribosomal subunit protein eL14	target
Artenimol	Large ribosomal subunit protein eL18	target
Artenimol	Large ribosomal subunit protein uL23	target
Artenimol	Large ribosomal subunit protein uL29	target
Artenimol	Large ribosomal subunit protein uL4	target
Artenimol	Small ribosomal subunit protein uS15	target
Artenimol	Small ribosomal subunit protein eS17	target
Artenimol	Small ribosomal subunit protein uS13	target
Artenimol	Small ribosomal subunit protein eS19	target
Artenimol	Small ribosomal subunit protein eS28	target
Artenimol	Small ribosomal subunit protein uS7	target
Artenimol	Small ribosomal subunit protein eS6	target
Artenimol	Small ribosomal subunit protein eS8	target
Artenimol	Small ribosomal subunit protein uS4	target
Artenimol	Splicing factor 1	target
Artenimol	Splicing factor, proline- and glutamine-rich	target
Artenimol	Small nuclear ribonucleoprotein Sm D2	target
Artenimol	Signal recognition particle 14 kDa protein	target
Artenimol	Serine/arginine-rich splicing factor 4	target
Artenimol	Transgelin	target
Artenimol	Transgelin-2	target
Artenimol	Triosephosphate isomerase	target
Artenimol	Tropomyosin alpha-1 chain	target
Artenimol	Tubulin alpha-1A chain	target
Artenimol	Vimentin	target
Artenimol	Zyxin	target
Artenimol	Heat shock cognate 71 kDa protein	target
Artenimol	Tubulin beta-6 chain	target
Artenimol	Tubulin beta-4A chain	target
Artenimol	Tubulin beta chain	target
Artenimol	Fructose-bisphosphate aldolase A	target
Artenimol	Glyceraldehyde-3-phosphate dehydrogenase	target
Artenimol	Cytochrome c	target
Artenimol	Phosphoglycerate mutase 1	target
Artenimol	Myosin-9	target
Artenimol	Protein disulfide-isomerase	target
Artenimol	Probable ATP-dependent RNA helicase DDX5	target
Artenimol	Serine hydroxymethyltransferase, mitochondrial	target
Artenimol	Spliceosome RNA helicase DDX39B	target
Artenimol	Nucleophosmin	target
Artenimol	Translationally-controlled tumor protein homolog	target
Artenimol	P-type Ca2+-transporting ATPase	target
Artenimol	Ornithine aminotransferase	target
Artenimol	Elongation factor 1-alpha	target
Artenimol	Multidrug resistance protein	target
Artenimol	Elongation factor 2	target
Artenimol	Actin-1	target
Artenimol	Glyceraldehyde-3-phosphate dehydrogenase	target
Artenimol	Fructose-bisphosphate aldolase	target
Artenimol	Cell division cycle protein 48 homologue,putative	target
Artenimol	Heat shock protein 90	target
Artenimol	Eukaryotic initiation factor 4A	target
Artenimol	Pyruvate kinase	target
Artenimol	L-lactate dehydrogenase	target
Artenimol	Protein disulfide-isomerase	target
Artenimol	Thioredoxin-related protein, putative	target
Artenimol	Spermidine synthase	target
Artenimol	Probable ATP-dependent 6-phosphofructokinase	target
Artenimol	Glutamate dehydrogenase	target
Artenimol	Endoplasmin homolog, putative	target
Artenimol	Hypoxanthine-guanine-xanthine phosphoribosyltransferase	target
Artenimol	Enolase	target
Artenimol	40S ribosomal protein S3	target
Artenimol	Non-SERCA-type Ca2+-transporting P-ATPase	target
Artenimol	Tubulin alpha chain	target
Artenimol	Knob-associated histidine-rich protein	target
Artenimol	S-adenosylmethionine synthase	target
Artenimol	V-type H(+)-translocating pyrophosphatase, putative	target
Artenimol	60S ribosomal protein L4	target
Artenimol	Phosphoethanolamine N-methyltransferase	target
Artenimol	40S ribosomal protein S3a	target
Artenimol	Conserved Plasmodium membrane protein	target
Artenimol	60S ribosomal protein L3	target
Artenimol	High molecular weight rhoptry protein 2	target
Artenimol	Serine repeat antigen 5	target
Artenimol	40S ribosomal protein S19	target
Artenimol	Glycophorin-binding protein	target
Artenimol	Calcium-transporting ATPase	target
Artenimol	V-type proton ATPase catalytic subunit A	target
Artenimol	60S ribosomal protein L2	target
Artenimol	Acyl-CoA synthetase	target
Artenimol	Plasmepsin IV	target
Artenimol	Plasmepsin-1	target
Artenimol	Chloroquine resistance transporter	target
Artenimol	14-3-3 protein	target
Artenimol	Isoleucine--tRNA ligase, putative	target
Artenimol	Plasmodium exported protein	target
Artenimol	Tubulin beta chain	target
Artenimol	60S ribosomal protein L27	target
Artenimol	Sec62, putative	target
Artenimol	Autophagy-related protein 18, putative	target
Artenimol	Mature parasite-infected erythrocyte surface antigen	target
Artenimol	Importin-7, putative	target
Artenimol	Importin subunit alpha	target
Artenimol	Peptidyl-prolyl cis-trans isomerase	target
Artenimol	DnaJ protein, putative	target
Artenimol	Merozoite surface protein 1	target
Artenimol	Glutamate--tRNA ligase	target
Artenimol	T-complex protein 1 subunit eta	target
Artenimol	Plasmepsin-2	target
Artenimol	Chaperone, putative	target
Artenimol	Rhoptry neck protein 3	target
Artenimol	40S ribosomal protein S5, putative	target
Artenimol	Skeleton-binding protein 1	target
Artenimol	Purine nucleotide phosphorylase, putative	target
Artenimol	Adenosylhomocysteinase	target
Artenimol	Adenosine deaminase	target
Artenimol	Methionine--tRNA ligase	target
Artenimol	Carbamoyl phosphate synthetase	target
Artenimol	Aspartate carbamoyltransferase	target
Artenimol	Signal recognition particle receptor, beta subunit	target
Artenimol	Parasite-infected erythrocyte surface protein	target
Artenimol	Coatomer alpha subunit, putative	target
Artenimol	Hexokinase	target
Artenimol	Proteasome subunit alpha type	target
Artenimol	Haloacid dehalogenase-like hydrolase	target
Artenimol	Insulinase, putative	target
Artenimol	40S ribosomal protein S21	target
Artenimol	Ubiquitin-conjugating enzyme E2	target
Artenimol	Eukaryotic translation initiation factor 3 subunit C	target
Artenimol	60S ribosomal protein L24, putative	target
Artenimol	60S ribosomal protein L23	target
Artenimol	60S ribosomal protein L17, putative	target
Artenimol	HAP protein	target
Artenimol	Heat shock protein 110, putative	target
Artenimol	60S ribosomal protein L10, putative	target
Artenimol	Lysophospholipase, putative	target
Artenimol	Polyadenylate-binding protein	target
Artenimol	Ubiquitin-60S ribosomal protein L40	target
Artenimol	Phosphoribosylpyrophosphate synthetase	target
Artenimol	Thioredoxin peroxidase 1	target
Artenimol	Protein transport protein SEC31	target
Artenimol	Dipeptidyl aminopeptidase 1	target
Artenimol	Ring-infected erythrocyte surface antigen	target
Artenimol	ATP-dependent RNA helicase UAP56	target
Artenimol	Calcium-dependent protein kinase 4	target
Artenimol	GTP-binding nuclear protein Ran	target
Artenimol	Nucleoside transporter 2	target
Artenimol	Anamorsin homolog	target
Artenimol	Glutamine synthetase, putative	target
Artenimol	60S ribosomal protein L30e, putative	target
Artenimol	Casein kinase 2, alpha subunit	target
Artenimol	Threonine--tRNA ligase	target
Artenimol	cAMP-dependent protein kinase regulatory subunit	target
Artenimol	Elongation factor 1-gamma, putative	target
Artenimol	Thioredoxin-like protein	target
Artenimol	60S ribosomal protein L21	target
Artenimol	60S ribosomal protein L14, putative	target
Artenimol	Inner membrane complex sub-compartment protein 3	target
Artenimol	HSP40, subfamily A, putative	target
Artenimol	Pyridoxal 5'-phosphate synthase subunit Pdx1	target
Artenimol	UDP-glucuronosyltransferase 1A9	enzyme
Artenimol	UDP-glucuronosyltransferase 2B7	enzyme
Artenimol	Albumin	target
Artenimol	Cytochrome P450 2D6	enzyme
Artenimol	Cytochrome P450 2C19	enzyme
Lopinavir	Pol polyprotein	target
Lopinavir	Cytochrome P450 3A4	enzyme
Lopinavir	Cytochrome P450 2D6	enzyme
Lopinavir	Cytochrome P450 2C19	enzyme
Lopinavir	ATP-dependent translocase ABCB1	transporter
Lopinavir	Cytochrome P450 2B6	enzyme
Lopinavir	Cytochrome P450 2C9	enzyme
Lopinavir	Cytochrome P450 3A Subfamily	enzyme
Lopinavir	Solute carrier organic anion transporter family member 1B1	transporter
Lopinavir	Solute carrier organic anion transporter family member 1B3	transporter
Lopinavir	Bile salt export pump	transporter
Lopinavir	Cytochrome P450 1A2	enzyme
Lopinavir	Alpha-1-acid glycoprotein 1	carrier
Lopinavir	Albumin	carrier
Omeprazole	Potassium-transporting ATPase alpha chain 1	target
Omeprazole	Cytochrome P450 2C19	enzyme
Omeprazole	Cytochrome P450 3A4	enzyme
Omeprazole	Cytochrome P450 2C9	enzyme
Omeprazole	Cytochrome P450 1A2	enzyme
Omeprazole	ATP-binding cassette sub-family C member 3	transporter
Omeprazole	ATP-dependent translocase ABCB1	transporter
Omeprazole	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Omeprazole	Cytochrome P450 1A1	enzyme
Omeprazole	Cytochrome P450 1B1	enzyme
Omeprazole	Cytochrome P450 2C18	enzyme
Omeprazole	Cytochrome P450 2C8	enzyme
Omeprazole	Cytochrome P450 2D6	enzyme
Omeprazole	Aryl hydrocarbon receptor	target
Omeprazole	Potassium-transporting ATPase subunit beta	target
Voriconazole	Cytochrome P450 2C19	enzyme
Voriconazole	Cytochrome P450 3A4	enzyme
Voriconazole	Cytochrome P450 2C9	enzyme
Voriconazole	Flavin-containing monooxygenase 1	enzyme
Voriconazole	Flavin-containing monooxygenase 3	enzyme
Voriconazole	Cytochrome P450 3A5	enzyme
Voriconazole	Cytochrome P450 3A7	enzyme
Voriconazole	Prostaglandin G/H synthase 1	enzyme
Voriconazole	Lanosterol 14-alpha demethylase	target
Voriconazole	Cytochrome P450 2B6	enzyme
Esomeprazole	Potassium-transporting ATPase alpha chain 1	target
Esomeprazole	Cytochrome P450 2C19	enzyme
Esomeprazole	Cytochrome P450 3A4	enzyme
Esomeprazole	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	target
Esomeprazole	ATP-dependent translocase ABCB1	transporter
Esomeprazole	Organic anion transporter 3	transporter
Esomeprazole	Potassium-transporting ATPase subunit beta	target
Pantoprazole	Potassium-transporting ATPase alpha chain 1	target
Pantoprazole	Cytochrome P450 2C19	enzyme
Pantoprazole	Cytochrome P450 3A4	enzyme
Pantoprazole	ATP-dependent translocase ABCB1	transporter
Pantoprazole	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Pantoprazole	Organic anion transporter 3	transporter
Pantoprazole	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	target
Pantoprazole	Potassium-transporting ATPase subunit beta	target
Rucaparib	Poly [ADP-ribose] polymerase 1	target
Rucaparib	Poly [ADP-ribose] polymerase 2	target
Rucaparib	Protein mono-ADP-ribosyltransferase PARP3	target
Rucaparib	Cytochrome P450 2D6	enzyme
Rucaparib	Cytochrome P450 1A2	enzyme
Rucaparib	Cytochrome P450 3A4	enzyme
Rucaparib	ATP-dependent translocase ABCB1	transporter
Rucaparib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Rucaparib	Multidrug and toxin extrusion protein 1	transporter
Rucaparib	Multidrug and toxin extrusion protein 2	transporter
Rucaparib	Solute carrier family 22 member 1	transporter
Rucaparib	ATP-binding cassette sub-family C member 4	transporter
Rucaparib	Solute carrier organic anion transporter family member 1B1	transporter
Rucaparib	Solute carrier organic anion transporter family member 1B3	transporter
Rucaparib	Solute carrier family 22 member 6	transporter
Rucaparib	Organic anion transporter 3	transporter
Rucaparib	Cytochrome P450 3A5	enzyme
Rucaparib	Cytochrome P450 3A7	enzyme
Rucaparib	Cytochrome P450 3A43	enzyme
Rucaparib	Cytochrome P450 2C19	enzyme
Rucaparib	Cytochrome P450 2C9	enzyme
Rucaparib	Cytochrome P450 2C8	enzyme
Rucaparib	UDP-glucuronosyltransferase 1A1	enzyme
Dovitinib	Cytochrome P450 1A1	enzyme
Dovitinib	Cytochrome P450 1A2	enzyme
Dovitinib	ATP-binding cassette sub-family C member 3	transporter
Dovitinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Dovitinib	UDP-glucuronosyltransferase 1A3	enzyme
Dovitinib	UDP-glucuronosyltransferase 2B7	enzyme
Dovitinib	Nuclear receptor subfamily 1 group I member 2	target
Dovitinib	Solute carrier organic anion transporter family member 1B1	transporter
Dovitinib	Solute carrier organic anion transporter family member 2B1	transporter
Dovitinib	Cytochrome P450 2C19	enzyme
Dovitinib	Cytochrome P450 3A4	enzyme
Dovitinib	Solute carrier organic anion transporter family member 1B3	transporter
Dovitinib	ATP-dependent translocase ABCB1	transporter
Oritavancin	Cytochrome P450 3A4	enzyme
Oritavancin	Cytochrome P450 2D6	enzyme
Oritavancin	Cytochrome P450 2C9	enzyme
Oritavancin	Cytochrome P450 2C19	enzyme
Oritavancin	Albumin	carrier
Oritavancin	Peptidoglycan precursors	target
Oritavancin	Bacterial cell wall peptide bridging segments	target
Oritavancin	Pentaglycyl bridging segment	target
Oritavancin	Dihydropteroate synthase	target
Zonisamide	Sodium channel protein type 1 subunit alpha	target
Zonisamide	Carbonic anhydrase 1	target
Zonisamide	Voltage-dependent T-type calcium channel subunit alpha-1G	target
Zonisamide	Cytochrome P450 3A4	enzyme
Zonisamide	Aldehyde oxidase	enzyme
Zonisamide	Amine oxidase [flavin-containing] B	target
Zonisamide	Carbonic anhydrase 2	target
Zonisamide	Carbonic anhydrase 3	target
Zonisamide	Carbonic anhydrase 4	target
Zonisamide	Carbonic anhydrase 5A, mitochondrial	target
Zonisamide	Carbonic anhydrase 5B, mitochondrial	target
Zonisamide	Carbonic anhydrase 6	target
Zonisamide	Carbonic anhydrase 7	target
Zonisamide	Carbonic anhydrase-related protein	target
Zonisamide	Carbonic anhydrase 9	target
Zonisamide	Carbonic anhydrase-related protein 10	target
Zonisamide	Carbonic anhydrase-related protein 11	target
Zonisamide	Carbonic anhydrase 12	target
Zonisamide	Carbonic anhydrase 13	target
Zonisamide	Carbonic anhydrase 14	target
Zonisamide	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Zonisamide	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Zonisamide	Sodium channel protein type 2 subunit alpha	target
Zonisamide	Sodium channel protein type 3 subunit alpha	target
Zonisamide	Sodium channel protein type 4 subunit alpha	target
Zonisamide	Sodium channel protein type 5 subunit alpha	target
Zonisamide	Sodium channel protein type 9 subunit alpha	target
Zonisamide	Sodium channel protein type 11 subunit alpha	target
Zonisamide	Sodium channel subunit beta-1	target
Zonisamide	Sodium channel subunit beta-2	target
Zonisamide	Sodium channel regulatory subunit beta-3	target
Zonisamide	Sodium channel subunit beta-4	target
Zonisamide	Amine oxidase [flavin-containing] A	target
Zonisamide	Cytochrome P450 2C19	enzyme
Zonisamide	UDP-glucuronosyltransferase 1A1	enzyme
Zonisamide	Cytochrome P450 3A5	enzyme
Zonisamide	ATP-dependent translocase ABCB1	transporter
Zonisamide	GABA(A) Receptor Benzodiazepine Binding Site	target
Luliconazole	Lanosterol 14-alpha demethylase	target
Luliconazole	Cytochrome P450 3A4	enzyme
Luliconazole	Cytochrome P450 2C19	enzyme
Bortezomib	Cytochrome P450 3A4	enzyme
Bortezomib	Cytochrome P450 2C19	enzyme
Bortezomib	Cytochrome P450 1A2	enzyme
Bortezomib	Cytochrome P450 2D6	enzyme
Bortezomib	Cytochrome P450 2C9	enzyme
Bortezomib	Proteasome subunit beta type-5	target
Bortezomib	Proteasome subunit beta type-1	target
Bortezomib	ATP-dependent translocase ABCB1	transporter
Bortezomib	Solute carrier organic anion transporter family member 1B3	transporter
Bortezomib	Serine protease 1	target
Nilutamide	Androgen receptor	target
Nilutamide	Cytochrome P450 2C19	enzyme
Nilutamide	NADPH--cytochrome P450 reductase	enzyme
Sitaxentan	Cytochrome P450 2C19	enzyme
Sitaxentan	Cytochrome P450 2C9	enzyme
Sitaxentan	Cytochrome P450 3A4	enzyme
Sitaxentan	Endothelin-1 receptor	target
Sitaxentan	Endothelin receptor type B	target
Clozapine	D(4) dopamine receptor	target
Clozapine	Histamine H1 receptor	target
Clozapine	D(2) dopamine receptor	target
Clozapine	Neuron-specific vesicular protein calcyon	target
Clozapine	Histamine H4 receptor	target
Clozapine	5-hydroxytryptamine receptor 2A	target
Clozapine	5-hydroxytryptamine receptor 1A	target
Clozapine	5-hydroxytryptamine receptor 2C	target
Clozapine	D(1A) dopamine receptor	target
Clozapine	Cytochrome P450 1A2	enzyme
Clozapine	Cytochrome P450 2D6	enzyme
Clozapine	D(3) dopamine receptor	target
Clozapine	Muscarinic acetylcholine receptor M1	target
Clozapine	Muscarinic acetylcholine receptor M2	target
Clozapine	Muscarinic acetylcholine receptor M3	target
Clozapine	Muscarinic acetylcholine receptor M4	target
Clozapine	Muscarinic acetylcholine receptor M5	target
Clozapine	5-hydroxytryptamine receptor 1B	target
Clozapine	5-hydroxytryptamine receptor 1D	target
Clozapine	5-hydroxytryptamine receptor 1E	target
Clozapine	5-hydroxytryptamine receptor 3A	target
Clozapine	5-hydroxytryptamine receptor 6	target
Clozapine	5-hydroxytryptamine receptor 7	target
Clozapine	Alpha-1A adrenergic receptor	target
Clozapine	Alpha-1B adrenergic receptor	target
Clozapine	Alpha-2A adrenergic receptor	target
Clozapine	Alpha-2B adrenergic receptor	target
Clozapine	Alpha-2C adrenergic receptor	target
Clozapine	Cytochrome P450 2C9	enzyme
Clozapine	ATP-dependent translocase ABCB1	transporter
Clozapine	Cytochrome P450 3A4	enzyme
Clozapine	Cytochrome P450 2C19	enzyme
Clozapine	Flavin-containing monooxygenase 3	enzyme
Clozapine	UDP-glucuronosyltransferase 1A4	enzyme
Clozapine	Cytochrome P450 1A1	enzyme
Clozapine	Cytochrome P450 2A6	enzyme
Clozapine	Cytochrome P450 2C8	enzyme
Clozapine	Glutathione S-transferase P	target
Clozapine	Alpha-1-acid glycoprotein 1	carrier
Clozapine	Albumin	carrier
Clozapine	D(1B) dopamine receptor	target
Clozapine	Gamma-aminobutyric acid type B receptor subunit 1	target
Clozapine	Gamma-aminobutyric acid type B receptor subunit 2	target
Clozapine	Solute carrier family 22 member 1	transporter
Clozapine	Solute carrier family 22 member 2	transporter
Clozapine	Solute carrier family 22 member 3	transporter
Clozapine	Gamma-aminobutyric acid receptor subunit alpha-1	target
Clozapine	Gamma-aminobutyric acid receptor subunit beta-1	target
Clozapine	Gamma-aminobutyric acid receptor subunit gamma-1	target
Ethanol	Gamma-aminobutyric acid receptor subunit alpha-1	target
Ethanol	Glutamate receptor ionotropic, NMDA 3A	target
Ethanol	Glycine receptor subunit alpha-1	target
Ethanol	Glycine receptor subunit alpha-2	target
Ethanol	Cytochrome P450 2E1	enzyme
Ethanol	Cytochrome P450 1A1	enzyme
Ethanol	Cytochrome P450 1A2	enzyme
Ethanol	Cytochrome P450 2B6	enzyme
Ethanol	Cytochrome P450 2C19	enzyme
Ethanol	Cytochrome P450 2C9	enzyme
Ethanol	Cytochrome P450 3A4	enzyme
Ethanol	Cytochrome P450 4A11	enzyme
Ethanol	Alcohol dehydrogenase 1A	enzyme
Ethanol	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	enzyme
Ethanol	Alcohol dehydrogenase 1C	enzyme
Ethanol	Alcohol dehydrogenase class-3	enzyme
Ethanol	Voltage-dependent L-type calcium channel subunit beta-1	target
Ethanol	5-hydroxytryptamine receptor 3A	target
Ethanol	All-trans-retinol dehydrogenase [NAD(+)] ADH4	enzyme
Ethanol	Gamma-aminobutyric acid receptor subunit alpha-2	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-10	target
Ethanol	Voltage-dependent L-type calcium channel subunit alpha-1C	target
Ethanol	Gamma-aminobutyric acid receptor subunit alpha-5	target
Ethanol	Gamma-aminobutyric acid receptor subunit alpha-4	target
Ethanol	All-trans-retinol dehydrogenase [NAD(+)] ADH7	enzyme
Ethanol	Gamma-aminobutyric acid receptor subunit alpha-3	target
Ethanol	Glutamate receptor 1	target
Ethanol	Voltage-dependent calcium channel gamma-1 subunit	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-2	target
Ethanol	Gamma-aminobutyric acid receptor subunit alpha-6	target
Ethanol	Glutamate receptor 2	target
Ethanol	Glutamate receptor 4	target
Ethanol	Glutamate receptor 3	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-4	target
Ethanol	Neuronal acetylcholine receptor subunit beta-2	target
Ethanol	G protein-activated inward rectifier potassium channel 1	target
Ethanol	G protein-activated inward rectifier potassium channel 2	target
Ethanol	Vascular cell adhesion protein 1	target
Ethanol	Equilibrative nucleoside transporter 1	target
Ethanol	G protein-activated inward rectifier potassium channel 4	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-7	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-9	target
Ethanol	Gamma-aminobutyric acid receptor subunit beta-1	target
Ethanol	Gamma-aminobutyric acid receptor subunit beta-3	target
Ethanol	Gamma-aminobutyric acid receptor subunit beta-2	target
Ethanol	Voltage-dependent L-type calcium channel subunit alpha-1S	target
Ethanol	Voltage-dependent L-type calcium channel subunit alpha-1D	target
Ethanol	Alcohol dehydrogenase 6	enzyme
Ethanol	Neuronal acetylcholine receptor subunit beta-4	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-3	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-5	target
Ethanol	Neuronal acetylcholine receptor subunit alpha-6	target
Ethanol	Neuronal acetylcholine receptor subunit beta-3	target
Ethanol	Gamma-aminobutyric acid receptor subunit gamma-1	target
Ethanol	Gamma-aminobutyric acid receptor subunit gamma-3	target
Ethanol	Gamma-aminobutyric acid receptor subunit epsilon	target
Ethanol	Gamma-aminobutyric acid receptor subunit pi	target
Ethanol	Gamma-aminobutyric acid receptor subunit theta	target
Ethanol	Gamma-aminobutyric acid receptor subunit delta	target
Ethanol	Aldo-keto reductase family 1 member A1	enzyme
Ethanol	Equilibrative nucleoside transporter 2	target
Ethanol	5-hydroxytryptamine receptor 3E	target
Ethanol	5-hydroxytryptamine receptor 3B	target
Ethanol	5-hydroxytryptamine receptor 3D	target
Ethanol	5-hydroxytryptamine receptor 3C	target
Ethanol	Voltage-dependent calcium channel gamma-2 subunit	target
Ethanol	G protein-activated inward rectifier potassium channel 3	target
Ethanol	Neural cell adhesion molecule L1	target
Ethanol	Acetylcholinesterase	target
Ethanol	All-trans-retinol dehydrogenase [NAD(+)] ADH7	target
Nilvadipine	Cytochrome P450 3A4	enzyme
Nilvadipine	Cytochrome P450 2A6	enzyme
Nilvadipine	Cytochrome P450 2C19	enzyme
Nilvadipine	Cytochrome P450 2C8	enzyme
Nilvadipine	Cytochrome P450 2E1	enzyme
Nilvadipine	Voltage-dependent L-type calcium channel subunit alpha-1C	target
Nilvadipine	Voltage-dependent calcium channel subunit alpha-2/delta-1	target
Nilvadipine	Voltage-dependent L-type calcium channel subunit beta-2	target
Nilvadipine	Voltage-dependent L-type calcium channel subunit alpha-1D	target
Nilvadipine	Voltage-dependent L-type calcium channel subunit alpha-1S	target
Nilvadipine	Voltage-dependent calcium channel subunit alpha-2/delta-3	target
Nilvadipine	Voltage-dependent T-type calcium channel subunit alpha-1H	target
Nilvadipine	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Nilvadipine	Voltage gated L-type calcium channel	target
Nilvadipine	Voltage-dependent T-type calcium channel	target
Olanzapine	D(1A) dopamine receptor	target
Olanzapine	Muscarinic acetylcholine receptor M1	target
Olanzapine	Muscarinic acetylcholine receptor M3	target
Olanzapine	5-hydroxytryptamine receptor 2A	target
Olanzapine	D(4) dopamine receptor	target
Olanzapine	Histamine H1 receptor	target
Olanzapine	Muscarinic acetylcholine receptor M4	target
Olanzapine	Muscarinic acetylcholine receptor M2	target
Olanzapine	D(2) dopamine receptor	target
Olanzapine	5-hydroxytryptamine receptor 2C	target
Olanzapine	D(3) dopamine receptor	target
Olanzapine	Alpha-1B adrenergic receptor	target
Olanzapine	Cytochrome P450 1A2	enzyme
Olanzapine	5-hydroxytryptamine receptor 3A	target
Olanzapine	5-hydroxytryptamine receptor 6	target
Olanzapine	Alpha-1A adrenergic receptor	target
Olanzapine	D(1B) dopamine receptor	target
Olanzapine	Albumin	carrier
Olanzapine	Alpha-1-acid glycoprotein 1	carrier
Olanzapine	Flavin-containing monooxygenase 3	enzyme
Olanzapine	Cytochrome P450 2D6	enzyme
Olanzapine	ATP-dependent translocase ABCB1	transporter
Olanzapine	Cytochrome P450 2C19	enzyme
Olanzapine	D(1) dopamine receptor	target
Olanzapine	Beta adrenergic receptor	target
Olanzapine	5-hydroxytryptamine receptor 1	target
Olanzapine	GABA(A) Receptor Benzodiazepine Binding Site	target
Olanzapine	Cytochrome P450 2C9	enzyme
Olanzapine	UDP-glucuronosyltransferase 1A4	enzyme
Olanzapine	Cytochrome P450 3A4	enzyme
Olanzapine	Cytochrome P450 3A Subfamily	enzyme
Tipranavir	Pol polyprotein	target
Tipranavir	Cytochrome P450 3A4	enzyme
Tipranavir	Cytochrome P450 2D6	enzyme
Tipranavir	Cytochrome P450 2C19	enzyme
Tipranavir	Bile salt export pump	transporter
Tipranavir	UDP-glucuronosyltransferase 1A1	enzyme
Tipranavir	Solute carrier organic anion transporter family member 2B1	transporter
Tipranavir	Solute carrier organic anion transporter family member 1B1	transporter
Tipranavir	Solute carrier organic anion transporter family member 1B3	transporter
Tipranavir	ATP-dependent translocase ABCB1	transporter
Tipranavir	Gag-Pol polyprotein	target
Naloxegol	Cytochrome P450 3A4	enzyme
Naloxegol	Cytochrome P450 2D6	enzyme
Naloxegol	Cytochrome P450 2C19	enzyme
Naloxegol	Mu-type opioid receptor	target
Midostaurin	Protein kinase C alpha type	target
Midostaurin	Vascular endothelial growth factor receptor 2	target
Midostaurin	Mast/stem cell growth factor receptor Kit	target
Midostaurin	Platelet-derived growth factor receptor alpha	target
Midostaurin	Platelet-derived growth factor receptor beta	target
Midostaurin	Receptor-type tyrosine-protein kinase FLT3	target
Midostaurin	Cytochrome P450 3A Subfamily	enzyme
Midostaurin	Cytochrome P450 1A2	enzyme
Midostaurin	Cytochrome P450 2B6	enzyme
Midostaurin	Cytochrome P450 2C8	enzyme
Midostaurin	Cytochrome P450 2C9	enzyme
Midostaurin	Cytochrome P450 2C19	enzyme
Midostaurin	Cytochrome P450 2D6	enzyme
Midostaurin	Cytochrome P450 2E1	enzyme
Midostaurin	Cytochrome P450 3A4	enzyme
Midostaurin	Cytochrome P450 3A5	enzyme
Midostaurin	Cytochrome P450 3A7	enzyme
Midostaurin	Cytochrome P450 3A43	enzyme
Midostaurin	Protein kinase C gamma type	target
Etoricoxib	Prostaglandin G/H synthase 2	target
Etoricoxib	Cytochrome P450 3A4	enzyme
Etoricoxib	Cytochrome P450 2C9	enzyme
Etoricoxib	Cytochrome P450 2D6	enzyme
Etoricoxib	Cytochrome P450 1A2	enzyme
Etoricoxib	Cytochrome P450 2C19	enzyme
Etoricoxib	Cytochrome P450 2E1	enzyme
Sildenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Sildenafil	Cytochrome P450 2C9	enzyme
Sildenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Sildenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Sildenafil	Cytochrome P450 3A4	enzyme
Sildenafil	Cytochrome P450 3A5	enzyme
Sildenafil	Cytochrome P450 3A7	enzyme
Sildenafil	ATP-binding cassette sub-family C member 4	transporter
Sildenafil	ATP-binding cassette sub-family C member 5	transporter
Sildenafil	ATP-binding cassette sub-family C member 10	transporter
Sildenafil	Cytochrome P450 2C19	enzyme
Sildenafil	Cytochrome P450 2D6	enzyme
Sildenafil	Cytochrome P450 2E1	enzyme
Sildenafil	Solute carrier organic anion transporter family member 1B1	transporter
Sildenafil	ATP-dependent translocase ABCB1	transporter
Sildenafil	Ornithine decarboxylase	target
Sildenafil	Programmed cell death 1 ligand 1	target
Sildenafil	Plasma protease C1 inhibitor	target
Citalopram	Sodium-dependent serotonin transporter	target
Citalopram	Cytochrome P450 2C19	enzyme
Citalopram	Cytochrome P450 2D6	enzyme
Citalopram	Cytochrome P450 3A4	enzyme
Citalopram	ATP-dependent translocase ABCB1	transporter
Citalopram	Cytochrome P450 1A2	enzyme
Citalopram	Histamine H1 receptor	target
Citalopram	Amine oxidase [flavin-containing] A	enzyme
Citalopram	Amine oxidase [flavin-containing] B	enzyme
Citalopram	Aldehyde oxidase	enzyme
Memantine	Cytochrome P450 2B6	enzyme
Memantine	Solute carrier family 22 member 2	transporter
Memantine	5-hydroxytryptamine receptor 3A	target
Memantine	Neuronal acetylcholine receptor subunit alpha-7	target
Memantine	Cytochrome P450 2A6	enzyme
Memantine	Cytochrome P450 2C19	enzyme
Memantine	D(2) dopamine receptor	target
Memantine	Glutamate receptor ionotropic, NMDA 1	target
Memantine	Sodium/hydrogen exchanger 1	transporter
Memantine	Solute carrier family 22 member 4	transporter
Memantine	Multidrug and toxin extrusion protein 1	transporter
Memantine	Glutamate (NMDA) receptor	target
Memantine	GABA(A) Receptor	target
Dexlansoprazole	Potassium-transporting ATPase alpha chain 1	target
Dexlansoprazole	Cytochrome P450 2C19	enzyme
Dexlansoprazole	Cytochrome P450 3A4	enzyme
Dexlansoprazole	Potassium-transporting ATPase subunit beta	target
Dexlansoprazole	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	target
Isoniazid	Catalase-peroxidase	target
Isoniazid	Enoyl-[acyl-carrier-protein] reductase [NADH]	target
Isoniazid	Cytochrome P450 2E1	enzyme
Isoniazid	Cytochrome P450 1A2	enzyme
Isoniazid	Cytochrome P450 2C9	enzyme
Isoniazid	Cytochrome P450 2D6	enzyme
Isoniazid	Cytochrome P450 2C19	enzyme
Isoniazid	Arylamine N-acetyltransferase 2	enzyme
Isoniazid	Arylamine N-acetyltransferase	enzyme
Isoniazid	Cytochrome P450 2A6	enzyme
Isoniazid	Cytochrome P450 2C8	enzyme
Isoniazid	Cytochrome P450 2C8	target
Isoniazid	Cytochrome P450 1A2	target
Isoniazid	Cytochrome P450 3A4	target
Isoniazid	Cytochrome P450 2C19	target
Isoniazid	Dihydrofolate reductase	target
Isoniazid	Albumin	carrier
Isoniazid	Cytochrome P450 3A4	enzyme
Clinafloxacin	Cytochrome P450 1A2	enzyme
Clinafloxacin	Cytochrome P450 2C19	enzyme
Clinafloxacin	Cytochrome P450 2D6	enzyme
Clinafloxacin	Cytochrome P450 2C9	enzyme
Clinafloxacin	DNA gyrase subunit A	target
Clinafloxacin	DNA gyrase subunit B	target
Fenofibrate	Peroxisome proliferator-activated receptor alpha	target
Fenofibrate	Matrix metalloproteinase-25	target
Fenofibrate	Cytochrome P450 2C8	enzyme
Fenofibrate	Cytochrome P450 2C9	enzyme
Fenofibrate	Nuclear receptor subfamily 1 group I member 2	target
Fenofibrate	UDP-glucuronosyltransferase 1A9	enzyme
Fenofibrate	Bile salt export pump	transporter
Fenofibrate	Albumin	carrier
Fenofibrate	Cytochrome P450 2C19	enzyme
Fenofibrate	Cytochrome P450 2A6	enzyme
Fenofibrate	Liver carboxylesterase 1	enzyme
Fenofibrate	Carbonyl reductase [NADPH] 1	enzyme
Fenofibrate	Aldo-keto reductase family 1 member C1	enzyme
Fenofibrate	Aldo-keto reductase family 1 member C2	enzyme
Fenofibrate	Aldo-keto reductase family 1 member C3	enzyme
Fenofibrate	Aldo-keto reductase family 1 member B1	enzyme
Loratadine	Histamine H1 receptor	target
Loratadine	Cytochrome P450 3A4	enzyme
Loratadine	Cytochrome P450 2C19	enzyme
Loratadine	Cytochrome P450 2D6	enzyme
Loratadine	Cytochrome P450 2C8	enzyme
Loratadine	ATP-dependent translocase ABCB1	transporter
Loratadine	Potassium voltage-gated channel subfamily H member 2	target
Loratadine	Bile salt export pump	transporter
Loratadine	Cytochrome P450 1A1	enzyme
Loratadine	Cytochrome P450 1A2	enzyme
Loratadine	Cytochrome P450 2B6	enzyme
Loratadine	Cytochrome P450 2C9	enzyme
Loratadine	Cytochrome P450 3A5	enzyme
Loratadine	UDP-glucuronosyltransferase 2B10	enzyme
Loratadine	UDP-glucuronosyltransferase 1A1	enzyme
Loratadine	UDP-glucuronosyltransferase 1A3	enzyme
Loratadine	UDP-glucuronosyltransferase 2B15	enzyme
Aprepitant	Substance-P receptor	target
Aprepitant	Cytochrome P450 3A4	enzyme
Aprepitant	Cytochrome P450 2C9	enzyme
Aprepitant	Cytochrome P450 2C19	enzyme
Ubrogepant	ATP-dependent translocase ABCB1	transporter
Ubrogepant	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Ubrogepant	Cytochrome P450 3A4	enzyme
Ubrogepant	Cytochrome P450 2C8	enzyme
Ubrogepant	Cytochrome P450 2C9	enzyme
Ubrogepant	Cytochrome P450 2D6	enzyme
Ubrogepant	Cytochrome P450 2C19	enzyme
Ubrogepant	Amine oxidase [flavin-containing] A	enzyme
Ubrogepant	UDP-glucuronosyltransferase 1A1	enzyme
Ubrogepant	Solute carrier organic anion transporter family member 1B1	transporter
Ubrogepant	Solute carrier organic anion transporter family member 1B3	transporter
Ubrogepant	Solute carrier family 22 member 6	transporter
Ubrogepant	Solute carrier family 22 member 2	transporter
Ubrogepant	Calcitonin gene-related peptide type 1 receptor	target
Amiodarone	Beta adrenergic receptor	target
Amiodarone	HERG human cardiac K+ channel	target
Amiodarone	Cytochrome P450 2C8	enzyme
Amiodarone	Cytochrome P450 2C9	enzyme
Amiodarone	Cytochrome P450 2D6	enzyme
Amiodarone	Voltage-dependent T-type calcium channel subunit alpha-1I	target
Amiodarone	Voltage gated L-type calcium channel	target
Amiodarone	Cytochrome P450 3A4	enzyme
Amiodarone	Cytochrome P450 1A2	enzyme
Amiodarone	Cytochrome P450 1A1	enzyme
Amiodarone	ATP-dependent translocase ABCB1	transporter
Amiodarone	Cytochrome P450 2C19	enzyme
Amiodarone	Cytochrome P450 2A6	enzyme
Amiodarone	Thyroid hormone receptor	target
Amiodarone	Peroxisome proliferator-activated receptor gamma	target
Amiodarone	Bile salt export pump	transporter
Amiodarone	Solute carrier family 22 member 2	transporter
Amiodarone	Cytochrome P450 2J2	enzyme
Amiodarone	Peroxisome proliferator-activated receptor alpha	target
Amiodarone	Peroxisome proliferator-activated receptor gamma coactivator 1-beta	target
Amiodarone	Albumin	carrier
Osilodrostat	Cytochrome P450 11B1, mitochondrial	target
Osilodrostat	Cytochrome P450 11B2, mitochondrial	target
Osilodrostat	Cytochrome P450 3A4	enzyme
Osilodrostat	Cytochrome P450 2B6	enzyme
Osilodrostat	Cytochrome P450 2D6	enzyme
Osilodrostat	UDP-glucuronosyltransferase 1A4	enzyme
Osilodrostat	UDP-glucuronosyltransferase 2B7	enzyme
Osilodrostat	UDP-glucuronosyltransferase 2B10	enzyme
Osilodrostat	Cytochrome P450 3A5	enzyme
Osilodrostat	Cytochrome P450 1A2	enzyme
Osilodrostat	Cytochrome P450 2C19	enzyme
Osilodrostat	Cytochrome P450 2E1	enzyme
Osilodrostat	Solute carrier organic anion transporter family member 1B1	transporter
Osilodrostat	Solute carrier family 22 member 1	transporter
Osilodrostat	Solute carrier family 22 member 2	transporter
Osilodrostat	Solute carrier family 22 member 6	transporter
Osilodrostat	Organic anion transporter 3	transporter
Osilodrostat	Multidrug and toxin extrusion protein 1	transporter
Osilodrostat	UDP-glucuronosyltransferase 1A1	enzyme
Clascoterone	Androgen receptor	target
Clascoterone	Cytochrome P450 1A2	enzyme
Clascoterone	Cytochrome P450 2B6	enzyme
Clascoterone	Cytochrome P450 2C8	enzyme
Clascoterone	Cytochrome P450 2C9	enzyme
Clascoterone	Cytochrome P450 2C19	enzyme
Clascoterone	Cytochrome P450 2D6	enzyme
Clascoterone	Cytochrome P450 2E1	enzyme
Clascoterone	Cytochrome P450 3A4	enzyme
Tirbanibulin	Proto-oncogene tyrosine-protein kinase Src	target
Tirbanibulin	Tubulin beta chain	target
Tirbanibulin	Cytochrome P450 3A4	enzyme
Tirbanibulin	Cytochrome P450 2C8	enzyme
Tirbanibulin	Cytochrome P450 1A2	enzyme
Tirbanibulin	Cytochrome P450 2B6	enzyme
Tirbanibulin	Cytochrome P450 2C9	enzyme
Tirbanibulin	Cytochrome P450 2C19	enzyme
Tirbanibulin	Cytochrome P450 2D6	enzyme
Tirbanibulin	Multidrug and toxin extrusion protein 1	transporter
Tirbanibulin	Multidrug and toxin extrusion protein 2	transporter
Tirbanibulin	Solute carrier organic anion transporter family member 1B1	transporter
Tirbanibulin	Solute carrier organic anion transporter family member 1B3	transporter
Tirbanibulin	Solute carrier family 22 member 1	transporter
Tirbanibulin	Solute carrier family 22 member 2	transporter
Valproic acid	Histone deacetylase 9	target
Valproic acid	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	target
Valproic acid	Cytochrome P450 2A6	enzyme
Valproic acid	Cytochrome P450 2B6	enzyme
Valproic acid	Cytochrome P450 2C9	enzyme
Valproic acid	Organic cation/carnitine transporter 2	transporter
Valproic acid	Solute carrier family 22 member 6	transporter
Valproic acid	Organic anion transporter 3	transporter
Valproic acid	Monocarboxylate transporter 1	transporter
Valproic acid	Solute carrier family 22 member 7	transporter
Valproic acid	Cytochrome P450 3A5	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A9	enzyme
Valproic acid	Prostaglandin G/H synthase 1	enzyme
Valproic acid	Cytochrome P450 1A2	enzyme
Valproic acid	Cytochrome P450 2C19	enzyme
Valproic acid	Cytochrome P450 3A4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A4	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A8	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A10	enzyme
Valproic acid	UDP-glucuronosyltransferase 1-6	enzyme
Valproic acid	UDP-glucuronosyltransferase 1A3	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B7	enzyme
Valproic acid	UDP-glucuronosyltransferase 2B15	enzyme
Valproic acid	2-oxoglutarate dehydrogenase complex component E1	target
Valproic acid	Succinate-semialdehyde dehydrogenase, mitochondrial	target
Valproic acid	Sodium channel protein	target
Valproic acid	Histone deacetylase 2	target
Valproic acid	Peroxisome proliferator-activated receptor alpha	target
Valproic acid	Peroxisome proliferator-activated receptor delta	target
Valproic acid	Peroxisome proliferator-activated receptor gamma	target
Valproic acid	Albumin	carrier
Valproic acid	UDP-glucuronosyltransferase 1A1	enzyme
Valproic acid	Solute carrier organic anion transporter family member 2B1	transporter
Valproic acid	Histone deacetylase	target
Valproic acid	Cyclin-dependent kinase inhibitor 1	target
Valproic acid	Hepatocyte growth factor	target
Valproic acid	Ornithine decarboxylase	target
Valproic acid	Programmed cell death 1 ligand 1	target
Valproic acid	4-aminobutyrate aminotransferase, mitochondrial	target
Valproic acid	Glycogen synthase kinase-3 alpha	target
Somatotropin	Growth hormone receptor	target
Somatotropin	Prolactin receptor	target
Somatotropin	Cytochrome P450 1A2	enzyme
Somatotropin	Cytochrome P450 2C19	enzyme
Somatotropin	ATP-dependent translocase ABCB1	transporter
Ethambutol	Probable arabinosyltransferase B	target
Ethambutol	Probable arabinosyltransferase A	target
Ethambutol	Probable arabinosyltransferase C	target
Ethambutol	Cytochrome P450 1A2	enzyme
Ethambutol	Cytochrome P450 2E1	enzyme
Ethambutol	Cytochrome P450 2C19	enzyme
Ethambutol	Cytochrome P450 2D6	enzyme
Ethambutol	Cytochrome P450 2A6	enzyme
Ethambutol	Cytochrome P450 2C9	enzyme
Ethambutol	Cytochrome P450 3A4	enzyme
Rotigotine	D(3) dopamine receptor	target
Rotigotine	D(1B) dopamine receptor	target
Rotigotine	D(4) dopamine receptor	target
Rotigotine	D(2) dopamine receptor	target
Rotigotine	5-hydroxytryptamine receptor 1A	target
Rotigotine	D(1A) dopamine receptor	target
Rotigotine	Cytochrome P450 2D6	enzyme
Rotigotine	Cytochrome P450 3A4	enzyme
Rotigotine	Alpha-2B adrenergic receptor	target
Rotigotine	Cytochrome P450 2C19	enzyme
Lonapegsomatropin	11-beta-hydroxysteroid dehydrogenase 1	enzyme
Lonapegsomatropin	Growth hormone receptor	target
Lonapegsomatropin	Prolactin receptor	target
Lonapegsomatropin	Cytochrome P450 1A2	enzyme
Lonapegsomatropin	Cytochrome P450 2C19	enzyme
Lonapegsomatropin	ATP-dependent translocase ABCB1	transporter
Cariprazine	Cytochrome P450 3A4	enzyme
Cariprazine	Cytochrome P450 2D6	enzyme
Cariprazine	ATP-dependent translocase ABCB1	transporter
Cariprazine	Cytochrome P450 3A5	enzyme
Cariprazine	D(3) dopamine receptor	target
Cariprazine	D(2) dopamine receptor	target
Cariprazine	5-hydroxytryptamine receptor 1A	target
Cariprazine	5-hydroxytryptamine receptor 2B	target
Cariprazine	5-hydroxytryptamine receptor 2A	target
Cariprazine	Histamine H1 receptor	target
Cariprazine	5-hydroxytryptamine receptor 2C	target
Cariprazine	Alpha-1A adrenergic receptor	target
Cariprazine	Cytochrome P450 1A2	enzyme
Cariprazine	Cytochrome P450 2C9	enzyme
Cariprazine	Cytochrome P450 2C19	enzyme
Cariprazine	Cytochrome P450 2E1	enzyme
Tecovirimat	Envelope protein F13	target
Tecovirimat	UDP-glucuronosyltransferase 1A1	enzyme
Tecovirimat	UDP-glucuronosyltransferase 1A4	enzyme
Tecovirimat	Cytochrome P450 3A4	enzyme
Tecovirimat	Cytochrome P450 2C8	enzyme
Tecovirimat	Cytochrome P450 2C19	enzyme
Tecovirimat	UDP-glucuronosyltransferase 1A3	enzyme
Tecovirimat	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Tecovirimat	Cytochrome P450 2B6	enzyme
Pirtobrutinib	Cytochrome P450 3A4	enzyme
Pirtobrutinib	UDP-glucuronosyltransferase 1A8	enzyme
Pirtobrutinib	UDP-glucuronosyltransferase 1A9	enzyme
Pirtobrutinib	Cytochrome P450 2C8	enzyme
Pirtobrutinib	Cytochrome P450 2C9	enzyme
Pirtobrutinib	Cytochrome P450 1A2	enzyme
Pirtobrutinib	Cytochrome P450 2B6	enzyme
Pirtobrutinib	Cytochrome P450 2C19	enzyme
Pirtobrutinib	Cytochrome P450 2D6	enzyme
Pirtobrutinib	Cytochrome P450 3A5	enzyme
Pirtobrutinib	Tyrosine-protein kinase BTK	target
Pirtobrutinib	ATP-dependent translocase ABCB1	transporter
Pirtobrutinib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Vardenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
Vardenafil	Cytochrome P450 3A4	enzyme
Vardenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Vardenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
Vardenafil	Cytochrome P450 3A5	enzyme
Vardenafil	ATP-dependent translocase ABCB1	transporter
Vardenafil	Cytochrome P450 2C9	enzyme
Vardenafil	Cytochrome P450 2C8	enzyme
Vardenafil	Cytochrome P450 2C19	enzyme
Vardenafil	Cytochrome P450 2D6	enzyme