Decompensated Cirrhosis (DBCOND0041058)

Identifiers

Synonyms
Decompensated cirrhosis / Decompensated cirrhosis of liver (disorder) / Unspecified cirrhosis of liver / Liver Cirrhosis / Cirrhosis of liver / Cirrhosis of liver (disorder) / Cirrhosis liver / Hepatic cirrhosis NOS / Hepatic cirrhosis

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ledipasvir
A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
Resmetirom
A thyroid hormone receptor-beta agonist used to treat noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis in adults.
Sofosbuvir
A direct-acting antiviral agent used to treat specific hepatitis C virus (HCV) infections in combination with other antiviral agents.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05783661
Trial Comparing Conventional Antibiotic Strategies Versus Regimens Guided by Epidemiological Surveillance in Infected Patients With Cirrhosis (SURVIC_STUDY)No drug interventionstreatment4recruiting
NCT05984303
Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-1b)No drug interventionstreatment1not_yet_recruiting
NCT06245590
Evaluation of Low-dose Albumin and Midodrine Versus Midodrine Alone in Outcome of Recurrent Ascites in Patients With Decompensated Cirrhosis.treatmentNot Availablenot_yet_recruiting
NCT05863364
Rifaximin for Preventing Progression and Complications in Patients With Decompensated Liver CirrhosispreventionNot Availablerecruiting
NCT01701687
Biomarkers for the Prognosis of Decompensated Alcoholic Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT05421351
Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLFNo drug interventionsNot AvailableNot Availablerecruiting
NCT02219477
A Study to Evaluate the Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir With Ribavirin in Adults With Genotype 1 and Ombitasvir/Paritaprevir/Ritonavir With Ribavirin in Adults With Genotype 4 Chronic Hepatitis C Virus Infection and Decompensated Cirrhosistreatment3completed
NCT03014505
Fecal Microbiota Transplantation for Decompensated Cirrhosistreatment1 / 2unknown_status
NCT01701297
VSL#3 and Spontaneous Bacterial Peritonitistreatment2terminated
NCT06396897
Hospital @ Home Model of Care for CirrhosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT04906083
Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopeniatreatment4unknown_status
NCT01370161
Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced CirrhosistreatmentNot Availablecompleted
NCT06374511
Prospective Cohort Study of Complications and Outcomes in CirrhosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01902511
A Trial to Study the Influence of Growth Factors on Bone Marrow and Hepatic Regeneration in Patients With Decompensated Cirrhosis.treatmentNot Availablecompleted
NCT04679571
Efficacy of Targeted And Response-Guided Albumin Therapy Versus Standard Medical Treatment In Outcomes Of Recurrent Ascites In Patients With Decompensated Cirrhosis.treatmentNot Availableunknown_status
NCT05121870
Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosistreatment2unknown_status
NCT01326949
Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Prevention of Variceal Rebleeding in Cirrhotic Patients With Portal Vein ThrombosisNo drug interventionstreatmentNot Availablecompleted
NCT06147518
To Compare the Safety and Efficacy of Dapagliflozin Plus Metformin Versus Sitagliptin Plus Metformin for Treatment of Diabetes in Patients With Compensated and Stable Decompensated CirrhosistreatmentNot Availablenot_yet_recruiting
NCT05045924
CirrhoCare in COVID-19: A Pilot, Remote, Home Monitoring Study in Advanced CirrhosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT02467322
To Study The Incidence And Outcome Of Paracentesis Induced Circulatory Dysfunction in Decompensated Cirrhotics Undergoing Less Than 5 Litres Of Ascitic Fluid Tap With Or Without Albumin Infusion.treatmentNot Availablecompleted
NCT05683548
Replicor Compassionate Access ProgramNot AvailableNot Availableavailable
NCT03462576
Companion Protocol for Methacetin Breath Test (MBT) in Conatus Protocol IDN-6556-17diagnosticNot Availableterminated
NCT04208776
Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.treatmentNot Availablecompleted
NCT06134544
Effect of IMO on Intestinal Microbiota Translocation in CirrhosisNo drug interventionspreventionNot Availablerecruiting
NCT05227846
Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-1)No drug interventionstreatment1recruiting
NCT06306781
A Clinical Trial Evaluating the Safety, Tolerability, and Preliminary Efficacy of HCL001 Cell Injection (Homologous Allogeneic Hepatocytes) in Patients With Decompensated CirrhosisNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT05719051
Albumin Infusion in Inpatients With Decompensated CirrhosisNot AvailableNot Availablenot_yet_recruiting
NCT06538077
BCAA vs. Rifaximin in Patients With Cirrhosis for Secondary Prophylaxis of HEtreatmentNot Availablenot_yet_recruiting
NCT03205345
Emricasan, a Caspase Inhibitor, for Treatment of Subjects With Decompensated NASH Cirrhosistreatment2unknown_status
NCT05956197
Efficacy of High Dose Albumin Therapy in Improving Liver Transplant-free Survival in Patients With Acute Decompensation of CirrhosisNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06344611
Incidence & Predictive Factors of Recompensation in Children With Decompensated Cirrhosis as Per the Baveno VII CriteriaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06223893
CirrhoCare- Using Smart-phone Technology to Enhance Care and Access to Treatment for CirrhosisNo drug interventionspreventionNot Availablerecruiting
NCT03820271
New Prognostic Predictive Models of Mortality of Decompensated Cirrhotic Patients Waiting for Liver TransplantationNo drug interventionsotherNot Availableunknown_status
NCT06533852
Fecal Microbiome Transplantation in Cirrhosis: Trial in Patients With Decompensated CirrhosisNo drug interventionstreatment3not_yet_recruiting
NCT04112199
A Study for Evaluation of BIV201 to Reduce Ascites and Complications in Patients With Cirrhosis and Refractory Ascitestreatment2terminated
NCT05086536
Re-compensation and Its Clinical Characteristics in HBV Decompensated CirrhosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT06431919
Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and SurvivaltreatmentNot Availablenot_yet_recruiting
NCT02786017
Injectable Collagen Scaffold™ Combined With HUC-MSCs Transplantation for Patients With Decompensated CirrhosisNo drug interventionstreatment1 / 2unknown_status
NCT03214796
Effect of Albumin Infusion on Oxidative Albumin Modification, Albumin Binding Capacity and Plasma Thiol StatusNot AvailableNot Availableactive_not_recruiting
NCT03632148
Effect of Liver MSCs in Blood of Patients With Liver Disease.No drug interventionsNot AvailableNot Availablecompleted
NCT05937048
Coagulation Parameters With Albumin in Decompensated Cirrhosis (CoPA-D).treatmentNot Availablenot_yet_recruiting
NCT02597166
Effects of Harvoni in Patients With Decompensated Cirrhosis Due to Hepatitis C Genotype 1 Infectiontreatment3completed
NCT00663182
Entecavir for Patients With Decompensated Hepatitis B Virus (HBV)-Related Cirrhosistreatment4unknown_status
NCT05224960
Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-2)treatment2not_yet_recruiting
NCT01410591
TIPS With 8- OR 10-mm Covered Stent for Preventing Variceal RebleedingNo drug interventionstreatmentNot Availablecompleted
NCT04775329
Primary Prophylaxis for Spontaneous Bacterial Peritonitisprevention2 / 3terminated
NCT01440829
The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPStreatment2 / 3completed
NCT05734001
Rotational Thromboelastometry Versus Conventional Haemostatic Tests in Children With Decompensated Cirrhosis Undergoing Invasive Procedures.No drug interventionsdiagnosticNot Availablerecruiting
NCT03547895
Management of Decompensated HCV Cirrhotic PatientstreatmentNot Availablecompleted
NCT04422223
Prospective Cohort Study of Disease and Outcomes in CirrhosisNo drug interventionsNot AvailableNot Availablerecruiting