Actinic Keratosis (AK)

Also known as: Solar keratosis / Actinic keratosis / Actinic Keratoses / Keratosis, Actinic / Senile keratoma / Senile keratosis / Keratosis NOS

DrugDrug NameDrug Description
DB00586DiclofenacAn NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis.
DB00544FluorouracilA pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
DB08818Hyaluronic acidA glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.
DB05013Ingenol mebutateA topical agent used for the treatment of actinic keratosis.
DB00992Methyl aminolevulinateA porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp.
DB09152NitrogenA cryogenic agent used to treat various benign and malignant skin lesions.
DB00936Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
DrugDrug NameTargetType
DB00586DiclofenacProstaglandin G/H synthase 1target
DB00586DiclofenacProstaglandin G/H synthase 2target
DB00586DiclofenacTransthyretincarrier
DB00586DiclofenacCytochrome P450 2C9enzyme
DB00586DiclofenacCytochrome P450 2C19enzyme
DB00586DiclofenacCytochrome P450 1A2enzyme
DB00586DiclofenacCytochrome P450 2C8enzyme
DB00586DiclofenacSerum albumincarrier
DB00586DiclofenacMultidrug resistance-associated protein 4transporter
DB00586DiclofenacMultidrug resistance-associated protein 1transporter
DB00586DiclofenacSolute carrier family 22 member 6transporter
DB00586DiclofenacSolute carrier family 22 member 8transporter
DB00586DiclofenacSolute carrier organic anion transporter family member 1C1transporter
DB00586DiclofenacSolute carrier family 22 member 11transporter
DB00586DiclofenacUDP-glucuronosyltransferase 2B7enzyme
DB00586DiclofenacCytochrome P450 3A4enzyme
DB00586DiclofenacCytochrome P450 2B6enzyme
DB00586DiclofenacCytochrome P450 2C18enzyme
DB00586DiclofenacCytochrome P450 2E1enzyme
DB00586DiclofenacSolute carrier organic anion transporter family member 1B1transporter
DB00586DiclofenacBile salt export pumptransporter
DB00586DiclofenacUDP-glucuronosyltransferase 1-3enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 1-9enzyme
DB00586DiclofenacUDP-glucuronosyltransferase 2B4enzyme
DB00586DiclofenacArachidonate 5-lipoxygenaseenzyme
DB00586DiclofenacSodium channel protein type 4 subunit alphatransporter
DB00586DiclofenacAcid-sensing ion channel 1transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 2transporter
DB00586DiclofenacPotassium voltage-gated channel subfamily KQT member 3transporter
DB00586DiclofenacPhospholipase A2, membrane associatedenzyme
DB00586DiclofenacP-glycoprotein 1transporter
DB00544FluorouracilThymidylate synthasetarget
DB00544FluorouracilCytochrome P450 1A2enzyme
DB00544FluorouracilThymidine phosphorylaseenzyme
DB00544FluorouracilSerum albumincarrier
DB00544FluorouracilCytochrome P450 2C9enzyme
DB00544FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
DB00544FluorouracilUridine phosphorylase 1enzyme
DB00544FluorouracilUridine phosphorylase 2enzyme
DB00544FluorouracilDNAtarget
DB00544FluorouracilRNAtarget
DB00544FluorouracilCytochrome P450 2A6enzyme
DB00544FluorouracilCytochrome P450 2C8enzyme
DB00544FluorouracilMethylenetetrahydrofolate reductaseenzyme
DB00544FluorouracilThymidylate synthaseenzyme
DB00544FluorouracilUridine 5'-monophosphate synthaseenzyme
DB00544FluorouracilAmidophosphoribosyltransferaseenzyme
DB00544FluorouracilSolute carrier family 22 member 7transporter
DB00544FluorouracilEquilibrative nucleoside transporter 1transporter
DB00544FluorouracilATP-binding cassette sub-family G member 2transporter
DB00544FluorouracilCanalicular multispecific organic anion transporter 2transporter
DB00544FluorouracilMultidrug resistance-associated protein 4transporter
DB00544FluorouracilMultidrug resistance-associated protein 5transporter
DB00544FluorouracilThyroxine-binding globulincarrier
DB08818Hyaluronic acidCD44 antigentarget
DB08818Hyaluronic acidIntercellular adhesion molecule 1target
DB08818Hyaluronic acidHyaluronan mediated motility receptortarget
DB08818Hyaluronic acidNeurocan core proteintarget
DB08818Hyaluronic acidVersican core proteintarget
DB08818Hyaluronic acidComplement component 1 Q subcomponent-binding protein, mitochondrialtarget
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 1target
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 3target
DB08818Hyaluronic acidHyaluronan-binding protein 2target
DB08818Hyaluronic acidLayilintarget
DB08818Hyaluronic acidStabilin-2target
DB08818Hyaluronic acidTumor necrosis factor-inducible gene 6 proteintarget
DB08818Hyaluronic acidInterphotoreceptor matrix proteoglycan 2target
DB08818Hyaluronic acidIntracellular hyaluronan-binding protein 4target
DB08818Hyaluronic acidHyaluronidase enzymesenzyme
DB08818Hyaluronic acidMultidrug resistance-associated protein 5transporter
DB08818Hyaluronic acidLymphatic vessel endothelial hyaluronic acid receptor 1target
DB05013Ingenol mebutateProtein kinase C delta typetarget
DB05013Ingenol mebutateProtein kinase C alpha typetarget
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DrugDrug NamePhaseStatusCount
DB00855Aminolevulinic acid0Not Yet Recruiting1
DB11105Benzalkonium0Completed1
DB02300Calcipotriol0Completed1
DB02300Calcipotriol0Terminated1
DB00544Fluorouracil0Completed1
DB00544Fluorouracil0Terminated1
DB05013Ingenol mebutate0Withdrawn1
DB02701Nicotinamide0Completed1
DB09321Zinc oxide0Completed1
DB09321Zinc oxide0Terminated1
DB00855Aminolevulinic acid1Completed1
DB00482Celecoxib1Recruiting1
DB00586Diclofenac1Completed1
DB00724Imiquimod1Completed2
DB15109Ingenol disoxate1Completed3
DB05013Ingenol mebutate1Completed11
DB00281Lidocaine1Completed1
DB11062Octisalate1Completed1
DB09535Octocrylene1Completed1
DB00750Prilocaine1Completed1
DB12700Solamargine1Completed1
DB06137Tirbanibulin1Completed2
DB09321Zinc oxide1Completed2
DB00855Aminolevulinic acid1 / 2Recruiting1
DB06261Hexaminolevulinate1 / 2Completed1
DB15109Ingenol disoxate1 / 2Completed3
DB05013Ingenol mebutate1 / 2Completed2
DB00992Methyl aminolevulinate1 / 2Completed1
DB09321Zinc oxide1 / 2Completed1
DB04931Afamelanotide2Unknown Status1
DB00855Aminolevulinic acid2Completed8
DB00855Aminolevulinic acid2Terminated1
DB11105Benzalkonium2Completed1
DB11105Benzalkonium2Not Yet Recruiting2
DB09096Benzoyl peroxide2Completed1
DB02300Calcipotriol2Not Yet Recruiting2
DB00169Cholecalciferol2Active Not Recruiting1
DB00390Digoxin2Recruiting1
DB00544Fluorouracil2Not Yet Recruiting2
DB00695Furosemide2Recruiting1
DB00724Imiquimod2Completed4
DB15109Ingenol disoxate2Completed1
DB05013Ingenol mebutate2Active Not Recruiting1
DB05013Ingenol mebutate2Completed7
DB00982Isotretinoin2Completed1
DB11062Octisalate2Completed1
DB09535Octocrylene2Completed1
DB01229Paclitaxel2Completed1
DB11058Petrolatum2Not Yet Recruiting2
DB06530Resiquimod2Completed1
DB06137Tirbanibulin2Completed1
DB00755Tretinoin2Completed1
DB09321Zinc oxide2Completed7
DB00855Aminolevulinic acid3Completed5
DB00855Aminolevulinic acid3Withdrawn1
DB11105Benzalkonium3Completed1
DB00586Diclofenac3Completed4
DB00586Diclofenac3Recruiting1
DB00544Fluorouracil3Completed5
DB00544Fluorouracil3Terminated1
DB00724Imiquimod3Completed9
DB15109Ingenol disoxate3Completed4
DB15109Ingenol disoxate3Terminated1
DB05013Ingenol mebutate3Completed13
DB05013Ingenol mebutate3Terminated1
DB00992Methyl aminolevulinate3Completed5
DB09152Nitrogen3Completed1
DB11062Octisalate3Completed1
DB09535Octocrylene3Completed1
DB00936Salicylic acid3Completed1
DB06137Tirbanibulin3Completed2
DB08604Triclosan3Completed1
DB09321Zinc oxide3Completed14
DB09321Zinc oxide3Recruiting1
DB09321Zinc oxide3Unknown Status1
DB00855Aminolevulinic acid4Completed3
DB00855Aminolevulinic acid4Recruiting2
DB00855Aminolevulinic acid4Terminated1
DB00855Aminolevulinic acid4Unknown Status1
DB09495Avobenzone4Completed1
DB00626Bacitracin4Completed1
DB00586Diclofenac4Completed4
DB00544Fluorouracil4Completed2
DB00544Fluorouracil4Recruiting1
DB00544Fluorouracil4Unknown Status1
DB11064Homosalate4Completed1
DB08818Hyaluronic acid4Completed1
DB00724Imiquimod4Completed5
DB00724Imiquimod4Not Yet Recruiting1
DB00724Imiquimod4Terminated2
DB00724Imiquimod4Unknown Status3
DB05013Ingenol mebutate4Completed6
DB05013Ingenol mebutate4Unknown Status1
DB00825Levomenthol4Completed1
DB00281Lidocaine4Completed1
DB00992Methyl aminolevulinate4Completed2
DB11062Octisalate4Completed2
DB09535Octocrylene4Completed2
DB01428Oxybenzone4Completed1
DB00781Polymyxin B4Completed1
DB00750Prilocaine4Completed1
DB09321Zinc oxide4Completed6
DB09321Zinc oxide4Not Yet Recruiting1
DB09321Zinc oxide4Terminated2
DB09321Zinc oxide4Unknown Status1
DB00316AcetaminophenNot AvailableNot Yet Recruiting1
DB00855Aminolevulinic acidNot AvailableCompleted4
DB00855Aminolevulinic acidNot AvailableWithdrawn2
DB00341CetirizineNot AvailableCompleted1
DB00586DiclofenacNot AvailableCompleted1
DB00544FluorouracilNot AvailableCompleted2
DB00544FluorouracilNot AvailableWithdrawn1
DB00724ImiquimodNot AvailableCompleted3
DB00724ImiquimodNot AvailableRecruiting1
DB00724ImiquimodNot AvailableWithdrawn1
DB05013Ingenol mebutateNot AvailableCompleted7
DB00992Methyl aminolevulinateNot AvailableUnknown Status1
DB00799TazaroteneNot AvailableCompleted1
DB09321Zinc oxideNot AvailableCompleted2