Chorea (DBCOND0017943)

Identifiers

Synonyms

Other chorea / Choreiform movement / Choreiform movements / Chorea NOS / Chorea (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Deutetrabenazine	A vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of tardive dyskinesia and chorea associated with Huntington's disease.	Synaptic vesicular amine transportertarget Carbonyl reductase [NADPH] 1enzyme Carbonyl reductase [NADPH] 3enzyme Cytochrome P450 2D6enzyme Cytochrome P450 1A2enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme
Fluphenazine	A phenothiazine used to treat patients requiring long-term neuroleptic therapy.	D(2) dopamine receptortarget D(1A) dopamine receptortarget Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2E1enzyme Androgen receptortarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget 5-hydroxytryptamine receptor 1Btarget Calmodulintarget
Tiapride	A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism.	D(2) dopamine receptortarget D(3) dopamine receptortarget Serotonin Receptorstarget Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget Sodium channel protein type 10 subunit alphatarget
Valbenazine	A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia and chorea associated with Huntington's disease.	Synaptic vesicular amine transportertarget Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06585605	A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes	No drug interventions	Not Available	Not Available	recruiting
NCT01795859	First Time Use of SD-809 in Huntington Disease	Deutetrabenazine	treatment	3	completed
NCT00001930	Treatment of Huntington's Chorea With Amantadine	Amantadine	treatment	2	completed
NCT00368849	Atomoxetine and Huntington's Disease	Atomoxetine	treatment	2	completed
NCT04201834	Risperidone for the Treatment of Huntington's Disease Involuntary Movements	Risperidone	treatment	2	completed
NCT00950196	Amantadine for Improving Neurologic Symptoms in Ataxia-Telangiectasia	Amantadine	treatment	4	completed
NCT00271596	Citalopram to Enhance Cognition in HD	Citalopram	treatment	2	completed
NCT01019473	Efficacy, Safety and Tolerability of AFQ056 in Patients With Huntington's Disease in Reducing Chorea	Mavoglurant	treatment	2	terminated