Hepatic Failure (DBCOND0042778)

Identifiers

Synonyms
Liver Failure / Hepatic failure / Hepatic failure, unspecified / Hepatic failure (disorder) / Failure liver / Hepatic Insufficiency

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Pyridoxine
A vitamin used to correct vitamin B6 deficiency and to treat nausea during pregnancy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01366144
Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunctiontreatment1active_not_recruiting
NCT04617522
Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairmenttreatment1recruiting
NCT01218464
Safety and Efficacy of Human Mesenchymal Stem Cells for Treatment of Liver FailureNo drug interventionstreatment1 / 2unknown_status
NCT02812121
UC-MSC Infusion for HBV-Related Acute-on-Chronic Liver FailureNo drug interventionstreatment2unknown_status
NCT03000621
Comparative Study of Circulating microRNA Changes in Patients With Liver Injury and Healthy SubjectsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01597102
Cerebrovascular Autoregulation During and After Liver TransplantationNo drug interventionsNot AvailableNot Availableunknown_status
NCT02882347
The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)treatment3unknown_status
NCT02635347
Remote Ischemic Conditioning (RIC) in Recipients of Brain Death Donor Livers - A Feasibility and Safety StudyNo drug interventionstreatmentNot Availablecompleted
NCT02331745
RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failuretreatment4unknown_status
NCT03864497
Myocardial Perfusion Imaging in Liver Transplantation CandidatesNo drug interventionsNot AvailableNot Availablecompleted
NCT03833297
Monitoring the HePAtological TOXicity of Drugs (HePATOX)No drug interventionsNot AvailableNot Availablecompleted
NCT01394497
Use of N-Acetylcysteine During Liver Procurementprevention2completed
NCT04906083
Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopeniatreatment4unknown_status
NCT02584283
Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantationprevention3completed
NCT03640728
The Efficacy and Safety of Nucleos(t)Ide Analogues in the Treatment of HBV-related Acute-on-chronic Liver FailureNot AvailableNot Availablerecruiting
NCT01404793
SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver TransplantationNot AvailableNot Availablecompleted
NCT05170971
Fecal Microbiota Transplantation for Liver FailureNo drug interventionstreatmentNot Availablerecruiting
NCT01160978
Donor Simvastatin Treatment in Organ Transplantationtreatment2 / 3completed
NCT01425385
Autoregulation Assessment During Liver TransplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT01921985
Terlipressin Administration in Patients Undergoing Major Liver Resectiontreatment2terminated
NCT01575015
Intraoperative Dialysis in Liver TransplantationNo drug interventionstreatmentNot Availableterminated
NCT02455115
Renal Perfusion, Filtration and Oxygenation After Liver Transplantation -Effects of av Postoperative Blood PressuretreatmentNot Availablecompleted
NCT01322906
Allogeneic Bone Marrow Mesenchymal Stem Cells Transplantation in Patients With Liver Failure Caused by Hepatitis B Virus (HBV)No drug interventionstreatment2unknown_status
NCT05592106
Gd-EOB-DTPA-enhanced T1 Map for Predicting Postoperative Liver FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT03265249
BRIDGE Device for Post-operative Pain ControlNo drug interventionstreatmentNot Availableterminated
NCT04789213
Mortality, Morbidity and Risk Factors of Liver RetransplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT06181318
Quantitative MRI and Outcomes of Liver ResectionNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00695617
Citrate Anticoagulation During MARS TreatmentNo drug interventionstreatment2 / 3unknown_status
NCT04107324
ARAPS Study on Accelerated Liver RegenerationNo drug interventionstreatmentNot Availableunknown_status
NCT02343016
NIRS as a Continuous Noninvasive Monitoring System of Liver/Kidney Graft PerfusionNo drug interventionsNot AvailableNot Availableterminated
NCT05744635
Assessment of the Pharmacokinetic Profile of Tacrolimus Medications and Their Relation to Effectiveness and Safety in Liver Transplant PatientsNot AvailableNot Availablerecruiting
NCT01844063
Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver FailureNo drug interventionstreatment1 / 2unknown_status
NCT06366048
A Study on Relationship Between Resected Normal Liver Parenchymal Volume(RNLV)and Post-Hepatectomy Liver Failure (PHLF)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01709565
Lactate Clearance According to the Presence of Hepatic DysfunctionNo drug interventionsNot AvailableNot Availableunknown_status
NCT03589820
Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver FailureNo drug interventionstreatmentNot Availableunknown_status
NCT01785082
Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-testdiagnostic3completed
NCT04139473
Randomized Trial of Hepaticojejunostomy Versus Duct-to-duct Anastomosis in Right Lobe Living Donor Liver TransplantationNo drug interventionstreatmentNot Availableunknown_status
NCT00832273
Use of the ELAD® in Patients With Liver Failure to Provide Expanded Access With Cost RecoveryNo drug interventionsNot AvailableNot Availableno_longer_available
NCT04122027
A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver TransplantationNo drug interventionsotherNot Availableunknown_status
NCT04705194
Hepatectomy Risk Assessment With Functional Magnetic Resonance ImagingNo drug interventionsNot AvailableNot Availableunknown_status
NCT05045794
Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver TransplantationNo drug interventionstreatmentNot Availablecompleted
NCT01254994
The Efficacy and Safety of Entecavir Treatment of Patients With Acute on Chronic Hepatitis B Liver Failuretreatment2completed
NCT00956891
Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs TransplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT00886262
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver TransplanttreatmentNot Availablecompleted
NCT04732689
Intraoperative Hemodynamic Management and Postoperative Outcomes in Liver TransplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT03285867
Liver Stiffness Measurement (LSM) in Predicting Progress of Liver Fibrosis After TACE for Hepatocellular CarcinomaNo drug interventionsNot AvailableNot Availableunknown_status
NCT06300372
Modified Thoracoabdominal Nerve Plane Block In Living Liver DonorsNo drug interventionstreatmentNot Availablerecruiting
NCT00805610
Hepatocyte Transplantation in Liver FailureNo drug interventionstreatment1 / 2withdrawn
NCT00915681
Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoningtreatment2terminated
NCT03908255
Branched-chain Amino Acid Supplementation for Hepatocellular Carcinomasupportive_care2withdrawn
NCT05441150
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donorsprevention4unknown_status
NCT04574050
SELF-BREATHE RCT for Chronic BreathlessnessNo drug interventionstreatmentNot Availablecompleted
NCT06224023
Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver FailureNo drug interventionsNot AvailableNot Availablerecruiting
NCT01423708
Everolimus in de Novo Liver Transplantation: a Multicentre Randomized Studytreatment2unknown_status
NCT05234190
Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant PatientsNo drug interventionstreatment1 / 2recruiting
NCT03791190
RCA for CRRT in Liver Failure and High Risk Bleeding PatientsNo drug interventionstreatmentNot Availableunknown_status
NCT02307890
The Relationship of Initial Liver Profile and Outcome After TransplantationNo drug interventionsNot AvailableNot Availableunknown_status
NCT04347902
Lipid Emulsions and Liver Function - Results After 5 Years.prevention4completed
NCT05480787
Pharmacokinetic Study of Continuous Infusion of Remazolam in Mechanically Ventilated Patients in ICUtreatment4unknown_status
NCT01221454
Allogenic Bone Marrow Stem Cell Transplantation in Liver FailureNo drug interventionstreatment2unknown_status
NCT03992898
Nomogram Analysis for HBV Related Acute-on-chronic Liver FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT01724398
Umbilical Cord Mesenchymal Stem Cells Transplantation Combined With Plasma Exchange for Patients With Liver FailureNo drug interventionstreatment1 / 2unknown_status
NCT01081197
Somatic Disease Among Alcohol Abusers in an Out-day Patients' ClinicNo drug interventionsNot AvailableNot Availablecompleted
NCT00325611
Multidisciplinary Inpatient Palliative Care InterventionNo drug interventionspreventionNot Availablecompleted
NCT04447911
Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremiatreatment4recruiting
NCT06272071
A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With InfectionNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03082885
The Efficacy and Safety of Thymosin-α1 in Patients With HBV-related ACLFtreatmentNot Availablecompleted
NCT02041637
Unknown Cause of Acute Liver FailureNo drug interventionsNot AvailableNot Availablecompleted
NCT05726032
Empagliflozin in Patients With Cirrhosis and Ascitesother2recruiting
NCT00162552
Clinical Trial of Pentoxifylline in Patient With Cirrhosistreatment3completed
NCT00772252
Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support TreatmentNo drug interventionsNot AvailableNot Availableunknown_status
NCT04116242
MERTK Signalling in Monocytes/Macrophages in Patients With Liver DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02318836
Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjectstreatment1completed
NCT02390713
Pneumatic Reversible Portal Vein Diameter Modulation After Major HepatectomyNo drug interventionstreatment1 / 2unknown_status
NCT02544113
A Randomized Controlled Clinical Trial of Thymoglobulin® After Liver Transplantationtreatment2completed
NCT02818218
SVC and Its Relationship to CVP Measurements in Liver TransplantationNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02846441
Interstage Assessment of Remnant Liver Function in ALPPSNo drug interventionsNot AvailableNot Availablecompleted
NCT03723317
Associated Balance of Risk Score - Comprehensive Complication Index for the Prediction of Post-transplant SurvivalNo drug interventionsNot AvailableNot Availablecompleted
NCT01774617
Comparative Analysis of Different Tests to Evaluate Prognosis of Patients on Liver Transplant Waiting ListNo drug interventionsNot AvailableNot Availablecompleted
NCT00420134
Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical TrialNo drug interventionstreatment1 / 2completed
NCT02557724
Mobilization of Mesenchymal Stem Cells During Liver TransplantationNo drug interventionsNot AvailableNot Availablecompleted
NCT05740696
Registry Study for Optimal Management of Liver Failure in the Chinese PopulationNo drug interventionsNot AvailableNot Availablerecruiting
NCT04548596
NOninVasive Intracranial prEssure From Transcranial doppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00823758
Understanding Patient's Knowledge and Use of AcetaminophenNo drug interventionsNot AvailableNot Availableunknown_status
NCT05989958
The Safety and Tolerability Study of HepaCure in Chinese Subjects with Acute-On-Chronic Liver FailureNo drug interventionstreatment1recruiting
NCT00287235
Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recirculating System (MARS)No drug interventionstreatmentNot Availablecompleted
NCT02837939
Transfer Factor Efficacy in the Management of Cirrhosis-associated Immune DysfunctionNo drug interventionsprevention2 / 3withdrawn
NCT03044639
Parenteral Lipid Emulsions and the Liver FunctionNo drug interventionsprevention4completed
NCT04160039
Early Cycle Ergometry for Critically-Ill Liver Failure Patients in a Transplant Intensive Care UnitNo drug interventionstreatmentNot Availableterminated
NCT00522730
Safety and Tolerance on Lipids of Parenteral and Enteral Nutrition in Critically Ill Patients With Liver FailureNo drug interventionstreatment4completed
NCT00772148
Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patientstreatment2completed
NCT03667157
Liver Function After Intravenous Methylprednisolone AdministrationNo drug interventionssupportive_care4completed
NCT01344174
A Study Evaluating the Efficacy of Glucocorticoids in Patients With Pre-ACLF-HBVtreatmentNot Availableunknown_status
NCT05958420
Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy DonorsNo drug interventionsNot AvailableNot Availablecompleted
NCT03650920
Hepatitis C Virus (HCV) Positive Liver Grafts in HCV Negative RecipientsNo drug interventionstreatmentNot Availablecompleted
NCT01201720
Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"No drug interventionstreatmentNot Availablecompleted
NCT06014320
Alterations in Coagulation Factor Levels in Patients With End Stage Liver DiseaseNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01022476
Raltegravir in Patients With End Stage Liver Disease and in Transplant Recipientstreatment1 / 2completed
NCT00808691
Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care UnitNo drug interventionsNot AvailableNot Availablecompleted
NCT01137591
Acetaminophen in Combination With N-Acetylcysteine (NAC) Versus Placebo in Treating FeverpreventionNot Availablewithdrawn
NCT00623662
Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver ResectionNo drug interventionspreventionNot Availableunknown_status
NCT04351880
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital DischargeNo drug interventionsotherNot Availablecompleted
NCT03878329
Telemedicine Based Remote Home Monitoring After Liver TransplantationNo drug interventionspreventionNot Availablecompleted
NCT04618692
Biliary Anastomosis Using Surgical Loupe Versus Microscope in Living Donor Liver TransplantationNo drug interventionstreatmentNot Availablecompleted
NCT00608244
Pharmacokinetics of LCP-Tacro in Stable Liver Transplant Patientstreatment2completed
NCT01961440
Prognosis Scoring System for Acute-on-Chronic Liver FailureNo drug interventionsNot AvailableNot Availableunknown_status
NCT02552901
Cardiox Liver Function Test Pivotal TrialNo drug interventionsdiagnostic3withdrawn
NCT00407004
Elimination of Albumin-Bound Substances by MARS and PrometheusNo drug interventionstreatmentNot Availablecompleted
NCT04221672
The Effect of Terlipressin on Recovery of Liver Function After Hepatectomytreatment3unknown_status
NCT05517668
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdosetreatment2recruiting
NCT00614146
Recompensation of Exacerbated Liver Insufficiency With Hyperbilirubinemia and/or Encephalopathy and/or Renal FailureNo drug interventionstreatmentNot Availablecompleted
NCT04237246
Comparative FK506 Drug Levels of Once Daily Advagraf in First Nations and Caucasian Patients With Liver Transplantstreatment4completed
NCT06532214
Clinical Retrospective Study Analysis of Postoperative Complications Following HepatectomyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01895114
Assessment of Renal Function in Cirrhotic PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT01698723
A Trial of Ribavirin in Patients With ACLF Due to Hepatitis E Virustreatment2unknown_status
NCT05484908
Efficacy and Safety of ALSS Treatment for ICIs-LF in Patients With HCCNo drug interventionstreatmentNot Availablerecruiting
NCT01429038
Mesenchymal Stem Cells After Renal or Liver TransplantationNo drug interventionstreatment1 / 2completed
NCT06179368
Throid Dysfunction in Liver Failure and Its Eddects Upon OutcomeNo drug interventionsNot AvailableNot Availablerecruiting
NCT05604469
The Role of Skin Microbiota in Hepatic or Renal PruritusNo drug interventionsNot AvailableNot Availablerecruiting
NCT03560414
The Plasma Diafiltration Therapy of Hepatic FailureNo drug interventionstreatmentNot Availableunknown_status
NCT01846455
Single Dose Pharmacokinetics of Suboxone Study in Hepatic Impaired Subjectstreatment4completed
NCT00831532
Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Functiontreatment1completed
NCT03576859
Pyrophosphate Homeostasis and Hepatic Expression of ABCC6.Pyro-THNo drug interventionsbasic_scienceNot Availablecompleted
NCT02516319
Liver Function Assessment - Feasibility and Dosing StudyNo drug interventionsdiagnosticNot Availableterminated
NCT04587622
Pharmacokinetic Study of Icenticaftor in Participants With Hepatic ImpairmentNo drug interventionstreatment1completed
NCT03515980
An Investigational Study of Experimental Medication BMS-986231 Given in Participants With Different Levels of Liver Functiontreatment1completed