Therapeutic Agent Toxicity (DBCOND0083667)

Identifiers

Synonyms
Drug Toxicity / Toxicity, Drug / Toxicity / Therapeutic agent toxicity / Drug intoxication / Drug poisoning / Poisoning by unspecified drug or medicinal substance / Drug toxicity NOS / Drug toxicity (NOS) / Poisoning by drug AND/OR medicinal substance (disorder) / Poisoning (disorder) / Toxic effect of unspecified substance, accidental (unintentional) / Poisoning / Poisoning NOS / Toxicity to various agents

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Hydroxocobalamin
A synthetic form of vitamin B12 used to treat vitamin B12 associated disorders and cyanide poisoning.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03994302
Monitoring the Antiphospholipid Syndrome:TOXicity of Drugs (APSTOX)No drug interventionsNot AvailableNot Availablecompleted
NCT05899751
Retrospective Registry Study of Patients With Cancer Treated With High-dose MethotrexateNot AvailableNot Availablerecruiting
NCT04305145
Infliximab for Treatment of Immune Checkpoint Inhibitor Colitistreatment2recruiting
NCT05022797
Reduction of MTX Levels After Glucarpidase Treatment in DLBCL Patients at Risk of CNStreatment2terminated
NCT03651778
GHB Poisoning and Poisoning Induced by OthersNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03885388
Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma (GTN) Patients With Score of 5-6treatment2 / 3unknown_status
NCT00213642
Tc-99m Renography and Cisplatin-induced NephrotoxicityNo drug interventionsNot AvailableNot Availableterminated
NCT03882541
Could Music be an Alternative to Sedation in Patients Treated Total Knee Arthroplasty With Regional Anesthesia?otherNot Availablecompleted
NCT03745417
Efficacy and Safety of Expanded UCMSCs On Patients With Moderate to Severe PsoriasisNo drug interventionstreatment1 / 2unknown_status
NCT03947034
Monitoring the Hyperammonaemia:TOXicity of Drugs (AmmoTOX)No drug interventionsNot AvailableNot Availablecompleted
NCT03825224
Evaluation of MyoStrain™ in Clinical PracticeNo drug interventionsNot AvailableNot Availablecompleted
NCT00002586
13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancerprevention2completed
NCT06019520
Role of N-Acetylcysteine for Prevention of Cisplatin-induced NephrotoxicitypreventionNot Availableactive_not_recruiting
NCT01135680
Double-Blind Randomized Crossover Trial to Access Electrocardiogram Effects of HPN-100diagnostic1completed
NCT01614080
Outcome of Patients Treated by iv Rt-PA for Cerebral Ischaemia According to the Ratio Sc-tPA/Tc-tPANo drug interventionsNot AvailableNot Availablecompleted
NCT05237492
The Influence of Tramadol on Platelet Functionother4completed
NCT00017004
Radiation Therapy and Cisplatin With or Without Epoetin Alfa in Treating Patients With Cervical Cancer and Anemiasupportive_care3completed
NCT06214468
Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicitydiagnostic1recruiting
NCT05512169
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic LeukemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT00491595
Phase I Clinical Study of Soy Isoflavones in Healthy, Post-Menopausal WomenNot Available1completed
NCT05472350
Efficacy and Safety of Perioperative Use of Breztri Aerosphere to Relieve Cough After LobectomytreatmentNot Availableunknown_status
NCT00166608
Cytokines Polymorphisms and Acetaminophen ToxicityNo drug interventionsNot AvailableNot Availablecompleted
NCT01239121
Regional Data Exchange to Improve Medication SafetyNo drug interventionshealth_services_researchNot Availablecompleted
NCT04120233
MW151-101: First-in-human Study of MW151No drug interventionsother1completed
NCT03461445
A Pilot Study to Evaluate Impact on Neurological Side Effects (Cognition, Memory, and Tremor) in Elderly (Age>65) Patientstreatment4completed
NCT01374061
Pre Hospital Evaluation of Video LaryngoscopyNo drug interventionstreatment4withdrawn
NCT03392311
Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment in Patients With Moderate to Severe Psoriasistreatment1 / 2completed
NCT00743093
Aminotransferase Trends During Prolonged Acetaminophen DosingNot Available4completed
NCT04747678
Adverse Effects of Ivermectin Used in Egypt During COVID-19Not AvailableNot Availableunknown_status
NCT05691309
Optimizing Vancomycin Therapy in ChildrenNo drug interventionsNot AvailableNot Availablecompleted
NCT01965275
High-Dose,Pulsatile Erlotinib/Gefitinib for Advanced NSCLC Patients After Failure of Standard Dose EGFR-TKIstreatment2unknown_status
NCT05329142
ASSIST: A Surveillance Study of Illicit Substance ToxicityNo drug interventionsNot AvailableNot Availableunknown_status
NCT03265613
Safety and Efficacy of Expanded Allogeneic AD-MSCs in Patients With Moderate to Severe PsoriasisNo drug interventionstreatment1 / 2completed
NCT04275024
Efficacy and Safety of AD-MSCs Plus Calpocitriol Ointment and PSORI-CM01 Granule in Psoriasis PatientstreatmentNot Availablecompleted
NCT02439658
Genetics of QT Prolongation With AntiarrhythmicsNot AvailableNot Availableunknown_status
NCT03469063
Impact of AferBio® on Quality of Life and Chemotherapy Toxicity in Lung Cancer PatientsNo drug interventionssupportive_careNot Availableunknown_status
NCT05851222
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02864030
PAINTER: Polymorphism And INcidence of Toxicity in ERibulin Treatmenthealth_services_research4completed
NCT01979380
Phase I Clinical Trial to Investigate the Safety, Tolerability, Pharmacokinetics of KD101 in Healthy Male SubjectsNo drug interventionsNot Available1completed
NCT04671589
Antidote for Valproic Acid Toxicity: a New Indication for Meropenem Antibiotic.treatment4unknown_status
NCT00090844
Triptorelin for Preserving Ovarian Function in Premenopausal Women Receiving Chemotherapy for Early-Stage Breast Cancersupportive_care2terminated
NCT04987801
Evaluation of Drug Overdose Poisoning Cases and Indications for ICU AdmissionNo drug interventionsNot AvailableNot Availableunknown_status
NCT03280368
Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial FibrillationNo drug interventionsNot AvailableNot Availablecompleted
NCT04696081
Atrial Fibrillation in Active Cancer PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04138381
Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST)treatment1 / 2active_not_recruiting
NCT04659343
TDM for Optimized Outcome in Patients With mRCC.No drug interventionsNot AvailableNot Availablerecruiting
NCT02719002
Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic AntimalarialsNo drug interventionsscreeningNot Availablecompleted
NCT04824352
Apatinib Plus IE Chemotherapy (Ifosfamide and Etoposide) for Relapsed or Refractory Osteosarcomatreatment2suspended
NCT04916392
Observation Study of the Pharmacokinetics of Adductor Canal BlockNot AvailableNot Availablecompleted
NCT05355168
Neoadjuvant Chemoradiotherapy Combined With Camrelizumab and Nimotuzumab for Esophageal Squamous Cell CarcinomaNo drug interventionstreatment1 / 2recruiting
NCT04351308
Comparison of MAPI+Camrelizumab Versus API+Apatinib Versus MAPI in Patients With a Poor Response to Preoperative Chemotherapy for Newly Diagnosed High-grade Osteosarcomatreatment2unknown_status
NCT06558084
Real-World Clinical Outcomes and Toxicity in Metastatic Breast Cancer Patients Treated With First or Second Line CDK 4/6 Inhibitors and Endocrine TherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT04499885
Potential Role of Gastric Lavage by Paraffin Oil in Acute Aluminum Phosphide PoisoningNo drug interventionstreatmentNot Availablerecruiting
NCT03638375
TIL and Anti-PD1 in Metastatic MelanomaNo drug interventionstreatment1 / 2active_not_recruiting
NCT04260113
Apatinib for Inoperable Advanced ChondrosarcomatreatmentNot Availablecompleted
NCT04690231
Apatinib + Ifosfamide and Etoposide for Relapsed or Refractory OsteosarcomatreatmentNot Availablecompleted
NCT05652673
Safe Stop Ipilimumab-nivolumab (IPI-NIVO) TrialtreatmentNot Availablerecruiting
NCT02957864
Switching From Tenofovir Disoproxil Fumarate to Abacavir or Tenofovir Alafenamidetreatment4unknown_status
NCT04400786
A Randomized Open-labeled Study for Comparing Methods of Using Imrecoxib to Treat ASNo drug interventionstreatmentNot Availableunknown_status
NCT04425564
Study of Metronomic Capecitabine and Oxaliplatin Versus XELOX in Egyptian Metastatic Colorectal Cancer Patientsother2completed
NCT01760356
Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT03325400
Cytogenetic Damage in Buccal Cells Caused by ToothpasteNo drug interventionsscreeningNot Availablecompleted
NCT01343459
Intra-Operative Electron Boost and Hypofractionated Whole-Breast Irradiation During Breast-conserving Treatment (BCT)No drug interventionstreatmentNot Availablecompleted
NCT02143219
Efficacy and Tolerance Evaluation in FOLFIRINOX Dose Adjusted in Elderly Patients With a Metastatic Pancreatic Cancertreatment2completed
NCT02054741
Geriatric Assessment Intervention for Reducing Toxicity in Older Patients With Advanced CancerNo drug interventionssupportive_careNot Availablecompleted
NCT05605834
Assessment of Peroxide Level in Saliva During Teeth Bleaching With 9.5% Hydrogen Peroxide GelNo drug interventionspreventionNot Availablecompleted
NCT04879563
Artificial Intelligence Supporting CAncer Patients Across Europe - the ASCAPE ProjectNo drug interventionssupportive_care2active_not_recruiting
NCT00890448
Case Control Study of Pharmacogenomic Factors Associated With Hepatocellular Injury Following Exposure to Lapaquistat AcetateNo drug interventionsNot AvailableNot Availablecompleted
NCT03953248
L-Carnitine as an Adjuvant Treatment in Acute Phosphide Poisoning (LC)treatment0completed
NCT01091766
Sensitivity of ECG on Detection of Three Different Intravascular Applied Test Doses of Bupivacaine and Epinephrineprevention4completed
NCT05277480
Apatinib With Ifosfamide Plus Etoposide for Relapsed or Refractory Osteosarcoma (OAIE)treatment2completed
NCT03663881
Safety Assessment of P2Et Extract in Healthy Voluntary Subjects in ColombiaNo drug interventionstreatment1completed
NCT01602250
Local Anaesthetics Toxicity and Intralipid®prevention2completed
NCT01276938
Exclusive Intraoperative Radiation Therapy for Breast CancerNo drug interventionstreatment2 / 3completed
NCT01192243
Study of Gefitinib Compared With Pemetrexed/Cisplatin in Advanced Non-Small Cell Lung Cancer Patientstreatment2unknown_status
NCT06512298
Plasticizer Exposure and Its Consequences on HealthNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04676711
A Study of GFH312 in Healthy SubjectsNo drug interventionstreatment1completed
NCT03491371
Apatinib for Advanced Sarcoma: Results From Multiple Institutions' Off-label UsetreatmentNot Availablecompleted
NCT02512809
Isoflurane-induced Neuroinflammation in Children With Hydrocephalusprevention3terminated
NCT03975452
Volume De-escalation in Neoadjuvant Radiochemotherapy of Rectal CancerNo drug interventionstreatmentNot Availableunknown_status
NCT02748200
External Beam Radiotherapy for Muscle Invasive Bladder CancerNo drug interventionstreatment1completed
NCT03342300
Pegylated Liposomal Doxorubicin Versus Pirarubicin Plus Ifosfamide, Dacarbazine in Locally Advanced, Unresectable or Metastatic Soft-tissue Sarcomatreatment2 / 3withdrawn
NCT06542159
Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary OligometastasesNo drug interventionstreatment2recruiting
NCT03978949
Prevention of Radiotherapy Induced Enteropathy by Probiotics (PREP)prevention3unknown_status
NCT02273713
The Addition of Nab-paclitaxel (Abraxane) to First Line Treatment of Metastasized Oesophagogastric Carcinoma (ACTION)treatment1 / 2completed
NCT03359018
Apatinib Plus Anti-PD1 Therapy for Advanced Osteosarcomatreatment2completed
NCT06087718
Feasibility of the Maastro Applicator in Rectal CancerNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00618917
MnSOD (Esophageal Protectant) to Prevent Esophagitis During Radiation/Chemotherapy Treatment for Non-Small Cell Lung Cancer (NSCLC)treatment1 / 2terminated
NCT02397434
Adjuvant Radiotherapy After Cystectomy for Muscle Invasive Bladder CancerNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06281886
Induction Immuno-chemotherapy and Concurrent Chemoradiotherapy With or Without Apatinib in Unresectable, Locally Advanced Esophageal Squamous Cell Carcinomatreatment2recruiting
NCT02778386
Evaluating the Safety and Plasma Levels of N-Methanocarbathymidine (N-MCT) in Normal Patientshealth_services_research1unknown_status
NCT01059474
Transdermal Absorption of Dimercaptopropane-1-Sulfonate (DMPS) and Effect on Urinary Mercury ExcretionNo drug interventionsbasic_science1completed
NCT03790631
The OPTIMAL TDM Study: Determining Optimal Beta-lactam Plasma Concentrations Through Therapeutic Drug MonitoringNo drug interventionsNot AvailableNot Availablerecruiting
NCT04700527
The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled Studytreatment1 / 2recruiting
NCT00531076
Safety Study of Bevacizumab (Avastin) With Thoracic Radiation in Non-small Cell Cell Lung Cancertreatment1terminated
NCT02649491
Using an Electronic Nose to Predict Gastrointestinal Consequences of Pelvic RadiotherapyNo drug interventionsNot AvailableNot Availableunknown_status
NCT03612544
The ESTxENDS Trial- Substudy on the Effect on Toxins From Using Electronic Nicotine Delivery Systems (ENDS/Vaporizer/E-cig)No drug interventionspreventionNot Availablecompleted
NCT02484040
Two-week Course Versus Conventionally Fractionated Chemoradiotherapy in Rectal CancerNo drug interventionstreatment3unknown_status
NCT02734069
Impact of Fat-free Mass in the Carboplatin Calculated Dose and Chemotherapeutic Toxicity in Patients With Advanced NSCLCNot AvailableNot Availablerecruiting
NCT06044623
Implementing Geriatric Assessment for Dose Optimization of Cyclin-dependent Kinase (CDK) 4/6-inhibitors in Older Breast Cancer PatientsNo drug interventionstreatment3recruiting
NCT02760823
Alpha Lipoic Acid as an Adjuvant Treatment in Acute Phosphide Poisoningtreatment2unknown_status