Stage IV Colorectal Cancer (DBCOND0042053)

Identifiers

Synonyms
Colorectal Cancer Stage IV / Metastatic Colorectal Carcinoma / Colorectal cancer Dukes D

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01722903
Detection of CTCs in Patients Undergoing Surgery for Stage IV Colorectal CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT01704703
Study of FOLFIRI + Panitumumab Using Ultra-selection Technology of Patients With Stage IV Colorectal Cancer Refractory to Irinotecan Without Any Mutation on KRAS, PIK3Ca, BRAF and NRAS Genes Detected With Highly Sensitive Techniquestreatment2completed
NCT03800602
Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancertreatment2completed
NCT04670445
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced CancerNo drug interventionshealth_services_researchNot Availableactive_not_recruiting
NCT01074385
Dignity Therapy in mCRC to Increase Peaceful Awareness & Impact Goals of Care Decision-MakingNo drug interventionssupportive_careNot Availablecompleted
NCT04267575
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor SitesNo drug interventionstreatmentNot Availableunknown_status
NCT03368963
TAS102 in Combination With NAL-IRI in Advanced GI Cancerstreatment1 / 2recruiting
NCT03275974
Glutamine PET Imaging Colorectal Cancerdiagnostic1active_not_recruiting
NCT01271582
Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patientstreatment4unknown_status
NCT02960282
Gut Microbiome in Fecal Samples From Patients With Metastatic Cancer Undergoing Chemotherapy or ImmunotherapyNo drug interventionsNot AvailableNot Availableterminated
NCT01550510
Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CAtreatment1 / 2terminated
NCT03095781
Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancertreatment1completed
NCT06287723
French Assessment of MRD by Liquid Biopsies in Colorectal With Liver Metastasis Patients (FRENCH.MRD.CRLM)Not AvailableNot Availablenot_yet_recruiting
NCT03111823
Exercise Program During Chemotherapy in Metastatic Colorectal CancerNo drug interventionssupportive_careNot Availableterminated
NCT03005002
Durvalumab and Tremelimumab in Treating Patients With Microsatellite Stable Metastatic Colorectal Cancer to the Livertreatment1completed
NCT03373188
VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancertreatment1completed
NCT01998152
Individualized Nutritional Counselling During Chemotherapy for Colorectal Cancer (COLONUT)No drug interventionstreatmentNot Availablecompleted
NCT02809716
High Definition Single Cell Analysis in Colorectal CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04044430
Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancertreatment1terminated
NCT05025748
Ask Questions (ASQ):Implementation of a Communication InterventionNo drug interventionshealth_services_researchNot Availablecompleted
NCT05631574
Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal CancerNo drug interventionstreatment1recruiting
NCT03087591
APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by SurgeryNo drug interventionstreatment1completed
NCT02919644
Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumour Homogenate After Curative Resection for Stage IV Colorectal Cancer.No drug interventionstreatment2unknown_status
NCT03112668
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their PartnersNo drug interventionssupportive_careNot Availablecompleted
NCT00784446
First-line Therapy of Stage IV Colorectal Cancertreatment1 / 2completed
NCT04715061
Impact of Aerobic Exercise on Immune Response and Side Effects of Cancer TreatmentsNo drug interventionssupportive_careNot Availablecompleted
NCT06296056
Phase I Study of Combined Immune Cell Therapy in Patients With Stage 4 Colorectal Cancer With Metastatic Lesion Who Failed Prior Standard of CareNo drug interventionstreatment1not_yet_recruiting
NCT01570452
Matrilysin Expression in Different Stages of Colorectal TumorsNo drug interventionsNot AvailableNot Availablecompleted
NCT05164419
Impact de la Marge de résection Sur la Survie à Long Terme et le Taux de récidive Des Patients Atteints de Cancers Colorectaux opérés au CHUS Entre 2006 et 2016 Pour Des métastases hépatiquesNo drug interventionsNot AvailableNot Availablecompleted
NCT05451719
Fruquintinib Plus Capecitabine Versus Capecitabine as Maintenance Therapy for Metastatic Colorectal Cancer After First-line Chemotherapytreatment2not_yet_recruiting
NCT05354817
Impact of FOLFIRINOX Chemotherapy in IV Stage Colorectal Cancer Patients Previously Exposed to Irinotecan, Fluoropyrimidine and OxaliplatinNo drug interventionstreatment2unknown_status
NCT05576896
Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractorytreatment2recruiting
NCT04157322
Plasma 5hmC Signatures as a Marker of Colorectal / Appendiceal Peritoneal MetastasisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03594448
Detection of MSI in Circulating Tumor DNA of Colorectal Carcinoma PatientsNo drug interventionsNot AvailableNot Availableterminated
NCT04917276
Treatment Response Prediction System of mCRC Patients Based on CTCNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06342440
Early Detection of Advanced Adenomas and Colorectal CancerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05550701
Prognostic Impact of Increased Lymph Node Yield in Colorectal Cancer Patients With Synchronous Distant Metastasis: a Population-based Study of the US Database and a Chinese RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT03542214
Calcium Electroporation for the Treatment of Colorectal Cancerdevice_feasibility1completed
NCT03149679
The p53 Colorectal Cancer Trialtreatment2terminated
NCT05426005
Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancertreatment1 / 2recruiting
NCT06329700
Parenchymal Sparing Hepatectomy in Post-chemotherapy Liver AtrophyNo drug interventionsNot AvailableNot Availablecompleted
NCT04149613
Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal CancerNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05382741
Adjuvant Durvalumab Plus Regorafenib vs Untreated Control in Stage IV Colorectal Cancer Patients With no Evidence of Disease (NED): VIVA Trialtreatment2recruiting
NCT03986541
AREG, EREG and EGFR: Response to Anti-EGFR Agents in Colorectal CancerNo drug interventionsNot AvailableNot Availablecompleted
NCT04425239
Intermittent or Continuous Panitumumab Plus FOLFIRI for RAS/B-RAF Wild-type Metastatic Colorectal Cancertreatment2completed
NCT06509126
Intermittent or Continuous Panitumumab Plus FOLFIRI for Left Sided RAS/B-RAF Wild-type Metastatic Colorectal Cancertreatment3recruiting
NCT05289726
Study on the Prevention of Dermal Toxicity Caused by Regorafenib by Traditional Chinese Medicine TDX105No drug interventionsprevention2unknown_status
NCT05171660
Combination With Sintilimab and XELOX+Bevacizumab as 1st Line Therapy in RAS-mutant Metastatic Colorectal Cancertreatment3recruiting
NCT03031444
Perioperative Chemotherapy Plus Cetuximab Versus Chemotherapy Alone for High Risk Resectable Colorectal Liver Metastasistreatment2 / 3completed
NCT06342401
Early Onset Colorectal Cancer DetectionNo drug interventionsNot AvailableNot Availablerecruiting
NCT04714814
Mechanisms of Fate Evolution of Colorectal Adenocarcinoma MetastasisNo drug interventionsNot AvailableNot Availableunknown_status
NCT02618850
PET/CT Scan as a Tool to Rationalize the Treatment of Patients With Advanced ColoRectal Cancer Undergoing First-line Medical TreatmentNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT06147037
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients with Advanced Solid TumoursNo drug interventionstreatment1recruiting
NCT06349642
Predicting Response to Immune Checkpoint Inhibitors Across Solid Tumors Using a Live Tumor Diagnostic PlatformNo drug interventionsNot AvailableNot Availablerecruiting
NCT05322590
BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinomatreatment1 / 2recruiting
NCT04616183
LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancertreatment1 / 2active_not_recruiting
NCT04221893
Radiation Therapy for the Treatment of Metastatic Gastrointestinal CancersNo drug interventionstreatmentNot Availablerecruiting
NCT06269978
Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancertreatment1recruiting
NCT03290937
Utomilumab, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Metastatic Colorectal Cancertreatment1active_not_recruiting
NCT02298959
Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancertreatment1active_not_recruiting
NCT03096899
A Study to Estimate Overall Survival in Patients Receiving Best Supportive Care for Treatment-Resistant, Metastatic Colorectal CarcinomaNo drug interventionsNot AvailableNot Availablewithdrawn
NCT02738606
Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by SurgeryNo drug interventionstreatment2active_not_recruiting
NCT06115174
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancerother4not_yet_recruiting
NCT03993327
An Imaging Agent (I-124 M5A) in Detecting CEA-Positive Liver Metastases in Patients With Colorectal Cancerdiagnostic1completed
NCT05130060
A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancertreatment1completed
NCT04329494
PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancertreatment1recruiting
NCT02757391
CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumorstreatment1terminated
NCT04599140
SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trialtreatment1 / 2recruiting
NCT04535401
Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestinestreatment1active_not_recruiting
NCT02873195
Capecitabine and Bevacizumab With or Without Atezolizumab in Treating Patients With Refractory Metastatic Colorectal Cancertreatment2completed
NCT03981614
Binimetinib and Palbociclib or TAS-102 in Treating Patients With KRAS and NRAS Mutant Metastatic or Unresectable Colorectal Cancertreatment2completed
NCT04673955
BRAF Inhibitor Encorafenib And Cetuximab Real Life Investigation of Next Generation CRC TreatmentNot AvailableNot Availablerecruiting
NCT02888743
Durvalumab and Tremelimumab With or Without High or Low-Dose Radiation Therapy in Treating Patients With Metastatic Colorectal or Non-small Cell Lung Cancertreatment2active_not_recruiting
NCT04294264
TAS-102 and Oxaliplatin for the Treatment of Refractory Stage IV Colon Cancertreatment2active_not_recruiting
NCT03337087
Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancertreatment1 / 2active_not_recruiting
NCT04693377
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME TrialNo drug interventionssupportive_careNot Availablerecruiting
NCT03992456
Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancertreatment2active_not_recruiting
NCT06265285
Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Programhealth_services_research2recruiting
NCT01937715
A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic Colorectal Cancertreatment1 / 2terminated
NCT06449937
Local Liver Treatment for Multi-organ Colorectal Cancer MetastasesNo drug interventionstreatmentNot Availablerecruiting
NCT05733000
CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumorstreatment2recruiting
NCT04796818
An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment ResponseNo drug interventionsdiagnosticNot Availableactive_not_recruiting
NCT03317119
Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgerytreatment1completed
NCT04096417
Pemigatinib for the Treatment of Metastatic or Unresectable Colorectal Cancer Harboring FGFR Alterationstreatment2active_not_recruiting
NCT05061017
Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/Refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (mCRC)treatment2completed
NCT04362839
Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancertreatment1active_not_recruiting
NCT04430725
Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT05803382
Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancerstreatment1recruiting
NCT02595931
M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgerytreatment1active_not_recruiting
NCT03823144
Intravital Microscopy in Human Solid TumorsdiagnosticNot Availablecompleted
NCT04164069
Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumabprevention1active_not_recruiting
NCT05863195
Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trialtreatment3recruiting
NCT04761614
Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancertreatment1active_not_recruiting
NCT05759923
First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients With Selected Advanced and/or Metastatic Solid TumoursNo drug interventionstreatment1recruiting