Minimal Change Disease (DBCOND0044791)

Identifiers

Synonyms

Minimal change nephropathy / Nephrosis, Lipoid / Glomerulonephritis minimal lesion / Minimal Change Disease (MCD) / MCD - Minimal Change Disease / Lipoid nephrosis / Minimal change disease / Nephrotic syndrome / Minimal change glomerulonephritis / Minimal change disease (disorder) / Nephrotic Syndrome, Minimal Change / Nephrotic syndrome with lesion of minimal change glomerulonephritis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cyclosporine	A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.	Guided entry of tail-anchored proteins factor CAMLGtarget Peptidyl-prolyl cis-trans isomerase Atarget Calcineurin subunit B type 2target Cytochrome P450 3A5enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Bile salt export pumptransporter Ileal sodium/bile acid cotransportertransporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 6transporter ATP-binding cassette sub-family C member 10transporter ATP-binding cassette sub-family C member 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Peptidyl-prolyl cis-trans isomerase F, mitochondrialtarget Solute carrier organic anion transporter family member 1B3transporter Protein phosphatase 3 catalytic subunit alphatarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06065852	National Registry of Rare Kidney Diseases	No drug interventions	Not Available	Not Available	recruiting
NCT05797051	Application of Hyperspectral Imaging in the Diagnosis of Glomerular Diseases	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01185197	Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study	Mycophenolic acid Prednisolone	treatment	4	completed
NCT00577525	Latent Viral Infection of Lymphoid Cells in Idiopathic Nephrotic Syndrome	No drug interventions	Not Available	Not Available	completed
NCT04387448	A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change Disease	No drug interventions	treatment	2	terminated
NCT06500702	A Study to Evaluate the Efficacy and Safety of Frexalimab, SAR442970, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease	Frexalimab Rilzabrutinib	treatment	2	not_yet_recruiting
NCT03210688	Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy	Alfacalcidol Prednisolone Prednisone	treatment	4	active_not_recruiting
NCT05505500	Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.	No drug interventions	Not Available	Not Available	recruiting
NCT02896270	Valproic Acid for Idiopathic Nephrotic Syndrome	Valproic acid	treatment	2 / 3	unknown_status
NCT05650619	Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change Disease	No drug interventions	Not Available	Not Available	recruiting
NCT04571658	NEPTUNE Match Study	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT06466135	Study of WAL0921 in Patients With Glomerular Kidney Diseases	No drug interventions	treatment	2	recruiting
NCT05588063	taVNS for FRNS in Children	No drug interventions	treatment	Not Available	recruiting
NCT05441826	Efficacy and Safety of VB119 in Subjects With Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS)	Budoprutug	treatment	2	terminated
NCT06315504	Circulating Factors in Nephrotic Syndrome	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT03949972	The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)	No drug interventions	Not Available	Not Available	recruiting
NCT04235621	A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN)	No drug interventions	Not Available	Not Available	terminated
NCT03929887	KOrea Renal Biobank NEtwoRk System TOward NExt-generation Analysis	No drug interventions	Not Available	Not Available	recruiting
NCT03298698	Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome	Prednisolone Prednisone Rituximab	treatment	3	unknown_status
NCT02592798	Pilot Study to Evaluate the Safety and Efficacy of Abatacept in Adults and Children 6 Years and Older With Excessive Loss of Protein in the Urine Due to Either Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD)	Abatacept	treatment	2	completed
NCT04369183	Rituximab for Refractory or Relapsed Focal Segmental Glomerulosclerosis or Minimal Change Disease	No drug interventions	Not Available	Not Available	completed
NCT06405100	Efficacy and Safety of Tacrolimus in Combination With Ripertamab in the Initial Treatment of Patients With MCD	Prednisone Ripertamab Tacrolimus	treatment	3	not_yet_recruiting
NCT05583942	A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)	No drug interventions	treatment	Not Available	recruiting
NCT05003986	Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases	Sparsentan	treatment	2	recruiting
NCT01084980	Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome	Tacrolimus	treatment	2 / 3	completed
NCT03068572	Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERD	No drug interventions	Not Available	Not Available	unknown_status
NCT00982072	Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease	Prednisolone Tacrolimus	treatment	4	completed
NCT04009668	Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Disease	Adalimumab	basic_science	2	completed
NCT01209000	Nephrotic Syndrome Study Network	No drug interventions	Not Available	Not Available	recruiting