Miscellaneous GI Drugs

Miscellaneous GI Drugs
Accession Number

Not Available

DrugDrug Description
LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
OrlistatA reversible inhibitor of gastrointestinal lipases indicated for weight loss and weight maintenance.
Obeticholic acidA bile acid analog and farnesoid X receptor agonist used to treat primary biliary cholangitis in adult patients with inadequate clinical response or intolerance to UDCA.
PrucaloprideA 5-HT4 receptor agonist indicated to treat adults with chronic idiopathic constipation.
MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
LinaclotideA guanylate cyclase-C agonist used to treat constipation associated with irritable bowel syndrome or that is idiopathic in nature.
TeduglutideA glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support.
NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
PinaveriumA spasmolytic agent used for the symptomatic treatment of irritable bowel syndrome (IBS) and functional disorders of the biliary tract.
Sodium citrateAn ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
EluxadolineA mixed mu-opioid receptor agonist used to treat irritable bowel syndrome with diarrhea.
AdalimumabA monoclonal anti-tumor necrosis factor alpha antibody used in the treatment of a wide variety of inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and ankylosing spondylitis.
VedolizumabAn integrin blocker and anti-inflammatory agent used to manage ulcerative colitis and Crohn's disease in adults with inadequate clinical response to immunomodulators.
PlecanatideA laxative used to treat chronic idiopathic constipation and IBS with constipation.
Drugs & Drug Targets
LubiprostoneChloride channel protein 2target
LubiprostoneCarbonyl reductase [NADPH] 1enzyme
OrlistatPancreatic triacylglycerol lipasetarget
OrlistatFatty acid synthasetarget
OrlistatGastric triacylglycerol lipasetarget
OrlistatCytochrome P450 3A4enzyme
OrlistatCytosolic phospholipase A2enzyme
OrlistatSerum albumincarrier
OrlistatFatty acid synthaseenzyme
Obeticholic acidBile acid receptortarget
Obeticholic acidCytochrome P450 1A2enzyme
Obeticholic acidBile salt export pumptransporter
Prucalopride5-hydroxytryptamine receptor 4target
PrucaloprideCytochrome P450 3A4enzyme
PrucaloprideSerum albumincarrier
PrucaloprideP-glycoprotein 1transporter
MethylnaltrexoneMu-type opioid receptortarget
MethylnaltrexoneKappa-type opioid receptortarget
LinaclotideHeat-stable enterotoxin receptortarget
TeduglutideGlucagon-like peptide 2 receptortarget
NaloxegolCytochrome P450 3A4enzyme
NaloxegolCytochrome P450 2D6enzyme
NaloxegolCytochrome P450 2C19enzyme
NaloxegolMu-type opioid receptortarget
PinaveriumVoltage-dependent L-type calcium channel subunit alpha-1Starget
PinaveriumCytochrome P450 3A4enzyme
Sodium citrateMitochondrial 2-oxodicarboxylate carriertransporter
Sodium citrateSolute carrier family 13 member 2transporter
Sodium citrateSolute carrier family 13 member 5transporter
Sodium citrateTricarboxylate transport protein, mitochondrialtransporter
EluxadolineMu-type opioid receptortarget
EluxadolineDelta-type opioid receptortarget
EluxadolineKappa-type opioid receptortarget
EluxadolineSolute carrier organic anion transporter family member 1B1transporter
EluxadolineCanalicular multispecific organic anion transporter 1transporter
EluxadolineSolute carrier family 22 member 8transporter
AdalimumabTumor necrosis factortarget
VedolizumabIntegrin alpha-4target
VedolizumabIntegrin beta-7target
PlecanatideGuanylate cyclase soluble subunit alpha-2target