Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors

Accession Number

DBCAT005739

Description

Not Available

ATC Classification

Drugs

Drug	Drug Description
Cediranib	For the treatment of liver cancer, advanced non-small cell lung cancer (NSCLC), advanced colorectal cancer (CRC) and other solid tumors.
Axitinib	An oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
Tivozanib	A kinase inhibitor to treat adult patients with renal cell carcinoma (RCC) who have failed prior systemic therapies or experienced relapsed disease.

Drugs & Drug Targets

Drug	Target	Type
Cediranib	Vascular endothelial growth factor receptor 2	target
Axitinib	Vascular endothelial growth factor receptor 1	target
Axitinib	Vascular endothelial growth factor receptor 2	target
Axitinib	Vascular endothelial growth factor receptor 3	target
Axitinib	Cytochrome P450 3A4	enzyme
Axitinib	Cytochrome P450 3A5	enzyme
Axitinib	Cytochrome P450 1A2	enzyme
Axitinib	Cytochrome P450 2C19	enzyme
Axitinib	UDP-glucuronosyltransferase 1-1	enzyme
Axitinib	P-glycoprotein 1	transporter
Axitinib	Solute carrier organic anion transporter family member 1B1	transporter
Tivozanib	Cytochrome P450 3A4	enzyme
Tivozanib	Serum albumin	carrier
Tivozanib	Vascular endothelial growth factor receptor 1	target
Tivozanib	Vascular endothelial growth factor receptor 2	target
Tivozanib	Vascular endothelial growth factor receptor 3	target
Tivozanib	Mast/stem cell growth factor receptor Kit	target
Tivozanib	Platelet-derived growth factor receptor beta	target
Tivozanib	P-glycoprotein 1	transporter
Tivozanib	ATP-binding cassette sub-family G member 2	transporter
Tivozanib	Receptor-type tyrosine-protein kinase FLT3	target
Tivozanib	Platelet-derived growth factor receptor alpha	target
Tivozanib	Protein-tyrosine kinase 6	target
Tivozanib	Angiopoietin-1 receptor	target
Tivozanib	Fibroblast growth factor receptor 1	target
Tivozanib	Hepatocyte growth factor receptor	target