Recurrent Non-small Cell Lung Cancer (DBCOND0028805)

Identifiers

Synonyms
Recurrent Non-Small Cell Lung Cancer (NSCLC) / Non-small Cell Lung Cancer (NSCLC), Recurrent / Recurrent Non-Small Lung Cell Cancer / Lung Cancer, Nonsmall Cell, Recurrent / Recurrent Lung Cancer, Nonsmall Cell / Recurrent Nonsmall Cell Lung Cancer / Non Small Cell Lung Cancer Recurrent / Recurrent Non Small Cell Lung Cancer / Non-Small Cell Lung Cancer Recurrent / Recurrent Non-Small Cell Lung Cancer / Lung cancer non-small cell recurrent

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Ipilimumab
A human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
Nivolumab
A PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT02312622
Phase 2 Etirinotecan Pegol in Refractory Brain Metastases & Advanced Lung Cancer / Metastatic Breast Cancertreatment2completed
NCT01515969
Phase 1 Erlotinib and Dovitinib (TKI258) in Advanced Non-small Cell Lung Cancer (NSCLC)treatment1terminated
NCT04340882
Phase 2 DoceRamPem for Patients With Metastatic or Recurrent NSCLC Who Progressed on Platinum-Doublet and PD-1/PD-L1 Blockadetreatment2recruiting
NCT03029273
NY-ESO-1 TCR (TAEST16001)for Patients With Advanced NSCLCtreatment1unknown_status
NCT03004105
MEDI4736 With Selumetinib for KRAS Mutant Non-Small Cell Lung Cancer (NSCLC)treatment2withdrawn
NCT02967133
A Study of Nivolumab +/- Nab-paclitaxel in Non-small Cell Lung Cancertreatment2terminated
NCT05110118
Pharmacokinetic Characteristics, Safety, Tolerability and Immunogenicity of LY01008 and Avastin in Healthy Chinese Male Subjectstreatment1completed
NCT05842018
Toripalimab in Combination With Chemotherapy and Antiangiogenic Agents in Patients With Non-Small Cell Lung Cancer After Failure of Immunotherapy (PD-1/L1 Inhibitors)treatment2not_yet_recruiting
NCT03533127
A Study of LY01008 and Bevacizumab Combined With Paclitaxel and Carboplatin for Treatment of Naïve Subjects With Metastatic or Recurrent Nonsquamous Non-small Cell Lung Cancertreatment3unknown_status
NCT03235765
Cancer Panel From Blood of Lung Cancer PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05736731
A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Subjects With Solid Tumors That Express CEA and Have Lost HLA-A*02 ExpressionNo drug interventionstreatment1 / 2recruiting
NCT04965090
A Study of Amivantamab and Lazertinib in People With Non-Small Cell Lung Cancer (NSCLC)treatment2active_not_recruiting
NCT01773109
Etirinotecan Pegol (NKTR-102) in NSCLCtreatment2completed
NCT05617313
Study of GT103 in Combination With Pembrolizumab in Refractory, Metastatic Non-Small Cell Lung Cancertreatment2active_not_recruiting
NCT00652340
APRiCOT-L: Study to Evaluate Efficacy and Safety of Apricoxib With Erlotinib in Patients With Non-small Cell Lung Cancertreatment2completed
NCT04878952
Testing the Addition of Activity Monitoring With a Wearable Electronic Device to Improve Patient Care During Treatment for Lung CancerNo drug interventionssupportive_careNot Availableterminated
NCT00769600
Phase II Study of Itraconazole and Pemetrexed in Patients With Previously Treated Non-Squamous NSCLCtreatment2terminated
NCT05681780
Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLCtreatment1 / 2recruiting
NCT06463665
Efficacy & Safety of Olvimulogene Nanivacirepvec & Platinum-doublet + Physician's Choice of Immune Checkpoint Inhibitor Compared to Docetaxel in NSCL Cancertreatment2recruiting
NCT01471964
Study to Assess Safety and Tolerability of MLN8237, In Combination With Erlotinib to Treat Non-Small Cell Lung Cancertreatment1 / 2terminated
NCT02423343
A Study of Galunisertib (LY2157299) in Combination With Nivolumab in Advanced Refractory Solid Tumors and in Recurrent or Refractory NSCLC, or Hepatocellular Carcinomatreatment1 / 2completed
NCT01774578
Immunotherapy Study in Progressive or Relapsed Non-Small Cell Lung Cancertreatment2 / 3terminated
NCT03445000
ALEctinib for the Treatment of Pretreated RET-rearranged Advanced Non-small Cell Lung Cancertreatment2terminated
NCT01523340
A Prospective Observational Study Evaluating c-MET Expression and EGFR Gene Mutation Correlation With Erlotinib ResponseNo drug interventionsNot AvailableNot Availablecompleted
NCT02460367
Immunotherapy Combination Study in Advanced Previously Treated Non-Small Cell Lung Cancertreatment1terminated
NCT06525246
Study of ONO-7475 in Combination With Osimertinib in EGFR Gene Mutation-positive Non-small Cell Lung Cancertreatment1active_not_recruiting
NCT01249443
Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors and HIV Infectiontreatment1terminated
NCT00029003
Gefitinib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT02132884
Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung CancerNo drug interventionstreatmentNot Availableterminated
NCT00088933
Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With Metastatic Lung Cancer or Metastatic Colorectal Cancertreatment1terminated
NCT01345851
Image-Guided Hypofractionated Radiation Therapy With Stereotactic Body Radiation Therapy Boost and Combination Chemotherapy in Treating Patients With Stage II-III Non-Small Cell Lung Cancer That Cannot Be Removed By SurgerytreatmentNot Availableactive_not_recruiting
NCT00075751
Gemcitabine, Carboplatin, and Bortezomib in Advanced or Recurrent Non-Small Cell Lung Cancertreatment2completed
NCT01325753
Cryotherapy in Treating Patients With Lung Cancer That Has Spread to the Other Lung or Parts of the BodyNo drug interventionstreatmentNot Availablewithdrawn
NCT00976677
Carboplatin, Paclitaxel, and Bevacizumab With or Without Erlotinib Hydrochloride in Treating Non-Smokers With Advanced Non-Small Cell Lung Cancertreatment2terminated
NCT01411098
Radiation Therapy, Cisplatin, and Etoposide in Treating Patients With Non-small Cell Lung Cancer That Cannot Be Removed by Surgerytreatment1terminated
NCT00068497
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung CancertreatmentNot Availablecompleted
NCT00118183
Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT02145078
Gene Expression Levels in Predicting Treatment Response in Patients With Stage IV Non-small Cell Lung CancertreatmentNot Availableterminated
NCT00481078
Vorinostat, Carboplatin, and Paclitaxel in Treating Patients With Advanced or Metastatic Non-Small Cell Lung Cancertreatment2completed
NCT01911507
INC280 and Erlotinib Hydrochloride in Treating Patients With Non-small Cell Lung Cancertreatment1completed
NCT01723800
PI3K Inhibitor BKM120, Carboplatin, and Pemetrexed Disodium in Treating Patients With Stage IV Non-Small Cell Lung Cancertreatment1completed
NCT01557959
Docetaxel, Cisplatin, Pegfilgrastim, and Erlotinib Hydrochloride in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT01806675
18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapydiagnostic1 / 2completed
NCT04623775
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)treatment2active_not_recruiting
NCT00459342
Dasatinib in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancertreatment2completed
NCT02919449
Dose Escalation Trial of Intra-Tumoral Injection of NIS Measles Virus in Combination With Atezolizumabtreatment1terminated
NCT02655913
Safety and Efficacy of Vitamin C Infusion in Combination With Local mEHT to Treat Non Small Cell Lung Cancertreatment1 / 2completed
NCT01948141
Nintedanib in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Failed Up to Two Previous Chemotherapy Regimenstreatment2completed
NCT01781741
Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Stage III-IV Non-small Cell Lung CancerNo drug interventionstreatment0completed
NCT00245063
AZD2171 in Treating Patients With Recurrent Small Cell Lung Cancertreatment2completed
NCT00074022
GTI-2040 and Docetaxel in Treating Patients With Recurrent, Metastatic, or Unresectable Locally Advanced Non-Small Cell Lung Cancer, Prostate Cancer, or Other Solid Tumorstreatment1 / 2completed
NCT02243748
Palliative Care Intervention in Improving Symptom Control and Quality of Life in Patients With Stage II-IV Non-small Cell Lung Cancer and Their Family CaregiversNo drug interventionssupportive_careNot Availablecompleted
NCT02889666
A Randomised Trial of Chemotherapy Plus Surgery for Recurrent Non-Small Cell Lung Cancertreatment1recruiting
NCT00986674
Carboplatin and Paclitaxel Combined With Cetuximab and/or IMC-A12 in Patients With Advanced Non-Small Cell Lung Cancertreatment2completed
NCT00362882
Docetaxel and Bortezomib in Treating Patients With Progressive or Recurrent Non-Small Cell Lung Cancertreatment2completed
NCT01928160
Pemetrexed Disodium and Carboplatin or Cisplatin With or Without Erlotinib Hydrochloride in Treating Patient With Stage IV Non-Small Cell Lung Cancer Resistant to First-Line Therapy With Erlotinib Hydrochloride or Gefitinibtreatment2withdrawn
NCT00021060
Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Advanced, Metastatic, or Recurrent Non-Small Cell Lung Cancertreatment2 / 3completed
NCT00006929
Suramin, Paclitaxel, and Carboplatin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancertreatment2completed
NCT00400829
E7389 in Treating Patients With Recurrent or Progressive Stage IIIB or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT00368992
S0536: Cetuximab, Paclitaxel, Carboplatin, and Bevacizumab in Treating Patients With Advanced Non-Small Cell Lung Cancertreatment2completed
NCT01784640
Pemetrexed Disodium and Hsp90 Inhibitor AUY922 in Treating Patients With Previously Treated Stage IV Non-Small Cell Lung Cancertreatment1completed
NCT00098540
Sorafenib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT00410904
AZD2171 and Pemetrexed Disodium in Treating Patients With Relapsed Non-Small Cell Lung Cancertreatment2completed
NCT00066768
Suramin and Either Docetaxel or Gemcitabine in Treating Patients With Stage IIIB or Stage IV Platinum-Refractory Non-Small Cell Lung Cancertreatment1completed
NCT01193868
RO4929097 in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Have Recently Completed Treatment With Front-Line Chemotherapytreatment2terminated
NCT00040768
Bortezomib in Treating Patients With Advanced Non-small Cell Lung Cancertreatment2terminated
NCT02134912
S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinibtreatment2terminated
NCT01746810
IR-guided Ablation (IRGA) Combined With Stereotactic Ablative Radiation (SABR) for Large Lung TumorsNo drug interventionstreatment1terminated
NCT00084981
Decitabine and Valproic Acid in Treating Patients With Non-Small Cell Lung Cancertreatment1completed
NCT00031681
7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)treatment1completed
NCT00655655
Everolimus and Vatalanib in Treating Patients With Advanced Solid Tumorstreatment1completed
NCT00499655
Erlotinib Hydrochloride With or Without Celecoxib in Treating Patients With Stage IIIB-IV Non-Small Cell Lung Cancertreatment2completed
NCT01668823
Photodynamic Therapy in Treating Patients With Lung Cancertreatment1completed
NCT01707823
Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancerbasic_science0terminated
NCT00138203
Suberoylanilide Hydroxamic Acid in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancertreatment2completed
NCT00020202
FR901228 in Treating Patients With Refractory or Progressive Small Cell Lung Cancer or Non-small Cell Lung Cancertreatment2completed
NCT00397384
Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancertreatment1completed
NCT01649947
Modulation of Autophagy in Patients With Advanced/Recurrent Non-small Cell Lung Cancer - Phase IItreatment2completed
NCT00030498
Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunctiontreatment1completed
NCT00004883
Trastuzumab in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer That Overexpresses HER2treatment2completed
NCT01217411
RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancertreatment1terminated
NCT02250378
Stereotactic Radiosurgery Followed by Wedge Resection in Treating Patients With Early Stage Peripheral Non-small Cell Lung CancerNo drug interventionstreatmentNot Availablewithdrawn
NCT00093756
Bortezomib, Paclitaxel, Carboplatin and Radiation Therapy for Non-Small Cell Lung Cancertreatment1 / 2completed
NCT02845856
Combination of Cetuximab and NK Immunotherapy for Recurrent Non-small Cell Lung Cancertreatment1 / 2completed
NCT00638937
AZD0530 to Treat Recurrent Stage IIIB/IV NSCLC Previously Treated With Combination Chemotherapytreatment2completed
NCT00088959
Celecoxib and Erlotinib in Treating Former Smokers With Stage IIIB or Stage IV Non-Small Cell Lung Cancertreatment1completed
NCT01935336
Study of Ponatinib in Patients With Lung Cancer Preselected Using Different Candidate Predictive Biomarkerstreatment2completed
NCT01155258
Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumorstreatment1completed
NCT00228358
Cyclophosphamide or Denileukin Diftitox Followed By Expanding a Patient's Own T Cells in the Laboratory in Treating Patients With HER-2/Neu Overexpressing Metastatic Breast Cancer, Ovarian Cancer, or Non-Small Cell Lung Cancer Previously Treated With HER-2/Neu Vaccinetreatment1completed
NCT00028535
Interleukin-12, Paclitaxel, and Trastuzumab in Treating Patients With Solid Tumorstreatment1completed
NCT00079235
CCI-779 in Treating Patients With Stage IIIB (With Pleural Effusion) or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT02178163
Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung CancerNo drug interventionsotherNot Availablerecruiting
NCT02262325
Hypofractionated Boost Before Chemoradiation for Patients With Stage II-III Non-small Cell Lung Cancer Unsuitable for Surgerytreatment2active_not_recruiting
NCT02017925
Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced Non-Small Cell Lung Cancer Undergoing ChemoradiationNo drug interventionssupportive_careNot Availablewithdrawn
NCT00101348
Erlotinib and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Kidney, Colorectal, Head and Neck, Pancreatic, or Non-Small Cell Lung Cancertreatment1 / 2completed
NCT00004074
Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neutreatment1completed
NCT02126527
Auranofin and Sirolimus in Treating Patients With Advanced Solid Tumors or Recurrent Non-Small Cell Lung Cancertreatment1withdrawn
NCT00408460
Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancertreatment2completed
NCT00087191
EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung CancerdiagnosticNot Availableterminated
NCT00039091
Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancertreatment1terminated
NCT00085280
Erlotinib in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung CancertreatmentNot Availablecompleted
NCT02059889
Diffusion-weighted MRI for Individualized Radiation Therapy Planning of Lung CancerNo drug interventionsdiagnosticNot Availablewithdrawn
NCT01729689
Cognitive Behavioral Therapy in Treating Anxiety in Patients With Stage IV Non-Small Cell Lung Cancer and Their CaregiversNo drug interventionssupportive_careNot Availablecompleted
NCT00118144
Bortezomib in Treating Patients With Stage IIIB or Stage IV Lung Cancertreatment2completed
NCT01026467
Frailty Index and Geriatric Assessment in Predicting Toxicity to Front-Line Chemotherapy in Treating Patients With Stage IV Non-Small Cell Lung CancerNot AvailableNot Availablecompleted
NCT00778167
Erlotinib Hydrochloride With or Without Cixutumumab in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancertreatment1 / 2completed
NCT01824901
Docetaxel With or Without FGFR Inhibitor AZD4547 in Treating Patients With Recurrent Non-Small Cell Lung Cancertreatment1 / 2completed
NCT00062101
Erlotinib and Celecoxib in Treating Patients With Stage IIIB or Stage IV Recurrent Non-Small Cell Lung Cancertreatment2completed
NCT01958372
Radiation Therapy, Chemotherapy, and Soy Isoflavones in Treating Patients With Stage IIIA-IIIB Non-Small Cell Lung Cancertreatment1completed
NCT01383668
Sirolimus and Gold Sodium Thiomalate in Treating Patients With Advanced Squamous Non-Small Cell Lung Cancertreatment1withdrawn
NCT00087412
S0341: Erlotinib in Treating Patients With Advanced Primary Non-Small Cell Lung Cancertreatment2completed
NCT01999881
Impacts of Exercise on Prognostic Biomarkers in Lung Cancer PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT00063895
Erlotinib in Treating Patients With Advanced Non-Small Cell Lung Cancer, Ovarian Cancer, or Squamous Cell Carcinoma of the Head and Necktreatment1 / 2completed
NCT01839955
Erlotinib Hydrochloride and Quinacrine Dihydrochloride in Stage IIIB-IV Non-Small Cell Lung Cancertreatment1completed
NCT00077350
A Phase II Trial of Triapine (NSC #663249) in Combination With Gemcitabine as Second Line Treatment of Non-Small Cell Lung Cancertreatment2completed
NCT00052338
Bortezomib Plus Gemcitabine and Carboplatin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancertreatment1completed