Coronary Revascularization (DBCOND0048469)

Identifiers

Synonyms

Repeat coronary revascularization / Coronary revascularization / Coronary revascularisation

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cangrelor	A P2Y12 platelet receptor antagonist used during percutaneous coronary intervention to reduce the risk for periprocedural myocardial infarction (MI), repeat coronary revascularization, and stent thrombosis (ST).	P2Y purinoceptor 12target
Colchicine	An alkaloid used to treat gout and Familial Mediterranean Fever as well as prevent major cardiovascular events.	Tubulin beta chaintarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2E1enzyme Albumincarrier
Evolocumab	A PCSK9 (proprotein convertase subtilisin kexin type 9) inhibitor antibody used as an adjunct to LDL cholesterol reducing therapies, aiding in the prevention of cardiovascular events and cardiovascular revascularization procedures.	Proprotein convertase subtilisin/kexin type 9target
Lovastatin	An HMG-CoA reductase inhibitor used to lower LDL cholesterol and reduce the risk of cardiovascular disease and associated conditions, including myocardial infarction and stroke.	3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme Integrin alpha-Ltarget Histone deacetylase 2target Serum paraoxonase/lactonase 3enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B7enzyme ATP-binding cassette sub-family C member 2transporter Bile salt export pumptransporter Albumincarrier Cytochrome P450 2C19enzyme Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1B3transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02425345	Women's Health Initiative Strong and Healthy Study	No drug interventions	prevention	Not Available	active_not_recruiting
NCT02880605	Validation of Chinese Version Appropriate Use Criteria for Coronary Revascularization	No drug interventions	Not Available	Not Available	completed
NCT03229941	Transfusion Trigger After Operations in High Cardiac Risk Patients	No drug interventions	other	Not Available	completed
NCT01190904	Hormones and Sexual Function Predict Outcomes in Revascularized Men With Diabetes	No drug interventions	Not Available	Not Available	completed
NCT05284747	EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction	Evolocumab	treatment	4	active_not_recruiting
NCT06583161	Emulation of the Moderate Alcohol and Cardiovascular Health Trial (MACH15)	No drug interventions	Not Available	Not Available	completed
NCT06520215	Correlation Hand Grip Strength and Walking Distance in Elderly	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT03068858	Real-time Feedback of SYNTAX Score Category During Coronary Angiographies to Improve Appropriateness of Coronary Revascularization for Patients With Stable Coronary Artery Diseases: a Before-and-after Controlled Study	No drug interventions	treatment	Not Available	completed