Central Nervous System Infections (DBCOND0055550)

Identifiers

Synonyms

Central Nervous System Infection / Infectious disease of central nervous system (disorder) / Central nervous system infection NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amikacin	An aminoglycoside used to treat infections caused by more resistant strains of Gram negative bacteria and some Gram positive bacteria.	30S ribosomal protein S12target
Ceftazidime	An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others.	Solute carrier family 22 member 6transporter Peptidoglycan synthase FtsItarget Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Penicillin-binding protein 2target Albumincarrier Beta-lactamase Toho-1target
Gentamicin	An aminoglycoside used to treat a wide variety of aerobic infections in the body.	30S ribosomal protein S12target 16S ribosomal RNAtarget NH(3)-dependent NAD(+) synthetasetarget Dihydrofolate reductasetarget 23S ribosomal RNAtarget Bacterial outer membranetarget Cytoplasmic membranetarget Low-density lipoprotein receptor-related protein 2transporter Solute carrier family 22 member 2transporter ATP-binding cassette sub-family C member 2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01438879	Lymphocytic Herpesviruses and Cerebrospinal Fluid Polymerase Chain Reaction (PCR)	No drug interventions	Not Available	Not Available	unknown_status
NCT03960905	A Study the Population Pharmacokinetics of Children of Infectious Disease in Central Nervous System	No drug interventions	Not Available	Not Available	unknown_status
NCT00172393	Long Term Outcomes of EV71 CNS Infection	No drug interventions	Not Available	Not Available	unknown_status
NCT01520597	National Study on Listeriosis and Listeria	No drug interventions	Not Available	Not Available	completed
NCT04737785	Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation	No drug interventions	Not Available	Not Available	completed
NCT05887037	Economic Impact of mNGS on Diagnosis of Post-neurosurgical Central Nervous System Infection	No drug interventions	diagnostic	Not Available	recruiting
NCT03418441	Central Nervous System Infections in Denmark	No drug interventions	Not Available	Not Available	recruiting
NCT04796935	A Study to Test Performance of Needle Placements for Neuraxial Procedures Using Tactile Imaging vs Control	No drug interventions	other	Not Available	completed
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT06412523	Device-related Central Nervous System Infections in Adult Intensive Care Units in Brazil	No drug interventions	Not Available	Not Available	active_not_recruiting
NCT04229511	Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT06358209	Safety and Efficacy of Ventricular Irrigation for Ventriculitis	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT02334670	Vietnam Cryptococcal Retention in Care Study Version 1.0	Fluconazole	Not Available	Not Available	unknown_status
NCT06412549	Effect of a Bundle of Interventions on the Outcomes of Patients With Intracranial Devices (ICP Monitor e EVD)	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT02506686	Meropenem Penetration Across BBB in Patients With CNS Infection and Optimization of Meropenem Treatment	Meropenem	treatment	4	completed
NCT06418048	INfectious DIsease REgistry BIObank	No drug interventions	Not Available	Not Available	recruiting
NCT02017665	Singapore Neurologic Infections Program	No drug interventions	Not Available	Not Available	unknown_status
NCT03776994	Venezuelan Equine Encephalitis Monovalent Virus-Like Particle Vaccine	No drug interventions	prevention	1	unknown_status