Systemic Embolism (DBCOND0077405)

Identifiers

Synonyms

Embolism / Systemic embolism / Embolism (disorder) / Embolism NOS / Embolus / Embolus (morphologic abnormality) / Arterial embolism (disorder) / Embolism arterial / Arterial embolism NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acenocoumarol	An anticoagulant drug used in the prevention of thromboembolic diseases in infarction and transient ischemic attacks, as well as management of deep vein thrombosis and myocardial infarction.	Vitamin K epoxide reductase complex subunit 1target Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme Albumincarrier Alpha-1-acid glycoprotein 1carrier Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter
Apixaban	An anticoagulant used for the prophylaxis of stroke and systemic embolism in nonvalvular atrial fibrillation, and deep vein thrombosis(DVT) leading to pulmonary embolism(PE), including in patients after a hip or knee replacement surgery.	Coagulation factor Xtarget Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2J2enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A5enzyme
Dabigatran etexilate	An anticoagulant used for the prevention of venous thromboembolic events or stroke in patients with recent elective hip or knee replacement surgery and atrial fibrillation.	Prothrombintarget ATP-dependent translocase ABCB1transporter Liver carboxylesterase 1enzyme Cocaine esteraseenzyme UDP-glucuronosyltransferase 1A9enzyme UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 2B15enzyme Ribosyldihydronicotinamide dehydrogenase [quinone]enzyme Albumincarrier
Edoxaban	A novel oral anticoagulant used for reducing the risk of stroke and systemic embolism (SE) in patients with nonvalvular atrial fibrillation (NVAF).	Coagulation factor Xtarget ATP-dependent translocase ABCB1transporter
Rivaroxaban	A factor Xa inhibitor used to treat deep vein thrombosis (DVT) and pulmonary embolism (PE). May also be used as thrombosis prophylaxis in specific situations.	Coagulation factor Xtarget Cytochrome P450 3A4enzyme Cytochrome P450 2J2enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 3A5enzyme Broad substrate specificity ATP-binding cassette transporter ABCG2transporter
Warfarin	A vitamin K antagonist used to treat venous thromboembolism, pulmonary embolism, thromboembolism with atrial fibrillation, thromboembolism with cardiac valve replacement, and thromboembolic events post myocardial infarction.	Vitamin K epoxide reductase complex subunit 1target Cytochrome P450 2C8enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C9enzyme Alpha-1-acid glycoprotein 1carrier Albumincarrier Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C18enzyme Nuclear receptor subfamily 1 group I member 2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06453642	Evaluation of a Simple-Prep Controlled Embolic	No drug interventions	treatment	Not Available	recruiting
NCT05907564	Aventus Thrombectomy System Pulmonary Embolism Clinical Study	No drug interventions	treatment	Not Available	recruiting
NCT03101384	Influence of Diagnostic Errors on the Prognosis of Acute Pulmonary Embolism	No drug interventions	Not Available	Not Available	unknown_status
NCT00311753	Efficacy and Safety of Low-molecular Weight Heparin for Thromboprophylaxis in Acutely Ill Medical Patients	Certoparin Heparin	prevention	3	completed
NCT04436978	What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?	No drug interventions	prevention	4	recruiting
NCT04618913	Anticoagulation in Patients With Venous Thromboembolism and Cancer	Apixaban Dabigatran Edoxaban Rivaroxaban	Not Available	Not Available	active_not_recruiting
NCT00345618	Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach	Avidin Enoxaparin Idraparinux Warfarin	treatment	3	completed
NCT00453518	The RETRIEVE Study: Use of the FiberNet® Embolic Protection System in Saphenous Vein Grafts	No drug interventions	treatment	Not Available	completed
NCT01878539	Oral Anticoagulation and Self-management	No drug interventions	prevention	Not Available	unknown_status
NCT03714048	Blood Management During ECMO for Cardiac Support	No drug interventions	Not Available	Not Available	completed
NCT04657120	Safety and Efficiency of the YEARS Algorithm Versus Computed Tomography Pulmonary Angiography Alone for Suspected Pulmonary Embolism in Patients With Malignancy	No drug interventions	diagnostic	Not Available	recruiting
NCT01042444	Use of the GARDEX™ Embolic Protection Device During Percutaneous Coronary Interventions of Saphenous Vein Graft	No drug interventions	treatment	Not Available	terminated
NCT04796740	Thrombembolism After Robot- Assisted Surgery in Urology	No drug interventions	Not Available	Not Available	unknown_status
NCT00403767	An Efficacy and Safety Study of Rivaroxaban With Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Patients With Non-Valvular Atrial Fibrillation	Rivaroxaban Warfarin	prevention	3	completed
NCT05684146	Protect the Head to Head Study	No drug interventions	treatment	2	recruiting
NCT04263038	Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism	Rivaroxaban	treatment	4	recruiting
NCT06018090	Microembolic Detection in Acute Ischemic Stroke Patients With Atrial Fibrillation and Outcome	No drug interventions	Not Available	Not Available	completed
NCT00509171	Effect of a Novel Reamer-Irrigator-Aspirator on the Incidence of Fat Embolism	No drug interventions	treatment	Not Available	completed
NCT01823185	Bedside Testing of CYP2C19 Gene for Treatment of Patients With PCI With Antiplatelet Therapy	Clopidogrel Prasugrel Ticagrelor	treatment	4	unknown_status
NCT00830570	The Clinical and Economic Impact of Pharmacogenomic Testing of Warfarin Therapy in Typical Community Practice Settings	No drug interventions	Not Available	Not Available	completed
NCT00001713	Treatment for Blood Clots in the Veins of the Legs	Alteplase Heparin Warfarin	treatment	1	completed
NCT04610463	Evaluation of the Severity of Right to Left Shunt in PFO Patients After Systemic Embolism	No drug interventions	diagnostic	Not Available	unknown_status
NCT06134739	Arterial Embolism After Catheter Ablation of Atrial Fibrillation. ATRIAL FIBRILLATION	No drug interventions	Not Available	Not Available	recruiting
NCT00235248	Aortic Arch Related Cerebral Hazard Trial (ARCH)	Acetylsalicylic acid Clopidogrel Warfarin	prevention	3	completed
NCT06103448	Prediction of the Risks of Cardiovascular Mortality	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04910360	Embolism in COVID-19 Positive Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT00781391	Global Study to Assess the Safety and Effectiveness of Edoxaban (DU-176b) vs Standard Practice of Dosing With Warfarin in Patients With Atrial Fibrillation	Edoxaban Warfarin	prevention	3	completed
NCT00479362	Anticoagulant Therapy During Pacemaker Implantation	Acetylsalicylic acid Warfarin	treatment	4	completed
NCT06062329	SYMPHONY-PE Study for Treatment of Pulmonary Embolism	No drug interventions	treatment	Not Available	recruiting
NCT01925755	Non-interventional Local Study on Prescription Behavior of Anticoagulation Therapy in Secondary Stroke Prevention in Atrial Fibrillation Patients	No drug interventions	Not Available	Not Available	completed
NCT01157338	Clinical Significance of Retinal Emboli During Diagnostic and Therapeutic Cardiac Catheterization	No drug interventions	prevention	Not Available	completed
NCT05478304	Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial	No drug interventions	treatment	Not Available	recruiting
NCT05963698	The Fourth Left Atrial Appendage Occlusion Study	No drug interventions	treatment	Not Available	recruiting
NCT05540587	Efficacy and Safety of Edoxaban in Patients With Atrial Fibrillation and Mitral Stenosis	Edoxaban Warfarin	treatment	2	recruiting
NCT04808934	NOAC Portuguese Real World Study	Apixaban Dabigatran Rivaroxaban	Not Available	Not Available	withdrawn
NCT02478294	LAA Excision With AF Ablation Versus Oral Anticoagulants for Secondary Prevention of Stroke	Warfarin	Not Available	Not Available	completed
NCT02889562	Apixaban Versus Warfarin for the Management of Post-operative Atrial Fibrillation	Apixaban Warfarin	prevention	2 / 3	completed