Infective Endocarditis (IE) (DBCOND0085024)

Identifiers

Synonyms
Endocarditis, Infective / Endocarditis infective / Infective Endocarditis / Infectious Endocarditis / Endocarditis, Bacterial / Endocarditis bacterial NOS / Bacterial endocarditis (disorder) / Bacterial endocarditis / Endocarditis bacterial / Infective endocarditis (disorder) / Endocarditis / Endocarditis NOS / Endocarditis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Clarithromycin
A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and helicobacter pylori infection.
Sulbactam
An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections.
Teicoplanin
A glycopeptide antibiotic with a similar mechanism of action and spectrum of activity to vancomycin used to treat various infections caused by gram-positive bacteria.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06423898
Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.No drug interventionstreatment4not_yet_recruiting
NCT02816307
Etiology of Endocarditis in Negative Blood CulturesNo drug interventionsdiagnosticNot Availablecompleted
NCT02856607
Impact of Clinical Care Pathway on Prognosis and Therapeutic Medical Care of Infective EndocarditisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03211975
Study of the Prognosis of Infectious Endocarditis (EPEI)No drug interventionsNot AvailableNot Availablerecruiting
NCT05791357
The Role of Polymerase Chain Reaction in the Management of Patients With Infective EndocarditisNo drug interventionsdiagnosticNot Availablerecruiting
NCT05398679
Oral Antimicrobial Treatment vs. Outpatient Parenteral for Infective Endocarditistreatment4not_yet_recruiting
NCT05037474
Contemporary Transvenous Lead Extraction OutcomesNo drug interventionsNot AvailableNot Availableunknown_status
NCT05329168
ERAdicate S. Aureus in Patients With Bacteremia and Endocarditistreatment2withdrawn
NCT05061355
Antibiotics vs Antibiotics and Surgical ThERapy for Infective EndocarditisNo drug interventionstreatmentNot Availablerecruiting
NCT05183555
Early Feasibility Study of Somatostatin Receptors PET Imaging for the Diagnosis of Infective Endocarditisdiagnostic2completed
NCT05721781
Reducing Risk for Infective EndocarditisNo drug interventionspreventionNot Availablerecruiting
NCT00695903
Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremiatreatment2terminated
NCT03153384
Impact of the Blood Culture Technique on the Diagnosis of Infective EndocarditisNo drug interventionsNot AvailableNot Availablecompleted
NCT06269679
CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.No drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT02887079
Research Interest Antiphospholipid in Predicting Embolic Risk During Infective EndocarditisNo drug interventionsNot AvailableNot Availablecompleted
NCT03199287
Clinical Metagenomics of Infective EndocarditisNo drug interventionsNot AvailableNot Availablecompleted
NCT00562653
Autoantibodies and Clinical Symptoms in Infective Endocarditis PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT02196753
PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance INo drug interventionsNot AvailableNot Availableunknown_status
NCT03612245
Hygiene and Bucco-dental Status of Patients With Oral Streptococcal EndocarditisNo drug interventionsNot AvailableNot Availablecompleted
NCT02388893
Endocarditis Registry of the University Hospital of Cologne (ER-UHC)No drug interventionsNot AvailableNot Availableunknown_status
NCT06563609
Multi-intervention Trial: Improving Inhospital ENDOcarditis Treatment and CARENo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT06194409
The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers.No drug interventionsNot AvailableNot Availablerecruiting
NCT02910856
Infective Endocarditis in the ElderlyNo drug interventionsNot AvailableNot Availablecompleted
NCT03688659
Vancomycin, Gentamycin in Infective EndocarditistreatmentNot Availableunknown_status
NCT02128139
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05862025
Evaluation of the Usefulness of Echocardiography in Patients With Staphylococcus Aureus Bacteremia (ET-AUREUS Study).No drug interventionsdiagnosticNot Availablerecruiting
NCT05446376
Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective EndocarditisNo drug interventionsdiagnostic2not_yet_recruiting
NCT05563662
SURgical Registry of ENDocarditis EuRopeNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05965362
Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR)No drug interventionsNot AvailableNot Availablerecruiting
NCT06309680
Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04257292
NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective EndocarditisNo drug interventionsNot AvailableNot Availableunknown_status
NCT00871104
Fosfomycin Plus Imipenem for Treatment of Infective Endocarditistreatment4completed
NCT05264181
Transcatheter Pulmonary Valve Implantation With SAPIEN 3 ValveNo drug interventionsNot AvailableNot Availableunknown_status
NCT03945708
Does Whole Blood Adsorber During CPB Reduce Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery?No drug interventionssupportive_careNot Availablecompleted
NCT04838938
Personalized Medicine in Patients With Infective EndocarditisNo drug interventionsNot AvailableNot Availablecompleted
NCT03961503
Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk PatientsNot AvailableNot Availablecompleted
NCT02033421
Beta-lactam Pharmacokinetics in Patients With Infective EndocarditisNo drug interventionsNot AvailableNot Availableunknown_status
NCT06583902
Management of Anemia in Patients with EndocaRditis Infectious Candidates for Cardiac Surgery: the AMERICA StudyNot AvailableNot Availablenot_yet_recruiting
NCT03266302
Hemoadsorption for Prevention of Vasodilatory Shock in Cardiac Surgery Patients With Infective EndocarditisNo drug interventionspreventionNot Availablecompleted
NCT03487653
Detection of the Most Common Microorganism of Infective Endocarditis in Assiut University HospitalNo drug interventionsNot AvailableNot Availableunknown_status
NCT03295045
Evolution of the Profile of Infectious Endocarditis in France in 2008 (EI2008)No drug interventionsNot AvailableNot Availablecompleted
NCT03465098
Evaluation of a Metabolic Preparation by a Low-carbohydrate Diet as Atkins-diet to Help in Detecting Infective Endocarditis by 18F-FDG PETNo drug interventionsdiagnosticNot Availablecompleted
NCT01731483
Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus InfectionsNo drug interventionsNot AvailableNot Availablecompleted
NCT03979261
Predisposition to Infectious EndocarditisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03365193
PRetest prObability of Infectious ENDOCARDITIS for Appropriate Criteria Regarding Transesophageal ECHOcardiography in Tertiary Care Facilities (PRO ENDOCARDITIS ECHO-Study)No drug interventionsNot AvailableNot Availablecompleted
NCT03626571
PET/MR Imaging In Patients With Infective EndocarditisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01512615
CopenHeart IE - Integrated Rehabilitation of Patients Treated for Infective EndocarditisNo drug interventionspreventionNot Availablecompleted
NCT04178915
Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial InfectionsNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04544306
Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject DrugsNo drug interventionstreatmentNot Availablerecruiting
NCT03590106
Cardiac Surgery Peer Recovery Support ProgramNo drug interventionspreventionNot Availablecompleted
NCT02727413
Inflammatory Mediator Profiles During Heart Valve Replacement SurgeryNo drug interventionsNot AvailableNot Availablecompleted
NCT04977518
Characteristics of Infective Endocarditis in East ChinaNo drug interventionsNot AvailableNot Availablecompleted
NCT06266741
The Predictive Value of Lubricin in Patients With Infective EndocarditisNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT00947817
Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of EmbolismNo drug interventionspreventionNot Availablecompleted
NCT03272724
French National Observatory on Infective EndocarditisNo drug interventionsNot AvailableNot Availablerecruiting
NCT06186258
Infective Endocarditis in Percutaneous Pulmonary Revalvulation: Comparison Between Melody and Sapien ValvesNo drug interventionsNot AvailableNot Availablecompleted
NCT06457386
Echocardiography Versus no Echocardiography in S. Aureus Bacteraemia and VIRSTA Score < 3No drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT02466139
Early Clinical, Laboratory and Microbiological Predictors of Treatment Outcomes in Infective EndocaridtisNo drug interventionsNot AvailableNot Availablecompleted
NCT02698930
Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgerysupportive_careNot Availableunknown_status
NCT06418048
INfectious DIsease REgistry BIObankNo drug interventionsNot AvailableNot Availablerecruiting
NCT00638157
Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)treatment4terminated
NCT04647331
Betalactam Pharmacokinetics in Endocarditis PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00624091
Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL)No drug interventionstreatment4unknown_status
NCT05692089
Incidence of Infective Endocarditis in End Stage Renal Disease Patients on Hemodialysis by Transesophageal Echocardiography in Assuit University HospitalNo drug interventionsNot AvailableNot Availablecompleted
NCT02287792
18-FDG PET/CT Imaging and Clinical Decisions in Infective EndocarditisNo drug interventionsdiagnosticNot Availablecompleted
NCT02940340
Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective EndocarditisNo drug interventionsNot AvailableNot Availablecompleted
NCT05253469
Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic HomograftNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06434012
Barts Endocarditis Research RegistryNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04792281
Impact of FDG-PET/CT on Management of Patients With Native Valve Infective EndocarditisNo drug interventionsNot AvailableNot Availablerecruiting
NCT02701595
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Streptococcustreatment3unknown_status
NCT03683355
Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected Transcatheter Aortic Valves.No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04992923
Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière HospitalNo drug interventionsNot AvailableNot Availablerecruiting
NCT00550823
Cardiac Computarized Tomography in Infective EndocarditisNo drug interventionsdiagnosticNot Availableunknown_status
NCT02701608
Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcustreatment3unknown_status
NCT03642379
Cardiac Surgery Peer Support RecoveryNo drug interventionssupportive_careNot Availablerecruiting
NCT02252900
Long-term Clinico-radiological Evolution of Patients With Brain Lesions During Infectious EndocarditisNo drug interventionsdiagnosticNot Availableunknown_status
NCT03681431
Evaluation of an Antibiotic Regimen Pharmacokinetic Applicable to Enterococcus Faecalis Infective Endocarditistreatment2completed
NCT05530837
Characterization of Enterococcus Faecalis Endocarditis and Impact of Amoxicillin MIC Elevation on Patient OutcomeNo drug interventionsNot AvailableNot Availablecompleted
NCT03851575
Accelerated Treatment of EndocarditisNo drug interventionstreatmentNot Availableunknown_status
NCT04691440
Hyperbaric Oxygen Treatment in Humans With Gram Positive Cocci EndocarditisNo drug interventionstreatment2unknown_status