amino acid supplementation (DBCOND0106345)

Identifiers

Synonyms

Amino acid supplementation therapy / Nutritional supplementation / Nutritional supplement

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alanine	An amino acid commonly found as a component of total parenteral nutrition.	Alanine--glyoxylate aminotransferasetarget Alanine aminotransferase 1target Cysteine desulfurasetarget Proton-coupled amino acid transporter 1target Large neutral amino acids transporter small subunit 2target Alanine--glyoxylate aminotransferase 2, mitochondrialtarget Alanine--tRNA ligase, cytoplasmictarget Neutral amino acid transporter Atarget 4-aminobutyrate aminotransferase, mitochondrialtarget Kynureninasetarget Alanine--tRNA ligase, mitochondrialtarget 5-phosphohydroxy-L-lysine phospho-lyasetarget Alanine aminotransferase 2target Monocarboxylate transporter 10transporter
Arginine	An amino acid commonly found as a component of total parenteral nutrition.	Cationic amino acid transporter 3target Antizyme inhibitor 2target Argininosuccinate lyasetarget Nitric oxide synthase, inducibletarget High affinity cationic amino acid transporter 1target Arginase-2, mitochondrialtarget Cationic amino acid transporter 4target Argininosuccinate synthasetarget Nitric oxide synthase 3target Organic cation/carnitine transporter 2transporter Monocarboxylate transporter 10transporter Solute carrier family 22 member 4transporter
Aspartic acid	An amino acid commonly found as a component in total parenteral nutrition.	Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrialtarget Aspartate aminotransferase, cytoplasmictarget Aspartoacylasetarget Asparagine synthetase [glutamine-hydrolyzing]target Argininosuccinate synthasetarget Aminoacylase-1target Aspartate aminotransferase, mitochondrialtarget Aspartate--tRNA ligase, cytoplasmictarget Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrialtarget Aspartyl/asparaginyl beta-hydroxylasetarget Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetasetarget Adenylosuccinate synthetase isozyme 2target Excitatory amino acid transporter 3target Aspartate--tRNA ligase, mitochondrialtarget Isoaspartyl peptidase/L-asparaginasetarget Ribonuclease pancreatictarget Lysozyme Ctarget Monocarboxylate transporter 10transporter Multifunctional protein CADenzyme Adenylosuccinate Synthetasestarget Glutamate receptor ionotropic, NMDA 2Atarget Glutamate receptor ionotropic, NMDA 2Btarget Glutamate receptor ionotropic, NMDA 1target
Cysteine	An amino acid commonly found as a component of total parenteral nutrition and used as an antidote for acetaminophen overdose.	Cysteine--tRNA ligase, cytoplasmictarget Glutamate--cysteine ligase regulatory subunittarget Glutamate--cysteine ligase catalytic subunittarget Aspartate aminotransferase, cytoplasmictarget Cystathionine gamma-lyasetarget Cystathionine beta-synthasetarget Cysteine dioxygenase type 1target Methylated-DNA--protein-cysteine methyltransferasetarget Glutathione synthetasetarget Probable cysteine--tRNA ligase, mitochondrialtarget Cysteine sulfinic acid decarboxylasetarget Cysteine desulfurasetarget Monocarboxylate transporter 10transporter Aspartate aminotransferase, mitochondrialtarget
D-Methionine	An amino acid found in mixture products used for nutrient supplementation.	Methionine aminopeptidase 2target Transcriptional regulator, HTH_3 familytarget
Glutamic acid	An amino acid commonly found as a component in total parenteral nutrition.	Glutamate dehydrogenase 1, mitochondrialtarget Glutamate receptor ionotropic, kainate 1target Glutamate receptor 1target Glutamate--cysteine ligase regulatory subunittarget Glutamate carboxypeptidase 2target Glutamate decarboxylase 2target Glutamate decarboxylase 1target Formimidoyltransferase-cyclodeaminasetarget Glutamate receptor 2target Glutamate receptor 3target Glutamate receptor 4target Delta-1-pyrroline-5-carboxylate synthasetarget Glutamate receptor ionotropic, kainate 2target Glutamate receptor ionotropic, kainate 3target Metabotropic glutamate receptor 1target Metabotropic glutamate receptor 4target Glutamate receptor ionotropic, kainate 4target Glutamate receptor ionotropic, kainate 5target Metabotropic glutamate receptor 7target Metabotropic glutamate receptor 8target Excitatory amino acid transporter 5target 5-oxoprolinasetarget Phosphoribosylformylglycinamidine synthasetarget Branched-chain-amino-acid aminotransferase, mitochondrialtarget Glutamate receptor ionotropic, NMDA 2Dtarget Glutaminase kidney isoform, mitochondrialtarget Aspartate aminotransferase, mitochondrialtarget Bifunctional glutamate/proline--tRNA ligasetarget Asparagine synthetase [glutamine-hydrolyzing]target Glutamine synthetasetarget Aspartate aminotransferase, cytoplasmictarget Tyrosine aminotransferasetarget Alanine aminotransferase 1target Vitamin K-dependent gamma-carboxylasetarget Excitatory amino acid transporter 1target Excitatory amino acid transporter 2target Excitatory amino acid transporter 3target Glutamate--cysteine ligase catalytic subunittarget Excitatory amino acid transporter 4target Glutamate dehydrogenase 2, mitochondrialtarget GMP synthase [glutamine-hydrolyzing]target Branched-chain-amino-acid aminotransferase, cytosolictarget 4-aminobutyrate aminotransferase, mitochondrialtarget Glutamate receptor ionotropic, NMDA 1target Folylpolyglutamate synthase, mitochondrialtarget Glutamyl aminopeptidasetarget Glutamate receptor ionotropic, NMDA 2Atarget Glutamate receptor ionotropic, NMDA 2Btarget Glutamate receptor ionotropic, NMDA 2Ctarget Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrialtarget Glutamine-dependent NAD(+) synthetasetarget N-acetylglutamate synthase, mitochondrialtarget Kynurenine/alpha-aminoadipate aminotransferase, mitochondrialtarget Glutamate receptor ionotropic, NMDA 3Atarget Alanine aminotransferase 2target Alpha-aminoadipic semialdehyde synthase, mitochondrialtarget Glutaminase liver isoform, mitochondrialtarget Aspartyl aminopeptidasetarget Cystine/glutamate transportertarget Carboxypeptidase Qtarget Phosphoserine aminotransferasetarget Monocarboxylate transporter 10transporter Monocarboxylate transporter 1transporter Mitochondrial glutamate carrier 2transporter Mitochondrial glutamate carrier 1transporter Aspartate aminotransferasetarget
Glycine	An amino acid commonly used as a component of total parenteral nutrition and is also used as irrigation during surgery.	Glutathione synthetasetarget Glycine receptor subunit alpha-1target Alanine--glyoxylate aminotransferasetarget Glycine receptor subunit betatarget Serine hydroxymethyltransferase, cytosolictarget Glycine receptor subunit alpha-3target Glycine receptor subunit alpha-2target Glycine N-methyltransferasetarget Glycine amidinotransferase, mitochondrialtarget Glutamate receptor ionotropic, NMDA 3Btarget 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialtarget 5-aminolevulinate synthase, non-specific, mitochondrialtarget 5-aminolevulinate synthase, erythroid-specific, mitochondrialtarget Glycine--tRNA ligasetarget Glutamate receptor ionotropic, NMDA 2Atarget Bile acid-CoA:amino acid N-acyltransferasetarget N-arachidonyl glycine receptortarget Glutamate receptor ionotropic, NMDA 2Ctarget Serine hydroxymethyltransferasetarget Glycine N-acyltransferasetarget Serine hydroxymethyltransferase, mitochondrialtarget Glycine N-acyltransferase-like protein 2target Glycine N-acyltransferase-like protein 1target Alanine--glyoxylate aminotransferase 2, mitochondrialtarget Peroxisomal sarcosine oxidasetarget Monocarboxylate transporter 10transporter Proton-coupled amino acid transporter 1transporter Vesicular inhibitory amino acid transportertransporter Sodium- and chloride-dependent glycine transporter 2transporter Sodium- and chloride-dependent glycine transporter 1transporter Aminomethyltransferase, mitochondrialenzyme Glycine dehydrogenase (decarboxylating), mitochondrialenzyme Dihydrolipoyl dehydrogenase, mitochondrialenzyme Glycine cleavage system H protein, mitochondrialenzyme
Histidine	An amino acid commonly found as a component of total parenteral nutrition.	Histidine decarboxylasetarget Histidine--tRNA ligase, cytoplasmictarget Sodium-coupled neutral amino acid transporter 3target Histidine ammonia-lyasetarget Monocarboxylate transporter 10transporter
Isoleucine	An amino acid commonly found as a component of total parenteral nutrition.	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget Branched-chain-amino-acid aminotransferase, cytosolictarget Branched-chain-amino-acid aminotransferase, mitochondrialtarget Isoleucine--tRNA ligase, cytoplasmictarget Isoleucine--tRNA ligase, mitochondrialtarget Monocarboxylate transporter 10transporter
Leucine	An amino acid commonly found as a component of total parenteral nutrition.	Leucine--tRNA ligase, mitochondrialtarget tRNA wybutosine-synthesizing protein 4target Leucine carboxyl methyltransferase 1target Leucine--tRNA ligase, cytoplasmictarget Branched-chain-amino-acid aminotransferase, mitochondrialtarget Branched-chain-amino-acid aminotransferase, cytosolictarget Monocarboxylate transporter 10transporter Monocarboxylate transporter 8transporter
Lysine	An amino acid commonly found as a component of total parenteral nutrition.	High affinity cationic amino acid transporter 1target Cationic amino acid transporter 4target Cationic amino acid transporter 3target Cationic amino acid transporter 2target Lysine--tRNA ligasetarget Monocarboxylate transporter 10transporter Solute carrier family 22 member 4transporter
Methionine	An amino acid commonly found as a component in total parenteral nutrition.	Methionine synthase reductasetarget Methionine synthasetarget Methionine aminopeptidase 2target Betaine--homocysteine S-methyltransferase 1target S-methylmethionine--homocysteine S-methyltransferase BHMT2target Glutamine synthetaseenzyme Methylenetetrahydrofolate reductase (NADPH)enzyme Monocarboxylate transporter 10transporter S-adenosylmethionine synthase isoform type-2enzyme Methionine-R-sulfoxide reductase B2, mitochondrialenzyme S-adenosylmethionine synthase isoform type-1enzyme Methionine-R-sulfoxide reductase B1enzyme Mitochondrial peptide methionine sulfoxide reductaseenzyme Methionine--tRNA ligase, cytoplasmicenzyme Methionine--tRNA ligase, mitochondrialenzyme Methionine adenosyltransferase 2 subunit betaenzyme S-methylmethionine--homocysteine S-methyltransferase BHMT2enzyme
Ornithine	An amino acid commonly found as a component in total parenteral nutrition.	Ornithine aminotransferase, mitochondrialtarget Ornithine transcarbamylase, mitochondrialtarget Arginase-1target Ornithine decarboxylase antizyme 1target Cationic amino acid transporter 2target Mitochondrial ornithine transporter 2target High affinity cationic amino acid transporter 1target Arginase-2, mitochondrialtarget Mitochondrial ornithine transporter 1target Glycine amidinotransferase, mitochondrialtarget
Phenylalanine	An amino acid commonly found as a component of total parenteral nutrition.	Tyrosine aminotransferasetarget Large neutral amino acids transporter small subunit 2target Phenylalanine--tRNA ligase alpha subunittarget Phenylalanine-4-hydroxylasetarget Phenylalanine--tRNA ligase, mitochondrialtarget Phenylalanine--tRNA ligase beta subunittarget Tyrosine 3-monooxygenasetarget Monocarboxylate transporter 10transporter
Proline	An amino acid commonly found as a component of total parenteral nutrition.	Pyrroline-5-carboxylate reductase 1, mitochondrialtarget Bifunctional glutamate/proline--tRNA ligasetarget Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)target Sodium-dependent proline transportertarget Pyrroline-5-carboxylate reductase 2target Prolyl 4-hydroxylase subunit alpha-2target Proline dehydrogenase 1, mitochondrialtarget Peptidyl-prolyl cis-trans isomerase Htarget Pyridoxal phosphate homeostasis proteintarget Prolyl 4-hydroxylase subunit alpha-1target Peptidyl-prolyl cis-trans isomerase Btarget Peptidyl-prolyl cis-trans isomerase F, mitochondrialtarget Peptidyl-prolyl cis-trans isomerase Ctarget Peptidyl-prolyl cis-trans isomerase Atarget Peptidyl-prolyl cis-trans isomerase Gtarget Prolyl 3-hydroxylase 1target Pyrroline-5-carboxylate reductasetarget Probable proline--tRNA ligase, mitochondrialtarget Prolyl 3-hydroxylase 2target Prolyl 3-hydroxylase 3target Pyrroline-5-carboxylate reductase 3target Trans-3-hydroxy-L-proline dehydratasetarget Proline dehydrogenase 1, mitochondrialenzyme Monocarboxylate transporter 10transporter
Serine	An amino acid commonly found as a component in total parenteral nutrition.	Cystathionine beta-synthasetarget L-serine dehydratase/L-threonine deaminasetarget Serine racemasetarget Serine palmitoyltransferase 2target Serine palmitoyltransferase 1target Serine--tRNA ligase, cytoplasmictarget Alanine--glyoxylate aminotransferasetarget Monocarboxylate transporter 10transporter
Threonine	An amino acid commonly found as a component of total parenteral nutrition.	Threonine--tRNA ligase 1, cytoplasmictarget Threonine--tRNA ligase, mitochondrialtarget Monocarboxylate transporter 10transporter Beta-lactamase Toho-1target
Tryptophan	An amino acid commonly found as a component of total parenteral nutrition.	Tryptophan--tRNA ligase, cytoplasmictarget Tryptophan--tRNA ligasetarget Tryptophan--tRNA ligase, mitochondrialtarget Tryptophan 2,3-dioxygenaseenzyme Aromatic-L-amino-acid decarboxylaseenzyme Monocarboxylate transporter 8transporter Monocarboxylate transporter 10transporter Tryptophan--tRNA ligaseenzyme Tryptophan--tRNA ligase, mitochondrialenzyme Tryptophan 5-hydroxylase 1enzyme Tryptophan 5-hydroxylase 2enzyme Tryptophan--tRNA ligase, cytoplasmicenzyme Indoleamine 2,3-dioxygenase 1enzyme Indoleamine 2,3-dioxygenase 1target
Tyrosine	An amino acid commonly found as a component in total parenteral nutrition.	Tyrosine 3-monooxygenasetarget Tyrosine--tRNA ligase, mitochondrialtarget Tyrosine--tRNA ligase, cytoplasmictarget Tyrosine aminotransferasetarget Monocarboxylate transporter 8transporter Monocarboxylate transporter 10transporter
Valine	An amino acid commonly found as a component of total parenteral nutrition.	Propionyl-CoA carboxylase beta chain, mitochondrialtarget Branched-chain-amino-acid aminotransferase, cytosolictarget Valine--tRNA ligasetarget Monocarboxylate transporter 10transporter Valine--tRNA ligaseenzyme Propionyl-CoA carboxylase beta chain, mitochondrialenzyme Branched-chain-amino-acid aminotransferase, cytosolicenzyme

Clinical Trials

Not Available