Hypergonadotropic Hypogonadism (DBCOND0048343)

Identifiers

Synonyms

Primary Hypogonadism / Hypergonadotropic hypogonadism / Primary gonadal failure / Primary hypogonadism (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Fluoxymesterone	A synthetic androgenic anabolic steroid that used in the treatment of hypogonadism and delayed puberty in males, as well as breast neoplasms in women.	Sex hormone-binding globulincarrier Estrogen receptortarget Androgen receptortarget Glucocorticoid receptortarget 11-beta-hydroxysteroid dehydrogenase type 2target
Follitropin	A form of recombinant human follicle stimulating hormone used to stimulate follicle development in women with primary ovarian hypogonadism and in men with hypogonadotropic hypogonadism.	Follicle-stimulating hormone receptortarget
Methyltestosterone	A synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females.	Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Androgen receptortarget Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Albumincarrier Sex hormone-binding globulincarrier Estrogen receptortarget Aromataseenzyme
Testosterone	A hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.	Androgen receptortarget Cytochrome P450 3A4enzyme Aromataseenzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Organic anion transporter 3transporter Solute carrier family 22 member 7transporter Hepatic sodium/bile acid cotransportertransporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget Solute carrier organic anion transporter family member 1B3transporter
Testosterone cypionate	An androgen used to treat low or absent testosterone.	Androgen receptortarget Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter ATP-dependent translocase ABCB1transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 3transporter Solute carrier family 22 member 4transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aromataseenzyme
Testosterone enanthate	An androgen used to treat low or absent testosterone.	Androgen receptortarget Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter ATP-dependent translocase ABCB1transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 3transporter Solute carrier family 22 member 4transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme Estrogen receptortarget Mineralocorticoid receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aromataseenzyme
Testosterone undecanoate	An androgen indicated for testosterone replacement therapy in adult males with primary hypogonadism and hypogonadotropic hypogonadism.	Androgen receptortarget Cytochrome P450 3A4enzyme Amine oxidase [flavin-containing] Aenzyme Cholesterol side-chain cleavage enzyme, mitochondrialenzyme Albumincarrier Sex hormone-binding globulincarrier Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier organic anion transporter family member 1A2transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter ATP-dependent translocase ABCB1transporter Hepatic sodium/bile acid cotransportertransporter Solute carrier family 22 member 4transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2A13enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A43enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Solute carrier family 22 member 2transporter Multidrug and toxin extrusion protein 1transporter Solute carrier organic anion transporter family member 1B3transporter Aromataseenzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05752591	Hypothalamic-pituitary Dysfunction in Diabetes	No drug interventions	Not Available	Not Available	completed
NCT01206270	Androgen for Leydig Cell Proliferation	Castor oil Testosterone undecanoate	treatment	2 / 3	completed
NCT00911586	Pharmacokinetic Study to Determine Time to Steady-state	Testosterone undecanoate	treatment	2	completed
NCT02110368	Bioequivalence Study of Test and Reference Testosterone Topical Gel, 1.62% Metered Pump in Testosterone Deficient Adult Male Subjects Under Fasting Conditions	Testosterone	treatment	3	completed
NCT00467870	Long-term Safety Study of Intramuscular Injections of 750 mg and 1000 mg Testosterone Undecanoate in Hypogonadal Men	Testosterone undecanoate	treatment	3	completed