Lung Abscess (DBCOND0000321)

Identifiers

Synonyms

Lung abscess / Abscess of lung without pneumonia / Abscess of lung / Abscess of lung (disorder) / Lung abscess NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Biapenem	A carbapenem antibiotic indicated in the treatment of bacterial infections.	No drug targets
Cefoxitin	A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection.	Penicillin-binding protein 1Atarget Penicillin-binding protein 1Btarget Peptidoglycan synthase FtsItarget D-alanyl-D-alanine carboxypeptidase DacAtarget D-alanyl-D-alanine carboxypeptidase DacBtarget D-alanyl-D-alanine carboxypeptidase DacCtarget D-alanyl-D-alanine endopeptidasetarget Beta-lactamaseenzyme Penicillin-binding protein 3target Penicillin-binding protein 1btarget Penicillin-binding protein 2atarget Penicillin-binding protein 1Atarget Penicillin-binding protein 2Btarget
Metronidazole	A nitroimidazole used to treat trichomoniasis, amebiasis, inflammatory lesions of rosacea, and bacterial infections, as well as prevent postoperative infections.	Oxygen-insensitive NADPH nitroreductasetarget Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1A1enzyme Anaerobic bacterial DNAtarget Protozoal DNAtarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2A6enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01085864	Biomarkers for Diagnosis of Lung Nodules	No drug interventions	Not Available	Not Available	recruiting
NCT01045902	BAY12-8039, iv/Oral Pulmonary Abscess/Aspiration Pneumonia	Ampicillin Moxifloxacin Sulbactam	treatment	3	completed
NCT01793688	Special Use-Result Surveillance of Unasyn-S (Kit) for Intravenous Use - A Surveillance on High-dose (>6 g Daily) Administration -	Ampicillin Sulbactam	Not Available	Not Available	completed