Neurogenic Detrusor Overactivity (DBCOND0040895)

Identifiers

Synonyms

Detrusor overactivity, neurologic conditions / Neurogenic detrusor overactivity / Neurogenic detrusor overactivity (disorder) / Detrusor hyperreflexia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Botulinum toxin type A	A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.	Synaptosomal-associated protein 25target Rho-related GTP-binding protein RhoBtarget Albumincarrier
Fesoterodine	An antimuscarinic agent used in the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.	Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M3target Cytochrome P450 3A4enzyme Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter
Mirabegron	A beta-3 adrenergic agonist used to treat overactive bladder and neurogenic detrusor overactivity.	Cytochrome P450 3A4enzyme Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Albumincarrier Alpha-1-acid glycoprotein 1carrier Cholinesteraseenzyme Beta-3 adrenergic receptortarget UDP-glucuronosyltransferase 2B7enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 1A8enzyme Solute carrier family 22 member 1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter Beta-1 adrenergic receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05621616	A Study to Learn How Effective and Safe the Drug 'Mirabegron' is and How Long it Stays in the Body of Children Aged 6 Months to Less Than 3 Years of Age With Neurogenic Detrusor Overactivity	Mirabegron	treatment	3	recruiting
NCT06596291	Dose Escalation Study of EG110A, Administered by Intradetrusor Injections to Adults with Neurogenic Detrusor Overactivity-related Incontinence Following Spinal Cord Injury Who Regularly Perform Clean Intermittent Catheterization	No drug interventions	treatment	1 / 2	not_yet_recruiting
NCT03482037	Effects of Rec 0/0438 in Patients With Neurogenic Detrusor Overactivity Due to Spinal Cord Injury	No drug interventions	treatment	1 / 2	completed
NCT02138149	Is the Nerve Growth Factor (NGF) a Useful Biomarker in Neurogenic Bladder Dysfunction After Spinal Cord Injury?	No drug interventions	Not Available	Not Available	completed
NCT00857896	Study Of Fesoterodine In Pediatric Overactive Bladder Patients Aged 8-17 Years	Fesoterodine	treatment	2	completed
NCT00712322	A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity	Darifenacin	treatment	2	terminated
NCT05491525	A Study of Vibegron in Pediatric Participants 2 Years to Less Than (<) 18 Years of Age With NDO and on CIC	Vibegron	treatment	2 / 3	recruiting
NCT02751931	Open-label Phase 3 Study With Mirabegron in Children From 3 to Less Than 18 Years of Age With Neurogenic Detrusor Overactivity	Mirabegron	treatment	3	completed
NCT01091727	Intravesical Injection of Botulinum Toxin A Versus Saline for Neurogenic Detrusor Overactivity	Botulinum toxin type A	treatment	3	completed
NCT00800462	Comparative Study of the Efficacy and Safety of Muscarinic M3 Receptors Antagonists in the Treatment of Neurogenic Detrusor Overactivity	Darifenacin Oxybutynin Trospium	treatment	4	completed
NCT04452838	Study To Assess The Bioequivalence Under Fed And Fasted Conditions Of The Fesoterodine Beads-In-Capsule SR4 And SR7 Formulations And To Estimate The Bioavailability of SR7 Beads Sprinkled On Apple Sauce Relative To The Beads-In-Capsule SR7 Formulation Administer	Fesoterodine	other	1	completed
NCT02526979	A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron Oral Suspension in Pediatric Subjects From 3 to Less Than 12 Years of Age With Neurogenic Detrusor Overactivity (NDO) or Overactive Bladder (OAB)	Mirabegron	basic_science	1	completed
NCT01981954	A Clinical Study to Investigate How Solifenacin Fluid is Taken up, How Long it Stays in the Body and How Effective and Safe it is in Treating Children Aged From 6 Months to Less Than 5 Years With Symptoms of Neurogenic Detrusor Overactivity (NDO)	Solifenacin	treatment	3	completed
NCT03168828	Safety and Tolerability of TAR-302-5018 in Subjects With Neurogenic Detrusor Overactivity Resulting From Spinal Cord Injury	Trospium	treatment	1	completed
NCT01539707	Single Dose Study to Measure Blood Levels and Safety of a Drug for Children With Overactive Bladder	Solifenacin	other	1	completed
NCT01043848	Treatment of Neurogenic Detrusor Overactivity: Early Versus Late Pudendal Nerve Stimulation in Spinal Cord Injury (SCI) Patients	No drug interventions	treatment	Not Available	withdrawn
NCT04478357	BIOEQUIVALENCE STUDY IN HEALTHY PARTICIPANTS COMPARING 4 MG AND 8 MG FESOTERODINE EXTENDED-RELEASE TABLETS (TOVIAZ™), MANUFACTURED AT ZWICKAU VERSUS FREIBURG	Fesoterodine	other	1	completed
NCT06059066	Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction	No drug interventions	treatment	Not Available	recruiting
NCT01565694	A Study to Assess the Long Term Effect, Safety and Metabolism of a Solifenacin Liquid Suspension in Participants 5 to 18 Years of Age With Neurogenic Detrusor Overactivity	Solifenacin	treatment	3	completed
NCT02211846	A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Mirabegron OCAS (Oral Controlled Absorption System) in Pediatric Subjects With Neurogenic Detrusor Overactivity or Overactive Bladder	Mirabegron	basic_science	1	completed
NCT05502614	Dorsal Genital Nerve Stimulation for Bladder Management After SCI	No drug interventions	device_feasibility	Not Available	active_not_recruiting
NCT06515223	Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury	No drug interventions	treatment	Not Available	not_yet_recruiting