Chronic Lymphocytic Leukaemia (CLL) (DBCOND0050885)

Identifiers

Synonyms
Chronic Lymphoid Leukemia / Chronic Lymphoid Leukaemia / Chronic Lymphatic Leukemia / CLL / Chronic Lymphocytic Leukaemia / Leukaemias chronic lymphocytic / Chronic lymphocytic leukemia of B-cell type not having achieved remission / Chronic lymphocytic leukemia of B-cell type / B-cell chronic lymphocytic leukaemia / B-cell chronic lymphocytic leukemia / Chronic lymphocytic leukemia / Leukemia lymphocytic chronic / Lymphoid leukaemia, chronic / Chronic lymphoid leukemia, disease (disorder) / Lymphoid leukemia, chronic / Chronic lymphatic leukaemia / Leukaemia lymphocytic chronic / Chronic lymphocytic leukaemia NOS / Chronic lymphocytic leukemia, morphology (morphologic abnormality) / Leukemia, Lymphocytic, Chronic, B-Cell

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Acalabrutinib
A Bruton tyrosine kinase inhibitor used to treat mantle cell lymphoma, chronic lymphocytic leukemia, and small lymphocytic lymphoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04407845
Atrial Fibrillation in Patients Receiving IbrutinibNo drug interventionsNot AvailableNot Availableunknown_status
NCT02020109
Evaluation of Splenic Irradiation in Chronic Lymphatic LeukemiaNo drug interventionsNot AvailableNot Availablewithdrawn
NCT01246557
Study Assessing Safety and Efficiency of the Lenalidomide and Dexamethasone Combination in Patients With Chronic Lymphatic Leukemia (CLL) Relapsing or Resistant to Treatmenttreatment1 / 2completed
NCT02802943
iVAC-CLL01: Patient-individualized Peptide Vaccination After First Line Therapy of CLLtreatment2completed
NCT01809847
Ofatumumab Induction and Maintenance in Elderly Patients With Poor Risk CLL in the Context of Allogeneic Transplantationtreatment2completed
NCT03204188
Ibrutinib, Fludarabine, and Pembrolizumab in High-Risk or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphomatreatment2active_not_recruiting
NCT06508775
Long-Term Follow-up of Patients Treated With Miltenyi Cell and Gene TherapiesotherNot Availablerecruiting
NCT04728893
Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)treatment2recruiting
NCT02267590
Tissue Collection for Biomarkers Determining Resistance to IbrutinibNo drug interventionsNot AvailableNot Availableunknown_status
NCT06357754
Transgene Assay Testing Service of Tumor Samples From Patients Who Received a Bristol-Myers Squibb Manufactured Gene Modified Cell Therapy and Have a Qualifying Secondary MalignancyNot AvailableNot Availablerecruiting
NCT03582098
Clinical Outcomes and Routine Management of Adults With Chronic Lymphocytic Leukaemia Treated With Idelalisib and Rituximab in the United Kingdom (UK) and IrelandNot AvailableNot Availablecompleted
NCT02164071
Validation of a Comprehensive Health Status Assessment Scale in Elderly Patients (≥ 65 Years) With Hematological MalignanciesNo drug interventionsNot AvailableNot Availablecompleted
NCT00802737
Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL)treatment4completed
NCT01446900
R-2cda and Prolongation of Therapy With Rituximab Alone in Chronic Lymphocytic Leukaemia and Small Lymphocytic Lymphomatreatment2terminated
NCT01805375
A Phase I Trial of DI-B4 in Patients With Advanced CD19 Positive Indolent B-cell MalignanciesNo drug interventionstreatment1completed
NCT01127542
RESPeCT: Revlimid Early Stage Poor Prognosis Chronic Lymphocytic Leukaemia (CLL) Trialtreatment2terminated
NCT00410163
Ofatumumab With Fludarabine and Cyclophosphamide in B-CLL Patientstreatment2completed
NCT01678430
A Trial Looking at Ofatumumab for People With Chronic Lymphocytic Leukaemia Who Cannot Have More Intensive Treatmenttreatment3unknown_status
NCT00824265
Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemiatreatment3completed
NCT02933320
BI-1206 and an Anti-CD20 Antibody in Patients With CD32b Positive B-cell Lymphoma or Leukaemiatreatment1 / 2completed
NCT01110031
Ofatumumab Cardiac Repolarization (QTc) Study in Fludarabine-Refractory Chronic Lymphocytic Leukemia Subjectsother1completed
NCT01039376
Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapytreatment3terminated
NCT00292760
A Single-arm Phase II Study of Alemtuzumab in Combination With High-dose Methylprednisolone in CLL Patients With p53 Deletiontreatment2completed
NCT01453062
Phase IV Observational Study in Chronic Lymphocytic LeukemiaNot AvailableNot Availablecompleted
NCT00748189
Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemiatreatment3terminated
NCT01563055
A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemiatreatment2completed
NCT06564038
A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignanciestreatment1 / 2not_yet_recruiting
NCT01832597
Efficacy and Safety Study of Bendamustine With or Without Rituximab in Chronic Lymphoproliferative DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT04763083
First in Human Study of NVG-111 in Relapsed/Refractory ROR1+ MalignanciesNo drug interventionstreatment1recruiting
NCT00349349
HuMax-CD20 in B-Cell Chronic Lymphocytic Leukemia (B-CLL) Patients Failing Fludarabine and Alemtuzumabtreatment2completed
NCT01597219
Trial of Haploidentical Stem Cell Transplantation for Haematological CancersNo drug interventionstreatment2completed
NCT00751296
Study of Lenalidomide in Previously Untreated, Symptomatic Chronic Lymphocytic Leukemia (CLL)treatment2terminated
NCT01520922
Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL)treatment2completed
NCT01077622
A Phase I/II, a Single Arm, Open-label Study of Ofatumumab (GSK1841157) in Patients With Previously Treated Chronic Lymphocytic Leukemiatreatment2completed
NCT00457782
A Phase I Safety, PK and PD Study of KW-2478 in Patients With Multiple Myeloma, Chronic Lymphocytic Leukaemia or B-cell Non-Hodgkin's LymphomaNo drug interventionstreatment1completed
NCT00504491
R-CHOP and Alemtuzumab in Patients With Chronic Lymphocytic Leukemiatreatment2withdrawn
NCT01659255
Study to Evaluate the Safety and Tolerability of Tirabrutinib (ONO/GS-4059) Given as Monotherapy in Participants With Relapsed/Refractory NHL and CLLtreatment1completed
NCT05645172
Retention Rate of Acalabrutinib in a Non-interventional SettingNo drug interventionsNot AvailableNot Availablerecruiting
NCT02273856
Multicentre Registry of Treatments and Outcomes in Patients With Chronic Lymphocytic Leukaemia (CLL) Or Indolent Non Hodgkin's Lymphoma (iNHL)No drug interventionsNot AvailableNot Availableterminated
NCT02920697
Dose-escalation Study of Oral Administration of S 55746 in Patients With Chronic Lymphocytic Leukaemia and B-Cell Non-Hodgkin Lymphomatreatment1completed
NCT01279252
CLL Empirical Antibiotic Regimentreatment2completed
NCT03852407
Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity Conditioningtreatment2recruiting
NCT01518959
The Effect of 25-OH-Vitamin-D3 Substitution in Patients With Malignant and Immune-hematologic Diseasestreatment3terminated
NCT04608318
Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL)treatment3active_not_recruiting
NCT03804372
The Incidence of Hepatitis B in Diffuse Large B-Cell Lymphoma/Chronic Lymphoid Leukemia HBsAg-positive Treated With Rituximab, Chemotherapy and Tenofovir Alafenamidetreatment2unknown_status
NCT04515238
Sequential Regimen of Bendamustine Followed by Obinutuzumab (GA101), Zanubrutinib (BGB-3111) and Venetoclax (ABT-199) in Patients With Relapsed/Refractory CLLtreatment2active_not_recruiting
NCT03787264
Sequential Regimen of Bendamustin-Debulking Followed by Obinutuzumab, Acalabrutinib and Venetoclax in Patients With Relapsed/Refractory CLLtreatment2completed
NCT00788684
Safety Study of ABT-263 in Combination With Rituximab in Lymphoid Cancerstreatment1active_not_recruiting
NCT00406809
A Study of ABT-263 in Subjects With Relapsed or Refractory Lymphoid Malignanciestreatment1 / 2completed
NCT04883749
Efficacy of Acalabrutinib in Very Old or Frail Patients With Treatment-naïve or Relapsed/Refractory CLLtreatment2active_not_recruiting
NCT03766763
Preemptive Therapy for High Risk Chronic Lymphoid Leukemia Stage Atreatment2recruiting
NCT05350826
Evaluation of the Ambulatory Medical Assistance Nurse Program in Chronic Lymphocytic LeukemiaNo drug interventionsotherNot Availablerecruiting
NCT04512105
Pitavastatin in Combination With Venetoclax for Chronic Lymphocytic Leukemia or Acute Myeloid Leukemiatreatment1active_not_recruiting
NCT05517265
Acalabrutinib in Patients With Chronic Lymphocytic Leukemia With Direct Oral Anticoagulation (CICERO)Not AvailableNot Availablerecruiting
NCT05947851
A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010)treatment3recruiting
NCT06073821
Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)treatment3recruiting
NCT06506643
Safety and Efficacy of KLS-1 Monotherapy in Malignant Neoplasmstreatment1 / 2recruiting
NCT01168921
Phase II Eltrombopag in Chronic Lymphocytic Leukemia (CLL)treatment2completed
NCT01675102
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in 17p- Chronic Lymphocytic Leukemia (CLL)No drug interventionsNot AvailableNot Availablecompleted
NCT05246345
Venetoclax Resistance Landscape in Chronic Lymphocytic LeukemiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT00546793
Ph I/II Study of Subcutaneously Administered Veltuzumab (hA20) in NHL and CLLtreatment1 / 2completed
NCT00636909
Nonmyeloablative Allo SCT for the Treatment of Hematologic Disorderstreatment2completed
NCT03283137
Combination of Pembrolizumab With TGR-1202 in Patients With Relapsed/Refractory CLL and B-cell NHLtreatment1active_not_recruiting
NCT01199575
Phase II Trial of Revlimid® and Rituximab for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)treatment2completed
NCT00021749
Phase I/II Study of Genasense in Patients With Chronic Lymphocytic LeukemiaNo drug interventionstreatment1 / 2completed
NCT04016636
A Study to Evaluate Impact of Ibrutinib on the Quality of Life (QOL) in Patients With Chronic Lymphocytic LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT01465334
Ofatumumab With High Dose Methylprednisone Followed by Ofatumumab and Alemtuzumab in 17p CLLtreatment2terminated
NCT03639324
Rituximab, Idelalisib, and Venetoclax in Relapsed/Refractory CLL/SLLNo drug interventionstreatment1withdrawn
NCT02362035
ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignanciestreatment1 / 2active_not_recruiting
NCT03524235
Haploidentical Stem Cell Transplant With Prophylactic Natural Killer DLI for Lymphoma, Multiple Myeloma, and CLLtreatment1active_not_recruiting
NCT04806035
Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemiatreatment1terminated
NCT03868722
Acalabrutinib and Venetoclax Treatment of Newly Diagnosed Patients With CLL at High Risk of Infection or Early Treatmentprevention2 / 3recruiting
NCT05316831
Immune Response After Pneumococcal Vaccination in Patient With Chronic Lymphocytic LeukemiaNo drug interventionsprevention4completed
NCT04746092
The Capability of Haemato-oncology Patients to Generate Antibodies Against COVID-19No drug interventionsNot AvailableNot Availableunknown_status
NCT06557304
The Real World Study of BTK Inhibitor in the Treatment of Chronic Lymphocytic Leukemia in ChinaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT02377869
Heavy Light Chain in Chronic Lymphocytic LeukemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT03919214
Hypertension Management in Cancer PatientsNo drug interventionssupportive_careNot Availableterminated
NCT00628238
Multi-center Trial of Revlimid® and Rituximab, for First-Line Treatment of Chronic Lymphocytic Leukemia (CLL)treatment2unknown_status
NCT01191190
Ofatumumab and High-dose Methylprednisolone in Patients With Chronic Lymphocytic Leukemia (CLL)treatment2completed
NCT01703364
Fludarabine/Rituximab Combined With Escalating Doses of Lenalidomide in Untreated CLLtreatment1 / 2completed
NCT06489184
The Real World Study of Zanubrutinib in the Treatment of Chronic Lymphocytic Leukemia in ChinaNot AvailableNot Availablenot_yet_recruiting
NCT03231579
Chronic Lymphocytic Leukemia Electronic Patient Reported Outcomes StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05869279
Allogeneic CARCIK-CD19 in Adults/Pediatric B-cell NHL or Chronic Lymphocytic LeukemiaNo drug interventionstreatment1 / 2recruiting
NCT00792077
A Pilot Study to Investigate the Effect of Cytotoxic Therapy and/or Radiotherapy on Cancer Related Sleep Disturbances in CLL and Breast Cancer Patients Experiencing Fatiguetreatment2completed
NCT01862445
Retrospective Study: Efficacy and Safety of Chlorambucil + Rituximab in CLL PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT05610228
Study of the Metabolism in the Lymphatic Niche of CLLNo drug interventionsNot AvailableNot Availablerecruiting
NCT02046928
Safety, Tolerability and Efficacy of A6 in Patients With Chronic Lymphocytic Leukemia (CLL)No drug interventionstreatment2terminated
NCT04640909
Impact of Treatment With Targeted Therapies on the Generation of CAR T Cells in CLL PatientsNo drug interventionsbasic_scienceNot Availablerecruiting
NCT03572634
Phase 1/2 Study of TP-0903 (an Inhibitor of AXL Kinase) in Patients With Previously Treated CLLtreatment1 / 2terminated
NCT01397916
Indoleamine 2,3-dioxygenase (IDO) Activity in Patients With Chronic Lymphocytic Leukemia (CLL)No drug interventionsNot AvailableNot Availablecompleted
NCT01532635
A Two-Step Approach to Bone Marrow Transplant Using Cells From Two Partially-Matched Relativestreatment2terminated
NCT02229422
A Study of Obinutuzumab(GA101) in Combination With High-Dose Methylprednisolone(HDMP) in Chronic Lymphocytic Leukemia(CLL) Patients (GA101 & HDMP)treatment1 / 2active_not_recruiting
NCT04923048
A Safety, Tolerability, Pharmacokinetics and Efficacy Study of GB261 in B-Cell NHL and CLL.No drug interventionstreatment1 / 2recruiting
NCT02828774
Peptide-drug-conjugates for Personalized, Targeted Therapy of Chronic Lymphocytic LeukemiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT00535873
Lenalidomide as Initial Treatment of Patients With Chronic Lymphocytic Leukemia (CLL) Age 65 and Oldertreatment2completed
NCT04694560
A Time-Limited Approach to Treatment With Ibrutinib for Chronic Lymphocytic Leukemia and Small Lymphocytic LymphomaNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04639362
CLL Induction Treatment With Venetoclax and Ibrutinib, Followed by Ibrutinib and Obinutuzumab in Patients With MRD.treatment2active_not_recruiting
NCT00185692
Allogeneic Transplantation From Related Haploidentical Donorstreatment2completed
NCT02863692
Registry of the German CLL Study GroupNo drug interventionsNot AvailableNot Availablerecruiting
NCT03997968
A Phase 1/2 Study of CYT-0851 in B-Cell Malignancies and Advanced Solid Tumorstreatment1 / 2active_not_recruiting
NCT03113695
Obinutuzumab, High Dose Methylprednisolone (HDMP), and Lenalidomide for the Treatment of Patients With Richter's Syndrometreatment1completed
NCT00533923
Nonmyeloablative Allogeneic Stem Cell Transplantation From HLA-Matched Unrelated Donor for the Treatment of Hematologic Disorderstreatment2completed
NCT05209308
Rituximab Plus Venetoclax in Combination With Zandelisib in Subjects With CLLtreatment2withdrawn
NCT03294980
Chronic Lymphoid Leukaemia Observatory in Finistere Area, FranceNo drug interventionsNot AvailableNot Availablerecruiting