NCT01238237
Super-Selective Intraarterial Cerebral Infusion of Cetuximab (Erbitux) for Treatment of Relapsed/Refractory GBM and AA treatment 1 completed NCT01392209
Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma No drug interventions treatment 1 completed NCT01339039
Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma treatment 1 terminated NCT01475006
AMG 595 First-in-Human in Recurrent Gliomas No drug interventions treatment 1 completed NCT00243490
Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors No drug interventions treatment 2 withdrawn NCT01663012
Phase II NKTR-102 In Bevacizumab-Resistant High Grade Glioma treatment 2 completed NCT05099003
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) treatment 1 / 2 recruiting NCT05839379
Targeted Pediatric High-Grade Glioma Therapy No drug interventions Not Available Not Available recruiting NCT05843253
Study of Ribociclib and Everolimus in HGG and DIPG treatment 2 recruiting NCT04047264
Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies No drug interventions basic_science Not Available recruiting NCT05956821
Treatment of Relapsed/Refractory Intracranial Glioma in Patients Under 22 Years of Age treatment 1 / 2 recruiting NCT00100802
Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed Gliomas treatment 2 completed NCT01156584
A Study of a Retroviral Replicating Vector Combined With a Prodrug Administered to Patients With Recurrent Malignant Glioma treatment 1 completed NCT02022384
Immunophenotyping From Blood of Patients With Malignant Gliomas No drug interventions Not Available Not Available completed NCT00612651
PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas treatment 1 completed NCT01269853
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA treatment 1 / 2 recruiting NCT01721577
Phase I/II Trial of AXL1717 in the Treatment of Recurrent Malignant Astrocytomas treatment 1 / 2 terminated NCT02457845
HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors treatment 1 completed NCT00431561
Phase IIb Clinical Trial With TGF-β2 Antisense Compound AP 12009 for Recurrent or Refractory High-grade Glioma treatment 2 completed NCT00430911
Radiotherapy for Malignant Astrocytomas in the Elderly No drug interventions treatment 3 completed NCT00004688
Phase II Study of Carmustine, Streptozocin, and Mercaptopurine for Refractory or Recurrent Brain Neoplasms treatment 2 completed NCT04780009
Loupe-Based Intraoperative Fluorescence Imaging No drug interventions Not Available Not Available recruiting NCT01985256
Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor treatment 1 completed NCT00589875
Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant Glioma treatment 2 completed NCT00751270
Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas treatment 1 completed NCT01151670
Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Treating Patients With Brain Tumors supportive_care 1 completed NCT00003470
Antineoplaston Therapy in Treating Patients With Anaplastic Astrocytoma treatment 2 completed NCT01502241
Phase III Trial of Primary Radio- or Chemotherapy in Malignant Astrocytoma of the Elderly treatment 3 completed NCT03072134
Neural Stem Cell Based Virotherapy of Newly Diagnosed Malignant Glioma No drug interventions treatment 1 completed NCT02885324
Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children treatment 2 terminated NCT01975116
p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors treatment 1 completed NCT00884416
Sorafenib in Newly Diagnosed High Grade Glioma treatment 1 completed NCT02238496
Perifosine and Torisel (Temsirolimus) for Recurrent/Progressive Malignant Gliomas treatment 1 completed NCT02684058
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors treatment 2 completed NCT02540135
Fluorescein vs. iMRI in Resection of Malignant High Grade Glioma No drug interventions other Not Available withdrawn NCT02800486
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA treatment 2 recruiting NCT02490930
A Safety Study of Fingolimod With Radiation and Temozolomide in Newly Diagnosed High Grade Glioma other 0 completed NCT00024557
Histologic Effect/Safety of Pre/Post-Operative IL13-PE38QQR in Recurrent Resectable Supratentorial Malignant Glioma Patients treatment 1 completed NCT02629757
A Study on β-elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas No drug interventions treatment 3 unknown_status NCT01189266
Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma treatment 1 / 2 completed NCT04105374
Testing the Addition of an Anti-cancer Viral Gene Therapy, Toca 511/Toca FC, to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed Glioblastoma treatment 2 / 3 withdrawn NCT01522820
Vaccine Therapy With or Without Sirolimus in Treating Patients With NY-ESO-1 Expressing Solid Tumors treatment 1 completed NCT01380782
BIBF 1120 for Recurrent High-Grade Gliomas treatment 2 completed NCT01281982
(11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas No drug interventions Not Available Not Available terminated NCT00035373
Eligibility Screening of Patients With Central Nervous System Tumors for the National Cancer Institute s (NCI) Clinical Research Protocols No drug interventions Not Available Not Available terminated NCT00667394
Tandutinib Plus Bevacizumab to Treat Recurrent Brain Tumors treatment 2 completed NCT01095094
Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma treatment 2 terminated NCT02644291
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors treatment 1 completed NCT06241391
Ga-68 Prostate Specific Membrane Antigen PET/CT in Gliomas No drug interventions diagnostic Not Available not_yet_recruiting NCT01837862
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas treatment 1 / 2 completed NCT03434262
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors treatment 1 completed NCT01711580
Re-irradiation of High Grade Gliomas: a Quality of Life Study No drug interventions Not Available Not Available withdrawn NCT01656980
Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma treatment 3 unknown_status NCT00761280
Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma treatment 3 terminated NCT03581292
Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations treatment 2 active_not_recruiting NCT01884740
Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 treatment 1 / 2 terminated NCT00968240
Super-Selective Intraarterial Intracranial Infusion of Avastin (Bevacizumab) treatment 1 completed NCT01514201
Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas treatment 1 / 2 completed NCT01171469
Vaccination With Dendritic Cells Loaded With Brain Tumor Stem Cells for Progressive Malignant Brain Tumor treatment 1 completed NCT04608812
Convection-enhanced Delivery of OS2966 for Patients With High-grade Glioma Undergoing a Surgical Resection treatment 1 terminated NCT00717210
Randomized Phase III Study of Sequential Radiochemotherapy of Anaplastic Glioma With PCV or Temozolomide treatment 3 completed NCT00606008
A Phase II Trial of Sutent (Sunitinib; SU011248) for Recurrent Anaplastic Astrocytoma and Glioblastoma treatment 2 completed NCT00473408
The Effect of Radiotherapy and Temozolomide on the Tumor Vasculature and Stem Cells in Human High-grade Astrocytomas No drug interventions Not Available Not Available terminated NCT01861990
Valproic Acid in Childhood Progressive Brain Tumors treatment 1 withdrawn NCT00734864
Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma No drug interventions treatment 1 withdrawn NCT03180502
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma supportive_care 2 active_not_recruiting NCT01204684
Dendritic Cell Vaccine for Patients With Brain Tumors treatment 2 completed NCT00064779
Imaging Study of the Distribution of IL13-PE38QQR Infused Before and After Surgery in Adult Patients With Recurrent Malignant Glioma treatment 1 completed NCT02755987
Expanded Access to ANG1005 for Individual Patients Not Available Not Available no_longer_available NCT00041587
Pre-operative IL13-PE38QQR in Patients With Recurrent or Progressive Malignant Glioma treatment 1 / 2 completed NCT01222754
Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas treatment 1 completed NCT01637753
Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Recurrent Malignant Glioma treatment Not Available unknown_status NCT01144247
Cellular Immunotherapy Study for Brain Cancer No drug interventions treatment 1 completed NCT02101905
Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma treatment 1 active_not_recruiting NCT03603405
HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM treatment 1 / 2 recruiting NCT00031083
Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade IV Gliomas No drug interventions treatment 1 completed NCT02796261
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients treatment 3 unknown_status NCT03919071
Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma treatment 2 recruiting NCT00610571
Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas treatment 1 completed NCT02039778
Stem Cell Radiotherapy and Temozolomide for Newly Diagnosed High-grade Glioma No drug interventions treatment Not Available terminated NCT01765088
A Phase III Trial on Adjuvant Temozolomide With or Without Interferon-alpha in Newly Diagnosed High-grade Gliomas treatment 3 unknown_status NCT06264388
DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma treatment 2 recruiting NCT03561207
3D Prediction of Patient-Specific Response No drug interventions Not Available Not Available active_not_recruiting NCT00995007
A Randomized Phase II Trial of Vandetanib (ZD6474) in Combination With Carboplatin Versus Carboplatin Alone Followed by Vandetanib Alone in Adults With Recurrent High-Grade Gliomas treatment 2 completed NCT02372409
Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors treatment 2 terminated NCT00114309
131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma treatment 2 unknown_status NCT01316809
AZD8055 for Adults With Recurrent Gliomas treatment 1 completed NCT00645385
Examination of Changes on Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) in Patients Who Receive Gliadel Wafers During Initial Surgery for Glioblastoma Multiforme. Response or Failure to Gliadel Wafers for Subjects With Glioblastoma Multiforme. No drug interventions Not Available Not Available withdrawn NCT00879437
Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma treatment 2 completed NCT01849952
Evaluating the Expression Levels of MicroRNA-10b in Patients With Gliomas No drug interventions Not Available Not Available recruiting NCT04295759
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas treatment 1 active_not_recruiting NCT01250470
Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma treatment 1 completed NCT02168270
Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma treatment 1 terminated NCT00024570
Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma treatment 1 / 2 completed NCT06333899
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion treatment 0 not_yet_recruiting NCT00390299
Viral Therapy in Treating Patients With Recurrent Glioblastoma Multiforme treatment 1 completed NCT06108206
Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma No drug interventions treatment Not Available recruiting NCT01836549
Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors treatment 2 terminated NCT03973918
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG treatment 2 terminated NCT00301418
Oral Tarceva Study for Recurrent/Residual Glioblastoma Multiforme and Anaplastic Astrocytoma treatment 1 / 2 completed NCT01227434
A Study of PD 0332991 in Patients With Recurrent Rb Positive Glioblastoma treatment 2 terminated NCT03971734
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas treatment 1 terminated NCT05698524
A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma treatment 1 recruiting NCT01180816
Super-Selective Intraarterial Cerebral Infusion Of Temozolomide (Temodar) For Treatment Of Newly Diagnosed GBM And AA treatment 1 completed NCT01967758
Phase I Study of Safety and Immunogenicity of ADU-623 treatment 1 completed NCT05084430
Study of Pembrolizumab and M032 (NSC 733972) treatment 1 / 2 recruiting NCT05934630
Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors No drug interventions Not Available Not Available active_not_recruiting NCT03370926
FET-PET and Multiparametric MRI for High-grade Glioma Patients Undergoing Radiotherapy No drug interventions Not Available Not Available unknown_status NCT01082926
Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 treatment 1 completed NCT02758366
Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma treatment 2 terminated NCT02414165
The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade Glioma treatment 2 / 3 terminated NCT01808820
Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma treatment 1 completed NCT04541082
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms No drug interventions treatment 1 recruiting NCT00734682
A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas treatment 1 completed NCT00089427
IL13-PE38QQR Infusion After Tumor Resection, Followed by Radiation Therapy With or Without Temozolomide in Patients With Newly Diagnosed Malignant Glioma treatment 1 completed NCT04978727
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma treatment 1 recruiting NCT01922076
Adavosertib and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas treatment 1 completed NCT03355794
A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) treatment 1 completed NCT01470794
Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor treatment 1 completed NCT03043391
Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children treatment 1 completed NCT03975829
Pediatric Long-Term Follow-up and Rollover Study treatment 4 recruiting NCT00115440
BNCT to Treat Glioma That Has Progressed Following Radiotherapy No drug interventions treatment 1 / 2 completed NCT00062504
Phase 2 Trial Using Talampanel in Patients With Recurrent High Grade Gliomas treatment 2 terminated NCT05039346
Quality of Life and Patient Needs in Advanced High Grade Gliomas No drug interventions Not Available Not Available completed NCT01386710
Repeated Super-selective Intraarterial Cerebral Infusion Of Bevacizumab Plus Carboplatin For Treatment Of Relapsed/Refractory GBM And Anaplastic Astrocytoma treatment 1 / 2 suspended NCT00409214
Phase IIa Safety and Light Dose-escalation Study in Patients With Primary or Recurrent/High-grade Glioma Using the Litx™ System to Confirm the Zone of Tumor Destruction During the Intraoperative Treatment of Glioma treatment 2 completed NCT03332355
Procaspase Activating Compound-1 (PAC-1) in the Treatment of Advanced Malignancies - Component 2 treatment 1 terminated NCT00031538
Genetic Analysis of Brain Tumors No drug interventions Not Available Not Available terminated