Clinical Stage IV Cutaneous Melanoma AJCC v8 (DBCOND0114122)

Identifiers

Synonyms
Stage IV Skin Melanoma / Melanoma (Skin) Stage IV / Melanoma Stage Iv / Stage IV Melanoma

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05896839
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancertreatment1 / 2recruiting
NCT06500455
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the BrainNo drug interventionstreatment3recruiting
NCT01989585
Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanomatreatment1 / 2active_not_recruiting
NCT04314401
National Cancer Institute "Cancer Moonshot Biobank"No drug interventionsNot AvailableNot Availablerecruiting
NCT04514484
Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIVtreatment1active_not_recruiting
NCT04557956
Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatmenttreatment1 / 2recruiting
NCT04697576
Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanomatreatment1recruiting
NCT05764395
Rigosertib Plus Pembrolizumab in Treating Patients With Unresectable/Metastatic Melanoma Refractory to PD-1 Inhibitorstreatment2suspended
NCT03873818
Low Dose Ipilimumab with Pembrolizumab in Treating Patients with Melanoma That Has Spread to the Braintreatment2active_not_recruiting
NCT05098210
Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma or Hormone Receptor Positive Her2 Negative Metastatic Refractory Breast Cancertreatment1recruiting
NCT04940299
Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinomatreatment2active_not_recruiting
NCT05388877
E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanomatreatment1recruiting
NCT05967533
The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint InhibitorsNo drug interventionstreatment1recruiting
NCT06151847
Lifileucel With Reduced Dose Fludarabine/Cyclophosphamide Lymphodepletion and Interleukin-2 for the Treatment of Patients With Unresectable or Metastatic Melanomatreatment2recruiting
NCT05026983
Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastasestreatment2recruiting
NCT03816332
Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancerstreatment1active_not_recruiting
NCT02298959
Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancertreatment1active_not_recruiting
NCT04462406
Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trialtreatment2recruiting
NCT05341349
Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastasestreatment1recruiting
NCT04511013
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastasestreatment2recruiting
NCT03698019
A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanomatreatment2active_not_recruiting
NCT05136196
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Studytreatment2suspended
NCT02650986
Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1treatment1 / 2active_not_recruiting
NCT01738139
Ipilimumab and Imatinib Mesylate in Advanced Cancertreatment1completed
NCT04516122
Bone Loss in Melanoma Survivors Receiving ImmunotherapyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04375527
Binimetinib and Nivolumab for the Treatment of Locally Advanced Unresectable or Metastatic BRAF V600 Wildtype Melanomatreatment2recruiting
NCT01644591
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain MetastasesNo drug interventionstreatment2active_not_recruiting
NCT03727789
CBL0137 in Treating Patients With Advanced Extremity Melanoma or SarcomaNo drug interventionstreatment1terminated
NCT04007744
Sonidegib and Pembrolizumab in Treating Patients With Advanced Solid Tumorstreatment1recruiting
NCT04902040
Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodiestreatment1 / 2recruiting
NCT05039801
IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumorstreatment1recruiting
NCT04789668
Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastasestreatment1 / 2completed
NCT05269381
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumorstreatment1 / 2recruiting
NCT02224781
Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanomatreatment3active_not_recruiting
NCT02419495
Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignanciestreatment1active_not_recruiting
NCT05588453
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Braintreatment1 / 2recruiting
NCT02506153
Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgerytreatment3active_not_recruiting
NCT02020707
Nab-Paclitaxel and Bevacizumab in Treating Patients With Unresectable Stage IV Melanoma or Gynecological Cancerstreatment1completed
NCT03025256
Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Diseasetreatment1active_not_recruiting
NCT06265285
Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Programhealth_services_research2recruiting
NCT03175432
Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastasestreatment2active_not_recruiting
NCT06391099
Ketogenic Dietary Intervention to Improve Response to Immunotherapy in Patients With Metastatic Melanoma and Metastatic Kidney CancerNo drug interventionssupportive_careNot Availablenot_yet_recruiting
NCT04527549
Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanomatreatment2terminated
NCT06075524
Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer TypesNo drug interventionsNot AvailableNot Availablerecruiting
NCT04967196
Ipilimumab and Nivolumab for the Treatment of Stage III-IV Unresectable Metastatic Melanomatreatment1active_not_recruiting
NCT03819296
Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancertreatment1 / 2recruiting
NCT04941430
7T MRI Scan for the Early Detection of Melanoma Brain MetastasesNo drug interventionsdiagnosticNot Availablerecruiting
NCT02595866
Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancertreatment1completed
NCT05102773
The Effect of the Microbiome on Immune Checkpoint Inhibitor Response in Melanoma PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT03033576
Testing Treatment With Ipilimumab and Nivolumab Compared to Treatment With Ipilimumab Alone in Advanced Melanomatreatment2active_not_recruiting
NCT04067960
Pharmacogenomics Testing in the Optimal Use of Supportive Care Medications in Stage III-IV CancerNo drug interventionsscreening0completed
NCT04645680
Effect of Diet on the Immune System in Patients With Stage III-IV Melanoma Receiving Immunotherapy, DIET StudyNo drug interventionssupportive_care2active_not_recruiting
NCT05717140
Aerosolized Sargramostim Added to Immunotherapy for the Treatment of Patients With Metastatic Melanoma to the Lungtreatment1not_yet_recruiting
NCT04752267
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastasesdiagnostic0completed
NCT03865212
Modified Virus VSV-IFNbetaTYRP1 in Treating Patients With Stage III-IV Melanomatreatment1active_not_recruiting
NCT05907512
Endostar Plus Toripalimab as Adjuvant Therapy for Resectable Stage III-Oligometastatic Stage IV Cutaneous Melanomaprevention2recruiting