Gastrointestinal Symptoms (DBCOND0039183)

Identifiers

Synonyms

Gastrointestinal upset / Reaction gastrointestinal / Gastrointestinal reactions / Gastrointestinal Symptom / Gastrointestinal reaction / Gastrointestinal symptoms / Gastrointestinal irritation / Gastrointestinal irritation (finding) / Irritation gastrointestinal / Upset gastrointestinal / GI irritation / GI upset / Gastrointestinal tract irritation / Gastrointestinal symptoms (finding) / Gastrointestinal symptom NOS / Abdominal discomfort / Abdominal discomfort (finding) / Discomfort abdominal / Gastrointestinal disorders / Gastrointestinal disorder NOS / Disorder gastrointestinal / Gastrointestinal disorder / Gastrointestinal Diseases / Gastro-intestinal disorder NOS / Disease of digestive system (disorder) / Disease of gastrointestinal tract (disorder) / Inflammation of stomach and intestine (disorder) / Gastroenteropathy NOS

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cimetidine	A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion.	Histamine H2 receptortarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme ATP-dependent translocase ABCB1transporter Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Organic cation/carnitine transporter 2transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Multidrug and toxin extrusion protein 1transporter Solute carrier family 22 member 4transporter Solute carrier family 22 member 11transporter Solute carrier family 22 member 7transporter Cytochrome P450 11B1, mitochondrialenzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Flavin-containing monooxygenase 3enzyme Flavin-containing monooxygenase 1enzyme Bile salt export pumptransporter Multidrug and toxin extrusion protein 2transporter Albumincarrier
Domperidone	A dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting.	D(2) dopamine receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter Cytochrome P450 1A2enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2D6enzyme D(3) dopamine receptortarget
Lysozyme	An enzyme indicated in the treatment of gastrointestinal disorders in infants, as well as Herpes zoster and Herpes simplex.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05972291	Mechanisms of Gulf War Illness	No drug interventions	treatment	Not Available	recruiting
NCT00677378	Transient Receptor Potential Vanilloid One (TRPV1) Receptor Expression in Children With Retrosternal Pain	No drug interventions	Not Available	Not Available	completed
NCT01184456	A Controlled Trial to Evaluate the Effects of GanedenBC30 on the Immune System	No drug interventions	treatment	2	completed
NCT01927900	The Effects Of HMO On The Faecal Microbiota And On Gastrointestinal Symptoms In Healthy Volunteers	No drug interventions	basic_science	Not Available	completed
NCT04919265	Mother-Infant Cohort Study in Malaysia and China	No drug interventions	Not Available	Not Available	recruiting
NCT02054455	Proton Pump Inhibitors and Gastrointestinal Symptoms	No drug interventions	prevention	4	completed
NCT04228003	Pendulum D2D Glucose Control for Adults With Type 2 Diabetes	No drug interventions	treatment	Not Available	withdrawn
NCT03714464	Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study	No drug interventions	basic_science	Not Available	completed
NCT03514784	Combination Probiotic: BB-12 With LGG (Different Doses) in Treating Children With Autism Spectrum Disorder	Bifidobacterium longum Lactobacillus acidophilus Maltodextrin	treatment	1 / 2	recruiting
NCT03403387	Effects of GlutenShield, a Prebiotic, Probiotic, and Enzyme Supplement, on the Gut Microbiome of Adults With GI Symptoms	No drug interventions	basic_science	Not Available	unknown_status
NCT03696953	The Efficacy of Probiotics to Reduce Antepartum Group B Streptococcus Colonization.	Bifidobacterium longum Lactobacillus acidophilus	prevention	2	active_not_recruiting
NCT06248177	Probiotic Effect on Gastrointestinal Symptoms (FLORABIOTIC REFUERZO).	No drug interventions	treatment	Not Available	recruiting
NCT03659747	Effect of Probiotic Supplementation on Lactose Maldigestion Induced by Fat-free Milk	No drug interventions	prevention	Not Available	completed
NCT00574197	Enteric-coated Mycophenolate Sodium (Myfortic®) in Heart Transplant Recipients	Mycophenolic acid	treatment	4	completed
NCT01116388	A Study to Assess the Role of a Gluten Free-dairy Free (GFCF) Diet in the Dietary Management of Autism Associated Gastrointestinal Disorders	No drug interventions	treatment	Not Available	completed
NCT03685552	Safety Evaluation of a Diet and Nutritional Supplementation Program- Purify 2.0	No drug interventions	treatment	Not Available	completed
NCT01964599	Potato Fiber and Gastrointestinal Function: Phase 3	No drug interventions	other	Not Available	completed
NCT03959722	The Effect of Probiotics on GI Symptoms	No drug interventions	treatment	Not Available	completed
NCT02277431	Probiotic Supplementation Among Adults With Recurrent Gastrointestinal Symptoms	No drug interventions	other	2 / 3	completed
NCT05831527	An Exploratory Investigation of a Supplement to Promote Gut Health	Bos taurus colostrum	other	Not Available	completed
NCT06425094	Effects of a Microalgae Extract Dietary Supplement on Gut Health, Anxiety, and Immune Function	No drug interventions	supportive_care	1	recruiting
NCT01171014	Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms	No drug interventions	supportive_care	2 / 3	completed
NCT04134364	The Effect of Lamina-G on Gastrointestinal Symptom After Gastric Biopsy	Alginic acid	prevention	4	completed