Fatty Acids, Volatile

Name
Fatty Acids, Volatile
Accession Number
DBCAT000426
Description

Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.

Drugs
DrugDrug Description
FenofibrateA peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia.
GemfibrozilA lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia.
TirbanibulinA tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp.
SelexipagA non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension.
ClascoteroneAn androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older.
MontelukastA leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis.
Butyric AcidA four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
Propanoic acidAn antimicrobial food additive.
AcetateNot Annotated
Calcium acetateA phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.
Valproic acidAn anticonvulsant used to control complex partial seizures and both simple and complex absence seizures.
CandoxatrilCandoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor.
RidogrelUsed as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction.
gamma-Hydroxybutyric acidUsed as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance.
Tiaprofenic acidA nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis.
Propyl acetateNot Available
4-(2-Thienyl)Butyric AcidNot Available
Isobutyric acidNot Available
Indolepropionic acidNot Available
Acetic acidAn antimicrobial agent used to treat susceptible infections of the external auditory canal.
2-Methylbutanoic AcidNot Available
Isovaleric AcidNot Available
Isocaproic acidNot Available
5-phenylpentanoic acidNot Available
ValpromideA valproic acid derivative used to treat epilepsy and as adjunct therapy for psychomotor agitation, depression, and manic episodes of bipolar disorder.
Mdl-29951Not Available
KH064Not Available
5-hydroxyvaleric acidNot Available
BenoxaprofenThe use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets...
DexloxiglumideFor the treatment of Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD).
AN-9Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid).
GemcabeneInvestigated for use/treatment in atherosclerosis, cardiovascular disorders, and hyperlipidemia.
ElafibranorInvestigated for use/treatment in atherosclerosis and diabetes mellitus type 2.
AM103For the treatment of asthma and cardiovascular disease.
Fenoxaprop-ethylChronic angina and Coronary Artery Disease
CaprospinolAlzheimer's Disease
EmricasanInvestigated for use/treatment in hepatitis (viral, C), liver disease, and transplantation (organ or tissue).
AZD-9684Investigated for use/treatment in thrombosis.
Varespladib methylInvestigated for use/treatment in atherosclerosis and coronary artery disease.
DP-VPAInvestigated for use/treatment in bipolar disorders, epilepsy, and migraine and cluster headaches.
AGI-1096Investigated for use/treatment in transplant (rejection).
FiboflaponInvestigated for use/treatment in inflammatory disorders (unspecified).
PriralfinamideInvestigated for use/treatment in pain (acute or chronic).
ZaltoprofenA non-steroidal anti-inflammatory drug approved for use in Japan in 1993.
GW-590735Not Available
SobetiromeNot Available
IDD594Not Available
EfaproxiralNot Available
TeriflunomideA pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis.
BeclamideHas been used in the management of epilepsy and epilepsy related behavioural disorders. It was used for generalised tonic-clonic seizures, and was not effective for absence seizures. More recently focus...
Uridine triacetateA pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine.
PivhydrazineFor the treatment of depression.
Calcium threonateNo approved therapeutic indications.
L-threonic acidNot Annotated
MonensinMonensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds.
VerinuradVerinurad has been used in trials studying the basic science and treatment of Gout, Gout and Hyperuricemia, and Gout and Asymptomatic Hyperuricemia.
VarespladibVarespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome.
IngavirinIngavirin has been used in trials studying the treatment of Influenza and Common Cold.
AtagabalinAtagabalin has been used in trials studying the treatment of Insomnia, Primary Insomnia, and Nonrestorative Sleep.
LetermovirAn antiviral medication used to treat CMV infections and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT).
OrantinibOrantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others.
RitobegronRitobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin...
SeladelparSeladelpar (MBX-8025) has been used in trials studying the treatment of Hyperlipidemia.
RalinepagRalinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension.
ImiglitazarImiglitazar has been used in trials studying the treatment of Diabetes Mellitus.
TaprenepagTaprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.
3,5-diiodothyropropionic acidDITPA has been investigated in Congestive Heart Failure.
BindaritBindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy.
MK-0752Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).
PradigastatPradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD).
LY-518674LY518674 has been used in trials studying the treatment of Metabolic Syndrome X.
IcosabutateIcosabutate is under investigation in clinical trial NCT02373176 ([14C] Icosabutate -A Phase I Absorption, Metabolism and Excretion Study).
MK-8245MK-8245 has been used in trials studying the treatment of Type 2 Diabetes Mellitus.
GlycovirGlycovir has been used in trials studying the treatment of HIV Infections.
FentiazacNot Annotated
AlminoprofenAlminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances.
CyclobutyrolNot Annotated
PranoprofenA topical anti-inflammatory agent used for the treatment of non-infectious inflammatory conditions such as blepharitis and conjunctivitis. Pranoprofen ophthalmic solution may also be used post-operatively to manage inflammation.
Magnesium acetateNot Available
Threonic acidNot Annotated
Aluminum acetateA medication used for temporary relief of skin irritation.
Acetyl chlorideNot Annotated
EtrasimodEtrasimod is under investigation in clinical trial NCT03945188 (Etrasimod Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis).
AZD-7687AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study).
PemafibratePemafibrate is under investigation in clinical trial NCT03350165 (A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)).
NavtemadlinNavtemadlin (AMG-232) is under investigation in clinical trial NCT03041688 (MDM2 Inhibitor AMG-232 and Decitabine in Treating Patients With Relapsed, Refractory, or Newly-Diagnosed Acute Myeloid Leukemia).
beta-Hydroxyisovaleric acidbeta-Hydroxyisovaleric acid is under investigation in clinical trial NCT03018496 (Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.).
GLPG-0974GLPG-0974 is under investigation in clinical trial NCT01721980 (Multiple Ascending Dose Study of GLPG0974 in Healthy Subjects).
SetogepramSetogepram is under investigation in clinical trial NCT03184584 (Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome).
AK106-001616AK106-001616 is under investigation in clinical trial NCT01285752 (A Study of AK106-001616 in Patients With Rheumatoid Arthritis (RA)).
FirsocostatFirsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)).
OdevixibatAn ileal sodium/bile acid cotransporter inhibitor indicated in the treatment of pruritus in patients with progressive familial intrahepatic cholestasis.
Drugs & Drug Targets
DrugTargetType
FenofibratePeroxisome proliferator-activated receptor alphatarget
FenofibrateMatrix metalloproteinase-25target
FenofibrateCytochrome P450 2C8enzyme
FenofibrateCytochrome P450 2C9enzyme
FenofibrateNuclear receptor subfamily 1 group I member 2target
FenofibrateUDP-glucuronosyltransferase 1-9enzyme
FenofibrateBile salt export pumptransporter
FenofibrateSerum albumincarrier
FenofibrateCytochrome P450 2C19enzyme
FenofibrateCytochrome P450 2A6enzyme
FenofibrateLiver carboxylesterase 1enzyme
FenofibrateCarbonyl reductase [NADPH] 1enzyme
FenofibrateAldo-keto reductase family 1 member C1enzyme
FenofibrateAldo-keto reductase family 1 member C2enzyme
FenofibrateAldo-keto reductase family 1 member C3enzyme
FenofibrateAldose reductaseenzyme
GemfibrozilPeroxisome proliferator-activated receptor alphatarget
GemfibrozilCytochrome P450 2C9enzyme
GemfibrozilCytochrome P450 2C8enzyme
GemfibrozilCytochrome P450 1A2enzyme
GemfibrozilCytochrome P450 2C19enzyme
GemfibrozilUDP-glucuronosyltransferase 1-1enzyme
GemfibrozilCytochrome P450 3A4enzyme
GemfibrozilUDP-glucuronosyltransferase 1-3enzyme
GemfibrozilSolute carrier organic anion transporter family member 1B1target
GemfibrozilUDP-glucuronosyltransferase 2B7enzyme
GemfibrozilUDP-glucuronosyltransferase 1-9enzyme
GemfibrozilUDP-glucuronosyltransferase 2B4enzyme
GemfibrozilUDP-glucuronosyltransferase 2B17enzyme
GemfibrozilSerum albumincarrier
GemfibrozilSolute carrier family 22 member 8target
GemfibrozilSolute carrier organic anion transporter family member 2B1target
GemfibrozilSolute carrier organic anion transporter family member 1B3target
TirbanibulinProto-oncogene tyrosine-protein kinase Srctarget
TirbanibulinTubulin beta chaintarget
TirbanibulinCytochrome P450 3A4enzyme
TirbanibulinCytochrome P450 2C8enzyme
TirbanibulinCytochrome P450 1A2enzyme
TirbanibulinCytochrome P450 2B6enzyme
TirbanibulinCytochrome P450 2C9enzyme
TirbanibulinCytochrome P450 2C19enzyme
TirbanibulinCytochrome P450 2D6enzyme
TirbanibulinMultidrug and toxin extrusion protein 1transporter
TirbanibulinMultidrug and toxin extrusion protein 2transporter
TirbanibulinSolute carrier organic anion transporter family member 1B1transporter
TirbanibulinSolute carrier organic anion transporter family member 1B3transporter
TirbanibulinSolute carrier family 22 member 1transporter
TirbanibulinSolute carrier family 22 member 2transporter
SelexipagProstacyclin receptortarget
SelexipagLiver carboxylesterase 1enzyme
SelexipagCytochrome P450 2C8enzyme
SelexipagCytochrome P450 3A4enzyme
SelexipagSolute carrier organic anion transporter family member 1B1transporter
SelexipagSolute carrier organic anion transporter family member 1B3transporter
SelexipagP-glycoprotein 1transporter
ClascoteroneAndrogen receptortarget
ClascoteroneCytochrome P450 1A2enzyme
ClascoteroneCytochrome P450 2B6enzyme
ClascoteroneCytochrome P450 2C8enzyme
ClascoteroneCytochrome P450 2C9enzyme
ClascoteroneCytochrome P450 2C19enzyme
ClascoteroneCytochrome P450 2D6enzyme
ClascoteroneCytochrome P450 2E1enzyme
ClascoteroneCytochrome P450 3A4enzyme
MontelukastCysteinyl leukotriene receptor 1target
MontelukastArachidonate 5-lipoxygenasetarget
MontelukastCytochrome P450 3A4enzyme
MontelukastCytochrome P450 2C9enzyme
MontelukastCytochrome P450 2C8enzyme
MontelukastSolute carrier organic anion transporter family member 2B1transporter
MontelukastProstaglandin G/H synthase 1enzyme
MontelukastCytochrome P450 2A6enzyme
Butyric Acid(S)-2-haloacid dehalogenasetarget
Butyric AcidCholinesterasetarget
Butyric Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Butyric AcidCholinesteraseenzyme
Propanoic acidAlanine racemasetarget
Propanoic acidGephyrintarget
Propanoic acidFatty acid-binding protein, adipocytecarrier
Propanoic acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Propanoic acidHistone deacetylaseenzyme
Calcium acetatePhosphatetarget
Valproic acidHistone deacetylase 9target
Valproic acidShort/branched chain specific acyl-CoA dehydrogenase, mitochondrialtarget
Valproic acidCytochrome P450 2A6enzyme
Valproic acidCytochrome P450 2B6enzyme
Valproic acidCytochrome P450 2C9enzyme
Valproic acidSolute carrier family 22 member 5transporter
Valproic acidSolute carrier family 22 member 6transporter
Valproic acidSolute carrier family 22 member 8transporter
Valproic acidMonocarboxylate transporter 1transporter
Valproic acidSolute carrier family 22 member 7transporter
Valproic acidCytochrome P450 3A5enzyme
Valproic acidUDP-glucuronosyltransferase 1-9enzyme
Valproic acidProstaglandin G/H synthase 1enzyme
Valproic acidCytochrome P450 1A2enzyme
Valproic acidCytochrome P450 2C19enzyme
Valproic acidCytochrome P450 3A4enzyme
Valproic acidUDP-glucuronosyltransferase 1-4enzyme
Valproic acidUDP-glucuronosyltransferase 1-8enzyme
Valproic acidUDP-glucuronosyltransferase 1-10enzyme
Valproic acidUDP-glucuronosyltransferase 1-6enzyme
Valproic acidUDP-glucuronosyltransferase 1-3enzyme
Valproic acidUDP-glucuronosyltransferase 2B7enzyme
Valproic acidUDP-glucuronosyltransferase 2B15enzyme
Valproic acid2-oxoglutarate dehydrogenase, mitochondrialtarget
Valproic acidSuccinate-semialdehyde dehydrogenase, mitochondrialtarget
Valproic acidSodium channel proteintarget
Valproic acidHistone deacetylase 2target
Valproic acidPeroxisome proliferator-activated receptor alphatarget
Valproic acidPeroxisome proliferator-activated receptor deltatarget
Valproic acidPeroxisome proliferator-activated receptor gammatarget
Valproic acidSerum albumincarrier
Valproic acidUDP-glucuronosyltransferase 1-1enzyme
Valproic acidSolute carrier organic anion transporter family member 2B1transporter
Valproic acidHistone deacetylasetarget
Valproic acidCyclin-dependent kinase inhibitor 1target
Valproic acidHepatocyte growth factortarget
Valproic acidOrnithine decarboxylasetarget
Valproic acidProgrammed cell death 1 ligand 1target
CandoxatrilNeprilysintarget
CandoxatrilAngiotensin-converting enzymetarget
RidogrelThromboxane-A synthasetarget
RidogrelThromboxane A2 receptortarget
gamma-Hydroxybutyric acidMonocarboxylate transporter 2transporter
gamma-Hydroxybutyric acidMonocarboxylate transporter 1transporter
gamma-Hydroxybutyric acidMonocarboxylate transporter 4transporter
gamma-Hydroxybutyric acidGamma-hydroxybutyrate (GHB) receptortarget
gamma-Hydroxybutyric acidGamma-aminobutyric acid receptor subunit beta-1target
Tiaprofenic acidProstaglandin G/H synthase 2target
Tiaprofenic acidProstaglandin G/H synthase 1target
Propyl acetateCarboxylesterasetarget
4-(2-Thienyl)Butyric AcidAromatic-amino-acid aminotransferasetarget
Isobutyric acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Indolepropionic acidAspartate aminotransferasetarget
Indolepropionic acidAromatic-amino-acid aminotransferasetarget
Indolepropionic acidGroup IIE secretory phospholipase A2target
Acetic acidSolute carrier organic anion transporter family member 2B1transporter
Acetic acidMonocarboxylate transporter 1transporter
2-Methylbutanoic Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Isovaleric AcidAspartate aminotransferasetarget
Isovaleric AcidPseudomonalisintarget
Isovaleric Acid2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolasetarget
Isocaproic acidBranched-chain-amino-acid aminotransferasetarget
5-phenylpentanoic acidAromatic-amino-acid aminotransferasetarget
ValpromideLimonene-1,2-epoxide hydrolasetarget
Mdl-29951Fructose-1,6-bisphosphatase 1target
KH064Phospholipase A2, membrane associatedtarget
5-hydroxyvaleric acidDelta-aminolevulinic acid dehydratasetarget
DexloxiglumideCholecystokinin receptor type Atarget
DexloxiglumideCytochrome P450 3A4enzyme
DexloxiglumideCytochrome P450 2C9enzyme
DexloxiglumideCytochrome P450 3A5enzyme
DexloxiglumideCytochrome P450 2B6enzyme
DexloxiglumideCytochrome P450 2E1enzyme
AN-9Apoptosis regulator Bcl-2target
AN-9Caspase-8target
ElafibranorPeroxisome proliferator-activated receptor alphatarget
ElafibranorPeroxisome proliferator-activated receptor deltatarget
ElafibranorPeroxisome proliferator-activated receptor gammatarget
AM103Arachidonate 5-lipoxygenase-activating proteintarget
Fenoxaprop-ethylNitric oxide synthase, inducibletarget
EmricasanCaspase-1target
EmricasanCaspase-3target
EmricasanCaspase-7target
AZD-9684Carboxypeptidase B2target
Varespladib methylPhospholipase A2, membrane associatedtarget
Varespladib methylGroup 10 secretory phospholipase A2target
FiboflaponArachidonate 5-lipoxygenase-activating proteintarget
ZaltoprofenUDP-glucuronosyltransferase 2B7enzyme
ZaltoprofenCytochrome P450 2C9enzyme
ZaltoprofenProstaglandin G/H synthase 1enzyme
GW-590735Nuclear receptor coactivator 1target
GW-590735Peroxisome proliferator-activated receptor alphatarget
SobetiromeThyroid hormone receptor, alpha isoform 1 varianttarget
SobetiromeThyroid hormone receptor betatarget
IDD594Aldose reductasetarget
EfaproxiralHemoglobin subunit alphatarget
EfaproxiralHemoglobin subunit betatarget
TeriflunomideATP-binding cassette sub-family G member 2transporter
TeriflunomideDihydroorotate dehydrogenase (quinone), mitochondrialtarget
TeriflunomideCytochrome P450 2C8enzyme
TeriflunomideSolute carrier organic anion transporter family member 1B1transporter
TeriflunomideCytochrome P450 1A2enzyme
MonensinP-glycoprotein 1transporter
LetermovirUDP-glucuronosyltransferase 1-1enzyme
LetermovirUDP-glucuronosyltransferase 1-3enzyme
LetermovirSolute carrier organic anion transporter family member 1B1transporter
LetermovirSolute carrier organic anion transporter family member 1B3transporter
LetermovirTripartite terminase subunit 1target
LetermovirTripartite terminase subunit 2target
LetermovirTripartite terminase subunit 3target
LetermovirCytochrome P450 2D6enzyme
LetermovirCytochrome P450 2C8enzyme
LetermovirCytochrome P450 2C19enzyme
LetermovirCytochrome P450 2C9enzyme
LetermovirCytochrome P450 2B6enzyme
LetermovirP-glycoprotein 1transporter
LetermovirATP-binding cassette sub-family G member 2transporter
LetermovirBile salt export pumptransporter
LetermovirSolute carrier family 22 member 8transporter
LetermovirCanalicular multispecific organic anion transporter 1transporter
LetermovirCytochrome P450 3A4enzyme
LetermovirCytochrome P450 3A5enzyme
LetermovirCytochrome P450 3A7enzyme
LetermovirCytochrome P450 3A43enzyme
3,5-diiodothyropropionic acidCytochrome P450 3A4enzyme
MK-0752Gamma-secretase subunit APH-1Atarget
PradigastatSolute carrier family 22 member 8transporter
PranoprofenHuman Cyclooxygenasesenzyme
PranoprofenSerum albumincarrier
Magnesium acetateSodium/potassium-transporting ATPase subunit alpha-1target
Aluminum acetateSerotransferrintarget
Aluminum acetateSodium/potassium-transporting ATPase subunit alpha-1target
Aluminum acetateSerum albumincarrier
Aluminum acetateKallikrein-1target
Aluminum acetateAmyloid beta A4 proteintarget
GLPG-0974Free fatty acid receptor 2target
OdevixibatIleal sodium/bile acid cotransportertarget
OdevixibatP-glycoprotein 1transporter