Fatty Acids, Volatile
- Fatty Acids, Volatile
- Accession Number
Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.
Drug Drug Description Indium In-111 satumomab pendetide For diagnosis of extrahepatic malignant cancers Gadodiamide A gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans. Calcium acetate A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Aminocaproic acid An antifibrinolytic agent used to induce clotting postoperatively. Foscarnet An antiviral used to treat CMV, HIV, and HSV infections. Candoxatril Candoxatril is the orally-active prodrug of candoxatrilat (UK-73967), a potent neutral endopeptidase (NEP) inhibitor. Clofibrate A fibric acid derivative used to treat hypertriglyceridemia and high cholesterol. Dextropropoxyphene An opioid analgesic used to treat mild to moderate pain. Flurbiprofen An NSAID used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. Gadopentetic acid A gadolinium compound used as a contrast agent in MRIs. Progabide Indicated for the treatment of epilepsy. Benzylpenicilloyl polylysine A penicillin derivative used to determine penicillin allergies. Etacrynic acid A diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease. Zaleplon A sedative used for short term treatment of insomnia in adults. Edetic acid A chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. Oxaprozin An NSAID used to treat osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. Mycophenolic acid An immunosuppressant used to prevent organ transplant rejections. Fenofibrate A peroxisome proliferator receptor alpha activator used to lower LDL-C, total-C, triglycerides, and Apo B, while increasing HDL-C in hypercholesterolemia, dyslipidemia, and hypertriglyceridemia. Phenacemide Used to control certain seizures in the treatment of epilepsy. Rabeprazole A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome. Ridogrel Used as an adjunctive therapy to induce thrombolysis in patients suffering acute myocardial infarction. Gemfibrozil A lipid regulator that is used in the reduction of serum triglyceride levels in high-risk patients with hyperlipidemia. Bezafibrate A lipid-lowering fibrate used in the management of primary and secondary hyperlipidaemia, when there is a lack of clinical improvement following lifestyle modifications or correction of the underlying disorder. gamma-Hydroxybutyric acid Used as a general anesthetic, to treat conditions such as insomnia, clinical depression, narcolepsy, and alcoholism, and to improve athletic performance. Tiaprofenic acid A nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis. Propyl acetate Not Available Aminooxyacetic acid A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem] 4-(2-Thienyl)Butyric Acid Not Available Isobutyric acid Not Available Adenosine Phosphonoacetic Acid Not Available Acetamide Not Available Canaline Not Available Phosphonoacetic Acid A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent. [PubChem] 2-aminoisobutyric acid Not Available Nitrilotriacetic acid Nitrilotriacetic acid is a derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.) Glycolic acid Not Available Acetic acid An antimicrobial agent used to treat susceptible infections of the external auditory canal. N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acid N(4)-adenosyl-n(4)-methyl-2,4-diaminobutanoic acid is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. Sparfosic acid Sparfosic acid is a solid. This compound belongs to the n-acyl-alpha amino acids. These are compounds containing an alpha amino acid which bears an acyl group at the terminal nitrogen... Butyric Acid A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester. 2-Methylbutanoic Acid Not Available Isovaleric Acid Not Available L-2,4-diaminobutyric acid Not Available Coelenteramide Not Available 5-phenylpentanoic acid Not Available Valpromide A valproic acid derivative used to treat epilepsy and as adjunct therapy for psychomotor agitation, depression, and manic episodes of bipolar disorder. Mdl-29951 Not Available L-2-amino-3-butynoic acid Not Available Alpha-Aminobutyric Acid Not Available 5-hydroxyvaleric acid Not Available Benoxaprofen The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets... Tienilic acid For the treatment of hypertension. Dexloxiglumide For the treatment of Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD). Erdosteine A mucolytic agent used to treat conditions characterized by pathological mucus such as respiratory tract infections and chronic obstructive pulmonary disease (COPD). AN-9 Investigated for use/treatment in liver cancer, lung cancer, melanoma, and leukemia (lymphoid). Asimadoline Investigated for use/treatment in irritable bowel syndrome (IBS). Rilapladib Investigated for use/treatment in atherosclerosis and cardiovascular disorders. Gemcabene Investigated for use/treatment in atherosclerosis, cardiovascular disorders, and hyperlipidemia. Elafibranor Investigated for use/treatment in atherosclerosis and diabetes mellitus type 2. AM103 For the treatment of asthma and cardiovascular disease. Fenoxaprop-ethyl Chronic angina and Coronary Artery Disease Caprospinol Alzheimer's Disease Tarenflurbil Investigated for use/treatment in alzheimer's disease and prostate cancer. Emricasan Investigated for use/treatment in hepatitis (viral, C), liver disease, and transplantation (organ or tissue). Bedoradrine Investigated for use/treatment in asthma and labor and delivery. BL-1020 Investigated for use/treatment in schizophrenia and schizoaffective disorders. Varespladib methyl Investigated for use/treatment in atherosclerosis and coronary artery disease. DP-b99 Investigated for use/treatment in strokes and traumatic brain injuries. DP-VPA Investigated for use/treatment in bipolar disorders, epilepsy, and migraine and cluster headaches. AGI-1096 Investigated for use/treatment in transplant (rejection). Tirbanibulin A tyrosine kinase and tubulin inhibitor used to treat actinic keratosis on the face or scalp. Indibulin Investigated for use/treatment in solid tumors. Lacosamide An antiepileptic drug used to treat partial onset seizures in adults. Senicapoc Investigated for use/treatment in anemia (sickle cell) and asthma. Fiboflapon Investigated for use/treatment in inflammatory disorders (unspecified). Avasimibe Investigated for use/treatment in peripheral vascular disease. Remacemide Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Priralfinamide Investigated for use/treatment in pain (acute or chronic). Almorexant Investigated for use/treatment in sleep disorders and insomnia. Zaltoprofen A non-steroidal anti-inflammatory drug approved for use in Japan in 1993. Bendamustine An antineoplastic agent used for the treatment of chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin lymphoma (NHL) that has progressed following rituximab therapy. Levopropoxyphene Levopropoxyphene was used as an antitussive. An antitussive is a medication often recommended for the treatment of cough and associated respiratory tract disorders. Its enantiomer, dextropropoxyphene, presents an analgesic effect. Mangafodipir An organ-specific paramagnetic contrast agent indicated for the imaging of the hepatobiliary system and detecting lesions in the liver and pancreas. Nepafenac An ophthalmic NSAID used for the symptomatic treatment of pain and inflammation associated with cataract surgery. Sobetirome Not Available IDD594 Not Available Efaproxiral Not Available Dichloroacetic acid Dichloroacetic acid, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms.... Gabapentin enacarbil A gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). Teriflunomide A pyrimidine synthesis inhibitor with anti-inflammatory and immunomodulatory properties used to treat patients with the relapsing-remitting form of multiple sclerosis. Gadoxetic acid A gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to help characterize lesions in the liver. Arbaclofen Placarbil Investigated for the treatment of spasticity in multiple sclerosis, acute back spasms, and GERD. Ibuproxam Ibuproxam is a non steroidal anti-inflammatory drug (NSAID). Etofibrate Etofibrate is a fibrate produced by the combination of clofibrate ester linked to niacin. These components separate in the body slowly allowing for pharmacokinetics similar to controlled-release formulations. Clinofibrate Clinofibrate is a fibrate drug sold and marketed in Japan. Beclamide Has been used in the management of epilepsy and epilepsy related behavioural disorders. It was used for generalised tonic-clonic seizures, and was not effective for absence seizures. More recently focus... Ciprofibrate Not Annotated Sodium oxybate A central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy. Uridine triacetate A pyrimidine analog used for the reversal of overdose, regardless of the presence of symptoms, and early-onset, severe or life-threatening CNS toxicity or cardiotoxicity of fluorouracil or capecitabine. Piracetam A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. Iproclozide For the treatment of depression. Pivhydrazine For the treatment of depression. Caroxazone For the treatment of depression. Sacubitril A neprilysin inhibitor used in combination with valsartan as an adjunct to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Sodium acetate A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy. Trichloroacetate Trichloroacetate, or trichloroacetic acid, is a strong acid prepared by the reaction of chlorine with acetic acid in the presence of a suitable catalyst. In clinical chemistry and biochemistry, it... Calcium threonate No approved therapeutic indications. L-threonic acid Not Annotated Selexipag A non prostanoid IP prostacyclin receptor agonist used to treat pulmonary arterial hypertension. Monensin Monensin is a polyether isolated from Streptomyces cinnamonensis that presents antibiotic properties. It is widely used in ruminant animal feeds. Lesinurad A uric acid 1 transporter inhibitor typically used in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout in patients with inadequate control of uric acid levels with xanthine oxidase inhibitor monotherapy. PF-06282999 Pf 06282999 is under investigation in clinical trial NCT01626976 (A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects). Antineoplaston A10 Antineoplaston A10 has been used in trials studying the treatment of Sarcoma, Lymphoma, Lung Cancer, Liver Cancer, and Kidney Cancer, among others. AZD-5672 Azd5672 has been used in trials studying the basic science and treatment of Pharmacokinetics, Renal Impairment, and Rheumatoid Arthritis. Arhalofenate Arhalofenate has been investigated for the treatment of Gout and Hyperuricemia. Etiracetam Etiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)). PF-00610355 PF-00610355 has been used in trials studying the treatment of Lung Disease, Moxifloxacin, Pulmonary Disease, Asthma, Bronchial, and Bronchial Diseases, among others. Sutezolid Sutezolid has been used in trials studying the treatment of Tuberculosis. Varespladib Varespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome. Ingavirin Ingavirin has been used in trials studying the treatment of Influenza and Common Cold. Atagabalin Atagabalin has been used in trials studying the treatment of Insomnia, Primary Insomnia, and Nonrestorative Sleep. Letermovir An antiviral medication used to treat CMV infections and disease in adult CMV-seropositive recipients of an allogeneic hematopoietic stem cell transplant (HSCT). Orantinib Orantinib has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Kidney Cancer, Gastric Cancer, and Prostate Cancer, among others. Ritobegron Ritobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin... Figopitant Figopitant is under investigation in clinical trial NCT02209714 (Safety, Tolerability and Pharmacodynamics After Oral Administration of BIIF 1149 BS in Healthy Male Volunteers). GSK-424887 Gsk424887 has been used in trials studying the basic science and treatment of Depressive Disorder and Anxiety Disorder. AZD-5423 AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD). MBX-8025 MBX-8025 has been used in trials studying the treatment of Hyperlipidemia. PD-217014 PD-217,014 has been used in trials studying the treatment of Pain and Irritable Bowel Syndrome. Clascoterone An androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. Imiglitazar Imiglitazar has been used in trials studying the treatment of Diabetes Mellitus. MK-0686 MK0686 has been used in trials studying the treatment of Osteoarthritis, Pain, Postoperative, and Neuralgia, Postherpetic. Pentetreotide A somatostatin receptor inhibitor, available in a kit with Indium-111, used as a contrast agent in the visualization of somatostatin receptor-positive neuroendocrine tumours. Taprenepag Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle. 3,5-diiodothyropropionic acid DITPA has been investigated in Congestive Heart Failure. Bindarit Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy. Lafutidine Lafutidine has been investigated in Peptic Ulcer, Community-acquired Pneumonia, and Gastroesophageal Reflux Disease (GERD). MK-0752 Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer). Pradigastat Pradigastat has been used in trials studying the treatment of Non-alcoholic Fatty Liver Disease (NAFLD). Pivagabine Pivagabine has been used in trials studying the treatment of Stress and Anxiety. MK-8245 MK-8245 has been used in trials studying the treatment of Type 2 Diabetes Mellitus. Glycovir Glycovir has been used in trials studying the treatment of HIV Infections. Fentiazac Not Annotated Etofamide Etofamide is used as an antiamoebic agent. Etofamide, under the brand name Kitnos, was marketed in Brazil by Pfizer but has been discontinued . Alminoprofen Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose physiochemical characteristics make it a member of the phenylpropionic acid class of chemical substances. Bufexamac An NSAID used to treat skin conditions like atopic eczema and inflammatory dermatoses. Difenpiramide Not Annotated Sodium feredetate Not Annotated Simfibrate Not Annotated Prethcamide Not Annotated Mazaticol Not Annotated Phenibut Not Annotated Cyclobutyrol Not Annotated Clefamide Not Annotated Pranoprofen A topical anti-inflammatory agent used for the treatment of non-infectious inflammatory conditions such as blepharitis and conjunctivitis. Pranoprofen ophthalmic solution may also be used post-operatively to manage inflammation. Lorcainide Not Annotated Epanolol Epanolol is an beta blocker. Meclofenoxate Not Annotated Clofibride Not Annotated Fenofibric acid A fibrate used to treat severe hypertriglyceridemia, primary hypercholesterolemia, or mixed dyslipidemia. Pentetic acid DTPA is widely used in industry and medicine. As a medical agent, it is approved for its use in medical imaging and for the decorporation of internally deposited radionuclides. It... Hopantenic acid Hopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal... Sacubitrilat A metabolite of LCZ696 with neprilysin inhibitory activity. Threonic acid Not Annotated Zinc acetate A medication used to treat zinc deficiency. Potassium acetate A medication used to treat hypokalemia. Aluminum acetate A medication used for temporary relief of skin irritation. Peracetic acid A liquid that functions as a strong oxidizing agent. It has an acrid odor and is used as a disinfectant. Acetyl chloride Not Annotated gamma-Aminobutyric acid The most common inhibitory neurotransmitter in the central nervous system. Oseltamivir acid Not Available Propanoic acid An antimicrobial food additive. LY-518674 LY518674 has been used in trials studying the treatment of Metabolic Syndrome X. Montelukast A leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis. Flurbiprofen axetil Flurbiprofen axetil is under investigation in clinical trial NCT02043366 (Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients). AZD-7687 AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study). Telaglenastat Telaglenastat is under investigation in clinical trial NCT02071862 (Study of the Glutaminase Inhibitor CB-839 in Solid Tumors). beta-Hydroxyisovaleric acid beta-Hydroxyisovaleric acid is under investigation in clinical trial NCT03018496 (Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.). GLPG-0974 GLPG-0974 is under investigation in clinical trial NCT01721980 (Multiple Ascending Dose Study of GLPG0974 in Healthy Subjects). Thioglycolic acid Thioglycolic acid is under investigation in clinical trial NCT03238105 (Treatment of Periorbicular Hyperchromia Comparing 10% Thioglycolic Acid Peeling Versus Pulsed Intense Light). Norleucine Norleucine is under investigation in clinical trial NCT00081952 (Amino Acid Therapy for Hot Flashes in Postmenopausal Women). Remifentanil An opioid analgesic used in anesthesia. p-Coumaric acid Not Available Glesatinib Investigated for use/treatment in cancer/tumors (unspecified). Verinurad Verinurad has been used in trials studying the basic science and treatment of Gout, Gout and Hyperuricemia, and Gout and Asymptomatic Hyperuricemia. Radiprodil Radiprodil has been used in trials studying the treatment of Infantile Spasms (IS) and Diabetic Peripheral Neuropathic Pain. Ralinepag Ralinepag has been used in trials studying the treatment of Pulmonary Arterial Hypertension. Icosabutate Icosabutate is under investigation in clinical trial NCT02373176 ([14C] Icosabutate -A Phase I Absorption, Metabolism and Excretion Study). Linrodostat Linrodostat is under investigation in clinical trial NCT03247283 (Pharmacokinetics and Metabolism Study in Healthy Male Participants). Pemafibrate Pemafibrate is under investigation in clinical trial NCT03350165 (A Study of Pemafibrate in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)). Olorofim Olorofim is under investigation in clinical trial NCT03340597 (Assessment of Varying Oral Dosing Regimens for F901318 in Healthy Subjects). KH064 Not Available GW-590735 Not Available Andarine Andarine is a non-steroidal selective androgen receptor modulator. 1-Naphthoxyacetic acid Not Available R-95845 R-95845 is an inhibitor of HIV-1 reverse transcriptase. Indolepropionic acid Not Available 6-hydroxynorleucine Not Available Isocaproic acid Not Available Gamma-amino-beta-hydroxybutyric acid An anticonvulsant indicated to treat convulsions in children and epilepsy. Gallium Ga-68 gozetotide A radiopharmaceutical agent used in the diagnosis of prostate-specific membrane antigen (PSMA) positive lesions in male patients during positron emission tomography. Firsocostat Firsocostat is under investigation in clinical trial NCT02781584 (Safety, Tolerability, and Efficacy of Selonsertib, Firsocostat, and Cilofexor in Adults With Nonalcoholic Steatohepatitis (NASH)).
- Drugs & Drug Targets