Primary Amyloidosis

Also known as: Primary Systemic Amyloidosis / Primary Systemic (AL) Amyloidosis / Primary Systemic Amyloidosis (AL) / Primary Amyloidosis of Light Chain Type / Amyloid Light Chain (AL) Amyloidosis / AL Amyloidosis / Light Chain (AL) Amyloidosis / Light-Chain Amyloidosis / Systemic Light Chain Disease / Amyloid light-chain amyloidosis / Immunoglobulin Light-chain Amyloidosis / Amyloid light-chain amyloidosis (disorder) / Primary amyloidosis [Ambiguous]

Drug	Drug Name	Drug Description
DB09331	Daratumumab	A CD38-directed cytolytic antibody used alone or as an adjunct drug in the treatment of multiple myeloma and light chain amyloidosis.
DB00480	Lenalidomide	A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome.
DB01041	Thalidomide	A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum.

Drug	Drug Name	Target	Type
DB09331	Daratumumab	ADP-ribosyl cyclase 1	target
DB00480	Lenalidomide	Prostaglandin G/H synthase 2	target
DB00480	Lenalidomide	Tumor necrosis factor ligand superfamily member 11	target
DB00480	Lenalidomide	Cadherin-5	target
DB00480	Lenalidomide	Protein cereblon	target
DB00480	Lenalidomide	P-glycoprotein 1	transporter
DB01041	Thalidomide	Cytochrome P450 2C19	enzyme
DB01041	Thalidomide	Cytochrome P450 2C9	enzyme
DB01041	Thalidomide	Prostaglandin G/H synthase 1	enzyme
DB01041	Thalidomide	Prostaglandin G/H synthase 2	enzyme
DB01041	Thalidomide	Cytochrome P450 3A5	enzyme
DB01041	Thalidomide	DNA	target
DB01041	Thalidomide	Protein cereblon	target
DB01041	Thalidomide	alpha1-acid glycoprotein	target
DB01041	Thalidomide	Cytochrome P450 3A4	enzyme
DB01041	Thalidomide	Cytochrome P450 1A1	enzyme
DB01041	Thalidomide	Cytochrome P450 2B6	enzyme

Drug	Drug Name	Phase	Status	Count
DB01234	Dexamethasone	0	Withdrawn	1
DB11942	Selinexor	0	Withdrawn	1
DB17492	Anselamimab	1	Completed	3
DB00188	Bortezomib	1	Recruiting	1
DB00188	Bortezomib	1	Terminated	1
DB16741	Bortezomib D-mannitol	1	Recruiting	1
DB16741	Bortezomib D-mannitol	1	Terminated	1
DB00531	Cyclophosphamide	1	Recruiting	1
DB01234	Dexamethasone	1	Completed	1
DB01234	Dexamethasone	1	Recruiting	2
DB01234	Dexamethasone	1	Terminated	3
DB00619	Imatinib	1	Completed	1
DB14811	Isatuximab	1	Recruiting	1
DB09570	Ixazomib	1	Completed	1
DB09570	Ixazomib	1	Recruiting	1
DB16627	Melphalan flufenamide	1	Terminated	1
DB08910	Pomalidomide	1	Terminated	1
DB01268	Sunitinib	1	Completed	1
DB11581	Venetoclax	1	Recruiting	1
DB11581	Venetoclax	1	Terminated	1
DB15719	Belantamab mafodotin	1 / 2	Not Yet Recruiting	1
DB06769	Bendamustine	1 / 2	Recruiting	1
DB16414	Birtamimab	1 / 2	Completed	1
DB00531	Cyclophosphamide	1 / 2	Completed	1
DB00091	Cyclosporine	1 / 2	Completed	1
DB09331	Daratumumab	1 / 2	Completed	1
DB09331	Daratumumab	1 / 2	Not Yet Recruiting	1
DB09331	Daratumumab	1 / 2	Recruiting	1
DB01234	Dexamethasone	1 / 2	Completed	2
DB01234	Dexamethasone	1 / 2	Not Yet Recruiting	1
DB01234	Dexamethasone	1 / 2	Recruiting	1
DB01073	Fludarabine	1 / 2	Completed	1
DB09570	Ixazomib	1 / 2	Completed	1
DB09570	Ixazomib	1 / 2	Recruiting	1
DB00688	Mycophenolate mofetil	1 / 2	Completed	1
DB08910	Pomalidomide	1 / 2	Completed	1
DB08910	Pomalidomide	1 / 2	Recruiting	1
DB11581	Venetoclax	1 / 2	Not Yet Recruiting	1
DB11581	Venetoclax	1 / 2	Recruiting	1
DB01118	Amiodarone	2	Terminated	1
DB17492	Anselamimab	2	Active Not Recruiting	1
DB15719	Belantamab mafodotin	2	Recruiting	1
DB06769	Bendamustine	2	Completed	1
DB06769	Bendamustine	2	Withdrawn	1
DB16414	Birtamimab	2	Completed	1
DB16414	Birtamimab	2	Terminated	2
DB00188	Bortezomib	2	Active Not Recruiting	2
DB00188	Bortezomib	2	Completed	2
DB16741	Bortezomib D-mannitol	2	Active Not Recruiting	1
DB16741	Bortezomib D-mannitol	2	Completed	2
DB14086	Cianidanol	2	Completed	1
DB00515	Cisplatin	2	Completed	1
DB00531	Cyclophosphamide	2	Active Not Recruiting	1
DB00531	Cyclophosphamide	2	Completed	3
DB09331	Daratumumab	2	Active Not Recruiting	1
DB09331	Daratumumab	2	Recruiting	2
DB01234	Dexamethasone	2	Active Not Recruiting	2
DB01234	Dexamethasone	2	Completed	5
DB01234	Dexamethasone	2	Recruiting	3
DB00997	Doxorubicin	2	Completed	1
DB00254	Doxycycline	2	Completed	1
DB03823	Epigallocatechin	2	Completed	1
DB12116	Epigallocatechin gallate	2	Completed	1
DB12116	Epigallocatechin gallate	2	Terminated	1
DB00005	Etanercept	2	Completed	1
DB00773	Etoposide	2	Completed	1
DB00099	Filgrastim	2	Completed	1
DB14811	Isatuximab	2	Active Not Recruiting	1
DB14811	Isatuximab	2	Recruiting	1
DB14811	Isatuximab	2	Withdrawn	1
DB09570	Ixazomib	2	Recruiting	1
DB00480	Lenalidomide	2	Completed	2
DB00742	Mannitol	2	Completed	1
DB01042	Melphalan	2	Active Not Recruiting	1
DB01042	Melphalan	2	Completed	2
DB08910	Pomalidomide	2	Completed	1
DB08910	Pomalidomide	2	Recruiting	3
DB11132	Silicon dioxide	2	Completed	1
DB09036	Siltuximab	2	Active Not Recruiting	1
DB01041	Thalidomide	2	Completed	1
DB17492	Anselamimab	3	Recruiting	2
DB16414	Birtamimab	3	Recruiting	1
DB16414	Birtamimab	3	Terminated	1
DB00188	Bortezomib	3	Completed	1
DB00188	Bortezomib	3	Recruiting	2
DB00188	Bortezomib	3	Terminated	1
DB16741	Bortezomib D-mannitol	3	Terminated	1
DB00531	Cyclophosphamide	3	Recruiting	2
DB01234	Dexamethasone	3	Completed	2
DB01234	Dexamethasone	3	Recruiting	2
DB00099	Filgrastim	3	Terminated	1
DB09148	Florbetaben F-18	3	Recruiting	1
DB01042	Melphalan	3	Completed	3
DB01042	Melphalan	3	Terminated	1
DB01008	Busulfan	Not Available	Completed	1
DB00958	Carboplatin	Not Available	Completed	1
DB00262	Carmustine	Not Available	Completed	1
DB00531	Cyclophosphamide	Not Available	Completed	1
DB00091	Cyclosporine	Not Available	Completed	2
DB00773	Etoposide	Not Available	Completed	1
DB09148	Florbetaben F-18	Not Available	Recruiting	1
DB01073	Fludarabine	Not Available	Completed	2
DB00529	Foscarnet	Not Available	Completed	1
DB01004	Ganciclovir	Not Available	Completed	1
DB01042	Melphalan	Not Available	Completed	1
DB00688	Mycophenolate mofetil	Not Available	Completed	2
DB04572	Thiotepa	Not Available	Completed	1
DB01610	Valganciclovir	Not Available	Completed	1