Pemphigus Vulgaris (PV) (DBCOND0040643)

Identifiers

Synonyms

Pemphigus Vulgaris / Pemphigus vulgaris (disorder) / Pemphigus, unspecified / Pemphigus / Pemphigus (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dapsone	A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.	Inactive dihydropteroate synthase 2target Dihydropteroate synthasetarget Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Flavin-containing monooxygenase 3enzyme Prostaglandin G/H synthase 1enzyme Prostaglandin G/H synthase 2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Arylamine N-acetyltransferase 2enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Myeloperoxidaseenzyme Cytochrome P450 2C18enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00683930	A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV)	Mycophenolate mofetil	treatment	3	completed
NCT04598451	A Study to Assess the Efficacy and Safety of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)	Prednisone	treatment	3	completed
NCT04598477	A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod PH20 SC in Adults With Pemphigus (Vulgaris or Foliaceus)	Prednisone	treatment	3	terminated
NCT02753777	Autoimmune Blistering Diseases Study	No drug interventions	Not Available	Not Available	recruiting
NCT00063752	Safety Study of PI-0824 to Treat Pemphigus Vulgaris	PI-0824	treatment	1	completed
NCT01930175	Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris	Ianalumab	treatment	2	terminated
NCT03239470	Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus	No drug interventions	treatment	1	terminated
NCT04023149	Efficacy of Interleukin-2 Gargle in the Treatment of Oral Mucosa Lesion in Pemphigus Vulgaris	Aldesleukin	treatment	2	unknown_status
NCT00606749	Use of KC706 for the Treatment of Pemphigus Vulgaris	KC706	treatment	2	completed
NCT03780166	A Study of the Safety and Tolerability of INCB050465 in Pemphigus Vulgaris	Parsaclisib	treatment	2	withdrawn
NCT05635266	Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives	No drug interventions	Not Available	Not Available	recruiting
NCT05594472	Ozonated Olive Oil in Treatment of Pemphigus Vulgaris and Bullous Pemphigoid	Gentamicin Olive oil	treatment	3	recruiting
NCT04540133	Dexamethasone Solution and Dexamethasone in Mucolox™	Dexamethasone	treatment	2	completed
NCT00429533	Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris	Dapsone	treatment	2	terminated
NCT01920477	Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris	Ofatumumab	treatment	3	terminated
NCT00626678	Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone	Azathioprine Prednisone	treatment	2	completed
NCT03177213	Serum IL-21 Levels in Patients With Pemphigus Vulgaris	No drug interventions	Not Available	Not Available	unknown_status
NCT00483119	Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus	Cyclophosphamide Human immunoglobulin G	treatment	2	terminated
NCT05000216	COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders	Famtozinameran Imelasomeran Janssen COVID-19 Vaccine Methotrexate Moderna COVID-19 Vaccine Mycophenolate mofetil Mycophenolic acid Tozinameran	prevention	2	completed
NCT03334058	A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus	Efgartigimod alfa	treatment	2	completed
NCT04096222	Comparative Analysis of the Th17 Cellular Response in Active and Inactive Pemphigus Vulgaris Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT00135720	Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris	Etanercept	treatment	2	completed
NCT06581562	Open-label Single-Center Study to Evaluate the Safety and Efficacy of Combining Rituximab and AB-101 in B-cell Associated Autoimmune Diseases.	Cyclophosphamide Fludarabine Rituximab	treatment	1	recruiting
NCT04117529	Phenotypic and Functional Characterisation of Human B-cell Response in Pemphigus	No drug interventions	basic_science	Not Available	unknown_status
NCT02704429	A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris	Rilzabrutinib	treatment	2	completed
NCT02383589	A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV)	Mycophenolate mofetil Rituximab	treatment	3	completed
NCT03075904	A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus)	Orilanolimab	treatment	1 / 2	terminated
NCT05303272	A Study to Evaluate Efficacy and Safety of Abatacept in Participants of Pemphigus Vulgaris (PV)	Abatacept Mycophenolate mofetil	treatment	4	unknown_status
NCT04422912	A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)	No drug interventions	treatment	1	recruiting
NCT05338112	Role of Tzanck Smear in Determining Pemphigus Vulgaris Disease Activity	No drug interventions	Not Available	Not Available	unknown_status
NCT06167408	Identifying Factors Influencing In-Hospital Relapse in Pemphigus Patients	No drug interventions	Not Available	Not Available	completed