Type I Hypersensitivity (DBCOND0030618)

Identifiers

Synonyms
Immediate hypersensitivity reactions / Immediate hypersensitivity reaction / Immediate Type Hypersensitivity / Hypersensitivity, Immediate / Immediate Hypersensitivity / Allergen-mediated IgE Allergy / Type I hypersensitivity / Hypersensitivity type I / Hypersensitivity type I NOS / Immunoglobulin E-mediated allergic disorder (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Epinephrine
A hormone and neurotransmitter used to treat allergic reactions, to restore cardiac rhythm, and to control mucosal congestion, glaucoma, and asthma.
Histamine
An ingredient of topical drugs for the relief of joint pain or muscle aches and pains.
Omalizumab
A monoclonal anti-immunoglobulin E (IgE) antibody used to treat asthma, chronic idiopathic urticaria, chronic rhinosinusitis with nasal polyps, and IgE-mediated food allergy.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00104390
Assessment of Residual Allergenicity of Grass/Rye Pollen Allergoid Using Skin Prick TestingNo drug interventionstreatment1completed
NCT00107705
Assessment of Residual Allergenicity of Tree (Birch, Hazel, and Alder) Pollen Allergoid Using Skin Prick Testingtreatment1completed
NCT00387478
Investigation of Efficacy and Safety of Tree MATAMPL,Tree MATA, and Placebo in Patients With Birch-Induced Seasonal Allergic RhinitisNo drug interventionstreatment2terminated
NCT00116285
Assessment of Residual Allergenicity of Ragweed Pollen Allergoid With Monophosphoryl Lipid A (MPL) Using Skin Prick Testingtreatment1completed
NCT00133159
Different Doses of Tyrosine Adsorbed Grass Pollen Allergoid With Monophosphoryl Lipid A (MPL) in Patients Sensitized to Grass PollenNo drug interventionstreatment2completed
NCT00258635
Investigation of Safety+Efficacy of Different Doses of RagweedMATAMPL;Assessment of Residual Allergenicity Using Skin Prick TestNo drug interventionstreatment2completed
NCT00118625
Assessment of the Contribution of Monophosphoryl Lipid A (MPL) to a Tree Pollen Allergy Vaccinetreatment2completed
NCT00133146
Assessment of the Contribution of Monophosphoryl Lipid A (MPL) to a Grass Pollen Allergy Vaccinetreatment2completed
NCT00241410
Safety, Immunological Effect and Efficacy of the Combined Application of MPL and Grass Pollen AllergenNo drug interventionstreatment1completed
NCT00113750
Induction of Immunogenicity With Different Doses of TreeMATA in Subjects Allergic to Tree PollenNo drug interventionstreatment2completed
NCT00423787
Efficacy and Safety/Tolerability of Ragweed MATA MPLNo drug interventionstreatment3completed
NCT00104377
Induction of Immunogenicity With Different Doses of Grass MATA in Subjects Allergic to Grass and Rye PollenNo drug interventionstreatment2completed
NCT00109759
Evaluation of Safety and Tolerability of Tyrosine Adsorbed Ragweed Pollen Allergoid With MPL (Monophosphoryl Lipid A)No drug interventionstreatment1withdrawn
NCT00414141
Efficacy and Safety/Tolerability of Grass MATA MPLtreatment3completed
NCT00110786
Investigation of Efficacy and Safety of Ragweed MATAMPL, Pollinex-R and Placebo in Patients With Ragweed AllergyNo drug interventionstreatment2completed
NCT00118612
Different Doses of Tyrosine Adsorbed Tree Pollen Allergoid With Monophosphoryl Lipid A (MPL) in Patients Sensitized to Tree Pollentreatment2completed
NCT00325338
Follow-up Investigation of Efficacy of Ragweed MATAMPL,and Placebo in Patients With Ragweed-induced Seasonal Allergic RhinitisNo drug interventionstreatment2completed
NCT02764827
Comparison of Skin Prick Testing Results of Local and Imported Pollen Allergen Extracts and Specific IgENo drug interventionsNot AvailableNot Availablecompleted
NCT00887939
Pathogenesis of Physical Induced Urticarial SyndromesNo drug interventionsNot AvailableNot Availablecompleted
NCT05420935
Repertoire and Properties of Anti-drug Antibodies Involved in Immediate Hypersensitivity in the Operating RoomNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00102570
Clinical and Immunological Evaluation of Children With AllergiesNo drug interventionsNot AvailableNot Availablecompleted
NCT02163122
Cat Pilot Study - Environmental Exposure Chamber (EEC) vs. Nasal Allergen Challenge (NAC)No drug interventionsbasic_science0completed
NCT03688074
Study to Evaluate Tezepelumab on Airway Inflammation in Adults With Uncontrolled Asthma (CASCADE)treatment2completed
NCT02162576
Asthma Data Innovation Demonstration ProjectNo drug interventionstreatmentNot Availablecompleted
NCT06538129
Assessment of Er:YAG Laser for the Control of Hypersensitivity During Tooth Whitening With Hydrogen PeroxideNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT03627767
Study to Investigate Efficacy and Safety of PF-04965842 in Subjects Aged 12 Years and Over With Moderate to Severe Atopic Dermatitis With the Option of Rescue Treatment in Flaring Subjectstreatment3completed
NCT00312312
Allergy Towards Grass and Bronchial Inflammation - Related to Immunotherapy and Exhaled Nitrogen OxideNo drug interventionspreventionNot Availableunknown_status
NCT05661812
Norwegian Birch Rust Allergy StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT04322838
Tromsø Birch Rust Allergy Study. Allergy to Birch Rust, a Possible Explanation to Seasonal Airway Allergy During Autumn?No drug interventionsNot AvailableNot Availableunknown_status
NCT03054428
Efficacy and Safety of Dupilumab in Participants ≥12 to <18 Years of Age, With Moderate-to-severe Atopic Dermatitistreatment3completed
NCT02916888
A Study Comparing the Quality of Life of Patients in the Treatment of Eczema by Pediatric Generalists and SpecialistsNo drug interventionsNot AvailableNot Availablecompleted
NCT02503800
The Significance of Blood-tryptase and c-Kit Mutation in Insect Venom ImmunotherapyNo drug interventionsNot AvailableNot Availablecompleted
NCT03720470
Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical Therapytreatment3completed
NCT03563066
Effect of Benralizumab in Atopic Dermatitistreatment2completed
NCT01257191
A Study to Compare the Effects of Different Sized Particles on Cells in the NoseNot Available1completed
NCT04454229
The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin ChallengeNo drug interventionsdiagnosticNot Availablecompleted
NCT01904604
Peanut Epicutaneous Phase II Immunotherapy Clinical TrialNo drug interventionstreatment2completed
NCT03918772
Clinical Determinants and Perioperative Allergic Reactions (CADECAP Study)No drug interventionsNot AvailableNot Availablecompleted
NCT00461097
Oral Immunotherapy for Childhood Egg AllergyNo drug interventionstreatment2completed
NCT06065137
Standardised Drug Provocation Testing in Perioperative HypersensitivityNo drug interventionsdiagnosticNot Availablerecruiting
NCT00580606
A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy TrialNo drug interventionstreatment1 / 2completed
NCT01084174
A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut AllergyNo drug interventionstreatment1 / 2completed
NCT02561429
Comparison of Difference Histamine Concentration (1, 5 and 10 mg/ml) for Skin Prick Test Positive ControlNo drug interventionsdiagnosticNot Availablecompleted
NCT02561390
Comparison Between spIgE and Skin Prick Test of Local and Imported AeroallergensNo drug interventionsdiagnosticNot Availablecompleted
NCT01407640
Diagnosis and Physiopathology of Insulin AllergyNo drug interventionsdiagnosticNot Availablecompleted
NCT00850668
Peanut Allergy Vaccine Study in Healthy and Peanut-allergic AdultsNo drug interventionstreatment1completed
NCT03969862
Validation Study of NOVEOS® System (HYCOR)No drug interventionsNot AvailableNot Availableterminated