Calcium Nephrolithiasis (DBCOND0036164)

Identifiers

Synonyms

Lithiasis Renal / Renal lithiasis / Stone, Kidney / Renal Calculi / Stones, Kidney / Stone;Renal / Kidney Stone / Kidney Stones / Renal Calculus / Kidney Calculi / Renal Stone / Renal Stones / Nephrolithiasis / Kidney calculus / Kidney calculus (& [staghorn]) / Nephrolithiasis NOS / Nephrolithiasis NOS (disorder) / (Calculus of kidney) or (nephrolithiasis NOS) / Calculus renal NOS / Calculus of kidney / Urinary calculus (& [kidney &/or ureter]) / Calculus renal / Renal calculus NOS / Renal calculus NOS (disorder) / Urinary calculus (& [kidney &/or ureter) / Kidney stone (disorder) / Calculus kidney

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amiloride	A pyrizine compound used to treat hypertension and congestive heart failure.	Amiloride-sensitive sodium channel subunit betatarget Acid-sensing ion channel 1target Diamine oxidase [copper-containing]target Amiloride-sensitive sodium channel subunit alphatarget Amiloride-sensitive sodium channel subunit gammatarget Sodium/hydrogen exchanger 1target Acid-sensing ion channel 2target Amiloride-sensitive sodium channel subunit deltatarget Urokinase-type plasminogen activatortarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 4transporter Diamine oxidase [copper-containing]enzyme Amiloride-sensitive amine oxidase [copper-containing]enzyme
Chlorthalidone	A diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions.	Solute carrier family 12 member 1target Albumincarrier Carbonic anhydrase 1target
Hydrochlorothiazide	A thiazide diuretic used to treat edema associated with a number of conditions, and hypertension.	Solute carrier family 12 member 3target Solute carrier family 22 member 6transporter Calcium-activated potassium channel subunit alpha-1target Albumincarrier Solute carrier family 22 member 11transporter ATP-binding cassette sub-family C member 4transporter Organic anion transporter 3transporter Angiotensin-converting enzymetarget
Potassium citrate	An agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.	No drug targets
beta-Pinene	A mono-terpene indicated in combination with other plant-derived compounds for the treatment of bladder, kidney, and urinary stones.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00416052	Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers	No drug interventions	Not Available	Not Available	completed