Migraine Headache, With or Without Aura (DBCOND0039357)

Identifiers

Synonyms

Migraine With and Without Aura / Migraine, With or Without Aura / Migraine With or Without Aura

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dihydroergotamine	An ergot alkaloid used in the acute treatment of migraine headache and cluster headache.	5-hydroxytryptamine receptor 1Dtarget 5-hydroxytryptamine receptor 1Btarget Cytochrome P450 3A4enzyme Alpha-2A adrenergic receptortarget 5-hydroxytryptamine receptor 2Btarget ATP-dependent translocase ABCB1transporter 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Etarget 5-hydroxytryptamine receptor 2Atarget 5-hydroxytryptamine receptor 2Ctarget Alpha-1 adrenergic receptorstarget Alpha-2 adrenergic receptorstarget D(2) dopamine receptortarget D(3) dopamine receptortarget D(4) dopamine receptortarget 5-hydroxytryptamine receptor 1Ftarget 5-hydroxytryptamine receptor 4target Beta-3 adrenergic receptortarget
Lasmiditan	An oral 5HT1F agonist used for the acute treatment of migraine headache with or without aura.	5-hydroxytryptamine receptor 1Ftarget ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier family 22 member 1transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Cytochrome P450 2D6enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06203873	A Comparison of Biodegradable and Metal Occluders in Patients With PFO and Migraine	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT00610428	Staccato Prochlorperazine in Migraine (in Clinic)	Prochlorperazine	treatment	2	completed
NCT03185143	Low-Dose Naltrexone and Acetaminophen Combination and Sumatriptan in the Acute Treatment of Migraine With Nausea	Acetaminophen Naltrexone Sumatriptan	treatment	2 / 3	completed
NCT01720862	Migraine and Body Composition	No drug interventions	Not Available	Not Available	completed
NCT03237845	Safety and Efficacy in Adult Subjects With Acute Migraines	Rimegepant	treatment	3	completed
NCT03266588	Open Label Safety Study in Acute Treatment of Migraine	Rimegepant	treatment	2 / 3	completed
NCT03461757	Trial in Adult Subjects With Acute Migraines	Rimegepant	treatment	3	completed
NCT02828020	Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine	Ubrogepant	treatment	3	completed
NCT02873221	An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine	Ubrogepant	treatment	3	completed
NCT03235479	Safety and Efficacy Study in Adult Subjects With Acute Migraines	Rimegepant	treatment	3	completed
NCT02867709	Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine	Ubrogepant	treatment	3	completed
NCT02848326	Efficacy, Safety, and Tolerability of Multiple Dosing Regimens of Oral Atogepant (AGN-241689) in Episodic Migraine Prevention	Atogepant	prevention	2 / 3	completed
NCT02605174	Three Doses of Lasmiditan (50 mg, 100 mg and 200 mg) Compared to Placebo in the Acute Treatment of Migraine	Lasmiditan	treatment	3	completed
NCT06245902	An Acute Migraine Factorial Study	Acetaminophen Naltrexone	treatment	2	completed
NCT01986088	Eletriptan vs Sumatriptan: A Double-blind, Placebo-controlled, Multiple Migraine Attack Study	Eletriptan Sumatriptan	treatment	3	completed
NCT01986270	Comparative Study of Oral Eletriptan (40mg and 80mg), Oral Sumatriptan (25mg and 50mg) and Placebo	Eletriptan Sumatriptan	treatment	3	completed
NCT01989936	Eletriptan for the Treatment of Migraine in Patients With Previous Poor Response or Tolerance to Oral Sumatriptan	Eletriptan	treatment	3	completed
NCT03061734	Low-Dose Naltrexone and Acetaminophen Combination and Its Components in the Acute Treatment of Migraine	Acetaminophen Naltrexone	treatment	2	completed
NCT01978496	Efficacy, Safety, and Tolerability of Oral Eletriptan for Treatment of Acute Migraine	Eletriptan	treatment	3	completed
NCT03194555	The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination	Acetaminophen Naltrexone	treatment	2	completed