Primary Amyloidosis (DBCOND0040057)

Identifiers

Synonyms
Primary Systemic Amyloidosis (AL) / Primary Systemic (AL) Amyloidosis / Primary Systemic Amyloidosis / Primary Amyloidosis of Light Chain Type / Amyloid Light Chain (AL) Amyloidosis / AL Amyloidosis / Light Chain (AL) Amyloidosis / Light-Chain Amyloidosis / Systemic Light Chain Disease / Primary amyloidosis / Amyloid light-chain amyloidosis / Immunoglobulin Light-chain Amyloidosis / Amyloid light-chain amyloidosis (disorder) / Immunoglobulin deposition disease (morphologic abnormality)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Daratumumab
A CD38-directed cytolytic antibody used alone or as an adjunct drug in the treatment of multiple myeloma and light chain amyloidosis.
Lenalidomide
A thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome.
Thalidomide
A medication used to treat cancers, particularly newly diagnosed multiple myeloma, and erythema nodosum leprosum.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00344526
Intensive Versus Conventional Treatment in Patients With Primary Amyloidosistreatment3completed
NCT02312206
The VITAL Amyloidosis Study, a Global Phase 3, Efficacy and Safety Study of NEOD001 in Patients With AL Amyloidosistreatment3terminated
NCT01078454
Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosistreatment3completed
NCT00006251
Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancertreatment1 / 2completed
NCT00890747
Sunitinib Malate in Treating HIV-Positive Patients With Cancer Receiving Antiretroviral Therapytreatment1completed
NCT01849783
Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myelomatreatment2completed
NCT00224393
Phase II Trial of Enbrel in Patients With Primary Systemic Amyloidosistreatment2completed
NCT02207556
Doxycycline to Upgrade Organ Response in Light Chain (AL) Amyloidosis Trialtreatment2completed
NCT00025415
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunctiontreatment1completed
NCT00014235
Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic MalignanciestreatmentNot Availablecompleted
NCT01199562
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell TransplantNot AvailableNot Availablecompleted
NCT00112593
Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without CancertreatmentNot Availablecompleted
NCT01728259
First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDDtreatment1terminated
NCT01072773
Bortezomib, Cyclophosphamide, and Dexamethasone in Treating Patients With Primary Systemic Light Chain Amyloidosistreatment2completed
NCT01053494
Massage Therapy Given by Caregiver in Treating Quality of Life of Young Patients Undergoing Treatment for CancerNo drug interventionssupportive_careNot Availablecompleted
NCT01194791
Lendexal in Patients With Primary Systemic Amyloidosis (AL) Newly Diagnosedtreatment2completed
NCT00520767
Bortezomib, Melphalan, and Dexamethasone in Treating Patients With Primary Amyloidosis or Light Chain Deposition Diseasetreatment2completed
NCT00536601
High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid TumorstreatmentNot Availablecompleted
NCT00030381
Iododoxorubicin in Treating Patients With Primary Systemic AmyloidosisNo drug interventionstreatment1terminated
NCT03499808
S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosistreatment2active_not_recruiting
NCT01511263
Epigallocatechingallate (EGCG) in Cardiac AL Amyloidosistreatment2terminated
NCT03923920
Screening for Systemic Amyloidosis Via the Ligamentum FlavumNo drug interventionsNot AvailableNot Availablecompleted
NCT01531751
High Cut-off Hemodialysis in Patients With Advanced Cardiac AL Amyloidosis and End Stage Renal DiseaseNo drug interventionstreatment2withdrawn
NCT01510613
Pomalidomide and Dexamethasone (PDex) in AL Amyloidosistreatment2completed
NCT03886155
Cardiac Amyloidosis Screening at Trigger Finger ReleaseNo drug interventionsNot AvailableNot Availablecompleted
NCT02641145
Molecular Imaging of Primary Amyloid CardiomyopathyNo drug interventionsdiagnosticNot Availablerecruiting
NCT01707264
Phase 1/2, Open Label, Dose Escalation Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosistreatment1 / 2completed
NCT00651937
Trial of Two Stem Cell Doses To Reduce Transplant Induced Symptom Burdentreatment2completed
NCT00807872
Radioimmunoimaging of AL Amyloidosisdiagnostic1completed
NCT02555969
Minimal Residual Disease as a Possible Predictive Factor for Relapse in Patients With AL AmyloidosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00883623
A Trial of Treatment With Lenalidomide-Melphalan-Dexamethasone in Patients With Primary (AL) Amyloidosistreatment2completed
NCT04504825
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosistreatment3active_not_recruiting
NCT06649695
A Phase II Trial of Teclistamab in Participants With Previously Treated Immunoglobulin Light-chain (AL) AmyloidosisNo drug interventionstreatment2not_yet_recruiting
NCT04617925
A Study of Belantamab Mafodotin in Patients With Relapsed or Refractory AL Amyloidosistreatment2active_not_recruiting
NCT04512235
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosistreatment3active_not_recruiting
NCT05199337
Phase 1/2 Study of ZN-d5 for the Treatment of Relapsed or Refractory Light Chain (AL) AmyloidosisNo drug interventionstreatment1 / 2completed
NCT02841033
Daratumumab for the Treatment of Patients With AL Amyloidosistreatment1 / 2completed
NCT06205953
A EUropean REgistry and Sample Sharing networK to Promote the Diagnosis and Management of Light Chain Amyloidosis (EUREKA)No drug interventionsNot AvailableNot Availablerecruiting
NCT06569147
Elranatamab in Patients With Relapsed or Refractory AL Amyloidosistreatment1 / 2not_yet_recruiting
NCT04754945
Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosistreatment1active_not_recruiting
NCT05066607
Isatuximab Plus Pomalidomide and Dexamethasone Association for Patients With AL Amyloidosis Not in VGPR or Better After Any Previous Therapytreatment2recruiting
NCT06065852
National Registry of Rare Kidney DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT01758042
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood DisordersNo drug interventionstreatmentNot Availablerecruiting
NCT04895917
Daratumumab and Pomalidomide in Previously Treated Patients With AL Amyloidosistreatment2active_not_recruiting
NCT03431896
Monitoring of Early Disease Progression in Hereditary Transthyretin AmyloidosisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01815086
Radioimmunoimaging of Light Chain (AL) Amyloidosisdiagnostic1completed
NCT06022939
Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosistreatment3recruiting
NCT01408225
Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample ResourceNo drug interventionsNot AvailableNot Availablerecruiting
NCT04984330
Selinexor for Treatment of Light Chain Amyloidosis With Relapsed/Refractory Diseasetreatment0withdrawn
NCT01409148
Radioimmunoimaging of AL Amyloidosisdiagnostic1completed
NCT02574676
Quality of Life (QOL) Registry for Patients With AL AmyloidosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03000660
Trial of Venetoclax (ABT-199) and Dexamethasone for Relapsed or Refractory Systemic AL Amyloidosistreatment1terminated
NCT03236792
Ixazomib In Combination With Cyclophosphamide And Dexamethasone for Newly Diagnosed AL Amyloidosistreatment1 / 2completed
NCT04304144
A Study to Evaluate the Safety and Tolerability of CAEL-101 in Patients With AL Amyloidosistreatment2completed
NCT06186167
Amyloidosis Incidence in High-Risk Cardiac Device PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06383143
Promoting Diagnosis and Management of AL in Italy (ProDigALIty)No drug interventionsNot AvailableNot Availablerecruiting
NCT04839003
A Registry of AL Amyloidosis (ReAL)No drug interventionsNot AvailableNot Availablerecruiting
NCT06192979
Optimize First-line Treatment for AL Amyloidosis With t (11; 14)treatmentNot Availablerecruiting
NCT01570387
A Phase I/II Trial of Pomalidomide and Dexamethasone in Subjects With Previously-Treated AL Amyloidosistreatment1 / 2completed
NCT04847453
Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosistreatment1recruiting
NCT04937777
A Study on the Management and Outcome of Patients With Systemic AL Amyloidosis in EuropeNo drug interventionsNot AvailableNot Availablecompleted
NCT03154047
Study in Subjects With Light Chain (AL) Amyloidosistreatment2terminated
NCT02257905
Allo SCT in Amyloidosis Non-interventional StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT05277493
A Registry of Chinese AL Amyloidosis Patients Treated With Subcutaneous or Intravenous DaratumumabNo drug interventionsNot AvailableNot Availablerecruiting
NCT05451771
Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Amyloidosistreatment1 / 2recruiting
NCT05184088
Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosisdiagnostic3recruiting
NCT04115956
A Clinical Study of Melphalan Flufenamide (Melflufen) and Dexamethasone for Patients With Immunoglobulin Light Chain (AL) Amyloidosistreatment1terminated
NCT03618537
Ixazomib Maintenance Study in Patients With AL Amyloidosistreatment2active_not_recruiting
NCT02489500
Trial of High Dose Melphalan/Stem Cell Transplant With or Without Bortezomibtreatment3terminated
NCT04270175
Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumabtreatment2recruiting
NCT01277016
A Trial for Systemic Light-chain (AL) Amyloidosistreatment3completed
NCT05145816
Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosistreatment1 / 2recruiting
NCT02632786
The PRONTO Study, a Global Phase 2b Study of NEOD001 in Previously Treated Subjects With Light Chain (AL) Amyloidosistreatment2completed
NCT03315026
Siltuximab to Decrease Symptom Burden After Autologous Stem Cell Transplantation for Patients With Multiple Myeloma and AL Amyloidosistreatment2active_not_recruiting
NCT05028374
COVID-19 VAX Booster Dosing in Patients With Hematologic MalignanciesNo drug interventionstreatment2completed
NCT02613182
Open-label Extension Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosistreatment2terminated
NCT01222260
Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosistreatment2completed
NCT04392960
Novel Imaging Tools in Newly-diagnosed Patients With Cardiac AL AmyloidosisdiagnosticNot Availablerecruiting
NCT04210791
Autologous Stem Cell Transplantation for Patients With AL AmyloidosisNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05898646
Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trialtreatment2recruiting
NCT05486481
Venetoclax, Daratumumab, and Dexamethasone for Systemic Light-Chain Amyloidosis With Translocation (11;14) (ALTITUDE)treatment1 / 2recruiting
NCT04943302
Isatuximab and Bendamustine in Systemic Light Chain Amyloidosistreatment2withdrawn
NCT06629818
Daratumumab Combined with Venetoclax and Dexamethasone for Newly Diagnosed Light-Chain Amyloidosis with Translocation (11;14)treatment2not_yet_recruiting
NCT04973137
A Study to Evaluate the Efficacy and Safety of Birtamimab in Mayo Stage IV Patients With AL Amyloidosistreatment3recruiting
NCT06097832
Study of NXC-201 CAR-T in Patients With Light Chain (AL) AmyloidosisNo drug interventionstreatment1recruiting
NCT04316442
Study of the Safety and Efficacy of STI-6129 in Patients With Relapsed or Refractory Systemic AL AmyloidosisNo drug interventionstreatment1 / 2recruiting
NCT05996406
Venetoclax and Dexamethasone for Newly Diagnosed Light-Chain Amyloidosis With Translocation (11;14)treatment2active_not_recruiting
NCT02015312
A Trial for the Treatment of Cardiac AL-Amyloidosis With the Green Tea Compound Epigallocatechin-3-gallate (TAME-AL)treatment2completed
NCT06376214
Daratumumab for Patients With Light Chain AmyloidosistreatmentNot Availablerecruiting
NCT05692908
An Open-Label Study of the Safety of an Anti-CD38 Antibody Drug Conjugate (STI-6129) in Patients With AL AmyloidosisNo drug interventionstreatment1withdrawn
NCT01318902
Study of Oral Ixazomib in Adult Participants With Relapsed or Refractory Light Chain Amyloidosistreatment1completed
NCT05978661
FKC288 for Relapsed or Refractory Systemic Light Chain (AL) AmyloidosisNo drug interventionstreatment1recruiting