Cytomegalovirus Retinitis (DBCOND0000283)

Identifiers

Synonyms

CMV retinitis / Cytomegalovirus retinitis / Cytomegaloviral retinitis (disorder) / Cytomegalovirus chorioretinitis / Chorioretinitis caused by Cytomegalovirus (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cidofovir	An antiviral agent used to treat Cytomegalovirus (CMV) retinitis in patients with AIDS.	DNA polymerase catalytic subunittarget Solute carrier family 22 member 6transporter Thymidine phosphorylaseenzyme DNA polymerase catalytic subunittarget
Foscarnet	An antiviral used to treat CMV, HIV, and HSV infections.	DNA polymerase catalytic subunittarget DNA polymerase catalytic subunittarget Solute carrier family 22 member 6transporter Monocarboxylate transporter 1transporter
Ganciclovir	A DNA polymerase inhibitor used to treat cytomegalovirus and herpetic keratitis of the eye.	DNA polymerase catalytic subunittarget Solute carrier family 22 member 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Solute carrier family 22 member 7transporter DNAtarget Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Thymidine kinasetarget
Valganciclovir	An antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS).	DNAtarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter DNA polymerase catalytic subunittarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00002321	A Phase I Study of the Safety of Proleukin (Aldesleukin) in Combination With Ganciclovir and Antiretroviral Therapy in HIV Seropositive Patients With Cytomegalovirus (CMV) Retinitis	Aldesleukin	treatment	1	completed
NCT00002384	A Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS	Cidofovir	treatment	Not Available	unknown_status
NCT00091884	Efficacy of Elevated CD4 Counts on CMV Retinitis	No drug interventions	Not Available	Not Available	completed
NCT00017784	Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by Injection	Valganciclovir	treatment	3	unknown_status
NCT00002377	A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes	Ganciclovir Valganciclovir	treatment	3	completed
NCT00002247	A Randomized Study Comparing the Safety and Efficacy of Two Regimens of Oral Ganciclovir to Intravenous Ganciclovir Maintenance Therapy for Cytomegalovirus Retinitis in People With AIDS Who Have Received Prior Ganciclovir Therapy	Ganciclovir	treatment	Not Available	completed
NCT00000697	A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use Ganciclovir	Foscarnet	treatment	2	withdrawn
NCT00000693	Suppression of Cytomegalovirus Retinitis Utilizing High Dose Intravenous Acyclovir and Oral Zidovudine in Patients With AIDS	Acyclovir Zidovudine	treatment	Not Available	completed
NCT00000688	A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Peripheral Cytomegalovirus Retinitis in Patients With AIDS	Ganciclovir	treatment	3	completed
NCT00002156	A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )	Fomivirsen Ganciclovir	treatment	2	completed
NCT00002437	The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS	Cidofovir Probenecid	treatment	2	completed
NCT00002070	Phase III Ganciclovir +/- rGM-CSF for AIDS-Related CMV Retinitis	Ganciclovir Sargramostim	treatment	3	completed
NCT00000970	A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With Ganciclovir	Foscarnet Ganciclovir	treatment	1	completed
NCT00000799	HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol	Cidofovir Probenecid	treatment	Not Available	completed
NCT00001999	A Pilot Study to Obtain Preliminary Information Regarding the Efficacy and Safety of the Combination of Immune Globulin and Ganciclovir as Compared to Ganciclovir Alone in the Treatment of Sight-Threatening CMV Retinitis in Patients With AIDS	Ganciclovir	treatment	Not Available	completed
NCT00002299	The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS	Ganciclovir Interferon beta-1b	treatment	Not Available	completed
NCT00000136	Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT)	Foscarnet Ganciclovir	treatment	3	completed
NCT00002134	A Randomized, Controlled Study of the Safety and Preventive Efficacy of Oral Ganciclovir When Used in Conjunction With An Intravitreal Ganciclovir Implant in the Treatment of Cytomegalovirus Retinitis	Ganciclovir	treatment	Not Available	completed
NCT00001034	The Safety and Effectiveness of Ganciclovir in the Prevention of Cytomegalovirus (CMV) of the Eyes and Disease of the Stomach and Intestines in Patients With HIV	Ganciclovir	treatment	2	completed
NCT00000135	Studies of the Ocular Complications of AIDS (SOCA)--Monoclonal Antibody CMV Retinitis Trial (MACRT)	Sevirumab	treatment	2 / 3	completed
NCT00002039	An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS Patients	Foscarnet	treatment	Not Available	completed
NCT00002025	Open Label Ganciclovir Therapy for Sight- or Life-Threatening Cytomegalovirus Disease in the Immunocompromised Patient	Ganciclovir	treatment	Not Available	completed
NCT00002125	A Multicenter Study of Oral Versus Intravenous Hydration in AIDS Patients With CMV Retinitis Treated With Foscavir (Foscarnet Sodium)	Foscarnet	treatment	4	completed
NCT00002330	A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS	Ganciclovir	treatment	Not Available	completed
NCT00002257	A Randomized Controlled Study of the Efficacy and Safety of Maintenance Treatment With Oral Ganciclovir for Newly Diagnosed Cytomegalovirus Retinitis in People With AIDS	Ganciclovir	treatment	Not Available	completed
NCT00000726	Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency Syndrome	Foscarnet	treatment	1	completed
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT00000665	Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir Component	Foscarnet Ganciclovir	treatment	Not Available	completed
NCT00000673	A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic Therapy	Ganciclovir	treatment	1	completed
NCT00004794	Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus Retinitis	Cidofovir	treatment	2	completed
NCT00002301	A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Have Not Had Success With Ganciclovir	Foscarnet	treatment	Not Available	unknown_status
NCT00000668	A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral Ganciclovir	Ganciclovir	treatment	1	completed
NCT00002169	A Study of Viracept in AIDS Patients With Cytomegalovirus Retinitis	Nelfinavir	treatment	2	completed
NCT00000881	A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) Disease	Cidofovir Probenecid	treatment	1	withdrawn
NCT00002355	A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the Eyes	Fomivirsen	treatment	Not Available	completed
NCT00000143	Studies of Ocular Complications of AIDS (SOCA)--Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT)	Cidofovir	treatment	3	completed
NCT05911503	Clinical Study of High Concentration Ganciclovir Eye Drops in the Treatment of Cytomegalovirus Retinitis	Ganciclovir	treatment	0	recruiting
NCT00002187	A Study of ISIS 2922 in the Treatment of Advanced Cytomegalovirus Retinitis	Fomivirsen	treatment	Not Available	completed
NCT04831333	Deep Learning-based System and AIDS-related Cytomegalovirus Retinitis	No drug interventions	Not Available	Not Available	completed
NCT00000698	A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV Retinitis	Ganciclovir	treatment	3	completed
NCT00000905	A Study to Evaluate the Effects of Stopping Maintenance Therapy for Cytomegalovirus (CMV) Retinitis After Effective Anti-HIV Therapy	No drug interventions	Not Available	Not Available	completed
NCT01866397	Pharmacokinetics of Cidofovir During Continuous Venovenous Hemofiltration	No drug interventions	Not Available	4	completed
NCT00001061	Comparison of Two Methods in the Treatment of Cytomegalovirus of the Eyes in Patients With AIDS	Foscarnet Ganciclovir Sevirumab	treatment	2	completed
NCT00001611	Immune Activity Against CVM Retinitis	No drug interventions	Not Available	Not Available	completed
NCT00002356	The Safety and Effectiveness of ISIS 2922 in Patients With AIDS Who Have Cytomegalovirus (CMV) of the Eyes	Fomivirsen	treatment	2	completed
NCT00002015	An Open Label Evaluation of the Safety and Pharmacokinetics of Ganciclovir in Children	Ganciclovir	treatment	Not Available	completed
NCT00002432	A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS	Foscarnet	treatment	Not Available	completed
NCT00002142	An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS	Cidofovir Probenecid	treatment	Not Available	completed
NCT00000836	A Phase II/III Trial of Human Anti-CMV Monoclonal Antibody MSL 109 (MACRT)	Sevirumab	treatment	2	completed
NCT00000118	Ganciclovir Implant Study for Cytomegalovirus Retinitis	No drug interventions	treatment	3	completed
NCT00000134	Studies of the Ocular Complications of AIDS (SOCA)--Cytomegalovirus Retinitis Retreatment Trial (CRRT)	Foscarnet Ganciclovir	treatment	3	completed
NCT00002034	A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDS	Ganciclovir Zidovudine	treatment	Not Available	completed
NCT00002016	A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV Retinitis	Sevirumab	treatment	1	completed
NCT00002135	An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous Access	Ganciclovir	treatment	Not Available	completed
NCT00002222	A Study of Valganciclovir in the Treatment of Cytomegalovirus (CMV) Retinitis in Patients With AIDS	Valganciclovir	treatment	Not Available	completed
NCT00000766	CMV Retinitis Retreatment Trial	Foscarnet Ganciclovir	treatment	2	completed
NCT00000894	Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis	Cidofovir Ganciclovir Probenecid	treatment	4	completed
NCT00000691	A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure	Foscarnet	treatment	2	completed
NCT00001062	A Study of Ganciclovir in the Treatment of Cytomegalovirus of the Eyes	Ganciclovir	treatment	1	completed
NCT00000989	The Safety and Effectiveness of Ganciclovir Used Alone or in Combination With Granulocyte-Macrophage Colony Stimulating Factor in the Treatment of Cytomegalovirus (CMV) of the Eye in Patients With AIDS	Ganciclovir Sargramostim Zidovudine	treatment	Not Available	completed
NCT00005572	A Comparison of HIV-Infected Patients With and Without Opportunistic (AIDS-Related) Infection	No drug interventions	Not Available	Not Available	completed
NCT00000168	Longitudinal Study of Ocular Complications of AIDS (LSOCA)	No drug interventions	Not Available	Not Available	completed