Malaria caused by plasmodium vivax (DBCOND0022743)

Identifiers

Synonyms
Malaria Vivax / Plasmodium Vivax Malaria / Vivax Malaria / Malaria, Vivax / P. vivax malaria / Malaria caused by Plasmodium vivax / Plasmodium vivax malaria without complication / Tertian malaria / Vivax malaria (benign tertian) / Vivax malaria (disorder) / Plasmodium vivax infection

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Mefloquine
An antimalarial agent used in the prophylaxis and treatment of malaria caused by Plasmodium falciparum and Plasmodium vivax.
Primaquine
An antimalarial indicated to prevent relapse of vivax malaria.
Tafenoquine
An antiparasitic agent used for the treatment and prevention of relapse of Vivax malaria.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT00928083
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of OZ439 in Healthy Male and Female Subjectstreatment1completed
NCT01887821
Antimalarial Drug Susceptibility and Molecular Characterization of Plasmodium Vivax Isolates in Vietnamtreatment4completed
NCT01107145
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Vivax in Pregnancy in Brazil (PAACT-PV)treatment4terminated
NCT04416945
Targeting High Risk Populations With Enhanced Reactive Case Detection in Southern Lao Peoples Democratic RepublicNo drug interventionsscreeningNot Availableunknown_status
NCT02001428
Malaria in Early Life StudytreatmentNot Availablecompleted
NCT04704999
Southeast Asia Dose Optimization of Tafenoquinetreatment4recruiting
NCT05788094
ACT vs CQ With Tafenoquine for P. Vivax Mono-infectiontreatment4recruiting
NCT00295581
PpPfs25/ISA51 and ScPvs25/ISA51 Vaccines for MalariaNo drug interventionstreatment1completed
NCT02123290
DSM265 Phase IIa Investigation Treating Plasmodium Falciparum or Vivaxtreatment2completed
NCT05052502
Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in ThailandNo drug interventionsscreeningNot Availableunknown_status
NCT06575647
Vivax Elimination With Tafenoquine (VET) Studytreatment4not_yet_recruiting
NCT00138489
Papua New Guinean Duffy Negativity And Vivax MalarNo drug interventionsNot AvailableNot Availableterminated
NCT00935623
Clinical Trial for the Development of a Safe Malaria Challenge Model That Can be Reproduced in HumansNo drug interventionsprevention1completed
NCT00158587
Eight Week Primaquine Regimen for the Treatment of Vivax Malariatreatment3completed
NCT06044805
Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivaxtreatment4completed
NCT01546961
Chloroquine Population Pharmacokinetics in Pre and Post-partum WomentreatmentNot Availablecompleted
NCT02696928
Methylene Blue Against Vivax Malaria in Ethiopiatreatment2withdrawn
NCT01625871
Artemether/Lumefantrine and Vivax Malariatreatment3completed
NCT00682578
A Comparative Study of Artekin With Standard Malarial Treatment Regimes in Afghanistantreatment3completed
NCT00157859
To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, IndonesiatreatmentNot Availablecompleted
NCT02876549
G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malariadiagnostic4completed
NCT05879224
Short Course Primaquine for the Radical Cure of P. Vivax Malaria - IndonesiaNo drug interventionsotherNot Availablerecruiting
NCT03529396
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patientstreatment2active_not_recruiting
NCT00158548
ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistantreatment3completed
NCT01640574
Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD)treatment3completed
NCT06148792
A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malariatreatment3recruiting
NCT01076868
Incidence of Vivax Along the Thai Burma BorderpreventionNot Availablecompleted
NCT03916003
Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areastreatment4completed
NCT02118090
Assessment of Plasmodium Vivax Chloroquine Resistance in Cambodia:treatment4completed
NCT01178021
Estimating the Risk of Plasmodium Vivax Relapses in Afghanistantreatment4completed
NCT00157833
A Randomized Trial of Coartemether and Artekin for the Treatment of Uncomplicated Malaria in Papua, Indonesia.No drug interventionstreatmentNot Availablecompleted
NCT01780753
Primaquine Pharmacokinetics in Lactating Women and Their Infantstreatment1completed
NCT01074905
Study on the Treatment of Vivax Malariatreatment3completed
NCT05958797
TES of Chloroquine for Pv in the Philippines in 2016Not AvailableNot Availablecompleted
NCT00158561
Chlorproguanil/Dapsone Compared With Chloroquine and SP for Vivax MalariaNot Available3completed
NCT05874271
Short Course Primaquine for the Radical Cure of P. Vivax - Papua New GuineaNo drug interventionsotherNot Availablerecruiting
NCT04222088
TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014Not AvailableNot Availablecompleted
NCT04228315
Biomarkers of P. Vivax RelapsetreatmentNot Availablerecruiting
NCT01218932
Pharmacokinetic Study of Primaquine and Chloroquine in Healthy SubjectsNo drug interventionstreatment1completed
NCT04411836
Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquinetreatment3active_not_recruiting
NCT04706130
Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Curetreatment4recruiting
NCT01288820
Study of ACTs Plus Primaquine for Uncomplicated Plasmodium Vivax Malariatreatment3completed
NCT01716260
Safety and Efficacy of Chloroquine and Primaquine for Vivax Malaria in BhutanNot AvailableNot Availablecompleted
NCT04079621
Short Course Radical Cure of P. Vivax Malaria in Nepaltreatment4completed
NCT05044637
Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in Childrentreatment2recruiting
NCT05540470
Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese ShieldtreatmentNot Availablerecruiting
NCT03610399
Efficacy of 3 Regimens of Chloroquine and Primaquine for Treatment of P. Vivax Malaria, Cruzeiro do Sul, Acre, BraziltreatmentNot Availablecompleted
NCT05690841
FocaL Mass Drug Administration for Vivax Malaria EliminationNo drug interventionsprevention3not_yet_recruiting
NCT00811096
Pilot Human Study of Tinidazole Efficacy For Radical Cure Of Plasmodium Vivaxtreatment2completed
NCT04009096
VAC071: A Study to Assess Efficacy of the ChAd63/MVA PvDBP VaccinesNo drug interventionsprevention2completed
NCT05361486
Radical Cure (RC) With Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in PeruNot AvailableNot Availablerecruiting
NCT06036030
Combination Momordica Charantia Extract and Primaquine Againts Plasmodium Falciparum Uncomplicated and Plasmodium Vivax Uncomplicated Treatment in Manokwari, West Papuatreatment2completed
NCT04223674
Serological Screen and Treat Trial for Plasmodium VivaxNo drug interventionsscreeningNot Availableactive_not_recruiting
NCT04201431
Safety, Immunogenicity and Efficacy of the Blood-stage Plasmodium Vivax Malaria Vaccine Candidate PvDBPII in Matrix M1prevention1 / 2unknown_status
NCT05232227
Primaquine Double Dose for Radical Cure of Plasmodium Vivax in Colombiatreatment2 / 3withdrawn
NCT02751294
A Study to Assess the Effects of Dissolution Profile on the Pharmacokinetics of Single Oral Doses of Tafenoquine Tablets and Tafenoquine Stable Isotope Labelled Solutiontreatment1completed
NCT00486694
Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malariatreatment2completed
NCT03307369
A Retrospective Study of Severe Plasmodium VivaxNo drug interventionsNot AvailableNot Availablecompleted
NCT01083095
Establishment of a Sporozoite Challenge Model for Plasmodium Vivax in Human VolunteersNo drug interventionsNot Available0completed
NCT01928914
Tafenoquine Thorough QTc Study in Healthy Subjectsother1completed
NCT05753150
Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in ThailandNot AvailableNot Availablecompleted
NCT05096702
Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in BrazilNot AvailableNot Availableactive_not_recruiting
NCT02110784
Eurartesim® in Patients With Imported Uncomplicated Plasmodium Vivax Malariatreatment2terminated
NCT01081847
Safety and Immunogenicity Study of Plasmodium Vivax CS Derived Synthetic Peptides Formulated in Two AdjuvantsNot Available1completed
NCT03208907
DHA-PQP vs Chloroquine and Primaquine for Radical Cure of Vivax Malaria in BrazilNo drug interventionstreatment3completed
NCT00157885
A Randomised Trial of Artekin and Artesunate & Amodiaquine for Uncomplicated Malaria in Timika, Papua, Indonesia.treatmentNot Availablecompleted
NCT05058885
Plasmodium Vivax Among Duffy Negative Population in Cameroon.No drug interventionsNot AvailableNot Availablerecruiting
NCT02184637
A Study to Evaluate the Pharmacokinetics of a Single Dose of Tafenoquine Co-administered With Either Artemether + Lumefantrine or Dihydroartemisinin + Piperaquine Tetraphosphatetreatment1completed
NCT03337152
Assessing a Risk Model for G6PD Deficiencytreatment4terminated
NCT00951106
Therapeutic Efficacy Study of Pyrimethamine/Sulfdoxine (Fansidar®) for the Treatment of Uncomplicated Falciparum Malaria in the Peruvian AmazontreatmentNot Availablecompleted
NCT04739917
Efficacy of a Synthetic Vaccine Derived From Plasmodium Vivax Circumsporozoite Protein (PvCS) in naïve and Semi-immune VolunteersNo drug interventionsprevention2unknown_status
NCT03377296
Study of Controlled Human Plasmodium Vivax InfectionNo drug interventionsotherNot Availablecompleted
NCT02563496
A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malariatreatment2completed
NCT02658435
Assessment of Any Potential Retinal Effects of Tafenoquine (TQ)treatment1completed
NCT01213966
Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-infectiontreatment2completed
NCT05270265
Safety and Immunogenicity of Pvs25-IMX313/Matrix-M1 Vaccineprevention0terminated
NCT03797989
VAC069: A Study of Blood-stage Controlled Human P. Vivax InfectionNo drug interventionsother0unknown_status
NCT04709692
Efficacy of SJ733 in Adults With Uncomplicated Plasmodium Falciparum or Vivax Malariatreatment2completed
NCT01376167
Ph 2B/3 Tafenoquine (TFQ) Study in Prevention of Vivax Relapsetreatment2completed
NCT02802501
Efficacy and Safety Study of Tafenoquine (TQ) Co-administered With Dihydroartemisinin-piperaquine (DHA-PQP) for the Radical Cure of Plasmodium Vivax (P. Vivax) Malariatreatment3completed
NCT02691910
Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine for Plasmodium Vivax Infectiontreatment2 / 3completed
NCT02216123
Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malariatreatment3completed