Hemangiomas (DBCOND0034319)

Identifiers

Synonyms

Haemangioma / Hemangioma / Hemangioma unspecified site / Benign hemangioma (morphologic abnormality) / Hemangioma of unspecified site / Haemangioma of unspecified site / Hemangioma NOS / Haemangioma NOS / Hemangioma (disorder) / Cavernoma / Strawberry nevus of skin (disorder) / Haemangioma cavernous / Hemangioma cavernous / Hemangioma, Cavernous / Cavernous hemangioma (morphologic abnormality) / Cavernous hemangioma (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Propranolol	A non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.	Beta-1 adrenergic receptortarget Beta-2 adrenergic receptortarget Beta-3 adrenergic receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 1Btarget Cytochrome P450 1A2enzyme Cytochrome P450 2D6enzyme Alpha-1-acid glycoprotein 1carrier Cytochrome P450 2C19enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Amine oxidase [flavin-containing] Aenzyme Albumincarrier
Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.	Corticosteroid-binding globulincarrier Glucocorticoid receptortarget Cytochrome P450 3A4enzyme Prostaglandin G/H synthase 2enzyme Cholinesteraseenzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Albumincarrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02156700	Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors	No drug interventions	Not Available	Not Available	completed
NCT02145884	Topical Timolol Gel for the Treatment of Infantile Hemangiomas	Timolol	treatment	2	completed
NCT04836884	Vascular Anomaly Pathology and Genomics Biopsy Study	No drug interventions	basic_science	Not Available	completed
NCT02731287	Topical Timolol for Infantile Hemangioma in Early Proliferative Phase	Timolol	treatment	2	completed
NCT01685398	Topical Timolol for Superficial Infantile Hemangioma	Timolol Water	treatment	3	completed
NCT00394888	Hemangioma Associated With High Rates of Morbidity	No drug interventions	screening	Not Available	completed
NCT00490607	A Prospective Study Comparing the Incidence of Infantile Hemangiomas Following Normal Pregnancies Versus Pregnancies Complicated by Placental Abnormalities	No drug interventions	Not Available	Not Available	unknown_status
NCT05327309	Role of Propranolol as Compared to Bleomycin in Management of Hemangioma	Bleomycin Propranolol	treatment	Not Available	completed
NCT04077515	Safety and Efficacy of Low-dose Sirolimus to Kaposiform Hemangioendothelioma	Sirolimus	treatment	4	completed
NCT02342275	Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma	Atenolol Propranolol	treatment	3	completed
NCT00004436	Randomized Study of Hormonal Regulation of Infantile Hemangioma	Leuprolide Prednisone	treatment	Not Available	completed
NCT02496013	Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB	Evans blue	diagnostic	1	unknown_status
NCT04020419	Natural Berry Extract Treatment of Hemangiomas	No drug interventions	treatment	0	terminated
NCT04065217	The Effectiveness of Diode Laser 980-nm in Iraqi Face Hemangioma: a Randomized Within Patients Trial	No drug interventions	treatment	Not Available	completed
NCT00001417	Direct Injection of Alcohol for the Treatment of Spinal Tumors	No drug interventions	Not Available	Not Available	completed
NCT01598116	A Prospective Longitudinal Study to Identify Biomarkers in Children With Hemangiomas	No drug interventions	Not Available	Not Available	completed
NCT00374335	Incidence of Hepatic Hemangiomatosis in Patients With Cutaneous Hemangiomas	No drug interventions	screening	Not Available	completed
NCT02334930	Evaluation of New Biomarkers Predictive of Efficacy Betablockers in PEComa and Vascular Pediatric Tumors	No drug interventions	Not Available	Not Available	completed
NCT01873131	A Clinical Trial of Pulsed-dye Laser Versus Timolol Topical Solution Versus Observation on the Growth of Hemangioma in Newborn	Timolol	prevention	Not Available	recruiting
NCT00974129	A Study of CCCTC-binding Factor (CTCF) in Infantile Hemangiomas	No drug interventions	Not Available	Not Available	withdrawn
NCT03331744	Clinical Characteristics of Infantile Hemangioma	No drug interventions	Not Available	Not Available	recruiting
NCT01147601	Topical Timolol 0.5% Solution for Proliferating Infantile Hemangiomas	Timolol	treatment	0	terminated
NCT00555464	Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas	Prednisolone phosphate Prednisone Vincristine	treatment	2	terminated
NCT02351245	Clinical Characteristics of Lip Hemangiomas	No drug interventions	Not Available	Not Available	unknown_status
NCT01072045	Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma	Methylprednisolone Prednisone Propranolol	treatment	2	completed
NCT01743885	Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma	Acebutolol Propranolol	treatment	3	terminated
NCT01074437	Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)	Prednisolone Propranolol	treatment	2	terminated
NCT00540566	Optical Biopsy of Human Skin in Conjunction With Laser Treatment	No drug interventions	Not Available	Not Available	completed
NCT01211080	Off Label Use of Propranolol for Infancy Hemangiomas	Propranolol	Not Available	Not Available	completed
NCT00433940	Immune Suppression Of Infants Treated With Steroids	Prednisolone	Not Available	Not Available	completed
NCT01908972	The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma	Prednisolone Propranolol	treatment	4	completed
NCT00866827	Airway Vascular Lesions	No drug interventions	Not Available	Not Available	completed
NCT00576888	Registry for Vascular Anomalies Associated With Coagulopathy	No drug interventions	Not Available	Not Available	completed
NCT00577213	Diagnosis of Hemangiomas and Vascular Malformations	No drug interventions	Not Available	Not Available	completed
NCT00312520	Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy	Methylprednisolone Prednisolone	treatment	3	completed