Focal Segmental Glomerulosclerosis (FSGS) (DBCOND0038485)

Identifiers

Synonyms
Focal Glomerulosclerosis / Glomerulosclerosis, Focal / Focal Segmental Glomerulosclerosis / Glomerulosclerosis, Focal Segmental / APOL1-mediated focal segmental glomerulosclerosis / Focal & segmental glomerulosclerosis / Focal glomerular sclerosis (disorder) / Focal segmental glomerulosclerosis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Cyclosporine
A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03448692
A Study to Evaluate PF-06730512 in Adults With Focal Segmental Glomerulosclerosis (FSGS)No drug interventionstreatment2terminated
NCT05955872
A Study Evaluating the Relative Bioavailability and Food Effect of a Tablet Formulation of VX-147No drug interventionstreatment1completed
NCT00550342
Rituximab Treatment of Focal Segmental Glomerulosclerosistreatment2completed
NCT00001959
Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis)treatment2completed
NCT00302536
Tacrolimus Treatment of Patients With Idiopathic Focal Segmental GlomerulosclerosistreatmentNot Availablewithdrawn
NCT00193648
Pilot Studies of Novel Therapies to Treat Resistant Focal Segmental Glomerulosclerosis (FSGS)treatment1completed
NCT00040508
Sirolimus for Focal Segmental Glomerulosclerosistreatment2completed
NCT00404833
Mycophenolate Mofetil in Membranous Nephropathy and Focal Segmentaltreatment3completed
NCT00353535
Total Lymphoid Irradiation (TLI) to Prevent Focal Segmental Glomerulosclerosis (FSGS)Recurrence in the Renal GraftNo drug interventionstreatment1completed
NCT00135811
Focal Segmental Glomerulosclerosis Clinical Trial (FSGS-CT)treatment3completed
NCT01240564
The Nephrotic Syndrome Study Network (NEPTUNE)No drug interventionsNot AvailableNot Availablerecruiting
NCT00464321
Safety Study of GC1008 in Patients With Focal Segmental Glomerulosclerosis (FSGS) of Single Doses of GC1008 in Patients With Treatment Resistant Idiopathic FSGStreatment1completed
NCT06500702
A Study to Evaluate the Efficacy and Safety of Frexalimab, SAR442970, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Diseasetreatment2not_yet_recruiting
NCT00001393
Genetic Markers for Focal Segmental GlomerulosclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03493685
Study of Sparsentan in Patients With Primary Focal Segmental Glomerulosclerosis (FSGS)treatment3active_not_recruiting
NCT06065852
National Registry of Rare Kidney DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT00956059
Therapeutic Effect of Low-dose Prednisone Combined With MMF and FK506 in Focal Segmental GlomerulosclerosistreatmentNot Availableunknown_status
NCT00007475
Permeability Factor in Focal Segmental Glomerulosclerosistreatment1 / 2completed
NCT02896270
Valproic Acid for Idiopathic Nephrotic Syndrometreatment2 / 3unknown_status
NCT01613118
Randomized, Double-Blind, Safety and Efficacy Study of RE-021 (Sparsentan) in Focal Segmental Glomerulosclerosistreatment2completed
NCT05650619
Recurrence Post-transplant Observational Study in Focal Segmental Glomerulosclerosis and Minimal Change DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT04571658
NEPTUNE Match StudyNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT05588063
taVNS for FRNS in ChildrenNo drug interventionstreatmentNot Availablerecruiting
NCT05942625
A First in Human Study to Evaluate Safety, Tolerability, Pharmacology of HS-10390 in Healthy SubjectsNo drug interventionstreatment1recruiting
NCT02235857
Post Approval Study of Liposorber LA-15 System for the Treatment of Focal Segmental Glomerulosclerosis in ChildrenNo drug interventionstreatmentNot Availablerecruiting
NCT05441826
Efficacy and Safety of VB119 in Subjects With Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS)treatment2terminated
NCT02382874
Allogenic AD-MSC Transplantation in Idiopathic Nephrotic Syndrome (Focal Segmental Glomerulosclerosis)No drug interventionstreatment1unknown_status
NCT04573920
Atrasentan in Patients With Proteinuric Glomerular Diseasestreatment2active_not_recruiting
NCT02194582
Genetic Causes of FSGS, Nephrotic Syndrome, or Kidney FailureNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06090227
AMPK-activation by Metformin in FSGS: AMP-FSGStreatment1 / 2recruiting
NCT05267262
Study to Evaluate R3R01 in Patients With Alport Syndrome and Patients With Focal Segmental Glomerulosclerosistreatment2recruiting
NCT02585804
Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effectstreatment4completed
NCT04065438
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 SystemNo drug interventionstreatmentNot Availablerecruiting
NCT03763643
PRI-VENT FSGS: Preemptive Rituximab to Prevent Recurrent Focal Segmental Glomerulosclerosis Post-Transplantprevention0recruiting
NCT03929887
KOrea Renal Biobank NEtwoRk System TOward NExt-generation AnalysisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03536754
A Study of CCX140-B in Subjects With FSGStreatment2completed
NCT03298698
Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrometreatment3unknown_status
NCT00255398
Kidney Disease BiomarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT02592798
Pilot Study to Evaluate the Safety and Efficacy of Abatacept in Adults and Children 6 Years and Older With Excessive Loss of Protein in the Urine Due to Either Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD)treatment2completed
NCT04369183
Rituximab for Refractory or Relapsed Focal Segmental Glomerulosclerosis or Minimal Change DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT00782561
Safety and Pharmacokinetics of FG-3019 in Adolescents and Adults With Focal Segmental Glomerulosclerosis (FSGS)treatment1terminated
NCT05200871
Humanistic Burden of (FSGS) Focal Segmental Glomerulosclerosis and IgAN (Immunoglobulin A Nephropathy)No drug interventionsNot AvailableNot Availablecompleted
NCT00816478
Effect of Oral Galactose on Focal Segmental Glomerulosclerosis (FSGS) Permeability Factortreatment1terminated
NCT01113385
Oral Galactose in Children With Steroid Resistant Nephrotic SyndrometreatmentNot Availablecompleted
NCT03366337
A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases - PHOENIXtreatment2completed
NCT03649152
Safety and Effectiveness of Propagermanium in Focal Segmental Glomerulosclerosis Participants Receiving Irbesartantreatment2completed
NCT01370200
Regional Citrate Anticoagulation in Plasma Exchange TreatmentNo drug interventionstreatmentNot Availablecompleted
NCT05583942
A Pilot Trial of taVNS for SRNS in Children (kidNEY-VNS)No drug interventionstreatmentNot Availablerecruiting
NCT04088799
LDL-Apheresis for FSGS CardioRenal OutcomesNo drug interventionsNot AvailableNot Availablecompleted
NCT03598036
Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosistreatment2terminated
NCT00883636
Cardiomyopathy in Steroid-resistant Nephrotic Syndrome: Impact of Focal Segmental GlomerulosclerosisNo drug interventionsNot AvailableNot Availableterminated
NCT06443034
Predictive Determinants of Nephrotic Syndrome Remission in Patients With At-risk Polymorphism of APOL1No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00801463
Prednisone Plus Tripterygium Wilfordii Treatment of Adult Patients With Idiopathic Focal Segmental GlomerulosclerosistreatmentNot Availablecompleted
NCT05003986
Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseasestreatment2recruiting
NCT01129557
Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Diseasetreatment4terminated
NCT02693366
Stem Cell Therapy for Patients With Focal Segmental GlomerulosclerosisNo drug interventionstreatment1completed
NCT03126201
Predictors of Disease Progression in Primary Focal Segmental GlomerulosclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00816504
Effect of Galactose on Permeblity Factor in Patients With FSGS and CKD Stage 5treatment1withdrawn
NCT04009668
Tumor Necrosis Factor Inhibition in Focal Segmental Glomerulosclerosis and Treatment Resistant Minimal Change Diseasebasic_science2completed
NCT06162546
ARREST-NEPHROSIS - Austrian Resistant Nephrotic Syndrome Treatment Response Registry and BiobankNo drug interventionsNot AvailableNot Availablerecruiting
NCT00814255
Novel Therapies for Resistant FSGS (FONTII): Phase II Clinical Trialtreatment2completed
NCT03703908
A Study of CCX140-B in Subjects With Primary FSGS and Nephrotic Syndrometreatment2terminated
NCT01209000
Nephrotic Syndrome Study NetworkNo drug interventionsNot AvailableNot Availablerecruiting
NCT05505500
Interview Study of Adult and Child Patients and Parents of Children With Swelling Due to Nephrotic Syndrome.No drug interventionsNot AvailableNot Availablerecruiting
NCT02000440
A Phase II, Repeat Dose, Proof of Mechanism Study of Losmapimod to Reduce Proteinuria in Patients With Focal Segmental Glomerulosclerosis (FSGS)treatment2completed
NCT03949972
The FOrMe Registry (The German Focal Segmental Glomerulosclerosis and Minimal Change Disease Registry)No drug interventionsNot AvailableNot Availablerecruiting
NCT04235621
A Study to Understand the Genetics and Clinical Course of Focal Segmental Glomerulosclerosis (FSGS), Treatment-Resistant Minimal Change Disease (TR-MCD), and Diabetic Nephropathy (DN)No drug interventionsNot AvailableNot Availableterminated
NCT04387448
A Study of TRPC5 Channel Inhibitor in Patients With Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, and Treatment-Resistant Minimal Change DiseaseNo drug interventionstreatment2terminated
NCT00098020
Podocyte Retinoidstreatment2completed
NCT04340362
Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental GlomerulosclerosisNo drug interventionstreatment2completed