Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia (CML) (DBCOND0052580)

Identifiers

Synonyms
Chronic Myeloid Leukemia (CML) With Philadelphia Chromosome-positive (Ph+) / Ph1 Positive CML / Philadelphia Chromosome-Positive Chronic Myeloid Leukemia / Leukemia, Myeloid, Chronic, BCR-ABL Positive / BCR-ABL1 Positive Chronic Myelogenous Leukemia / Chronic Myeloid Leukemia (CML) Philadelphia Chromosome Positive / Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia / Philadelphia Positive (Ph+) Chronic Myeloid Leukemia / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Philadelphia Chromosome Positive CML / CML - Philadelphia Chromosome / BCR-ABL Positive Chronic Myelogenous Leukemia / Philadelphia Chromosome Positive Chronic Myelogenous Leukemia / Chronic Myelogenous Leukemia, BCR/ABL Positive / Chronic Myelogenous Leukemia, BCR-ABL Positive / Chronic Myelogenous Leukemia, BCR-ABL1 Positive / Chronic Myeloid Leukemia, BCR/ABL-Positive / Philadelphia Positive Chronic Myeloid Leukemia / Leukemia,Myeloid,Philadelphia-Positive / Leukemia, Myeloid, Philadelphia-Positive / Myeloid Leukemia, Philadelphia Positive / Philadelphia-Positive Myeloid Leukemia / Chronic myeloid leukaemia / Leukemia myelocytic chronic / Leukaemia myelocytic chronic / Chronic granulocytic leukaemia / Chronic myelogenous leukaemia / Myeloid leukemia, chronic / Chronic myelogenous leukemia / Chronic granulocytic leukemia / Myeloid leukaemia, chronic / CML / Chronic myelocytic leukaemia / Chronic myelocytic leukemia / Chronic myeloid leukemia / Leukaemias chronic myeloid / Chronic myeloid leukemia (disorder) / Chronic myeloid leukemia (morphologic abnormality) / Chronic myeloid leukemia, BCR/ABL-positive, not having achieved remission / Philadelphia positive chronic myeloid leukaemia

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01221376
Phase II Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Chronic Myeloid Leukemia (CML) Philadelphia Chromosome-positive (Ph+)treatment2unknown_status
NCT01374139
Bioequivalence And Food Effect Study Of Bosutinib In Healthy Subjectstreatment1completed
NCT01159028
Clinical Trial of BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDStreatment1completed
NCT05456191
A Study to Investigate Tolerability and Efficacy of Asciminib (Oral) Versus Nilotinib (Oral) in Adult Participants (≥18 Years of Age) With Newly Diagnosed Philadelphia Chromosome Positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP)treatment3active_not_recruiting
NCT01819389
Low-dose Nilotinib and Imatinib Combination in Chronic Myeloid Leukemia Patients, With Failure, Suboptimal Response or Treatment Intolerancetreatment3completed
NCT05007873
ASTX727 and Dasatinib for the Treatment of Newly Diagnosed Philadelphia Chromosome or BCR-ABL Positive Chronic Myeloid Leukemia in Chronic Phasetreatment2recruiting
NCT04971226
A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CPtreatment3active_not_recruiting
NCT01844765
Open Label, Phase II Study to Evaluate Efficacy and Safety of Oral Nilotinib in Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML) Pediatric Patients.treatment2completed
NCT02115386
Trial to Evaluate the Improvement of Chronic Low-grade AEs in Patients With Ph+ CML With Optimal Response to Imatinib When Switched to Nilotinibtreatment3terminated
NCT04877522
Asciminib Roll-over Studytreatment4recruiting
NCT01437202
Pharmacogenomics Validation for Imatinib in Chronic Myeloid LeukemiaNo drug interventionsNot AvailableNot Availablecompleted
NCT02903277
National Observatory of Chronic Myeloid Leukemia Adolescent and Young Adults Treated With Tyrosine Kinase Inhibitors in First IntentNo drug interventionsNot AvailableNot Availableunknown_status
NCT01464411
Dasatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia in JapanNo drug interventionsNot AvailableNot Availableunknown_status
NCT02896842
A Prospective Randomized Phase II Study Evaluating the Monitoring of Imatinib Mesylate Plasmatic Through Level in Patients Newly Diagnosed With CP-CMLNo drug interventionstreatment2completed
NCT01774630
Multicenter Single-arm Pilot Study Evaluating Efficacy of Nilotinib in CML Patients With Molecular Relapse After Glivec Discontinuation Within the Context of the STIM Trials (STIM and STIM2)treatment2completed
NCT02885766
Study to Evaluate Tolerability, Safety, Pharmacokinetics and Preliminary Efficacy of PF-114 for Oral Administration in Adults With Ph+ Chronic Myeloid Leukemia, Which is Resistant to the 2-nd Generation Bcr-Abl Inhibitors or Has T315I Mutation in the BCR-ABL Genetreatment1 / 2unknown_status
NCT01768689
Interventional Study to Improve Adherence to Tyrosine Kinase Inhibitors in Chronic Myeloid LeukemiaNo drug interventionstreatmentNot Availablecompleted
NCT02389972
Effectiveness of Dasatinib in Adult Patients With Chronic Myeloid Leukemia in China: A Multicenter, Registry StudyNot AvailableNot Availablecompleted
NCT00171223
An Extension Study to Determine the Efficacy and Safety of STI571 in Participants With Chronic Myeloid Leukemia Who Are Refractory to or Intolerant of Interferon-Alphatreatment2completed
NCT03090477
Impact of a Pharmaceutical Care Model in the Management of Chronic Myeloid Leukemia PatientsNo drug interventionshealth_services_researchNot Availablecompleted
NCT01602952
Philadelphia Chromosome Positive CML Patients Without Optimal Response or Tolerance to Bcr-Abl TKItreatment1 / 2completed
NCT02687425
Safety and Efficiency Study of Pioglitazone in Combination With Imatinib Mesylate to Treat Chronic Myelogenous Leukemiatreatment2unknown_status
NCT02421926
Extension Study of IDEAL (Imatinib) for Chronic Myelgenous Leukemia (CML)Not AvailableNot Availablewithdrawn
NCT01511289
Radotinib Versus Imatinib in Newly Diagnosed Philadelphia Chromosome and Chronic Myeloid Leukemia Chronic Phase Patientstreatment3completed
NCT02480608
Treatment of CML Patients With Imatinib and Hydroxyurea (CML2004)treatment1 / 2completed
NCT04258943
Bosutinib in Pediatric Patients With Newly Diagnosed Chronic Phase or Resistant/Intolerant Ph + Chronic Myeloid Leukemiatreatment1 / 2active_not_recruiting
NCT04070443
Safety and Efficacy of Ponatinib Followed by Imatinib in Patients With Chronic Myelogenous Leukemia in Chronic Phasetreatment2active_not_recruiting
NCT03241199
The Efficacy and Safety of Induction-Maintenance Protocol for Patients With Chronic Myelogenous Leukaemiatreatment2unknown_status
NCT00171158
An Extension Study of the Safety and Anti-leukemic Effects of Imatinib Mesylate in Participants With Philadelphia Chromosome-positive Chronic Myeloid Leukemia in Blast Crisistreatment2completed
NCT03459534
A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIstreatment3recruiting
NCT03885830
Precision Dosing of Tyrosine Kinase Inhibitors in CML PatientsNot AvailableNot Availablecompleted
NCT04578847
A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib)treatment2active_not_recruiting
NCT01456676
Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapytreatment1completed
NCT01916785
OPTIM DASATINIB (Optimized Tyrosine Kinase Inhibitors Monotherapy)treatment2completed
NCT04883125
Value of Using Pioglitazone in Chronic Myeloid Leukemia Treatmenttreatment2completed
NCT00316953
Dasatinib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Did Not Respond to Imatinib Mesylatetreatment1completed
NCT00003145
Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Peripheral Blood Stem Cell Transplant Followed by Donor Lymphocyte Infusion in Treating Older Patients With Chronic Myeloid Leukemiatreatment2completed
NCT00096161
Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplanttreatment2completed
NCT00101088
Temsirolimus and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemiatreatment1terminated
NCT03622788
Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplanttreatment1 / 2recruiting
NCT00719888
Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Diseasetreatment2active_not_recruiting
NCT00025415
Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunctiontreatment1completed
NCT00351975
Belinostat and Azacitidine in Treating Patients With Advanced Hematologic Cancers or Other Diseasestreatment1completed
NCT01426334
Dasatinib and Cyclosporine in Treating Patients With Chronic Myelogenous Leukemia Refractory or Intolerant to Imatinib Mesylatetreatment1terminated
NCT02210858
Tipifarnib in Treating Patients With Chronic Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or Undifferentiated Myeloproliferative Disorderstreatment1 / 2completed
NCT03267186
Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplanttreatment2completed
NCT03333486
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancertreatment2active_not_recruiting
NCT01751425
Ruxolitinib in Treating Participants With Chronic Myeloid Leukemia With Minimal Residual Disease While on Therapy With Tyrosine Kinase Inhibitorstreatment1terminated
NCT00023920
Bevacizumab, Idarubicin, and Cytarabine in Treating Patients With Blast Phase Chronic Myelogenous Leukemiatreatment2terminated
NCT03399773
Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromestreatment2recruiting
NCT00003694
Homoharringtonine Plus Low-Dose Cytarabine in Treating Patients With Newly Diagnosed Chronic Myelogenous Leukemia in Chronic Phasetreatment2completed
NCT00030394
Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemiatreatment2completed
NCT01445080
Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemiatreatment1 / 2completed
NCT00049192
Oblimersen and Imatinib Mesylate in Treating Patients With Chronic Myelogenous Leukemiatreatment2completed
NCT01858740
Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Childrentreatment2completed
NCT00060372
Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancertreatment1completed
NCT00796068
Treosulfan, Fludarabine Phosphate, and Total-Body Irradiation in Treating Patients With Hematological Cancer Who Are Undergoing Umbilical Cord Blood Transplanttreatment2completed
NCT02730195
Pioglitazone and Tyrosine Kinase Inhibitor in Treating Patients With Relapsed Chronic Myeloid Leukemiatreatment2terminated
NCT00036738
Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinibtreatment2completed
NCT04282343
DISCO Application for the Improvement of Financial Outcomes in Patients With Hematologic CancerNo drug interventionshealth_services_researchNot Availablecompleted
NCT00702403
Nilotinib and Imatinib Mesylate After Donor Stem Cell Transplant in Treating Patients With ALL or CMLtreatment1 / 2completed
NCT00006364
Homoharringtonine in Treating Patients With Chronic Phase Chronic Myelogenous Leukemiatreatment2completed
NCT01670084
Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia or Blastic Phase Chronic Myelogenous Leukemiatreatment2withdrawn
NCT05972577
Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS StudyNo drug interventionssupportive_careNot Availableactive_not_recruiting
NCT03128359
High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplantsupportive_care2completed
NCT04083170
Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancerstreatment2terminated
NCT03739606
Flotetuzumab in Treating Patients With Recurrent or Refractory CD123 Positive Blood Cancertreatment2withdrawn
NCT00015834
STI571 Plus Cytarabine in Treating Patients With Chronic Myelogenous Leukemiatreatment1 / 2completed
NCT04694820
A Mobile Intervention (txt4TKI) for the Improvement of Tyrosine Kinase Inhibitor Management in Patients With Chronic Myeloid LeukemiaNo drug interventionssupportive_careNot Availablecompleted
NCT03096782
Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphomatreatment2completed
NCT02877082
Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant Patientsprevention2terminated
NCT00054431
Imatinib Mesylate and Decitabine in Treating Patients With Chronic Myelogenous Leukemiatreatment2completed
NCT03630991
Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapytreatment1recruiting
NCT03941769
2018-0674 - IL-7 for T-Cell Recovery Post Haplo and CB Transplant - Phase I/IIsupportive_care1 / 2completed
NCT03195010
Management of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced ThrombocytopeniaNo drug interventionssupportive_care2terminated
NCT01789255
Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignanciessupportive_care2completed
NCT01760655
Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignanciestreatment2completed
NCT02734823
Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal TumorNo drug interventionsNot AvailableNot Availablewithdrawn
NCT06409936
PEARL Study: PotEntial of Asciminib in the eaRly Treatment of CMLtreatment2not_yet_recruiting
NCT05439889
Follow-up Study on Chronic Myeloid Leukemia Patients Achieving Treatment-free RemissionNo drug interventionsNot AvailableNot Availablerecruiting
NCT05413915
Asciminib Used in Consolidation With Imatinib vs. Imatinib to Achieve TFR in CP-CMLtreatment3recruiting
NCT00171249
An Extension Study to Determine the Safety and Anti-Leukemic Effects of Imatinib Mesylate in Adult Participants With Ph+ Leukemiatreatment2completed
NCT00027144
Study Using Vaccination With Heat Shock Protein 70 (HSP70) for the Treatment of CML in Chronic PhaseNo drug interventionstreatment1completed
NCT00037882
PEG-Intron For Chronic Myelogenous Leukemia Patients Unresponsive To Or Intolerant Of Roferon Or Introntreatment2terminated
NCT00297570
Imatinib Versus Imatinib and Peg-Interferon in Patients With Ph+ CML and Complete Cytogenetic Response After Imatinib Therapytreatment3unknown_status
NCT04925479
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid Leukemiatreatment1 / 2recruiting
NCT00101660
Study of BMS-354825 (Dasatinib) in Patients With Chronic Myeloid Leukemia Who Are Either Resistant or Intolerant to Imatinibtreatment2completed
NCT00103844
Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemiatreatment2completed