Acute Exacerbation of Chronic Bronchitis (AECB) (DBCOND0037906)
Identifiers
- Synonyms
- Acute Exacerbations of Chronic Bronchitis / Acute Exacerbation of Chronic Bronchitis / Acute episodes of chronic bronchitis / Acute exacerbation of chronic bronchitis NOS / Acute exacerbation of chronic bronchitis (disorder) / Acute on chronic bronchitis / Chronic obstructive pulmonary disease with (acute) exacerbation / Acute exacerbation of chronic obstructive airways disease (disorder) / Bronchitis NOS / Bronchitis / Bronchitis (disorder)
Associated Data
- Indicated Drugs and Targets
Drug Description Targets Aminophylline A bronchodilator consisting of theophylline that is used for the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3Atarget
- Adenosine receptor A3target
- Adenosine receptor A1target
- Cytochrome P450 1A2enzyme
- Cytochrome P450 2E1enzyme
- Cytochrome P450 3A4enzyme
- Histone deacetylase 2target
Amoxicillin A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections.- Solute carrier family 15 member 1transporter
- Solute carrier family 15 member 2transporter
- Solute carrier family 22 member 6transporter
- Cytochrome P450 2C8enzyme
- Albumincarrier
- Beta-lactamase 2enzyme
- Penicillin binding proteintarget
Cefdinir A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections.- Myeloperoxidasetarget
- Penicillin-binding protein 2target
- PBP3target
- Organic cation/carnitine transporter 2transporter
- Solute carrier family 15 member 1transporter
- Solute carrier family 15 member 2transporter
- Solute carrier family 22 member 6transporter
- Organic anion transporter 3transporter
- Peptidoglycan transpeptidasetarget
Dirithromycin An antibiotic used to treat a variety of respiratory, skin, and other infections.- 23S ribosomal RNAtarget
- Cytochrome P450 3A4enzyme
Etafedrine A beta-2 adrenoceptor agonist used to treat a cough associated with inflamed mucosa.Moxifloxacin A fluoroquinolone antibiotic used to treat various bacterial infections.- DNA gyrase subunit Atarget
- DNA topoisomerase 4 subunit Atarget
- DNA topoisomerase 2-alphatarget
- Cytochrome P450 1A2enzyme
- Serum paraoxonase/arylesterase 1target
- DNA gyrase subunit Atarget
- DNA gyrase subunit Btarget
- Clinical Trials
Identifier Title Drug(s) Purpose Phase Status NCT00546676 Ketek in CAP / AECB in Ambulatory Adult Patients treatment 4 completed NCT02157571 A Multi-center, Randomized, Double-blind, Double-dummy Clinical Study to Evaluate the Safety and Efficacy of Prulifloxacin Film-coated Tablet for the Treatment of Acute Exacerbations of Chronic Bronchitis With Levofloxacin Hydrochloride Tablet as Active Control treatment 3 unknown_status NCT02250027 A Multicenter, Randomized, Double-blind, Parallel Group Study to Determine the Optimal Dose of HL301 After 7 Days Oral Administration in Acute Bronchitis or Acute Exacerbations of Chronic Bronchitis Patients (HL301: Mixed Extract of Rehmannia Glutinosa, Schisandra and so on) treatment 2 completed NCT01979926 Comparative Evaluate the Efficacy to Acute and Chronic Bronchitis No drug interventions treatment 2 completed NCT03400735 Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults treatment 4 unknown_status NCT03132610 A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis treatment 4 unknown_status