Acute Exacerbation of Chronic Obstructive Pulmonary Disease (DBCOND0068835)

Identifiers

Synonyms
Acute Exacerbations of COPD / Acute COPD Exacerbation / Acute Exacerbation of COPD / Acute Exacerbation Chronic Obstructive Pulmonary Disease / Copd Exacerbation Acute / Acute Exacerbation COPD / COPD Acute Exacerbation / Acute exacerbation of chronic obstructive pulmonary disease / Chronic obstructive pulmonary disease with (acute) exacerbation / Acute exacerbation of chronic obstructive airways disease (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Prednisone
A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT03556475
Development of AECOPD Identification Tool (DETECT Study)No drug interventionsNot AvailableNot Availablecompleted
NCT05497986
Conventional Low Flow Oxygenation Versus High Flow Nasal Cannula in Hypercapnic Respiratory FailureNo drug interventionstreatmentNot Availableunknown_status
NCT06538376
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICUNo drug interventionsdiagnosticNot Availablerecruiting
NCT05854901
PCT-guided Treatment Regarding Antibiotic Use for Acute COPD ExacerbationsNo drug interventionsdiagnosticNot Availablerecruiting
NCT06461403
Inhaler Trainer Efficacy StudyNo drug interventionsotherNot Availablenot_yet_recruiting
NCT05539547
Effect of NMES on Quadriceps Muscle Strength and Endurance in Patients With COPDNo drug interventionsprevention0unknown_status
NCT05280132
Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter TrialNo drug interventionstreatmentNot Availablerecruiting
NCT05286918
Antibiotic Stewardship in AECOPD Through CRP-Guided ManagementNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06084117
High Flow Nasal Oxygen for Exacerbation COPDNo drug interventionsotherNot Availablerecruiting
NCT06014034
Randomized Controlled Study of Programmed Weaning From Noninvasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT04843696
Negative Pressure Ventilation-rehabilitation on Acute Exacerbation of Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT04640948
High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory FailureNo drug interventionstreatmentNot Availableunknown_status
NCT05480566
Functional Strength Training and Neuromuscular Electrical Stimulation in Severe Acute Exacerbations of COPDtreatmentNot Availablerecruiting
NCT05059873
Treatment Efficacy of Systemic Corticosteroids in AECOPD Patients With Higher Blood Eosinophil Levelstreatment4terminated
NCT04538976
Copd Exacerbation and Pulmonary Hypertension Trialtreatment4recruiting
NCT04414891
Non Invasive Ventilation With NAVA vs ASV for AECOPDNo drug interventionstreatmentNot Availablecompleted
NCT04147104
ecco2R to facilitatE earLy libEration From mechanicAl Ventilation inpatientS With Copd Acute ExacerbationNo drug interventionstreatmentNot Availableunknown_status
NCT05019911
Prediction of Exacerbations and Management of COPD Patients With SAH Based on Millimeter Wave Radar MonitoringNo drug interventionsNot AvailableNot Availableunknown_status
NCT05504993
Are Comorbidities Related to Frequent Severe Exacerbations of AECOPDNo drug interventionsNot AvailableNot Availablecompleted
NCT05563493
Effects of Chair-Based Exercise Training on Exercise Capacity in Patients With Acute Exacerbation of COPDNo drug interventionssupportive_careNot Availablecompleted
NCT05209607
Social Media-based Bundle Care of AECOPD Patients.No drug interventionssupportive_care4not_yet_recruiting
NCT03077152
Patient Factors Associated With Prescription of Antibiotics for Inappropriate Indication in Patients With AECOPDNo drug interventionsNot AvailableNot Availablecompleted
NCT04448236
Effect of Blood Flow Restriction Resistance Exercises in COPDAE In-patient RehabilitationNo drug interventionstreatmentNot Availablecompleted
NCT03255057
Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPDNo drug interventionstreatmentNot Availableterminated
NCT04098094
Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT02114567
Is it Necessary to Set External PEEP in AECOPD PatientsNo drug interventionsbasic_scienceNot Availablecompleted
NCT06242301
Is a Collective Person-centered Dialogue Intervention for Hospitalised COPD Patients Feasible?No drug interventionssupportive_careNot Availablecompleted
NCT06021990
Clopidogrel for the Prevention of Exacerbations in Severe COPDtreatment3recruiting
NCT05012033
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic SettingNo drug interventionsNot AvailableNot Availablerecruiting
NCT05764993
Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Preventionprevention2recruiting
NCT03984188
Effectiveness of Low-Dose Theophylline for the Management of Biomass-Associated COPDtreatment3completed
NCT04881409
Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation of Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT06514599
CRP, Procalcitonin and Pro-BNP as Diagnostic and Prognostic Markers in AECOPDNo drug interventionsNot AvailableNot Availablecompleted
NCT03661086
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPDNo drug interventionstreatmentNot Availablecompleted
NCT05218525
Testing a Prediction Algorithm Into a Running Telehealth System for Patients With COPDNo drug interventionstreatmentNot Availablecompleted
NCT04879030
Combination Antibiotic Therapy Compared to Monotherapy in the Treatment of Acute COPDtreatment2 / 3completed
NCT06211920
Prehospital Non-invasive Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT06149494
RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory InfectionNo drug interventionstreatment2recruiting
NCT05182294
Tolerance and Acute Effects of a New HFNT Nasal CannulaNo drug interventionsotherNot Availablecompleted
NCT05783544
Impact of A. Lumbricoides on Pulmonary Aspergillosis DevelopmentNo drug interventionspreventionNot Availablerecruiting
NCT06178068
Comparison of Bronchodilator Treatment Practices in Group E COPD PatientsNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04882410
Extracorporeal CO2 Removal in Acute Exacerbation of COPD Not Responding to Non-Invasive VentilationNo drug interventionsNot AvailableNot Availablecompleted
NCT03680495
Steroid Resistance During COPD Exacerbations With Respiratory FailureNot AvailableNot Availableunknown_status
NCT05568043
The Reducing REVISITS Study: A Cluster RCTNo drug interventionspreventionNot Availablerecruiting
NCT05095090
Study of Hospitalised Patients With Acute Respiratory ConditionsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06160687
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPDNo drug interventionstreatmentNot Availablerecruiting
NCT06221033
Comparing the Effects of Manual Hyperinflation and Diaphragmatic Proprioceptive Neuromuscular Facilitation on Pulmonary Functions in Patients on Mechanical VentilationNo drug interventionstreatmentNot Availablerecruiting
NCT04000451
A Therapy for Improving Symptoms in Patients With Acute Exacerbations of COPD by Hydrogen-Oxygen Generator With Neburlizer.No drug interventionstreatmentNot Availablecompleted
NCT05418777
Treatment of Pneumocystis in COPD (the TOPIC Study)treatment1 / 2terminated
NCT06495047
Assessing Optimal Inhaler Strategies During Acute Exacerbations of COPD (AECOPDs) Using OscillometryNo drug interventionsNot AvailableNot Availablerecruiting
NCT04140097
Predictors of Acute Exacerbation in Patients With COPD - an Observational StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT06544928
Study on Home Obstructive Respiratory ExacerbationsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04192175
Identification of Patients Admitted With COPD Exacerbations and Predicting Readmission Risk Using Machine LearningNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04710849
Relationship Between Plasma Metabolome and the Efficacy of Systemic Glucocorticoid in AECOPDNo drug interventionsNot AvailableNot Availableunknown_status
NCT06419036
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 1No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05703919
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatment4not_yet_recruiting
NCT06331416
Multiparametric Home Telemonitoring of Patients With Chronic Obstructive Pulmonary Disease ExacerbationNo drug interventionshealth_services_researchNot Availablerecruiting
NCT06274957
The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute ExacerbationNo drug interventionstreatmentNot Availablerecruiting
NCT05452226
Neuromuscular Electrical Stimulation in COPD/Community Acquired PneumoniaNo drug interventionstreatmentNot Availablerecruiting
NCT05734365
COPD-ICU Multicentre Prospective Observational RegisterNo drug interventionsNot AvailableNot Availablerecruiting
NCT06040931
Airway Inflammation, Small Airways Dysfunction, and Frequency of Exacerbations in COPDNo drug interventionsdiagnosticNot Availablecompleted
NCT05649891
Checklists Resuscitation Emergency DepartmentNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06419062
The Use of Medical Devices to Monitor Chronic Obstructive Pulmonary Disease Patients Study BREATH-TRACHER 2No drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04821869
ProAir Digihaler in COPD Disease Management: A Real World StudyNot AvailableNot Availablecompleted
NCT05400369
A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Diseasetreatment4recruiting
NCT03981081
Prednisone Reduction in ICU Patients With COPD Exacerbationtreatment4unknown_status
NCT03464695
Automated Oxygen Delivery by O2matic to Patients Admitted With an Exacerbation in COPDNo drug interventionstreatmentNot Availablecompleted
NCT03286855
Effectiveness of Vibrating Mesh Versus Small Volume Nebuliser in Chronic Obstructive Pulmonary Disease (COPD)No drug interventionstreatmentNot Availablecompleted
NCT03440060
Procalcitonin-guided Antibiotic Therapy During Severe Exacerbation of COPDNo drug interventionstreatmentNot Availableunknown_status
NCT03277001
Study of Prophylactic Effect of Rivaroxaban on Venous Thromboembolism in AECOPDtreatmentNot Availableunknown_status
NCT03823443
COPD Exacerbation Blood and Urine Biomarkers StudyNo drug interventionsNot AvailableNot Availableterminated
NCT03079661
Impact of Air Quality on Exacerbations of COPD in the SommeNo drug interventionsNot AvailableNot Availableterminated
NCT03466385
NHF vs NIV in Patients With Acute Exacerbation of COPDNo drug interventionstreatmentNot Availableunknown_status
NCT06123780
Pattern of Microbial Infection in AECOPD Patients and Its Sensitivity to AntibioticsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06143150
Prediction of Outcome of Non Invasive Ventilation COPD Patients by Assessment of Diaphragmatic PerformanceNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03751670
Pulmonary Rehabilitation During Acute Exacerbations of Chronic Obstructive Pulmonary Disease: a Mixed-methods ApproachNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT03083418
The Effect of EDP on Diaphragmatic Function and Neural Respiratory Drive in Patient With AECOPDNo drug interventionstreatmentNot Availablecompleted
NCT02985918
High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN TrialNo drug interventionstreatmentNot Availableterminated
NCT06189586
Comparison of Aerosol Inhalation and Intravenous Glucocorticoid in the Treatment of Severe AECOPDNo drug interventionstreatmentNot Availableenrolling_by_invitation
NCT04044625
Effects of High-intensity Noninvasive Positive Pressure Ventilation in AECOPDNo drug interventionstreatmentNot Availablecompleted
NCT04183530
The Individualized Accurate Diagnosis and Treatment of Chronic Objective Pulmonary Disease(COPD) Patients Based on Multidimensional DataNo drug interventionsNot AvailableNot Availablerecruiting
NCT02051166
Clinical Practice of AECOPD Management in ChinaNo drug interventionsNot AvailableNot Availablecompleted
NCT06175065
Safety, PK and PD Relationships of RLS-0071 in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatment2recruiting
NCT04212182
The Physiological Effect of High Flow Oxygen TherapyNo drug interventionstreatmentNot Availableunknown_status
NCT06114667
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic AcidosisNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04316312
The Inspiratory Muscle Activation Pattern and Training Efficacy in Patients With Chronic Obstructive Pulmonary Disease After Acute ExacerbationNo drug interventionstreatmentNot Availablecompleted
NCT05222711
The Use of a Monitoring Device by General Practitioners During Out-of-hours CareNo drug interventionsotherNot Availableunknown_status
NCT04101500
Effect of Compound Sodium Chlorate and Aminophylline Tablets on Chronic Obstructive Pulmonary Disease(COPD).treatment4recruiting
NCT06455670
Effects of Chinese Medicine on Patients With Severe Acute Exacerbation of COPDNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT04259736
Prospective Cohort Study of Molecular Mechanism of Lower Respiratory Tract Microbes in Patients With AECOPDNo drug interventionsNot AvailableNot Availableunknown_status
NCT06134063
A Clinical Study on the Efficacy and Safety of Xuanfei Baidu Granule in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary DiseaseNo drug interventionstreatmentNot Availablerecruiting
NCT03633838
Clinical Outcome of Corticosteroids in the Treatment of COPD Exacerbations in ChinaNo drug interventionsNot AvailableNot Availablecompleted
NCT00274222
The Role of Nebulized Budesonide in the Treatment of Acute Exacerbations of COPDNo drug interventionsNot AvailableNot Availableterminated
NCT05546606
CO2 Removal in Severe Acute exacerbatIons of Chronic Obstructive Lung DiseasesNo drug interventionsotherNot Availableactive_not_recruiting