Chlorpheniramine is a histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies. A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma.
- Mechanism
- Curator reviewed
Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
- Primary indication
- For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.Curator reviewed · 114 structured indications
- Formula / weight
- C16H19ClN2 · 274.788 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1987
- Also known as
- Chlorophenylpyridamine · Chlorphenamine · Chlorpheniramine polistirex
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
SOYKEARSMXGVTM-UHFFFAOYSA-NSMILESCN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1Transporters
What you can answer from here — as of September 23, 2026
4Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
2TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Chlorpheniramine, and which of those have an active Phase 3 trial?
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