Misc. Skin and Mucous Membrane Agents

Name
Misc. Skin and Mucous Membrane Agents
Accession Number
DBCAT003612
Description

Not Available

Drugs
DrugDrug Description
Collagenase clostridium histolyticumA collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease.
CalcitriolAn active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia.
AdapaleneA third-generation topical retinoid with anti-comedogenic, comedolytic, and anti-inflammatory properties used to treat acne vulgaris in adolescents and adults.
PimecrolimusA topical calcineurin inhibitor used in the treatment of mild-moderate atopic dermatitis who are not candidates for other types of therapy due to previous lack of response or other reasons.
MinoxidilAn antihypertensive vasodilating agent used for resistant hypertension that is symptomatic or has caused end organ damage.
AcitretinAn oral retinoid used in the treatment of severe psoriasis.
BrimonidineAn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
AlitretinoinA vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.
FluorouracilA pyrimidine analog used to treat basal cell carcinomas, and as an injection in palliative cancer treatment.
Azelaic acidA saturated dicarboxylic acid used to treat mild to moderate acne vulgaris.
ImiquimodA toll-like receptor 7 agonist used to treat non hyperkeratotic, non hypertrophic actinic keratosis, basal cell carcinoma, genital or perianal warts, and condyloma acuminata.
TazaroteneAn acetylenic retinoid used to treat fine wrinkles, mottled pigmentation of the skin, acne vulgaris, and plaque psoriasis.
TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
IsotretinoinA retinoid used to treat severe recalcitrant acne.
Methyl aminolevulinateA porphyrin precursor used to treat non-hyperkeratotic, non-pigmented actinic keratosis of the face and scalp.
PodofiloxA topical agent used for the treatment of external genital warts and perianal warts.
FinasterideAn antiandrogenic compound that is used for the treatment of symptomatic benign prostatic hyperplasia (BPH) and male pattern hair loss in adult males by inhibiting Type II 5-alpha reductase.
CalcipotriolA topical synthetic vitamin D2 derivative used in the treatment of plaque psoriasis.
Ingenol mebutateA topical agent used for the treatment of actinic keratosis.
EflornithineA medication used topically to reduce unwanted facial hair growth in women. The postulated mechanism of action is through irreversible inhibition of ornithine decarboxylase (ODC) in the skin.
SecukinumabAn immunomodulating agent and interleukin antagonist used to manage moderate to severe plaque psoriasis and active psoriatic arthritis or ankylosing spondylitis.
PodophyllinA cytotoxic agent used for the removal of soft genital (venereal) warts (condylomata acuminata).
Zinc sulfateA drug used to replenish low levels of zinc or prevent zinc deficiency, or to test for zinc deficiency.
DimethiconeAn ingredient used to treat dry and irritated eyes.
IxekizumabA monoclonal antibody used to treat moderate to severe plaque psoriasis.
BrodalumabA monoclonal antibody used to treat moderate to severe plaque psoriasis.
GuselkumabA monoclonal antibody used to treat moderate to severe plaque psoriasis.
DupilumabA monoclonal antibody used to treat moderate to severe atopic dermatitis, asthma, and nasal polyps accompanied by chronic rhinosinusitis in adolescents and adults.
Aminolevulinic acidA porphyrin precursor used to treat actinic keratosis of the face, scalp, and upper extremities, as well as to visualize a glioma.
UstekinumabA targeted antibody therapy used to manage inflammatory conditions such as plaque psoriasis, psoriatic arthritis, Crohn's Disease, and ulcerative colitis.
RisankizumabAn interleukin-23 antagonist used to treat moderate to severe plaque psoriasis.
TrifaroteneA topical retinoid indicated for the treatment of acne vulgaris.
Witch hazelAn ingredient used in a variety of natural health products.
Drugs & Drug Targets
DrugTargetType
Collagenase clostridium histolyticumCollagen alpha-1(I) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(II) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(III) chaintarget
CalcitriolVitamin D3 receptortarget
Calcitriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
CalcitriolCytochrome P450 3A4enzyme
CalcitriolHomeobox protein Hox-A10target
CalcitriolVitamin D-binding proteincarrier
AdapaleneRetinoic acid receptor betatarget
AdapaleneRetinoic acid receptor gammatarget
AdapaleneRetinoic acid receptor RXR-alphatarget
AdapaleneRetinoic acid receptor RXR-betatarget
AdapaleneRetinoic acid receptor RXR-gammatarget
AdapaleneTranscription factor AP-1target
AdapaleneRetinoic acid receptor alphatarget
AdapaleneAspartate aminotransferase, cytoplasmictarget
AdapaleneToll-like receptor 2target
PimecrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
PimecrolimusSerine/threonine-protein kinase mTORtarget
PimecrolimusCytochrome P450 3A4enzyme
MinoxidilATP-sensitive inward rectifier potassium channel 1target
MinoxidilProstaglandin G/H synthase 1target
MinoxidilRenintarget
MinoxidilUDP-glucuronosyltransferase 1-1enzyme
AcitretinRetinoic acid receptor alphatarget
AcitretinRetinoic acid receptor RXR-betatarget
AcitretinRetinoic acid receptor gammatarget
AcitretinRetinoic acid receptor betatarget
AcitretinRetinoic acid receptor RXR-gammatarget
AcitretinRetinoic acid receptor RXR-alphatarget
AcitretinSerum albumincarrier
AcitretinRetinol-binding protein 1target
AcitretinRetinoic acid receptor RXRtarget
BrimonidineAlpha-2A adrenergic receptortarget
BrimonidineAlpha-2B adrenergic receptortarget
BrimonidineAlpha-2C adrenergic receptortarget
BrimonidineAldehyde oxidaseenzyme
AlitretinoinRetinoic acid receptor alphatarget
AlitretinoinRetinoic acid receptor RXR-betatarget
AlitretinoinRetinoic acid receptor gammatarget
AlitretinoinRetinoic acid receptor betatarget
AlitretinoinRetinoic acid receptor RXR-gammatarget
AlitretinoinRetinoic acid receptor RXR-alphatarget
AlitretinoinCellular retinoic acid-binding protein 2carrier
AlitretinoinCellular retinoic acid-binding protein 1carrier
AlitretinoinP-glycoprotein 1transporter
AlitretinoinInsulin-like growth factor-binding protein 3target
AlitretinoinPregnancy-specific beta-1-glycoprotein 5target
AlitretinoinCytochrome P450 26C1target
FluorouracilThymidylate synthasetarget
FluorouracilCytochrome P450 1A2enzyme
FluorouracilThymidine phosphorylaseenzyme
FluorouracilSerum albumincarrier
FluorouracilCytochrome P450 2C9enzyme
FluorouracilDihydropyrimidine dehydrogenase [NADP(+)]enzyme
FluorouracilUridine phosphorylase 1enzyme
FluorouracilUridine phosphorylase 2enzyme
FluorouracilDNAtarget
FluorouracilRNAtarget
FluorouracilCytochrome P450 2A6enzyme
FluorouracilCytochrome P450 2C8enzyme
FluorouracilMethylenetetrahydrofolate reductaseenzyme
FluorouracilThymidylate synthaseenzyme
FluorouracilUridine 5'-monophosphate synthaseenzyme
FluorouracilAmidophosphoribosyltransferaseenzyme
FluorouracilSolute carrier family 22 member 7transporter
FluorouracilEquilibrative nucleoside transporter 1transporter
FluorouracilATP-binding cassette sub-family G member 2transporter
FluorouracilCanalicular multispecific organic anion transporter 2transporter
FluorouracilMultidrug resistance-associated protein 4transporter
FluorouracilMultidrug resistance-associated protein 5transporter
FluorouracilThyroxine-binding globulincarrier
Azelaic acid3-oxo-5-alpha-steroid 4-dehydrogenase 2target
Azelaic acidDNA polymerase Itarget
Azelaic acidThioredoxin reductasetarget
Azelaic acidTyrosinasetarget
Azelaic acid3-oxo-5-beta-steroid 4-dehydrogenasetarget
ImiquimodToll-like receptor 7target
ImiquimodToll-like receptor 8target
ImiquimodCytochrome P450 3A4enzyme
TazaroteneRetinoic acid receptor alphatarget
TazaroteneRetinoic acid receptor RXR-betatarget
TazaroteneRetinoic acid receptor gammatarget
TazaroteneRetinoic acid receptor betatarget
TazaroteneCytochrome P450 2C8enzyme
TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
TacrolimusCytochrome P450 3A4enzyme
TacrolimusCytochrome P450 3A5enzyme
TacrolimusP-glycoprotein 1transporter
TacrolimusATP-binding cassette sub-family A member 5transporter
TacrolimusSerum albumincarrier
TacrolimusAlpha-1-acid glycoprotein 1carrier
TacrolimusSolute carrier organic anion transporter family member 1B1transporter
IsotretinoinRetinoic acid receptor alphatarget
IsotretinoinSerum albumincarrier
IsotretinoinRetinoic acid receptor gammatarget
IsotretinoinCytochrome P450 3A4enzyme
PodofiloxDNA topoisomerase 2-alphatarget
PodofiloxTubulin alpha-4A chaintarget
PodofiloxTubulin beta chaintarget
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 1target
FinasterideCytochrome P450 3A4enzyme
Finasteride3-oxo-5-alpha-steroid 4-dehydrogenase 2target
Finasteride3-oxo-5-beta-steroid 4-dehydrogenasetarget
FinasterideCytochrome P450 3A5enzyme
FinasterideCytochrome P450 3A7enzyme
FinasterideSolute carrier family 12 member 5transporter
CalcipotriolVitamin D3 receptortarget
CalcipotriolMyeloperoxidaseenzyme
Calcipotriol1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialenzyme
Ingenol mebutateProtein kinase C delta typetarget
Ingenol mebutateProtein kinase C alpha typetarget
EflornithineOrnithine decarboxylasetarget
SecukinumabInterleukin-17Atarget
Zinc sulfateAlkaline phosphatase, placental-likeenzyme
IxekizumabInterleukin-17Atarget
GuselkumabInterleukin-23 subunit alphatarget
DupilumabInterleukin-4 receptor subunit alphatarget
Aminolevulinic acidDelta-aminolevulinic acid dehydratasetarget
Aminolevulinic acidSolute carrier family 15 member 1transporter
Aminolevulinic acidSolute carrier family 15 member 2transporter
UstekinumabInterleukin-12 subunit betatarget
UstekinumabInterleukin-23target
RisankizumabInterleukin-23target
TrifaroteneCytochrome P450 2C9enzyme
TrifaroteneCytochrome P450 3A4enzyme
TrifaroteneCytochrome P450 2C8enzyme
TrifaroteneCytochrome P450 2B6enzyme
TrifaroteneRetinoic acid receptor gammatarget
TrifaroteneRetinoic acid receptor alphatarget
TrifaroteneRetinoic acid receptor betatarget