Leukotriene Antagonists

Leukotriene Antagonists
Accession Number

A class of drugs designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.

ATC Classification
DrugDrug Description
MontelukastA leukotriene receptor antagonist used as part of an asthma therapy regimen, to prevent exercise induced bronchoconstriction, and to treat seasonal allergic rhinitis.
ZafirlukastA leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma.
PranlukastUsed as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists.
ZileutonA leukotriene synthesis inhibitor used in the prophylaxis and treatment of chronic asthma.
IbudilastFor the treatment of multiple sclerosis, asthma, and cerebrovascular disease.
Drugs & Drug Targets
MontelukastCysteinyl leukotriene receptor 1target
MontelukastArachidonate 5-lipoxygenasetarget
MontelukastCytochrome P450 3A4enzyme
MontelukastCytochrome P450 2C9enzyme
MontelukastCytochrome P450 2C8enzyme
MontelukastSolute carrier organic anion transporter family member 2B1transporter
MontelukastProstaglandin G/H synthase 1enzyme
MontelukastCytochrome P450 2A6enzyme
ZafirlukastCysteinyl leukotriene receptor 1target
ZafirlukastCytochrome P450 2C9enzyme
ZafirlukastCytochrome P450 2C8enzyme
ZafirlukastProstaglandin G/H synthase 1enzyme
ZafirlukastCytochrome P450 3A4enzyme
ZafirlukastCytochrome P450 1A2enzyme
ZafirlukastCytochrome P450 2C19enzyme
ZafirlukastATP-binding cassette sub-family G member 2transporter
ZafirlukastCytochrome P450 2D6enzyme
PranlukastTumor necrosis factortarget
PranlukastEosinophil cationic proteintarget
PranlukastNuclear factor NF-kappa-B p105 subunittarget
PranlukastCysteinyl leukotriene receptor 1target
PranlukastCytochrome P450 3A4enzyme
PranlukastCanalicular multispecific organic anion transporter 1transporter
PranlukastCytochrome P450 2C9enzyme
ZileutonArachidonate 5-lipoxygenasetarget
ZileutonCytochrome P450 2C9enzyme
ZileutonCytochrome P450 1A2enzyme
ZileutonCytochrome P450 3A4enzyme
ZileutonProstaglandin G/H synthase 1enzyme
ZileutonUDP-glucuronosyltransferase 1-9enzyme
ZileutonSerum albumincarrier
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
IbudilastcGMP-inhibited 3',5'-cyclic phosphodiesterase Atarget
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Ctarget
IbudilastcAMP-specific 3',5'-cyclic phosphodiesterase 4Dtarget