Lambert Eaton Myasthenic Syndrome (LEMS) (DBCOND0053084)

Identifiers

Synonyms

Eaton-Lambert Myasthenic Syndrome / Lambert Eaton Myasthenic Syndrome / Lambert-Eaton Myasthenic Syndrome (LEMS) / Lambert-Eaton Myasthenic Syndrome / Lambert-Eaton syndrome in neoplastic disease / Lambert-Eaton syndrome, unspecified / Eaton-Lambert syndrome (disorder) / Eaton-Lambert syndrome / Myasthenic syndrome

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amifampridine	A voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome.	Arylamine N-acetyltransferase 1enzyme Arylamine N-acetyltransferase 2enzyme Potassium voltage-gated channel subfamily A member 1target Solute carrier family 22 member 2transporter
Guanidine	A strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.	Ribonuclease pancreatictarget DNAtarget Disks large homolog 4target Endolysintarget Aldehyde dehydrogenase, mitochondrialtarget Guanidinoacetate N-methyltransferasetarget Arginasetarget Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Organic cation/carnitine transporter 2transporter Organic anion transporter 3transporter Solute carrier family 22 member 4transporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01511978	Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome	Amifampridine	treatment	2	completed
NCT00704925	Treatment of Lambert-Eaton Syndrome With 3,4 DAP	Amifampridine	Not Available	Not Available	no_longer_available
NCT01377922	A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS)	Amifampridine	treatment	3	completed
NCT00716066	Autologous Stem Cell Transplant for Neurologic Autoimmune Diseases	Aloe vera leaf Antilymphocyte immunoglobulin (horse) Antithymocyte immunoglobulin (rabbit) Ascorbic acid Beta-D-Glucose Carmustine Cortisone Cytarabine Etoposide Glycerin Mechlorethamine Nicotinamide Prednisone Vitamin A	treatment	2	active_not_recruiting
NCT01825395	Use of 3,4-Diaminopyridine in the Treatment of Lambert-Eaton Syndrome	No drug interventions	Not Available	Not Available	approved_for_marketing
NCT01378546	Treatment of Lambert-Eaton Myasthenic Syndrome (LEMS) With 3, 4 DAP	Amifampridine	Not Available	Not Available	no_longer_available
NCT02012933	3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM)	Amifampridine	Not Available	Not Available	no_longer_available
NCT05408702	Exercise in Autoimmune Myasthenia Gravis and Myasthenic Syndromes	No drug interventions	Not Available	Not Available	completed
NCT01373333	Use Of 3,4-Diaminopyridine (3,4-DAP) In The Treatment Of Lambert Eaton Myasthenic Syndrome	Amifampridine	Not Available	Not Available	no_longer_available
NCT00994916	Treatment of Lambert-Eaton Syndrome With 3,4 Diaminopyridine	Amifampridine	Not Available	Not Available	no_longer_available
NCT00004832	Randomized Study of 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome	Amifampridine	treatment	Not Available	completed
NCT06441825	Patient Observation With Environmental and Wearable Sensors in Myasthenia Gravis	No drug interventions	Not Available	Not Available	recruiting
NCT02189720	Expanded Access Study Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS),Congenital Myasthenic Syndrome	Amifampridine	Not Available	Not Available	no_longer_available
NCT02970162	Phase 3 Study to Evaluate Efficacy of Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS)	Amifampridine	treatment	3	completed
NCT00872950	3,4-Diaminopyridine Use in Lambert-Eaton Myasthenic Syndrome(LEMS) and Congenital Myasthenic Syndromes (CMS)	Amifampridine	Not Available	Not Available	approved_for_marketing