Monitored anesthesia care sedation (DBCOND0024701)

Identifiers

Synonyms

Monitored Anesthesia Care / Monitored anesthesia care sedation (procedure) / Monitored anaesthesia care sedation / Light anaesthesia / Light anesthesia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alfentanil	An opioid agonist used to induce and maintain anesthesia, as well as an analgesic.	Mu-type opioid receptortarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Alpha-1-acid glycoprotein 1carrier Albumincarrier Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter
Fospropofol	A sedative-­hypnotic agent indicated for monitored anesthesia care (MAC) sedation in adult patients undergoing diagnostic or therapeutic procedures.	Gamma-aminobutyric acid receptor subunit beta-2target Gamma-aminobutyric acid receptor subunit beta-3target Albumincarrier
Propofol	A medication used in general anesthesia and for sedation.	Cytochrome P450 2B6enzyme UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A9enzyme Gamma-aminobutyric acid receptor subunit beta-2target Gamma-aminobutyric acid receptor subunit beta-3target Albumincarrier Sodium channel protein type 4 subunit alphatarget Sodium channel protein type 2 subunit alphatarget Fatty-acid amide hydrolase 1enzyme Cytochrome P450 2C9enzyme UDP-glucuronosyltransferase 1A8enzyme Cytochrome P450 2E1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 1A1enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme UDP-glucuronosyltransferase 1-6enzyme GABA(A) Receptortarget ATP-dependent translocase ABCB1transporter
Remifentanil	An opioid analgesic used in anesthesia.	Mu-type opioid receptortarget Delta-type opioid receptortarget Kappa-type opioid receptortarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05137587	Importance of Integrated Pulmonary Index in Pediatric Bronchoscopy	Ketamine Propofol	diagnostic	Not Available	completed
NCT01308541	A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion	Fospropofol Propofol	treatment	1	completed
NCT05011617	Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass	No drug interventions	treatment	Not Available	completed
NCT06174168	The Decisiveness of MFI-11 in Predicting Complications in Patients > 65 Years Who Underwent EBUS-TBNA Under Sedation	No drug interventions	Not Available	Not Available	completed
NCT04123821	The Routine Use of Nasopharyngeal Airway in the Setting of Monitored Anesthesia Care During Gastrointestinal Endoscopy	No drug interventions	treatment	Not Available	completed
NCT05356819	The Value of Integrated Pulmonary Index Monitoring in Detecting Respiratory Events	No drug interventions	diagnostic	Not Available	completed
NCT05137574	Importance of Integrated Pulmonary Index in Pediatric Endoscopy	Ketamine Propofol	diagnostic	Not Available	completed
NCT03854812	Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery	Fentanyl Magnesium sulfate Propofol	supportive_care	2	completed