Acute Bacterial Skin and Skin Structure Infection (ABSSSI) (DBCOND0132808)

Identifiers

Synonyms

Acute Bacterial Skin and Skin Structure Infections / Acute Bacterial Skin and Skin Structure Infection / Acute Acute Bacterial Skin and Skin Structure Infections / Bacterial infection of skin (disorder) / Skin Diseases, Bacterial / Skin bacterial infection

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Ceftaroline fosamil	An antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia.	No drug targets
Dalbavancin	An antibacterial used to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible strains of Gram-positive bacteria.	D-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget Pancreatic triacylglycerol lipasetarget
Delafloxacin	A fluoroquinolone antibiotic used to treat skin and skin structure infections.	UDP-glucuronosyltransferase 1A1enzyme UDP-glucuronosyltransferase 1A3enzyme UDP-glucuronosyltransferase 2B15enzyme DNA topoisomerase 4 subunit Atarget DNA gyrase subunit Atarget Cytochrome P450 2E1enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme ATP-binding cassette sub-family B member 5transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier
Omadacycline	A tetracycline antibiotic used to treat community acquired bacterial pneumonia.	ATP-dependent translocase ABCB1transporter 30S ribosomal protein S3target 30S ribosomal protein S7target 30S ribosomal protein S8target 30S ribosomal protein S19target 30S ribosomal protein S14target 16S ribosomal RNAtarget Albumincarrier
Tedizolid	An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections.	23S ribosomal RNAtarget Amine oxidase [flavin-containing] Aenzyme Amine oxidase [flavin-containing] Benzyme
Tedizolid phosphate	An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections.	23S ribosomal RNAtarget Amine oxidase [flavin-containing] Aenzyme Amine oxidase [flavin-containing] Benzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06394518	Phase 1, Single-Dose and Multiple-Dose Continuous Intravenous Infusions of TNP-2092 for Injection in Healthy Chinese Participants	TNP-2092	treatment	1	completed
NCT03732365	Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds	Cefazolin	treatment	2	unknown_status
NCT03405064	Comparative Study of Levonadifloxacin (IV and Oral) With Linezolid (IV and Oral) in Acute Bacterial Skin and Skin Structure Infections (ABSSSI)	Levonadifloxacin Linezolid	treatment	3	completed
NCT02570490	Oral Sodium Fusidate (CEM-102) Versus Oral Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infections	Fusidic acid Linezolid	treatment	3	completed
NCT03176134	A Study of Safety and Efficacy of MK-1986 (Tedizolid Phosphate) and Comparator in Participants From Birth to Less Than 12 Years of Age With Acute Bacterial Skin and Skin Structure Infections (MK-1986-018)	Tedizolid phosphate	treatment	3	completed
NCT02961764	Evaluation of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)	Dalbavancin	treatment	4	completed
NCT01734694	Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients	Ceftaroline fosamil Daptomycin Linezolid Vancomycin	prevention	4	terminated
NCT03137173	Ceftobiprole in the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infections	Aztreonam Ceftobiprole Ceftobiprole medocaril Vancomycin	treatment	3	completed
NCT00949130	Comparative Study of NXL103 Versus Linezolid in Adults With Acute Bacterial Skin and Skin Structure Infections (ABSSSI)	Linezolid	treatment	2	completed
NCT03873987	Relative Exposure and Safety Study of Kimyrsa in ABSSSI Patients	Oritavancin	basic_science	1	completed
NCT05599295	Study to Evaluate the Safety and Tolerability of Single-Dose Intravenous (IV) Oritavancin	Oritavancin	treatment	2	recruiting
NCT04229511	Development of Risk Score Model and Decision Tree Algorithm for Predicting Infections With CRKp in Colonized Patients	No drug interventions	Not Available	Not Available	unknown_status
NCT02452918	A Study to Evaluate the Safety of a Single Intravenous (IV) Dose of Orbactiv (Oritavancin) in Participants on Chronic Warfarin Therapy Being Treated For Acute Bacterial Skin and Skin Structure Infection (ABSSSI)	Oritavancin Warfarin	treatment	4	completed
NCT04298463	Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of the Same Class in Patients With ABSSSI	Dalbavancin Daptomycin Teicoplanin Vancomycin	Not Available	Not Available	completed
NCT03233438	Development of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI)	Dalbavancin	treatment	4	completed