Depression, Involutional (DBCOND0028430)

Identifiers

Synonyms

Involutional Depression / Involutional melancholia / Involutional depression (disorder) / Major depressive disorder, single episode, unspecified / Major depressive disorder / Major depressive illness / Major depressive disorder (disorder) / Major depression / Major depressive disorder NOS / Depressive Disorder, Major

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Doxepin	A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.	Sodium-dependent serotonin transportertarget Sodium-dependent noradrenaline transportertarget Histamine H1 receptortarget Histamine H2 receptortarget Cytochrome P450 2D6enzyme Muscarinic acetylcholine receptor M1target Muscarinic acetylcholine receptor M2target Muscarinic acetylcholine receptor M3target Muscarinic acetylcholine receptor M4target Muscarinic acetylcholine receptor M5target Alpha-1A adrenergic receptortarget 5-hydroxytryptamine receptor 1Atarget 5-hydroxytryptamine receptor 2Atarget Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 1A2enzyme ATP-dependent translocase ABCB1transporter 5-hydroxytryptamine receptor 2Btarget 5-hydroxytryptamine receptor 2Ctarget Alpha-1B adrenergic receptortarget Alpha-1D adrenergic receptortarget Cytochrome P450 3A4enzyme 5-hydroxytryptamine receptor 6target Histamine H4 receptortarget Potassium voltage-gated channel subfamily H member 2target Albumincarrier Alpha-1-acid glycoprotein 1carrier

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00033787	Serotonin Function During Depression	No drug interventions	Not Available	Not Available	completed
NCT00078715	Rapid Antidepressant Effects of Yohimbine in Major Depression	Yohimbine	other	2	completed
NCT00001916	Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression	No drug interventions	Not Available	Not Available	completed
NCT00084162	Neurocardiac Control in Major Depression	No drug interventions	Not Available	Not Available	completed
NCT00001146	Omega-3 Fatty Acids in the Treatment of Bipolar Disorder: A Double-Blind, Placebo-Controlled Trial	Icosapent	treatment	2	completed
NCT00001170	Study of the Psychological Development of Children of Parents With and Without Affective Disorders	No drug interventions	Not Available	Not Available	completed
NCT00001413	Bone Mineral Density in Women With Major Depression	No drug interventions	Not Available	Not Available	completed
NCT00047944	MRI Study of Brain Activity and Risk for Depression in Adolescents	No drug interventions	Not Available	Not Available	completed
NCT00001969	Heart Disease Risk Factors in Major Depression	No drug interventions	Not Available	Not Available	completed
NCT00001543	Dynamics of Leptin and Endocrine Function	No drug interventions	Not Available	Not Available	completed