Achalasia (DBCOND0032922)

Identifiers

Synonyms

Achalasia of cardia / Achalasia (finding) / Cardiospasm / Achalasia oesophageal / Oesophageal achalasia / Achalasia esophageal / Esophageal achalasia / Achalasia cardiae / Oesophagus achalasia of / Achalasia of esophagus (disorder) / Esophagus achalasia of

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Nifedipine	A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.	Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent L-type calcium channel subunit beta-2target A-type voltage-gated potassium channel KCND3target Voltage-dependent T-type calcium channeltarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 3transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2B6enzyme Nuclear receptor subfamily 1 group I member 2target Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter Cytochrome P450 2C9enzyme Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 3A5enzyme Calmodulintarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01832779	Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia	No drug interventions	Not Available	Not Available	completed
NCT04641702	Comprehensive Esophageal Diagnostics Study	Atropine	treatment	4	recruiting
NCT03702647	Ropivacaine For Post-POEM Pain Control	Ropivacaine	other	Not Available	completed
NCT03546998	Epidermoid Cancer Development in Esophageal Achalasia	No drug interventions	Not Available	Not Available	recruiting
NCT02989883	Clinical Outcomes of Peroral Endoscopic Myotomy	No drug interventions	treatment	Not Available	unknown_status
NCT02259283	Prospective Study on the Feasibility and Results of POEM in Idiopathic Achalasia	No drug interventions	treatment	2	completed
NCT03450928	POEM: Long vs Short Myotomy for Achalasia. RCT	No drug interventions	treatment	Not Available	unknown_status
NCT02606578	Achalasia Patient Reported Outcomes	No drug interventions	Not Available	Not Available	terminated
NCT02073578	Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia	No drug interventions	treatment	Not Available	completed
NCT03587337	Risk of Microbial Translocation in Patients Undergoing Per-Oral Endoscopic Myotomy (POEM) for Achalasia: Antibiotic Prophylaxis or Short-therapy	No drug interventions	Not Available	Not Available	completed
NCT02482337	Per-Oral Endoscopic Myotomy for Esophageal Swallowing Disorders	No drug interventions	other	Not Available	active_not_recruiting
NCT02428959	Diagnostic Utility of Amyl Nitrite in Patients With Suspected Achalasia Undergoing High Resolution Esophageal Manometry (HREM)	Amyl Nitrite	diagnostic	Not Available	withdrawn
NCT06189859	Electrosurgical Modes for Endoscopic Submucosal Dissection in Peroral Endoscopic Esophageal Myotomy	No drug interventions	treatment	3	recruiting
NCT04752670	ConMed Beamer Study	No drug interventions	Not Available	Not Available	completed
NCT00604942	vMII for Measurement of Oesophageal Bolus Transport and Reflux	Domperidone Esomeprazole	diagnostic	Not Available	terminated
NCT04177342	Post Operative Pain Control of POEM Procedure	Fentanyl Oxycodone	treatment	4	unknown_status
NCT01692106	A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia	No drug interventions	treatment	Not Available	completed
NCT01770249	Evaluation of a Novel Endoscopic Treatment for Achalasia	No drug interventions	other	Not Available	completed
NCT05326113	The Effect of Physiotherapy on Post POEM Reflux	No drug interventions	treatment	Not Available	recruiting
NCT01402518	Per-Oral Endoscopic Myotomy	No drug interventions	Not Available	Not Available	completed
NCT01512719	POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders	No drug interventions	treatment	Not Available	unknown_status
NCT04180241	Development of Endoscopic Treatment for Achalasia	No drug interventions	treatment	Not Available	active_not_recruiting
NCT02314741	Peroral Endoscopic Myotomy (POEM) for Esophageal Motility	No drug interventions	treatment	Not Available	completed
NCT04770441	Transoral Incisionless Fundoplication in Post-POEM GERD	No drug interventions	Not Available	Not Available	completed
NCT05080634	Analysis of Prevalence and Risk Factors Associated With Gastroesophageal Reflux Disease and Esophagitis After Peroral Endoscopic Myotomy	No drug interventions	Not Available	Not Available	recruiting
NCT05905016	Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders	No drug interventions	Not Available	Not Available	recruiting
NCT04065516	ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia	No drug interventions	treatment	Not Available	unknown_status
NCT03228758	Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalasia	No drug interventions	treatment	Not Available	completed
NCT03063463	Mechanisms of Weight Loss in Patients Diagnosed With Achalasia	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT01863966	Hot Water Drinking Therapy in Achalasia	No drug interventions	treatment	Not Available	unknown_status
NCT03654066	Botox or Botox With Esophageal Dilation in Patients With Achalasia	Botulinum toxin type A	treatment	4	enrolling_by_invitation
NCT03875365	Institutional Outcome Data From Per-oral Plication of the Esophagus	No drug interventions	Not Available	Not Available	terminated
NCT00790465	Efficacy of Dark Chocolate in Achalasia Patients	No drug interventions	treatment	1 / 2	unknown_status
NCT01933373	A Prospective Study Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia	No drug interventions	treatment	Not Available	completed
NCT01399476	Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia	No drug interventions	treatment	Not Available	completed
NCT05550194	VZV in the Enteric Nervous System: Pathogenesis and Consequences	Human varicella-zoster immune globulin Valaciclovir Varicella zoster vaccine (recombinant)	treatment	4	recruiting
NCT01202929	Correlation of High Resolution Esophageal Manometry With Symptoms	No drug interventions	Not Available	Not Available	withdrawn
NCT02162589	Peroral Endoscopic Myotomy (POEM) For The Treatment Of Achalasia: A Registry	No drug interventions	Not Available	Not Available	unknown_status
NCT01799967	Minimally Invasive Surgery of the Gastro-esophageal Junction	No drug interventions	Not Available	Not Available	recruiting
NCT02086669	Pneumatic Dilatation or Surgical Myotomy for Achalasia	No drug interventions	treatment	2	completed
NCT06044155	redoPOEM : Failure of a First POEM	No drug interventions	Not Available	Not Available	completed
NCT01570621	Personalized Peroral Endoscopic Myotomy for Achalasia	No drug interventions	treatment	4	unknown_status
NCT00856921	Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients	No drug interventions	Not Available	Not Available	completed
NCT04640753	Peroral Endoscopic Myotomy for the Treatment of Achalasia	No drug interventions	Not Available	Not Available	recruiting
NCT04798547	Short Vs Standard Length Myotomy in Achalasia	No drug interventions	treatment	Not Available	completed
NCT01438398	Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia	No drug interventions	treatment	Not Available	completed
NCT05729971	Nasogastric Tube After Laparoscopic Heller-Dor Myotomy	No drug interventions	Not Available	Not Available	completed
NCT01524471	Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Primary Esophageal Motility Disorders	No drug interventions	Not Available	2	unknown_status
NCT01601678	Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia	No drug interventions	treatment	Not Available	completed
NCT01302288	Endolumenal Partial Myotomy for the Treatment of Esophageal Achalasia	No drug interventions	treatment	2	unknown_status
NCT04740437	Systematic IPP VS Symptomatic IPP in GERD Prevention After POEM for Achalasia. . A Comparative Retrospective Analysis	No drug interventions	Not Available	Not Available	unknown_status
NCT01525732	Per-Oral Endoscopic Myotomy (P.O.E.M.) for Treatment of Esophageal Motility Disorders	No drug interventions	treatment	Not Available	completed
NCT03411252	Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study	Mirabegron	treatment	0	terminated
NCT01873300	Endoscopic Myotomy for the Treatment of Achalasia (Motility Disorder) of the Esophagus - POEM Procedure	No drug interventions	treatment	1 / 2	completed
NCT02770859	Per-Oral Endoscopic Myotomy (POEM) for the Treatment of Achalasia, Database Repository	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT01405417	Endoscopic Peroral Myotomy for Treatment of Achalasia	No drug interventions	treatment	Not Available	terminated
NCT01584635	The Role That Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia	No drug interventions	treatment	Not Available	completed
NCT03123835	Outcome Analysis of POEM and Endoluminal Therapies	No drug interventions	treatment	Not Available	enrolling_by_invitation
NCT02454335	POEM Anterior Versus Posterior Approach	No drug interventions	treatment	Not Available	completed
NCT00204763	Comparison of Esophageal and Anorectal Manometry Catheters	No drug interventions	diagnostic	4	terminated
NCT01903486	Assessing the Efficacy of Steroid Treatment of Achalasia	Prednisone	treatment	4	withdrawn
NCT01793922	POEM Trial: Multi-center Study Comparing Endoscopic Pneumodilation and Per Oral Endoscopic Myotomy (POEM)	No drug interventions	treatment	Not Available	recruiting
NCT02931565	Study of IW-1701, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Type I or II Achalasia	Olinciguat	treatment	2	terminated
NCT01635374	Per-Oral Endoscopic Esophagomyotomy (POEM)	No drug interventions	treatment	Not Available	completed
NCT00519220	Outcome of Symptoms in Patients Undergoing a Heller Myotomy	No drug interventions	Not Available	Not Available	unknown_status
NCT06042127	POEM-F for Achalasia International Study	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT05772260	Autonomic Dysfunction and Hemodynamic Instability During Per-oral Endoscopic Myotomy	No drug interventions	Not Available	Not Available	recruiting
NCT02434991	Sensorimotor Dysfunction in Achalasia	No drug interventions	diagnostic	Not Available	withdrawn
NCT02055469	Achalasia: Mechanisms Underlying Treatment Failure	No drug interventions	Not Available	Not Available	terminated
NCT01405469	Endoscopic Peroral Myotomy for Treatment of Achalasia	No drug interventions	treatment	Not Available	completed
NCT04052581	Prospective Collection of Outcome Data Post POEM-TIF Procedure	No drug interventions	Not Available	Not Available	withdrawn
NCT05041608	Endoscopic Surgery for Gastrointestinal Disorders: A Multicenter Registry Study	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT05214443	POEM + F for Achalasia - a Pilot Study	No drug interventions	treatment	Not Available	recruiting
NCT02138643	Laparoscopy Heller Myotomy With Fundoplication Associated Versus Peroral Endoscopic Myotomy (POEM)	No drug interventions	treatment	Not Available	unknown_status