Advanced Ovarian Carcinoma (DBCOND0037455)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Carboplatin	A alkylating agent used to treat advanced ovarian cancer.	DNAtarget High affinity copper uptake protein 1transporter Protein SLC31A2transporter Xanthine dehydrogenase/oxidaseenzyme Myeloperoxidaseenzyme Glutathione S-transferase theta-1enzyme Metallothionein-1Aenzyme Metallothionein-2enzyme Superoxide dismutase [Cu-Zn]enzyme Glutathione S-transferase Penzyme Glutathione S-transferase Mu 1enzyme NAD(P)H dehydrogenase [quinone] 1enzyme Copper-transporting ATPase 1transporter Copper-transporting ATPase 2transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 2transporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06639074	Folate Receptor Alpha Dendritic Cells (FRαDCs) or Placebo for the Treatment of Patients With Stage III or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, FAROUT Trial	No drug interventions	treatment	2	not_yet_recruiting
NCT06630325	A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced, Recurrent Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer	Abemaciclib Carboplatin Doxorubicin Exemestane Fulvestrant Gefitinib Gemcitabine Letrozole Olaparib Osimertinib Paclitaxel Pemetrexed Tamoxifen Temozolomide Tetracycline	treatment	2	not_yet_recruiting
NCT04514484	Testing the Combination of the Anti-cancer Drugs XL184 (Cabozantinib) and Nivolumab in Patients With Advanced Cancer and HIV	Cabozantinib Nivolumab	treatment	1	active_not_recruiting
NCT05969860	At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients with Advanced Cancer	No drug interventions	health_services_research	2	recruiting
NCT06264921	A Study With NKT3447 for Adults With Advanced/Metastatic Solid Tumors	No drug interventions	treatment	1	recruiting
NCT05092373	Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax	Albumin human Atezolizumab Cabozantinib Paclitaxel	treatment	1	recruiting
NCT06586957	A Study with NKT3964 for Adults with Advanced/Metastatic Solid Tumors	No drug interventions	treatment	1	not_yet_recruiting
NCT02659241	Adavosertib Before Surgery in Treating Patients With Advanced High Grade Ovarian, Fallopian Tube, or Primary Peritoneal Cancer	Adavosertib	treatment	0	active_not_recruiting
NCT04616534	Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors	Elimusertib Gemcitabine	treatment	1	active_not_recruiting
NCT02650986	Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1	Cyclophosphamide Decitabine Lifileucel	treatment	1 / 2	active_not_recruiting
NCT05472857	Clinical Study of CLDN18.2-targeting CAR T Cells in Advanced Solid Tumors With Positive CLDN18.2 Expression	No drug interventions	treatment	1	recruiting
NCT05047926	Prehabilitation for Stage IIIC-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients	No drug interventions	supportive_care	Not Available	recruiting
NCT05733000	CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors	Devimistat Fluorouracil Gemcitabine Hydroxychloroquine Lipoic acid	treatment	2	recruiting
NCT04491942	Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer	Chloride ion Cisplatin Elimusertib Gemcitabine Platinum	treatment	1	active_not_recruiting
NCT05368506	ZN-c3 for the Treatment of Metastatic Triple-Negative Breast Cancer and Advanced Ovarian Cancer	Azenosertib	treatment	0	withdrawn
NCT04575935	Minimally Invasive Surgery After Neoadjuvant Chemotherapy for the Treatment of Stage IIIC-IV Ovarian, Primary Peritoneal, or Fallopian Tube Cancer, LANCE Trial	No drug interventions	treatment	3	recruiting
NCT05238831	SMMART Adaptive Clinical Treatment (ACT) Trial	Albumin human Alectinib Alpelisib Anastrozole Atezolizumab Bevacizumab Capecitabine Carboplatin Cobimetinib Entrectinib Eribulin Fulvestrant Hyaluronidase (human recombinant) Irinotecan Letrozole Niraparib Olaparib Paclitaxel Palbociclib Pertuzumab Trastuzumab Trastuzumab emtansine Vemurafenib Vinorelbine Vismodegib	treatment	0	withdrawn
NCT00511992	Study of Bevacizumab Followed by Bevacizumab Consolidation for Ovarian Cancer	Bevacizumab Cisplatin Paclitaxel	treatment	2	completed
NCT02270372	Study of ONT-10 and Varlilumab to Treat Advanced Ovarian or Breast Cancer	Varlilumab	treatment	1	completed
NCT05759923	First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients With Selected Advanced and/or Metastatic Solid Tumours	No drug interventions	treatment	1	recruiting