Relapsing Polychondritis (DBCOND0045626)

Identifiers

Synonyms

Polychondritis, Relapsing / Relapsing polychondritis / Chronic atrophic polychondritis / Relapsing polychondritis (disorder) / Polychondritis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Dapsone	A sulfone drug used to treat acne vulgaris, Hansen's disease, and dermatitis herpetiformis.	Inactive dihydropteroate synthase 2target Dihydropteroate synthasetarget Cytochrome P450 2C9enzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Flavin-containing monooxygenase 3enzyme Prostaglandin G/H synthase 1enzyme Prostaglandin G/H synthase 2enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C19enzyme Arylamine N-acetyltransferase 2enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Myeloperoxidaseenzyme Cytochrome P450 2C18enzyme
Prednisolone	A glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.	Corticosteroid-binding globulincarrier Cytochrome P450 3A4enzyme Glucocorticoid receptortarget Solute carrier organic anion transporter family member 1A2transporter ATP-dependent translocase ABCB1transporter Albumincarrier
Prednisone	A corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.	Glucocorticoid receptortarget Cytochrome P450 3A4enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2C19enzyme Albumincarrier Cytochrome P450 3A5enzyme Corticosteroid-binding globulincarrier Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2A6enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2B6enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme 11-beta-hydroxysteroid dehydrogenase 1enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02257866	Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis	No drug interventions	Not Available	Not Available	recruiting
NCT06019221	Pediatric Relapsing Polychondritis : Diagnosis and Management in a French Retrospective Study	No drug interventions	Not Available	Not Available	recruiting
NCT05168475	Biologics in Refractory Vasculitis	Infliximab Rituximab Tocilizumab	treatment	2	active_not_recruiting
NCT01041248	Single Patient Study to Treat Relapsing Polychondritis With Tocilizumab	Tocilizumab	treatment	Not Available	completed
NCT01104480	Tocilizumab for Relapsing Polychondritis	Tocilizumab	treatment	2	withdrawn
NCT04919538	Longitudinal Study for Relapsing Polychondritis	No drug interventions	Not Available	Not Available	recruiting
NCT03840928	PatientSpot Formerly Known as ArthritisPower	No drug interventions	Not Available	Not Available	recruiting
NCT01272856	Study on the Safety of Abatacept in Relapsing Polychondritis	Abatacept	treatment	1	completed
NCT04077736	Low-dose Recombinant Human IL-2 for the Treatment of Relapsing Polychondritis	Aldesleukin	treatment	2	completed