Erectile Dysfunction

Also known as: Sexual impotency / Difficult erection / Erectile Dysfunction (ED) / Impotency in men / Decreased erections / Erectile Dysfunctions / Male Erectile Disorder / Erectile Dysfunction, CTCAE / Male Erectile Dysfunction / Erectile difficulties / Male impotence / Inability to achieve or maintain erection / Difficulty maintaining an erection / Impotence / Erectile disorder / Male erectile disorder (disorder) / Impotence (disorder) / (Frigidity or impotence) or (lack or loss of libido) or (psychogen.dyspareunia) or (fear of ejaculation) or (premature ejaculation) / Erectile dysfunction NOS / Sexual impotence (finding) / [X] Failure of genital response (& [female sexual arousal disorder] or [male erectile disorder] or [psychogenic impotence]) / Impotent / Erectile disturbance / Erection failure / Psychogenic impotence / Psychogenic impotence (finding)

Drug	Drug Name	Drug Description
DB00770	Alprostadil	A medication used to treat erectile dysfunction.
DB06237	Avanafil	A phosphodiesterase 5 (PDE5) inhibitor used to treat erectile dysfunction.
DB04884	Dapoxetine	For the treatment of premature ejaculation.
DB00203	Sildenafil	A phosphodiesterase inhibitor used for the treatment of erectile dysfunction.
DB00820	Tadalafil	A phosphodiesterase 5 inhibitor used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
DB06267	Udenafil	Investigated for use/treatment in erectile dysfunction and hypertension.
DB00862	Vardenafil	A phosphodiesterase 5 inhibitor used to treat erectile dysfunction.

Drug	Drug Name	Target	Type
DB00770	Alprostadil	Prostaglandin E2 receptor EP2 subtype	target
DB00770	Alprostadil	Prostaglandin E2 receptor EP1 subtype	target
DB00770	Alprostadil	Multidrug resistance-associated protein 5	transporter
DB00770	Alprostadil	Solute carrier organic anion transporter family member 2B1	transporter
DB00770	Alprostadil	Solute carrier organic anion transporter family member 3A1	transporter
DB00770	Alprostadil	Multidrug resistance-associated protein 4	transporter
DB00770	Alprostadil	Solute carrier organic anion transporter family member 2A1	transporter
DB00770	Alprostadil	Prostaglandin D2 receptor 2	target
DB00770	Alprostadil	Solute carrier family 22 member 6	transporter
DB06237	Avanafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
DB06237	Avanafil	Cytochrome P450 3A4	enzyme
DB04884	Dapoxetine	5-hydroxytryptamine receptor 1A	target
DB04884	Dapoxetine	5-hydroxytryptamine receptor 1B	target
DB04884	Dapoxetine	5-hydroxytryptamine receptor 2C	target
DB04884	Dapoxetine	Cytochrome P450 3A4	enzyme
DB04884	Dapoxetine	Cytochrome P450 2D6	enzyme
DB00203	Sildenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
DB00203	Sildenafil	Cytochrome P450 2C9	enzyme
DB00203	Sildenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
DB00203	Sildenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
DB00203	Sildenafil	Cytochrome P450 3A4	enzyme
DB00203	Sildenafil	Cytochrome P450 3A5	enzyme
DB00203	Sildenafil	Cytochrome P450 3A7	enzyme
DB00203	Sildenafil	Multidrug resistance-associated protein 4	transporter
DB00203	Sildenafil	Multidrug resistance-associated protein 5	transporter
DB00203	Sildenafil	Multidrug resistance-associated protein 7	transporter
DB00203	Sildenafil	Cytochrome P450 2C19	enzyme
DB00203	Sildenafil	Cytochrome P450 2D6	enzyme
DB00203	Sildenafil	Cytochrome P450 2E1	enzyme
DB00203	Sildenafil	Solute carrier organic anion transporter family member 1B1	transporter
DB00203	Sildenafil	P-glycoprotein 1	transporter
DB00820	Tadalafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
DB00820	Tadalafil	Cytochrome P450 3A4	enzyme
DB00820	Tadalafil	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	target
DB00820	Tadalafil	Cytochrome P450 3A5	enzyme
DB06267	Udenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
DB06267	Udenafil	Cytochrome P450 3A4	enzyme
DB06267	Udenafil	Cytochrome P450 3A5	enzyme
DB00862	Vardenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
DB00862	Vardenafil	Cytochrome P450 3A4	enzyme
DB00862	Vardenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
DB00862	Vardenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
DB00862	Vardenafil	Cytochrome P450 3A5	enzyme
DB00862	Vardenafil	P-glycoprotein 1	transporter

Drug	Drug Name	Phase	Status	Count
DB00203	Sildenafil	0	Terminated	1
DB00624	Testosterone	0	Terminated	1
DB00381	Amlodipine	1	Completed	1
DB06237	Avanafil	1	Completed	8
DB01151	Desipramine	1	Completed	1
DB00590	Doxazosin	1	Completed	1
DB00584	Enalapril	1	Completed	1
DB11902	Gisadenafil	1	Completed	1
DB01026	Ketoconazole	1	Completed	1
DB12573	LY-2452473	1	Completed	1
DB11792	Mirodenafil	1	Completed	3
DB00218	Moxifloxacin	1	Completed	1
DB00727	Nitroglycerin	1	Completed	2
DB00338	Omeprazole	1	Completed	1
DB00503	Ritonavir	1	Completed	1
DB00412	Rosiglitazone	1	Completed	1
DB00203	Sildenafil	1	Completed	9
DB00820	Tadalafil	1	Completed	2
DB00706	Tamsulosin	1	Completed	4
DB06267	Udenafil	1	Completed	3
DB00862	Vardenafil	1	Completed	2
DB08893	Mirabegron	1 / 2	Completed	1
DB00203	Sildenafil	1 / 2	Completed	1
DB00862	Vardenafil	1 / 2	Unknown Status	1
DB00770	Alprostadil	2	Terminated	1
DB01217	Anastrozole	2	Completed	1
DB00125	Arginine	2	Completed	1
DB01076	Atorvastatin	2	Recruiting	1
DB06237	Avanafil	2	Completed	1
DB01128	Bicalutamide	2	Unknown Status	1
DB00083	Botulinum toxin type A	2	Completed	1
DB01156	Bupropion	2	Completed	1
DB00766	Clavulanic acid	2	Completed	1
DB01126	Dutasteride	2	Unknown Status	1
DB00016	Erythropoietin	2	Completed	1
DB06640	Fispemifene	2	Completed	1
DB06640	Fispemifene	2	Unknown Status	1
DB05814	GPI-1485	2	Completed	1
DB11902	Gisadenafil	2	Completed	1
DB12573	LY-2452473	2	Completed	1
DB08893	Mirabegron	2	Active Not Recruiting	1
DB11792	Mirodenafil	2	Terminated	1
DB00727	Nitroglycerin	2	Completed	1
DB12517	PF-00446687	2	Completed	1
DB00806	Pentoxifylline	2	Recruiting	1
DB01708	Prasterone	2	Completed	1
DB00203	Sildenafil	2	Completed	4
DB00820	Tadalafil	2	Completed	3
DB00820	Tadalafil	2	Unknown Status	1
DB00675	Tamoxifen	2	Unknown Status	1
DB00624	Testosterone	2	Completed	1
DB06267	Udenafil	2	Completed	2
DB06267	Udenafil	2	Withdrawn	1
DB00862	Vardenafil	2	Completed	3
DB00083	Botulinum toxin type A	2 / 3	Completed	1
DB00083	Botulinum toxin type A	2 / 3	Recruiting	1
DB00203	Sildenafil	2 / 3	Completed	1
DB00862	Vardenafil	2 / 3	Completed	1
DB00346	Alfuzosin	3	Completed	1
DB00770	Alprostadil	3	Terminated	1
DB06237	Avanafil	3	Completed	6
DB04884	Dapoxetine	3	Completed	4
DB04884	Dapoxetine	3	Not Yet Recruiting	1
DB00584	Enalapril	3	Recruiting	1
DB01095	Fluvastatin	3	Withdrawn	1
DB11792	Mirodenafil	3	Completed	2
DB00727	Nitroglycerin	3	Active Not Recruiting	1
DB00806	Pentoxifylline	3	Recruiting	1
DB09292	Sacubitril	3	Recruiting	1
DB00203	Sildenafil	3	Completed	4
DB00203	Sildenafil	3	Recruiting	1
DB00203	Sildenafil	3	Terminated	1
DB00203	Sildenafil	3	Unknown Status	2
DB00641	Simvastatin	3	Completed	1
DB00820	Tadalafil	3	Completed	15
DB00820	Tadalafil	3	Not Yet Recruiting	1
DB00820	Tadalafil	3	Terminated	1
DB00820	Tadalafil	3	Unknown Status	1
DB00706	Tamsulosin	3	Completed	1
DB00706	Tamsulosin	3	Not Yet Recruiting	1
DB00706	Tamsulosin	3	Unknown Status	1
DB00624	Testosterone	3	Completed	1
DB06267	Udenafil	3	Completed	6
DB00862	Vardenafil	3	Completed	21
DB00770	Alprostadil	4	Withdrawn	1
DB00125	Arginine	4	Completed	1
DB06237	Avanafil	4	Completed	3
DB06237	Avanafil	4	Unknown Status	1
DB04884	Dapoxetine	4	Active Not Recruiting	1
DB04884	Dapoxetine	4	Completed	1
DB00999	Hydrochlorothiazide	4	Completed	1
DB11927	Lodenafil carbonate	4	Completed	1
DB11927	Lodenafil carbonate	4	Withdrawn	1
DB04861	Nebivolol	4	Unknown Status	1
DB01037	Selegiline	4	Unknown Status	1
DB00203	Sildenafil	4	Active Not Recruiting	1
DB00203	Sildenafil	4	Completed	31
DB00203	Sildenafil	4	Unknown Status	4
DB00864	Tacrolimus	4	Completed	1
DB00820	Tadalafil	4	Active Not Recruiting	1
DB00820	Tadalafil	4	Completed	14
DB00820	Tadalafil	4	Unknown Status	3
DB00624	Testosterone	4	Completed	2
DB13944	Testosterone enanthate	4	Not Yet Recruiting	1
DB13946	Testosterone undecanoate	4	Completed	1
DB13946	Testosterone undecanoate	4	Unknown Status	1
DB00177	Valsartan	4	Completed	1
DB00862	Vardenafil	4	Completed	19
DB00862	Vardenafil	4	Unknown Status	4
DB01392	Yohimbine	4	Completed	1
DB02219	3-(cyclohexylamino)propanesulfonic acid	Not Available	Completed	1
DB00346	Alfuzosin	Not Available	Unknown Status	1
DB00770	Alprostadil	Not Available	Active Not Recruiting	1
DB00770	Alprostadil	Not Available	Unknown Status	1
DB00125	Arginine	Not Available	Completed	1
DB01373	Calcium	Not Available	Completed	1
DB01212	Ceftriaxone	Not Available	Completed	1
DB00586	Diclofenac	Not Available	Completed	1
DB00281	Lidocaine	Not Available	Completed	1
DB11792	Mirodenafil	Not Available	Terminated	1
DB00704	Naltrexone	Not Available	Completed	1
DB00203	Sildenafil	Not Available	Active Not Recruiting	1
DB00203	Sildenafil	Not Available	Completed	3
DB00203	Sildenafil	Not Available	Terminated	1
DB00203	Sildenafil	Not Available	Unknown Status	2
DB00820	Tadalafil	Not Available	Completed	3
DB00820	Tadalafil	Not Available	Recruiting	1
DB00820	Tadalafil	Not Available	Unknown Status	1
DB00706	Tamsulosin	Not Available	Completed	1
DB00862	Vardenafil	Not Available	Completed	6
DB00862	Vardenafil	Not Available	Terminated	1
DB00661	Verapamil	Not Available	Completed	1
DB01392	Yohimbine	Not Available	Completed	1