Name
Imides
Accession Number
DBCAT000725
Description

Organic compounds containing two acyl groups bound to NITROGEN.

Drugs
DrugDrug Description
ChlorthalidoneA diuretic used to treat hypertension or edema caused by heart failure, renal failure, hepatic cirrhosis, estrogen therapy, and other conditions.
LenalidomideA thalidomide derivative used to treat multiple myeloma and anemia in low to intermediate risk myelodysplastic syndrome.
EthosuximideAn anticonvulsant used to treat petit mal seizures.
PhensuximideFor the treatment of epilepsy.
ThalidomideA medication used to treat newly diagnosed multiple myeloma and erythema nodosum leprosum.
Pantothenic acidA vitamin B5 found in various nutritional supplements.
AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
MethsuximideA succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures.
PomalidomideA thalidomide analogue used in combination with dexamethasone to treat patients with multiple myeloma.
DexpanthenolAn alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).
PhosmetPhosmet is a phthalimide-derived organophosphate. It is a non-specific insecticide. It is mainly used on apple trees to control codling moths. It is also used on other fruit crops, ornamentals,...
RuboxistaurinRuboxistaurin has been investigated for the basic science of Type 2 Diabetes Mellitus and Type 1 Diabetes Mellitus.
LY-2090314Ly2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
SuccinimideNot Annotated
Hopantenic acidHopantenic acid (Pantogam) is a central nervous system depressant. Hopantenic acid has a unique spectrum of pharmacological effects (nootropic, anticonvulsant, mild activating) in the absence of addiction, hyperstimulation or withdrawal...
CEP-9722CEP-9722 is under investigation in clinical trial NCT01345357 (Study of CEP-9722 in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid Tumors or Mantle Cell Lymphoma).
AlbuvirtideAlbuvirtide is under investigation in clinical trial NCT03719664 (Albuvirtide and 3BNC117 as Long-Acting Maintenance Therapy in Virologically Suppressed Subjects).
GlucoraphaninGlucoraphanin is under investigation in clinical trial NCT01879878 (Pilot Study Evaluating Broccoli Sprouts in Advanced Pancreatic Cancer [POUDER Trial]).
PanthenolAn ingredient used in skin, hair care, and nutritional products but is not an approved medication.
Bisindolylmaleimide VIIINot Available
Bisindolylmaleimide INot Available
Bis(N-maleimidomethyl)etherNot Available
Drugs & Drug Targets
DrugTargetType
ChlorthalidoneSolute carrier family 12 member 1target
ChlorthalidoneSerum albumincarrier
ChlorthalidoneCarbonic anhydrase 1target
LenalidomideProstaglandin G/H synthase 2target
LenalidomideTumor necrosis factor ligand superfamily member 11target
LenalidomideCadherin-5target
LenalidomideProtein cereblontarget
LenalidomideP-glycoprotein 1transporter
EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
EthosuximideCytochrome P450 3A4enzyme
EthosuximideCytochrome P450 2E1enzyme
EthosuximideCytochrome P450 3A Subfamilyenzyme
ThalidomideTumor necrosis factortarget
ThalidomideNuclear factor NF-kappa-B p105 subunittarget
ThalidomideProstaglandin G/H synthase 2target
ThalidomideCytochrome P450 2C19enzyme
ThalidomideCytochrome P450 2C9enzyme
ThalidomideProstaglandin G/H synthase 1enzyme
ThalidomideProstaglandin G/H synthase 2enzyme
ThalidomideCytochrome P450 3A5enzyme
ThalidomideFibroblast growth factor receptor 2target
ThalidomideDNAtarget
ThalidomideProtein cereblontarget
Thalidomidealpha1-acid glycoproteintarget
Pantothenic acidPantothenate kinasetarget
AmonafideDNA topoisomerase 2-alphatarget
AmonafideDNA topoisomerase 2-betatarget
MethsuximideCytochrome P450 2C19enzyme
MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
PomalidomideCytochrome P450 1A2enzyme
PomalidomideCytochrome P450 3A4enzyme
PomalidomideP-glycoprotein 1transporter
PomalidomideProtein cereblontarget
PomalidomideTumor necrosis factortarget
PomalidomideProstaglandin G/H synthase 2target
Bisindolylmaleimide VIII3-phosphoinositide-dependent protein kinase 1target
Bisindolylmaleimide VIIIMyotonin-protein kinasetarget
Bisindolylmaleimide ISerine/threonine-protein kinase pim-1target
Bisindolylmaleimide I3-phosphoinositide-dependent protein kinase 1target
Bisindolylmaleimide IProtein kinase C iota typetarget
Bis(N-maleimidomethyl)etherAzurintarget