High-grade B Cell Lymphoma (HGBCL) (DBCOND0144835)

Identifiers

Synonyms
High-grade B Cell Lymphoma / High-grade B-cell Lymphoma (HGBL) / High Grade B Cell Lymphoma / High Grade B-cell Lymphoma (HGBCL) / High-grade B-cell Lymphoma (HGBCL) / High-grade B-cell Lymphoma / High Grade B-cell Lymphoma / High-grade B-cell lymphoma, NOS / High grade B-cell lymphoma (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Lisocabtagene maraleucel
A CAR T-cell therapy for treatment resistant or more severe B-cell lymphomas.
Polatuzumab vedotin
A CD79b antibody conjugate indicated to treat different types of large B-cell lymphoma.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT05757700
Study of 19(T2)28z1xx TRAC-Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell LymphomaNo drug interventionstreatment1recruiting
NCT01742988
Study to Assess the Safety, Tolerability and Pharmacokinetics of Fimepinostat (CUDC-907) in Patients With Lymphomatreatment1completed
NCT02623920
Brentuximab Vedotin, Bendamustine, and Rituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphomatreatment2withdrawn
NCT04792489
DALY II USA/ MB-CART2019.1 for DLBCLtreatment2recruiting
NCT02348216
Study Evaluating the Safety and Efficacy of KTE-C19 in Adult Participants With Refractory Aggressive Non-Hodgkin Lymphomatreatment1 / 2completed
NCT05733650
Expanded Access Program for EpcoritamabNot AvailableNot Availableapproved_for_marketing
NCT03625037
First-in-Human (FIH) Trial in Patients With Relapsed, Progressive or Refractory B-Cell Lymphomatreatment1 / 2active_not_recruiting
NCT04745559
Optimizing Cellular and Humoral Immunity by Vaccinating With PCV13 Before and After CAR-T Therapytreatment2recruiting
NCT05619367
A Compassionate Use (CU) Program of OdronextamabNot AvailableNot Availableavailable
NCT06208735
CLIC-2201 for the Treatment of Relapsed/Refractory B Cell MalignanciesNo drug interventionstreatment1not_yet_recruiting
NCT06458439
Epcoritamab-CAR T Cells for Large B-cell Lymphomastreatment2recruiting
NCT04542824
Trial of the Safety and Efficacy of Epcoritamab in Japanese Subjects With R/R B-NHLtreatment1 / 2active_not_recruiting
NCT04594642
A Study of AZD0486 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomatreatment1recruiting
NCT05544019
Study of SGR-1505 in Mature B-Cell NeoplasmsNo drug interventionstreatment1recruiting
NCT06544265
SynKIR-310 for Relapsed/Refractory B-NHLNo drug interventionstreatment1recruiting
NCT06588205
Exploring the Clinical Impact of MYC Aberrations and Their Relationship with Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade C Cell LymphomaNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT04257578
Acalabrutinib and Anti-CD19 CAR T-cell Therapy for the Treatment of B-cell Lymphomatreatment1 / 2recruiting
NCT03656835
Nanochip Technology in Monitoring Treatment Response and Detecting Relapse in Participants With Diffuse Large B-Cell LymphomaNo drug interventionsdiagnosticNot Availablerecruiting
NCT05455697
Tafasitamab, Retifanlimab, and Rituximab in Combination With Standard Therapy for the Treatment of Diffuse Large B-cell Lymphomatreatment1 / 2recruiting
NCT05890352
Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatmenttreatment2recruiting
NCT04855253
Study of E7777 Prior to Kymriah for R/R DLBCLtreatment1 / 2recruiting
NCT06287398
Epcoritamab (Epcor)-Containing Combination Salvage Therapy Followed by ASCT & Epcor Consolidation in Patients With Relapsed LBCLtreatment2recruiting
NCT05263583
Sepantronium Bromide for the Treatment of High-grade B-cell Lymphomatreatment2recruiting
NCT03620578
DA-EPOCH-R Induction Followed by Nivolumab Consolidation in Newly Diagnosed MYC, BCL2 and/or BCL6 Rearranged HGBLtreatment2active_not_recruiting
NCT04836507
Study of Efficacy and Safety of CRC01 in Adult Large B-cell Lymphoma Patientstreatment1 / 2recruiting
NCT01809600
Retrospective Analysis of Rituximab-containing Immunochemotherapy for Burkitt's or Burkitt-like Lymphoma in AdultsNo drug interventionsNot AvailableNot Availablecompleted
NCT04476459
Camrelizumab in Combination With Apatinib in Refractory and Relapsed DLBCLtreatment1 / 2unknown_status
NCT04058470
Toripalimab Plus Rituximab Followed by R-CHOP for Elderly Patients With Untreated Diffused B Cell Lymphomatreatment1 / 2recruiting
NCT06026319
CD79b-19 CAR T Cells in Non-Hodgkin Lymphomatreatment1recruiting
NCT05256641
Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphomatreatment1 / 2recruiting
NCT06550141
Emapalumab Prevention of CAR-T Cell Associated Toxicitiestreatment2not_yet_recruiting
NCT04914741
A Multicentre, Parallel Arm, Open-label Trial of Frontline R-CHOP/Pola-RCHP and Glofitamab in Younger, Higher Risk Patients With Diffuse Large B Cell Lymphoma (DLBCL)treatment1 / 2active_not_recruiting
NCT04933617
Copanlisib With Dose-Adjusted EPOCH-R in Relapsed and Refractory Burkitt Lymphoma and Other High-Grade B-cell Lymphomastreatment1terminated
NCT03255096
A Study to Evaluate Safety, Pharmacokinetics, and Clinical Activity of Combination of RO6870810 and Venetoclax, With or Without Rituximab, in Participants With Relapsed/Refractory DLBCL and/or High-Grade B-Cell Lymphoma and/or High Grade B-Cell Lymphoma With MYC and/or BCL2 and/or BCL6treatment1completed
NCT05621096
Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphomatreatment1recruiting
NCT04358458
First-in-Human (FIH) Trial of GEN3009 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomastreatment1 / 2terminated
NCT04796857
Tislelizumab in Combination With Lenalidomide in Refractory and Relapsed Elderly Patients With Non-GCB DLBCLtreatment1 / 2unknown_status
NCT06249191
Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphomatreatment1 / 2recruiting
NCT06015880
Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphomatreatment1recruiting
NCT03036904
Study of Venetoclax Plus DA-EPOCH-R for the Treatment of Aggressive B-Cell Lymphomastreatment1completed
NCT06014762
P-CD19CD20-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With B Cell Malignanciestreatment1recruiting
NCT05464329
Mosunetuzumab in Combination With Platinum-Based Salvage Chemotherapy in Autologous Stem Cell Transplant-Eligible Patients With Relapsed/Refractory Aggressive B Cell Lymphomatreatment1recruiting
NCT04858568
Immune Responses to COVID-19 Vaccination in Lymphoma PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05660395
A Study to Evaluate the Pharmacokinetics and Safety of Loncastuximab Tesirine in Participants With Relapsed or Refractory Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma With Hepatic Impairment (LOTIS-10)basic_science1recruiting
NCT04503538
Telemedicine for Early Detection of Cytokine Release Syndrome and NeurotoxicityNo drug interventionssupportive_careNot Availablewithdrawn
NCT05412290
Mosunetuzumab Consolidation Therapy After autoSCT in r/r Aggressive B Cell Lymphomatreatment1recruiting
NCT03132584
Cyclophosphamide and Alemtuzumab In Lymphomatreatment1terminated
NCT03995147
Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphomatreatment2recruiting
NCT04300998
Study of CAR-T Therapy in Older PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04555811
FT596 With Rituximab as Relapse Prevention After Autologous HSCT for NHLtreatment1completed
NCT06343311
T-Cell Therapy (EB103) in Adults With Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)No drug interventionstreatment1 / 2recruiting
NCT04226937
DLBCL Interim Response Evaluation for Customised TherapyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04205838
Anakinra in Preventing Severe Chimeric Antigen Receptor T-Cell Related Encephalopathy Syndrome in Patients With Recurrent or Refractory Large B-cell Lymphomaprevention2recruiting
NCT01859819
Treatment for Advanced B-Cell Lymphomatreatment2completed
NCT06093841
Relmacabtagene Autoleucel as Second-Line Therapy in Adult Patients With Aggressive B-cell NHLtreatment2not_yet_recruiting
NCT04844086
RPM CD19-mbIL15-CAR-T Cells in Patient With Advanced Lymphoid MalignanciesNo drug interventionstreatment1terminated
NCT05834426
Omic Technologies Applied to the Study of B-cell Lymphoma for the Discovery of Diagnostic and Prognosis BiomarkersNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03837873
DLCL002 Protocol for Patients With High Risk Aggressive B-cell Lymphomatreatment2unknown_status
NCT04479267
Polatuzumab Vedotin and Combination Chemotherapy for the Treatment of Previously Untreated Lymphomatreatment2recruiting
NCT06004167
Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)No drug interventionstreatmentNot Availablerecruiting
NCT04067414
Exploratory Study of CD19-targeted Chimeric Antigen Receptor T Cells(BZ019) for Relapsed and Refractory B-cell LymphomaNo drug interventionstreatment1unknown_status